TB-Profiler result

Run: ERR036200
Summary

Run ID: ERR036200

Sample name:

Date: 31-03-2023 08:29:33

Number of reads: 4396522

Percentage reads mapped: 86.35

Strain: lineage4.1.2

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 575932 p.Glu195Asp missense_variant 0.25
rpoB 759831 p.Thr9Pro missense_variant 0.33
rpoC 762836 c.-534C>G upstream_gene_variant 0.3
rpoC 765150 p.Gly594Glu missense_variant 1.0
rpoC 767305 p.Tyr1312* stop_gained 0.19
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpR5 779371 p.Ala128Pro missense_variant 0.26
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
embR 1417140 p.Ala70Ser missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472138 n.293C>T non_coding_transcript_exon_variant 0.18
rrs 1472147 n.302G>A non_coding_transcript_exon_variant 0.2
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.21
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.21
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.21
rrs 1472697 n.852T>G non_coding_transcript_exon_variant 0.12
rrs 1472700 n.855C>T non_coding_transcript_exon_variant 0.13
rrs 1472708 n.863T>A non_coding_transcript_exon_variant 0.22
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.38
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.39
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.38
rrs 1472786 n.941C>T non_coding_transcript_exon_variant 0.34
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.31
rrs 1472803 n.958T>C non_coding_transcript_exon_variant 0.27
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.15
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.11
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.25
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.22
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.21
rrs 1472958 n.1113A>T non_coding_transcript_exon_variant 0.22
rrs 1472975 n.1130T>A non_coding_transcript_exon_variant 0.18
rrs 1472982 n.1137G>A non_coding_transcript_exon_variant 0.11
rrs 1473150 n.1305T>G non_coding_transcript_exon_variant 0.1
rrs 1473161 n.1316A>C non_coding_transcript_exon_variant 0.18
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.19
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.3
rrs 1473194 n.1349A>G non_coding_transcript_exon_variant 0.3
rrs 1473343 n.1498G>T non_coding_transcript_exon_variant 0.22
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 0.13
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.14
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.16
rrl 1474228 n.571T>C non_coding_transcript_exon_variant 0.17
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.11
rrl 1474380 n.723G>T non_coding_transcript_exon_variant 0.28
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.18
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.1
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.15
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.15
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.12
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.12
rrl 1476229 n.2572C>G non_coding_transcript_exon_variant 0.12
rrl 1476251 n.2594T>A non_coding_transcript_exon_variant 0.11
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.11
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.14
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.14
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.18
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.21
rrl 1476353 n.2696G>A non_coding_transcript_exon_variant 0.25
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.25
rrl 1476359 n.2702C>T non_coding_transcript_exon_variant 0.25
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.32
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.32
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.41
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.42
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.4
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.41
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.32
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.28
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.28
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.24
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.13
fabG1 1673249 c.-191C>T upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169866 c.747G>C synonymous_variant 0.37
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.19
eis 2715586 c.-254G>C upstream_gene_variant 0.46
ahpC 2725954 c.-239C>T upstream_gene_variant 0.27
folC 2747022 p.Val193Ile missense_variant 1.0
pepQ 2859381 c.1038C>G synonymous_variant 0.28
pepQ 2859974 p.Ala149Pro missense_variant 0.17
ribD 2987307 p.Ala157Pro missense_variant 0.27
Rv2752c 3064741 p.Gly484Ala missense_variant 0.32
thyA 3073806 c.666C>G synonymous_variant 0.35
thyA 3074654 c.-183T>G upstream_gene_variant 0.26
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448894 p.Tyr131Asp missense_variant 1.0
Rv3083 3449642 p.Asn380Ser missense_variant 0.99
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fbiA 3641164 p.Ile208Val missense_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.31
ddn 3987013 p.Gly57Ala missense_variant 0.22
clpC1 4038857 c.1848C>A synonymous_variant 0.32
clpC1 4039363 p.Ala448Pro missense_variant 0.29
clpC1 4039932 p.Gly258Val missense_variant 0.2
embC 4241429 p.Phe523Val missense_variant 0.31
embC 4242425 p.Arg855Gly missense_variant 0.18
embC 4242476 p.Pro872Ala missense_variant 0.25
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 0.98
embC 4242822 p.Val987Gly missense_variant 0.43
embC 4242827 p.Leu989Val missense_variant 0.29
aftB 4268861 c.-25T>C upstream_gene_variant 0.98
ubiA 4269529 p.Ala102Gly missense_variant 0.2
ethA 4327672 c.-199G>A upstream_gene_variant 0.3
whiB6 4338595 c.-75delG upstream_gene_variant 1.0