TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
rrs	1472127	n.282C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472128	n.283G>C	non_coding_transcript_exon_variant	1.0	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472129	n.284G>A	non_coding_transcript_exon_variant	0.88	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472151	n.306C>A	non_coding_transcript_exon_variant	0.83	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.88	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472181	n.336G>A	non_coding_transcript_exon_variant	0.63	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472223	n.378C>G	non_coding_transcript_exon_variant	0.7	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472225	n.380C>A	non_coding_transcript_exon_variant	0.81	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472228	n.383G>C	non_coding_transcript_exon_variant	0.71	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472338	n.493A>C	non_coding_transcript_exon_variant	0.81	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472379	n.534T>G	non_coding_transcript_exon_variant	0.89	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472382	n.537G>A	non_coding_transcript_exon_variant	0.81	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472389	n.544G>A	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472396	n.551A>T	non_coding_transcript_exon_variant	0.9	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472405	n.560C>T	non_coding_transcript_exon_variant	0.74	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.91	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472537	n.692C>T	non_coding_transcript_exon_variant	0.91	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.9	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472571	n.726G>C	non_coding_transcript_exon_variant	0.97	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472573	n.728C>T	non_coding_transcript_exon_variant	0.69	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472574	n.729T>A	non_coding_transcript_exon_variant	0.59	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472579	n.734G>A	non_coding_transcript_exon_variant	0.97	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472581	n.736A>T	non_coding_transcript_exon_variant	0.7	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472592	n.747C>T	non_coding_transcript_exon_variant	0.51	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472598	n.753A>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472599	n.754G>T	non_coding_transcript_exon_variant	0.89	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472616	n.771G>A	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472647	n.802C>T	non_coding_transcript_exon_variant	0.46	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472655	n.810G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472715	n.870C>T	non_coding_transcript_exon_variant	1.0	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472716	n.871C>T	non_coding_transcript_exon_variant	0.73	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472719	n.874G>A	non_coding_transcript_exon_variant	0.85	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472733	n.888G>T	non_coding_transcript_exon_variant	0.79	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472734	n.889C>T	non_coding_transcript_exon_variant	0.61	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472741	n.896G>A	non_coding_transcript_exon_variant	0.51	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472742	n.897C>A	non_coding_transcript_exon_variant	0.79	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472744	n.899A>G	non_coding_transcript_exon_variant	0.9	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472767	n.922G>A	non_coding_transcript_exon_variant	0.71	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472781	n.936C>T	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472793	n.948A>T	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472803	n.958T>A	non_coding_transcript_exon_variant	0.9	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472828	n.983T>C	non_coding_transcript_exon_variant	0.85	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472895	n.1050C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473004	n.1159T>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473005	n.1160C>T	non_coding_transcript_exon_variant	0.6	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1473020	n.1175T>C	non_coding_transcript_exon_variant	0.61	kanamycin
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473053	n.1208T>A	non_coding_transcript_exon_variant	0.81	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473054	n.1209C>T	non_coding_transcript_exon_variant	0.44	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.48	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473062	n.1217T>A	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473068	n.1223A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrl	1474199	n.542G>C	non_coding_transcript_exon_variant	0.6	capreomycin
rrl	1474199	n.542G>C	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1474200	n.545delT	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1474200	n.545delT	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1474208	n.551C>T	non_coding_transcript_exon_variant	0.83	capreomycin
rrl	1474208	n.551C>T	non_coding_transcript_exon_variant	0.83	linezolid
rrl	1474213	n.556G>A	non_coding_transcript_exon_variant	0.86	capreomycin
rrl	1474213	n.556G>A	non_coding_transcript_exon_variant	0.86	linezolid
rrl	1474218	n.561T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474218	n.561T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474228	n.571T>G	non_coding_transcript_exon_variant	0.74	capreomycin
rrl	1474228	n.571T>G	non_coding_transcript_exon_variant	0.74	linezolid
rrl	1474252	n.595T>A	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1474252	n.595T>A	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1474563	n.906G>A	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1474563	n.906G>A	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1474584	n.927C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474584	n.927C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474586	n.929T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474586	n.929T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474594	n.937G>C	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1474594	n.937G>C	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1474597	n.940T>A	non_coding_transcript_exon_variant	0.64	capreomycin
rrl	1474597	n.940T>A	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.66	capreomycin	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.66	linezolid	Uncertain significance
rrl	1476381	n.2724G>A	non_coding_transcript_exon_variant	0.47	capreomycin
rrl	1476381	n.2724G>A	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.54	capreomycin	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.54	linezolid	Uncertain significance
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.52	capreomycin	Uncertain significance
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.52	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.67	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.66	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.66	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.8	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result