TB-Profiler

Lineage	Family	RDs	Frequency
La1.3	M.bovis	None	0.99
La1	M.bovis	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
pncA	2289073	p.His57Asp	missense_variant	1.0	pyrazinamide	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	45	c.45G>A	synonymous_variant	1.0	isoniazid
dnaA	467	p.His156Arg	missense_variant	1.0	isoniazid	Not assoc w R
gyrB	5752	c.513G>A	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	5752	c.513G>A	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6446	p.Ala403Ser	missense_variant	1.0	levofloxacin	Not assoc w R
gyrB	6446	p.Ala403Ser	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	8285	c.984C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8285	c.984C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	moxifloxacin	Not assoc w R
Rv0010c	13197	p.Thr121Ser	missense_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13228	c.330delG	frameshift_variant	1.0	isoniazid	Uncertain significance
Rv0010c	13460	c.99T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
fgd1	491742	c.960T>C	synonymous_variant	1.0	clofazimine	Not assoc w R
					pretomanid
					delamanid	Not assoc w R - Interim
Rv0565c	656579	p.Cys298Arg	missense_variant	1.0	ethionamide	Uncertain significance
Rv0565c	657578	c.-108T>C	upstream_gene_variant	1.0	ethionamide
rpoB	759589	c.-218G>A	upstream_gene_variant	1.0	rifampicin	Uncertain significance
rpoB	763031	c.3225T>C	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoC	764491	c.1122G>C	synonymous_variant	0.14	rifampicin
rpoC	764521	c.1152T>C	synonymous_variant	0.11	rifampicin	Not assoc w R - Interim
rpoC	764527	c.1158C>G	synonymous_variant	0.15	rifampicin
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
Rv1129c	1254562	c.-28T>C	upstream_gene_variant	1.0	moxifloxacin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
Rv1129c	1254582	c.-48A>G	upstream_gene_variant	1.0	moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
fbiC	1302899	c.-32A>G	upstream_gene_variant	1.0	clofazimine	Uncertain significance
					pretomanid
					delamanid	Uncertain significance
embR	1417554	c.-207C>G	upstream_gene_variant	1.0	ethambutol
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1471969	n.124T>C	non_coding_transcript_exon_variant	0.14	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471970	n.125G>A	non_coding_transcript_exon_variant	0.14	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471985	n.140T>C	non_coding_transcript_exon_variant	0.17	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471986	n.141C>T	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1471991	n.146T>C	non_coding_transcript_exon_variant	0.19	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1471997	n.152T>C	non_coding_transcript_exon_variant	0.19	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1471998	n.153G>T	non_coding_transcript_exon_variant	0.19	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472005	n.160T>G	non_coding_transcript_exon_variant	0.19	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472023	n.178G>T	non_coding_transcript_exon_variant	0.19	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472030	n.185G>C	non_coding_transcript_exon_variant	0.17	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472033	n.188A>C	non_coding_transcript_exon_variant	0.16	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472034	n.189T>C	non_coding_transcript_exon_variant	0.16	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472038	n.194dupG	non_coding_transcript_exon_variant	0.17	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472043	n.198T>G	non_coding_transcript_exon_variant	0.17	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472053	n.211_212delGC	non_coding_transcript_exon_variant	0.17	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472059	n.214T>C	non_coding_transcript_exon_variant	0.17	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472060	n.215T>C	non_coding_transcript_exon_variant	0.17	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472061	n.216A>G	non_coding_transcript_exon_variant	0.17	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472068	n.223T>C	non_coding_transcript_exon_variant	0.15	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472069	n.224G>A	non_coding_transcript_exon_variant	0.18	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472108	n.263C>T	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472507	n.662C>T	non_coding_transcript_exon_variant	0.2	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.33	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472571	n.726G>A	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472583	n.738T>A	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472584	n.739A>T	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473026	n.1181T>C	non_coding_transcript_exon_variant	0.26	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473055	n.1210C>T	non_coding_transcript_exon_variant	0.24	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473089	n.1244A>T	non_coding_transcript_exon_variant	0.24	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473091	n.1246G>A	non_coding_transcript_exon_variant	0.25	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.29	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1474777	n.1120T>G	non_coding_transcript_exon_variant	0.27	capreomycin
rrl	1474777	n.1120T>G	non_coding_transcript_exon_variant	0.27	linezolid
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1474783	n.1126G>A	non_coding_transcript_exon_variant	0.23	capreomycin
rrl	1474783	n.1126G>A	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.28	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.29	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.29	linezolid	Uncertain significance
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.26	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.29	capreomycin	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.29	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.4	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.4	linezolid	Uncertain significance
rrl	1476280	n.2623A>C	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1476280	n.2623A>C	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1476293	n.2636C>T	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1476293	n.2636C>T	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1476297	n.2640C>T	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1476297	n.2640C>T	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1476301	n.2644A>C	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1476301	n.2644A>C	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.37	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.37	linezolid	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.38	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.38	linezolid	Uncertain significance
rrl	1476313	n.2656G>A	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1476313	n.2656G>A	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.39	capreomycin	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.39	linezolid	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.37	capreomycin	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.37	linezolid	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.38	capreomycin	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.38	linezolid	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.33	linezolid	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.21	linezolid	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.18	linezolid	Uncertain significance
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.32	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.27	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.21	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.21	linezolid	Uncertain significance
rrl	1476728	n.3071T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476728	n.3071T>C	non_coding_transcript_exon_variant	1.0	linezolid
rpsA	1834859	p.Ala440Thr	missense_variant	1.0	pyrazinamide	Uncertain significance
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2062922	p.Ile603Val	missense_variant	1.0	streptomycin	Not assoc w R
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
ndh	2103173	c.-132delG	upstream_gene_variant	1.0	ethionamide
					delamanid
					isoniazid
katG	2154724	p.Arg463Leu	missense_variant	1.0	isoniazid	Not assoc w R
katG	2155503	c.609C>T	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156025	c.87C>A	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156465	c.-354C>T	upstream_gene_variant	1.0	isoniazid	Not assoc w R - Interim
PPE35	2167926	p.Leu896Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
PPE35	2168011	p.Ser868Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2168814	c.1798dupA	frameshift_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
kasA	2518132	c.18C>T	synonymous_variant	1.0	isoniazid
Rv2477c	2782927	c.1116A>G	synonymous_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					amikacin	Not assoc w R - Interim
Rv2681	2997325	p.Ala196Val	missense_variant	1.0	capreomycin	Uncertain significance
ald	3086728	c.-92C>T	upstream_gene_variant	1.0	cycloserine
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
ald	3087084	c.266delA	frameshift_variant	1.0	cycloserine
Rv3083	3448783	p.Val94Ile	missense_variant	1.0	ethionamide	Uncertain significance
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624350	c.561G>T	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624350	c.561G>T	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624593	c.318G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624593	c.318G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624710	c.201G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624710	c.201G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
mtrB	3625065	p.Met517Leu	missense_variant	1.0	bedaquiline	Uncertain significance
mtrB	3625065	p.Met517Leu	missense_variant	1.0	rifampicin	Not assoc w R
rpoA	3878630	c.-124delC	upstream_gene_variant	1.0	rifampicin	Not assoc w R
clpC1	4038403	c.2302T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
glpK	4138377	p.Val460Ala	missense_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
embC	4240671	p.Thr270Ile	missense_variant	1.0	ethambutol	Not assoc w R
embC	4241384	p.Pro508Thr	missense_variant	1.0	ethambutol
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embC	4242970	c.3108C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4244220	c.988C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4246551	p.Asn13Ser	missense_variant	1.0	ethambutol	Not assoc w R
embB	4246864	c.351C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4247646	p.Glu378Ala	missense_variant	1.0	ethambutol	Not assoc w R
embB	4249640	c.3127T>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
aftB	4267858	p.Ile327Val	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269351	c.483C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
ubiA	4269387	p.Glu149Asp	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269606	c.228T>C	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R

TB-Profiler result