TB-Profiler result

Run: ERR245846
Summary

Run ID: ERR245846

Sample name:

Date: 31-03-2023 18:24:49

Number of reads: 12315195

Percentage reads mapped: 87.76

Strain: lineage2.2.1

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 5347 c.108G>C synonymous_variant 0.15
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8445 p.Arg382Gly missense_variant 0.24
gyrA 9304 p.Gly668Asp missense_variant 0.99
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 759831 p.Thr9Pro missense_variant 0.22
rpoB 762249 p.Leu815Val missense_variant 0.19
rpoC 762836 c.-534C>G upstream_gene_variant 0.33
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764725 p.Phe452Leu missense_variant 0.21
rpoC 767305 p.Tyr1312* stop_gained 0.21
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 0.99
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
embR 1417501 c.-154A>C upstream_gene_variant 0.27
atpE 1461019 c.-26C>A upstream_gene_variant 0.22
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.22
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.24
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.29
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.32
rrs 1472151 n.306C>A non_coding_transcript_exon_variant 0.22
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.31
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.13
rrs 1472338 n.493A>C non_coding_transcript_exon_variant 0.15
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.22
rrs 1472379 n.534T>G non_coding_transcript_exon_variant 0.26
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.16
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.19
rrs 1472541 n.696T>G non_coding_transcript_exon_variant 0.13
rrs 1472544 n.699C>G non_coding_transcript_exon_variant 0.13
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.13
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.21
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.18
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.29
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.11
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.36
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.37
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.32
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.13
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.15
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.29
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.33
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.36
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.23
rrs 1472779 n.934G>A non_coding_transcript_exon_variant 0.23
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.43
rrs 1472786 n.941C>T non_coding_transcript_exon_variant 0.25
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.42
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.34
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.12
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.12
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.2
rrs 1473053 n.1208T>A non_coding_transcript_exon_variant 0.21
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.2
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.21
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.19
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.12
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.15
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.14
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.13
rrs 1473343 n.1498G>T non_coding_transcript_exon_variant 0.2
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.13
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.13
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.11
rrl 1474844 n.1187G>T non_coding_transcript_exon_variant 0.2
rrl 1474866 n.1209C>A non_coding_transcript_exon_variant 0.23
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.23
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.2
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 0.19
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.18
rrl 1474913 n.1256T>A non_coding_transcript_exon_variant 0.16
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.16
rrl 1475672 n.2015C>G non_coding_transcript_exon_variant 0.12
rrl 1475673 n.2016T>C non_coding_transcript_exon_variant 0.13
rrl 1475687 n.2030C>T non_coding_transcript_exon_variant 0.23
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.25
rrl 1475699 n.2042C>T non_coding_transcript_exon_variant 0.18
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 0.25
rrl 1475707 n.2050T>A non_coding_transcript_exon_variant 0.25
rrl 1475716 n.2059A>G non_coding_transcript_exon_variant 0.25
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.27
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.27
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.34
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.34
rrl 1475843 n.2186G>A non_coding_transcript_exon_variant 0.16
rrl 1475849 n.2192G>A non_coding_transcript_exon_variant 0.14
rrl 1475853 n.2196C>T non_coding_transcript_exon_variant 0.13
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.26
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.16
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.16
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.11
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.17
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.16
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.26
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.18
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.45
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.47
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.56
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.6
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.6
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.78
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.63
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.71
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.25
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.5
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.4
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.2
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.1
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.12
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.11
fabG1 1673449 p.Thr4Pro missense_variant 0.43
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102891 p.Phe51Ser missense_variant 0.21
ndh 2103226 c.-184C>G upstream_gene_variant 0.99
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2169866 c.747G>C synonymous_variant 0.36
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.32
eis 2715586 c.-254G>C upstream_gene_variant 0.52
ahpC 2725954 c.-239C>T upstream_gene_variant 0.27
folC 2746186 c.1413G>C synonymous_variant 0.24
pepQ 2859381 c.1038C>G synonymous_variant 0.22
Rv2752c 3064552 p.Arg547Pro missense_variant 0.15
ald 3086739 c.-81G>A upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3449058 p.Ser185Arg missense_variant 0.28
Rv3083 3449673 p.Tyr390* stop_gained 0.22
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.26
fbiB 3642734 c.1200G>C synonymous_variant 0.27
ddn 3987013 p.Gly57Ala missense_variant 0.27
clpC1 4039363 p.Ala448Pro missense_variant 0.32
clpC1 4039932 p.Gly258Val missense_variant 0.24
embC 4241429 p.Phe523Val missense_variant 0.42
embC 4241456 p.Ala532Pro missense_variant 0.36
embC 4242476 p.Pro872Ala missense_variant 0.15
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.3
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4243977 p.Ala249Pro missense_variant 0.31
aftB 4267647 p.Asp397Gly missense_variant 1.0
ubiA 4269529 p.Ala102Gly missense_variant 0.15
ethA 4327672 c.-199G>A upstream_gene_variant 0.37
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0