TB-Profiler result

Run: ERR751310
Summary

Run ID: ERR751310

Sample name:

Date: 02-04-2023 04:24:15

Number of reads: 3345612

Percentage reads mapped: 65.37

Strain: lineage5.1.3

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage5 West-Africa 1 AFRI_2;AFRI_3 RD711 1.0
lineage5.1.3 West-Africa 1 AFRI_2;AFRI_3 RD711 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6446 p.Ala403Ser missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9566 c.2265C>T synonymous_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764335 c.966G>A synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781676 c.117C>T synonymous_variant 1.0
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0
Rv1258c 1407273 p.Asp23Val missense_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.13
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.21
rrs 1472128 n.283G>C non_coding_transcript_exon_variant 0.2
rrs 1472129 n.284G>A non_coding_transcript_exon_variant 0.22
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.31
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.36
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.36
rrs 1472164 n.319G>A non_coding_transcript_exon_variant 0.43
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.44
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.48
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.47
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.39
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.3
rrs 1472253 n.408G>C non_coding_transcript_exon_variant 0.26
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.25
rrs 1472271 n.426T>C non_coding_transcript_exon_variant 0.15
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.23
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.26
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.25
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.25
rrs 1472579 n.734G>A non_coding_transcript_exon_variant 0.25
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.26
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.28
rrs 1472599 n.754G>A non_coding_transcript_exon_variant 0.27
rrs 1472606 n.761C>T non_coding_transcript_exon_variant 0.3
rrs 1472645 n.800G>A non_coding_transcript_exon_variant 0.15
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.13
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.28
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.29
rrs 1472733 n.888G>C non_coding_transcript_exon_variant 0.37
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.37
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.36
rrs 1472742 n.897C>G non_coding_transcript_exon_variant 0.38
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.38
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.35
rrs 1472779 n.934G>A non_coding_transcript_exon_variant 0.36
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.31
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.2
rrs 1472982 n.1137G>C non_coding_transcript_exon_variant 0.12
rrs 1472988 n.1143T>A non_coding_transcript_exon_variant 0.15
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.31
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.3
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.21
rrs 1473054 n.1209C>T non_coding_transcript_exon_variant 0.23
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.22
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.2
rrs 1473083 n.1238G>A non_coding_transcript_exon_variant 0.16
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.28
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.31
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.31
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.33
rrl 1474844 n.1187G>T non_coding_transcript_exon_variant 0.34
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.38
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.35
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.31
rrl 1474913 n.1256T>A non_coding_transcript_exon_variant 0.18
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.14
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.14
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.13
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.12
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.21
rrl 1475866 n.2209T>A non_coding_transcript_exon_variant 0.21
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.13
rrl 1476265 n.2608G>A non_coding_transcript_exon_variant 0.24
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.32
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.33
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.31
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.33
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.33
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.33
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.32
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.33
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.33
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.49
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.61
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.62
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.62
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.67
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.66
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.69
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.71
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.65
rrl 1476427 n.2770G>T non_coding_transcript_exon_variant 0.63
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.64
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.55
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.51
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.49
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.4
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.33
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.34
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.34
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.33
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.33
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.3
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.3
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.29
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.29
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.32
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.22
inhA 1673338 c.-864G>A upstream_gene_variant 1.0
tlyA 1917800 c.-140A>G upstream_gene_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 0.95
ndh 2101921 c.1122G>A synonymous_variant 1.0
ndh 2103112 c.-70G>T upstream_gene_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 0.99
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2290062 c.-821G>A upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
ald 3087084 c.266delA frameshift_variant 1.0
ald 3087184 c.368_373delCCGACG disruptive_inframe_deletion 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
alr 3840932 c.489C>T synonymous_variant 1.0
rpoA 3878493 c.15G>A synonymous_variant 1.0
ddn 3986987 c.144G>T synonymous_variant 1.0
ddn 3987180 p.Asp113Asn missense_variant 1.0
clpC1 4040824 c.-120C>T upstream_gene_variant 1.0
embC 4239843 c.-20A>C upstream_gene_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 0.98
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244220 c.988C>T synonymous_variant 1.0
embA 4244635 p.Val468Ala missense_variant 0.99
embA 4245147 p.Pro639Ser missense_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
ethR 4326928 c.-621G>A upstream_gene_variant 1.0
ethA 4327103 p.Gly124Asp missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0