TB-Profiler result

Run: SRR6046733
Summary

Run ID: SRR6046733

Sample name:

Date: 04-04-2023 12:22:23

Number of reads: 830010

Percentage reads mapped: 61.34

Strain: lineage2.2.1

Drug-resistance: Pre-XDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.99
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 0.99
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
gyrA 7570 p.Ala90Val missense_variant 1.0 ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin
rpoB 760314 p.Val170Phe missense_variant 1.0 rifampicin
rrs 1472644 n.799C>T non_coding_transcript_exon_variant 0.2 streptomycin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.71 streptomycin
katG 2155129 p.Trp328Leu missense_variant 1.0 isoniazid
pncA 2288933 p.Tyr103* stop_gained 0.9 pyrazinamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6639 c.1405delA frameshift_variant 0.17
gyrB 7105 p.Trp622* stop_gained 0.14
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7924 p.His208Pro missense_variant 0.15
gyrA 8576 c.1275C>T synonymous_variant 0.2
gyrA 9304 p.Gly668Asp missense_variant 1.0
gyrA 9799 p.Ala833Val missense_variant 0.12
fgd1 491259 c.477T>C synonymous_variant 0.17
fgd1 491277 c.495G>C synonymous_variant 0.19
fgd1 491283 p.Asp167Glu missense_variant 0.18
fgd1 491286 c.504G>C synonymous_variant 0.18
fgd1 491289 c.507C>T synonymous_variant 0.2
fgd1 491295 c.513C>G synonymous_variant 0.2
fgd1 491316 c.534C>T synonymous_variant 0.17
fgd1 491491 p.Pro237Thr missense_variant 0.18
fgd1 491502 p.Glu240Asp missense_variant 0.14
fgd1 491508 c.726A>G synonymous_variant 0.12
fgd1 491509 c.727T>C synonymous_variant 0.11
fgd1 491512 p.Asn244Glu missense_variant 0.11
fgd1 491525 c.744T>C synonymous_variant 0.11
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575769 p.Ala141Val missense_variant 0.14
mshA 575851 c.504C>G synonymous_variant 0.22
mshA 575872 c.525C>T synonymous_variant 0.18
mshA 575878 c.531A>G synonymous_variant 0.18
mshA 575893 c.546C>G synonymous_variant 0.18
mshA 575907 p.Ala187Val missense_variant 0.86
mshA 576099 p.Asp251Gly missense_variant 0.15
ccsA 619831 c.-60T>G upstream_gene_variant 0.33
ccsA 619955 p.Val22Ala missense_variant 0.2
ccsA 620254 c.364_366delCTCinsTTG synonymous_variant 0.13
ccsA 620625 p.Ile245Met missense_variant 1.0
ccsA 620731 p.Ala281Thr missense_variant 0.15
rpoB 760094 c.288G>T synonymous_variant 0.12
rpoB 760309 p.Val168Ala missense_variant 1.0
rpoB 760536 p.Glu244Lys missense_variant 0.13
rpoB 760591 p.Val262Ala missense_variant 0.12
rpoB 760611 c.805T>C synonymous_variant 0.14
rpoB 760892 c.1086C>T synonymous_variant 0.2
rpoB 761393 c.1587G>A synonymous_variant 0.17
rpoB 761531 c.1725C>T synonymous_variant 0.5
rpoB 762065 c.2259T>C synonymous_variant 0.2
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763468 c.99G>C synonymous_variant 0.21
rpoC 763486 c.117T>C synonymous_variant 0.24
rpoC 763492 c.123G>C synonymous_variant 0.24
rpoC 763528 c.159G>A synonymous_variant 0.18
rpoC 763546 c.177A>G synonymous_variant 0.21
rpoC 763614 p.Val82Glu missense_variant 0.14
rpoC 763672 c.303C>G synonymous_variant 0.14
rpoC 763702 c.333C>G synonymous_variant 0.12
rpoC 764359 c.990C>T synonymous_variant 0.18
rpoC 764713 c.1344G>A synonymous_variant 0.23
rpoC 764716 c.1347G>C synonymous_variant 0.2
rpoC 764746 c.1377G>T synonymous_variant 0.2
rpoC 764752 c.1383G>C synonymous_variant 0.2
rpoC 764758 c.1389C>G synonymous_variant 0.15
rpoC 764764 c.1395T>C synonymous_variant 0.19
rpoC 764791 c.1422C>G synonymous_variant 0.14
rpoC 765499 c.2130C>G synonymous_variant 0.11
rpoC 765791 p.Thr808Ala missense_variant 0.2
rpoC 766645 p.Glu1092Asp missense_variant 1.0
rpoC 766843 c.3474T>C synonymous_variant 0.11
rpoC 766861 c.3492G>C synonymous_variant 0.11
rpoC 767093 p.Ser1242Gly missense_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775867 p.Arg872Cys missense_variant 0.13
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpL5 777360 p.Ala374Val missense_variant 0.29
mmpL5 777507 p.Ser325Asn missense_variant 0.13
mmpL5 778123 p.Thr120Pro missense_variant 0.29
mmpR5 778169 c.-821G>T upstream_gene_variant 0.14
mmpS5 778588 p.Gln106His missense_variant 1.0
mmpR5 779041 p.Glu18* stop_gained 0.12
mmpL5 779097 c.-617C>T upstream_gene_variant 0.12
mmpL5 779325 c.-845G>A upstream_gene_variant 0.22
mmpR5 779393 p.Arg135Gln missense_variant 0.18
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rplC 801183 c.375C>T synonymous_variant 0.2
fbiC 1302897 c.-34G>C upstream_gene_variant 0.11
fbiC 1303150 p.Gly74Ser missense_variant 0.14
fbiC 1303453 p.Arg175Ser missense_variant 0.15
fbiC 1303740 c.810C>A synonymous_variant 0.17
fbiC 1303752 c.822A>G synonymous_variant 0.13
fbiC 1303755 c.825T>C synonymous_variant 0.13
fbiC 1303785 c.855G>C synonymous_variant 0.11
fbiC 1303794 c.864A>G synonymous_variant 0.11
fbiC 1303818 c.888C>G synonymous_variant 0.18
fbiC 1303827 c.897A>G synonymous_variant 0.14
fbiC 1304281 p.Ala451Pro missense_variant 0.12
fbiC 1304663 p.Ser578Leu missense_variant 0.18
fbiC 1304709 c.1779C>T synonymous_variant 0.17
Rv1258c 1406152 p.Leu397Met missense_variant 0.13
Rv1258c 1406760 c.580_581insC frameshift_variant 0.94
Rv1258c 1406955 p.Pro129Leu missense_variant 0.15
atpE 1461143 c.99C>T synonymous_variant 0.2
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.67
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.5
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.3
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 1.0
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.43
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.5
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.19
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.87
rrs 1472174 n.329C>T non_coding_transcript_exon_variant 0.13
rrs 1472179 n.334C>T non_coding_transcript_exon_variant 0.14
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.29
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 1.0
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 1.0
rrs 1472496 n.651T>A non_coding_transcript_exon_variant 1.0
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 1.0
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.43
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.25
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.5
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.4
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.4
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.33
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.43
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.43
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.3
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.59
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.59
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.48
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.36
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 1.0
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 1.0
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.31
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.65
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.68
rrs 1472612 n.767G>T non_coding_transcript_exon_variant 0.15
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.5
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.58
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 1.0
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 1.0
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.44
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.56
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.44
rrs 1472692 n.847T>C non_coding_transcript_exon_variant 0.5
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.5
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.79
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.2
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.8
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.68
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.68
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.55
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.43
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.5
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.5
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.86
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.5
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.75
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.64
rrs 1472952 n.1107T>C non_coding_transcript_exon_variant 0.11
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.17
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.9
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.2
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.7
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.75
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.89
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.67
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.71
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.93
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.19
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.2
rrs 1473009 n.1164T>C non_coding_transcript_exon_variant 0.12
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.11
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.9
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.68
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.89
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.83
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.17
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.33
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.8
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.13
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.25
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.64
rrs 1473101 n.1256C>T non_coding_transcript_exon_variant 0.17
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.83
rrs 1473109 n.1264T>C non_coding_transcript_exon_variant 0.21
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.71
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.71
rrs 1473118 n.1273T>C non_coding_transcript_exon_variant 0.14
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.71
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.79
rrs 1473148 n.1303G>T non_coding_transcript_exon_variant 0.64
rrs 1473163 n.1318C>A non_coding_transcript_exon_variant 0.5
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.24
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.43
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.17
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.24
rrs 1473199 n.1356delA non_coding_transcript_exon_variant 0.31
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.31
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.31
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.13
rrs 1473258 n.1413T>C non_coding_transcript_exon_variant 0.36
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.27
rrs 1473262 n.1417T>C non_coding_transcript_exon_variant 0.64
rrs 1473263 n.1418A>G non_coding_transcript_exon_variant 0.36
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.71
rrs 1473283 n.1438T>C non_coding_transcript_exon_variant 0.4
rrs 1473291 n.1446G>T non_coding_transcript_exon_variant 0.5
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.67
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.56
rrs 1473318 n.1473G>A non_coding_transcript_exon_variant 0.18
rrs 1473319 n.1474C>T non_coding_transcript_exon_variant 0.27
rrs 1473327 n.1482A>G non_coding_transcript_exon_variant 0.2
rrs 1473328 n.1483C>T non_coding_transcript_exon_variant 0.2
rrs 1473352 n.1507C>T non_coding_transcript_exon_variant 0.29
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 1.0
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 1.0
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 1.0
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 1.0
rrl 1474199 n.542G>A non_coding_transcript_exon_variant 1.0
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 1.0
rrl 1474201 n.545delT non_coding_transcript_exon_variant 1.0
rrl 1474201 n.545T>C non_coding_transcript_exon_variant 1.0
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.53
rrl 1474228 n.571T>C non_coding_transcript_exon_variant 0.36
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.64
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.22
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.75
rrl 1474275 n.618T>G non_coding_transcript_exon_variant 1.0
rrl 1474387 n.730C>T non_coding_transcript_exon_variant 1.0
rrl 1474393 n.736A>G non_coding_transcript_exon_variant 1.0
rrl 1474402 n.745T>C non_coding_transcript_exon_variant 1.0
rrl 1474437 n.781_782delAA non_coding_transcript_exon_variant 1.0
rrl 1474448 n.791T>C non_coding_transcript_exon_variant 1.0
rrl 1474467 n.810A>G non_coding_transcript_exon_variant 1.0
rrl 1474476 n.819C>T non_coding_transcript_exon_variant 0.18
rrl 1474483 n.826C>T non_coding_transcript_exon_variant 0.27
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 1.0
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 0.67
rrl 1474496 n.839C>A non_coding_transcript_exon_variant 0.33
rrl 1474497 n.840G>C non_coding_transcript_exon_variant 0.27
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 0.57
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 0.57
rrl 1474506 n.849C>G non_coding_transcript_exon_variant 0.3
rrl 1474507 n.850G>T non_coding_transcript_exon_variant 0.23
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 0.69
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 1.0
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 0.77
rrl 1474528 n.871T>A non_coding_transcript_exon_variant 0.23
rrl 1474529 n.872A>G non_coding_transcript_exon_variant 0.4
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.23
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 1.0
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.25
rrl 1474540 n.883T>C non_coding_transcript_exon_variant 0.44
rrl 1474541 n.884G>T non_coding_transcript_exon_variant 0.25
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 0.75
rrl 1474551 n.894G>A non_coding_transcript_exon_variant 0.23
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.27
rrl 1474584 n.927C>T non_coding_transcript_exon_variant 0.5
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 0.67
rrl 1474627 n.970G>A non_coding_transcript_exon_variant 0.33
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 0.83
rrl 1474634 n.977T>G non_coding_transcript_exon_variant 0.6
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 1.0
rrl 1474637 n.980C>T non_coding_transcript_exon_variant 0.4
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 1.0
rrl 1474734 n.1077G>C non_coding_transcript_exon_variant 1.0
rrl 1474740 n.1083G>T non_coding_transcript_exon_variant 0.5
rrl 1474747 n.1090C>G non_coding_transcript_exon_variant 0.5
rrl 1474749 n.1092C>T non_coding_transcript_exon_variant 0.5
rrl 1474753 n.1097delC non_coding_transcript_exon_variant 1.0
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.29
rrl 1474777 n.1120T>C non_coding_transcript_exon_variant 0.43
rrl 1474782 n.1125G>A non_coding_transcript_exon_variant 0.43
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.6
rrl 1474801 n.1144G>A non_coding_transcript_exon_variant 0.18
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.17
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 0.55
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.17
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.7
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.78
rrl 1474839 n.1182C>T non_coding_transcript_exon_variant 0.13
rrl 1474844 n.1187G>T non_coding_transcript_exon_variant 0.19
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.82
rrl 1474866 n.1209C>A non_coding_transcript_exon_variant 0.17
rrl 1474869 n.1212G>C non_coding_transcript_exon_variant 0.12
rrl 1474883 n.1226T>C non_coding_transcript_exon_variant 0.14
rrl 1474892 n.1235G>A non_coding_transcript_exon_variant 0.15
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.17
rrl 1474903 n.1246T>C non_coding_transcript_exon_variant 0.62
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.38
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.67
rrl 1475059 n.1403_1404insTA non_coding_transcript_exon_variant 0.4
rrl 1475062 n.1405A>T non_coding_transcript_exon_variant 0.4
rrl 1475065 n.1409_1411delCAA non_coding_transcript_exon_variant 0.4
rrl 1475080 n.1425_1426delCC non_coding_transcript_exon_variant 0.67
rrl 1475089 n.1432A>G non_coding_transcript_exon_variant 0.4
rrl 1475090 n.1433A>T non_coding_transcript_exon_variant 0.4
rrl 1475104 n.1447T>A non_coding_transcript_exon_variant 1.0
rrl 1475108 n.1451C>G non_coding_transcript_exon_variant 0.5
rrl 1475113 n.1456C>T non_coding_transcript_exon_variant 0.5
rrl 1475114 n.1457C>T non_coding_transcript_exon_variant 1.0
rrl 1475115 n.1458A>C non_coding_transcript_exon_variant 0.5
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.5
rrl 1475124 n.1467A>T non_coding_transcript_exon_variant 1.0
rrl 1475335 n.1678G>A non_coding_transcript_exon_variant 0.4
rrl 1475722 n.2065G>T non_coding_transcript_exon_variant 0.43
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 1.0
rrl 1475754 n.2097G>A non_coding_transcript_exon_variant 0.8
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.8
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.8
rrl 1475763 n.2107_2108delAA non_coding_transcript_exon_variant 1.0
rrl 1475774 n.2117C>T non_coding_transcript_exon_variant 0.67
rrl 1475775 n.2118G>T non_coding_transcript_exon_variant 0.33
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.67
rrl 1475783 n.2126T>G non_coding_transcript_exon_variant 0.3
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.45
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.45
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.5
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.58
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.5
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.5
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.67
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.75
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.43
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.33
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.33
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 1.0
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 1.0
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.43
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 1.0
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 1.0
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 1.0
rrl 1475945 n.2288C>A non_coding_transcript_exon_variant 0.4
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 1.0
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.6
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.8
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.6
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.67
rrl 1475978 n.2321C>T non_coding_transcript_exon_variant 0.67
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.67
rrl 1475993 n.2336C>T non_coding_transcript_exon_variant 0.67
rrl 1475997 n.2340A>T non_coding_transcript_exon_variant 0.67
rrl 1475998 n.2341C>T non_coding_transcript_exon_variant 0.67
rrl 1476001 n.2344T>C non_coding_transcript_exon_variant 0.67
rrl 1476113 n.2456T>G non_coding_transcript_exon_variant 0.67
rrl 1476116 n.2459A>G non_coding_transcript_exon_variant 0.4
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 1.0
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.38
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.67
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.71
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.71
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.57
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.33
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.43
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.43
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.22
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.33
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.44
rrl 1476229 n.2572C>G non_coding_transcript_exon_variant 0.5
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.36
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.79
rrl 1476252 n.2595T>A non_coding_transcript_exon_variant 0.15
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.36
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.86
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.75
rrl 1476282 n.2625T>C non_coding_transcript_exon_variant 0.17
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.67
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.75
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.75
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.75
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.6
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.6
rrl 1476301 n.2644A>T non_coding_transcript_exon_variant 0.67
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.75
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 1.0
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 1.0
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.75
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.54
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.54
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.53
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.32
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.53
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.45
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.43
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.54
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.41
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.59
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.59
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.15
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.7
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.8
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.79
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.46
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.91
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 1.0
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.38
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.54
rrl 1476515 n.2858C>T non_coding_transcript_exon_variant 0.33
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.62
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.29
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 1.0
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 1.0
rrl 1476528 n.2871A>G non_coding_transcript_exon_variant 0.33
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.67
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 1.0
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.8
rrl 1476539 n.2882A>G non_coding_transcript_exon_variant 0.6
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.6
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.6
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.43
rrl 1476573 n.2916A>C non_coding_transcript_exon_variant 0.29
rrl 1476577 n.2920T>G non_coding_transcript_exon_variant 0.29
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.88
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.62
rrl 1476600 n.2943A>C non_coding_transcript_exon_variant 0.67
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.88
rrl 1476614 n.2957A>T non_coding_transcript_exon_variant 0.83
rrl 1476616 n.2959A>G non_coding_transcript_exon_variant 0.83
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 1.0
rrl 1476628 n.2971T>G non_coding_transcript_exon_variant 1.0
rrl 1476629 n.2972C>A non_coding_transcript_exon_variant 0.71
rrl 1476633 n.2976A>G non_coding_transcript_exon_variant 0.71
rrl 1476664 n.3007T>A non_coding_transcript_exon_variant 0.5
rrl 1476668 n.3011C>T non_coding_transcript_exon_variant 0.5
rrl 1476675 n.3018C>A non_coding_transcript_exon_variant 0.5
rrl 1476689 n.3032A>T non_coding_transcript_exon_variant 1.0
rrl 1476692 n.3035T>A non_coding_transcript_exon_variant 1.0
rrl 1476695 n.3038T>A non_coding_transcript_exon_variant 1.0
rrl 1476710 n.3053C>A non_coding_transcript_exon_variant 1.0
fabG1 1674118 p.Glu227Lys missense_variant 0.22
inhA 1674672 c.471C>T synonymous_variant 0.12
inhA 1674866 p.Trp222* stop_gained 0.15
rpsA 1833661 c.120A>G synonymous_variant 0.21
rpsA 1833668 p.Ile43Val missense_variant 0.21
rpsA 1833676 c.135A>G synonymous_variant 0.17
rpsA 1833679 c.138G>C synonymous_variant 0.13
rpsA 1833685 c.144G>A synonymous_variant 0.13
rpsA 1833694 c.153G>C synonymous_variant 0.29
rpsA 1833700 c.159C>G synonymous_variant 0.15
rpsA 1833721 c.180A>G synonymous_variant 0.15
rpsA 1833727 c.186G>C synonymous_variant 0.27
rpsA 1833732 p.Pro64Leu missense_variant 0.18
rpsA 1833736 c.195C>T synonymous_variant 0.17
rpsA 1833742 c.201A>G synonymous_variant 0.25
rpsA 1833745 c.204G>C synonymous_variant 0.18
rpsA 1833776 p.Val79Ile missense_variant 0.12
rpsA 1833781 c.240T>C synonymous_variant 0.11
rpsA 1833802 c.261A>G synonymous_variant 0.14
rpsA 1834177 c.636A>C synonymous_variant 1.0
rpsA 1834600 c.1059G>C synonymous_variant 0.17
rpsA 1834604 p.Arg355Cys missense_variant 0.17
rpsA 1834609 c.1068T>C synonymous_variant 0.14
rpsA 1834612 c.1071G>C synonymous_variant 0.14
rpsA 1834618 c.1077G>C synonymous_variant 0.13
rpsA 1834619 c.1078T>C synonymous_variant 0.12
rpsA 1834627 c.1086C>G synonymous_variant 0.11
rpsA 1834633 c.1092A>G synonymous_variant 0.21
rpsA 1834639 c.1098T>C synonymous_variant 0.17
tlyA 1917819 c.-121C>G upstream_gene_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
tlyA 1918353 c.414C>T synonymous_variant 0.14
ndh 2102024 p.Ala340Gly missense_variant 0.15
ndh 2102026 c.1017G>C synonymous_variant 0.15
ndh 2102050 c.993T>C synonymous_variant 0.11
ndh 2102059 c.984T>C synonymous_variant 0.11
ndh 2102252 p.Gly264Asp missense_variant 0.13
ndh 2102658 p.Asp129Asn missense_variant 0.12
ndh 2102893 c.150G>C synonymous_variant 0.12
ndh 2102899 c.144T>C synonymous_variant 0.13
ndh 2102911 c.132G>C synonymous_variant 0.14
ndh 2102929 c.114T>C synonymous_variant 0.18
ndh 2102938 p.Arg35His missense_variant 0.2
ndh 2102960 p.Asn28Thr missense_variant 0.13
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2154971 p.Asp381Tyr missense_variant 0.18
katG 2155018 p.Pro365Gln missense_variant 0.14
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2169091 p.Val508Met missense_variant 0.14
PPE35 2169783 p.Thr277Arg missense_variant 0.12
PPE35 2169830 c.783C>T synonymous_variant 0.14
PPE35 2169902 p.Leu237Phe missense_variant 0.22
Rv1979c 2222179 p.Ala329Val missense_variant 0.15
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289355 c.-114C>T upstream_gene_variant 0.12
pncA 2289541 c.-300G>A upstream_gene_variant 0.17
kasA 2519326 c.1212C>T synonymous_variant 0.29
eis 2714449 p.Trp295Ser missense_variant 0.11
folC 2746173 p.Gly476Trp missense_variant 0.29
folC 2746958 p.Gly214Glu missense_variant 0.15
folC 2747130 p.Ala157Thr missense_variant 0.18
pepQ 2859939 c.480C>T synonymous_variant 0.17
ribD 2987139 p.Val101Phe missense_variant 0.12
ribD 2987495 c.657C>T synonymous_variant 0.22
Rv2752c 3064685 p.Ala503Thr missense_variant 0.33
Rv2752c 3064854 p.Lys446Asn missense_variant 0.17
Rv2752c 3064869 c.1323G>T synonymous_variant 0.18
thyX 3067772 c.174C>T synonymous_variant 0.33
thyA 3074507 c.-36G>A upstream_gene_variant 0.18
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3086891 c.72G>A synonymous_variant 0.17
ald 3086977 p.Ala53Val missense_variant 0.14
ald 3087221 c.402C>T synonymous_variant 0.12
fbiD 3339273 c.156T>G synonymous_variant 0.29
fbiD 3339279 c.162T>C synonymous_variant 0.12
Rv3083 3448956 c.453G>A synonymous_variant 0.2
Rv3083 3449134 p.Gln211* stop_gained 0.2
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475173 c.1167C>G synonymous_variant 0.12
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
Rv3236c 3613069 c.48G>A synonymous_variant 0.14
fbiB 3642837 c.1303T>C synonymous_variant 0.14
rpoA 3877962 c.546G>T synonymous_variant 0.14
rpoA 3877968 c.540C>G synonymous_variant 0.15
rpoA 3877974 c.534G>C synonymous_variant 0.17
rpoA 3877989 c.519A>G synonymous_variant 0.15
ddn 3987086 c.243C>G synonymous_variant 0.14
ddn 3987143 c.300A>G synonymous_variant 0.11
clpC1 4038409 p.Pro766Ser missense_variant 0.18
clpC1 4039508 c.1197G>C synonymous_variant 0.13
clpC1 4039929 p.Ser259Thr missense_variant 0.14
clpC1 4039932 p.Gly258Ala missense_variant 0.11
clpC1 4040059 p.Gly216Arg missense_variant 0.12
clpC1 4040231 c.474C>G synonymous_variant 0.15
clpC1 4040302 p.Arg135Cys missense_variant 0.18
clpC1 4040844 c.-140C>T upstream_gene_variant 0.12
clpC1 4040900 c.-196G>A upstream_gene_variant 0.22
embC 4240314 p.Thr151Asn missense_variant 0.22
embC 4240582 c.720C>G synonymous_variant 0.22
embC 4241196 p.Ser445Leu missense_variant 0.14
embC 4241217 p.Ala452Val missense_variant 0.17
embC 4241624 p.His588Asp missense_variant 0.15
embC 4241870 p.Val670Met missense_variant 0.12
embA 4242622 c.-611C>A upstream_gene_variant 0.25
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243268 c.36C>A synonymous_variant 0.14
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4246180 p.Thr983Asn missense_variant 0.12
embB 4246915 c.402C>T synonymous_variant 0.12
embB 4246968 p.Ser152Tyr missense_variant 0.15
embB 4247072 p.Gly187Arg missense_variant 0.15
embB 4247316 p.Leu268Pro missense_variant 0.13
embB 4247571 p.Pro353Gln missense_variant 0.14
embB 4247689 c.1176G>C synonymous_variant 0.18
embB 4247716 c.1203C>G synonymous_variant 0.18
embB 4247725 c.1212G>C synonymous_variant 0.15
embB 4249724 p.Val1071Ile missense_variant 0.14
aftB 4267647 p.Asp397Gly missense_variant 1.0
aftB 4268293 p.Ser182Gly missense_variant 0.17
ubiA 4269220 p.Ala205Glu missense_variant 0.14
ubiA 4270029 c.-196G>C upstream_gene_variant 0.18
ethA 4326502 c.972A>T synonymous_variant 0.15
ethA 4326523 c.951T>C synonymous_variant 0.11
ethR 4326556 c.-993A>G upstream_gene_variant 0.11
ethR 4326559 c.-990A>G upstream_gene_variant 0.11
whiB6 4338394 p.Thr43Arg missense_variant 0.2
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407741 c.462G>A synonymous_variant 0.12
gid 4407927 p.Glu92Asp missense_variant 1.0