TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
rrs	1472106	n.261G>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472113	n.268T>C	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472127	n.282C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472128	n.283G>C	non_coding_transcript_exon_variant	0.95	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472129	n.284G>A	non_coding_transcript_exon_variant	0.86	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472151	n.306C>A	non_coding_transcript_exon_variant	0.75	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472181	n.336G>A	non_coding_transcript_exon_variant	0.57	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472223	n.378C>G	non_coding_transcript_exon_variant	0.63	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>A	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Uncertain significance
rrs	1472228	n.383G>C	non_coding_transcript_exon_variant	0.58	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472240	n.395G>A	non_coding_transcript_exon_variant	0.43	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472338	n.493A>C	non_coding_transcript_exon_variant	0.95	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472344	n.499C>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472379	n.534T>G	non_coding_transcript_exon_variant	0.99	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472382	n.537G>A	non_coding_transcript_exon_variant	0.92	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472389	n.544G>A	non_coding_transcript_exon_variant	0.86	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472396	n.551A>T	non_coding_transcript_exon_variant	0.85	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472405	n.560C>T	non_coding_transcript_exon_variant	0.81	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472518	n.673G>A	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.85	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472537	n.692C>T	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472544	n.699C>T	non_coding_transcript_exon_variant	0.69	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.67	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472574	n.729T>A	non_coding_transcript_exon_variant	0.74	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472579	n.734G>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>T	non_coding_transcript_exon_variant	0.52	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472592	n.747C>T	non_coding_transcript_exon_variant	0.75	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472598	n.753A>C	non_coding_transcript_exon_variant	0.98	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472599	n.754G>T	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472616	n.771G>A	non_coding_transcript_exon_variant	0.61	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472647	n.802C>T	non_coding_transcript_exon_variant	0.5	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472655	n.810G>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472658	n.813G>A	non_coding_transcript_exon_variant	0.91	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472715	n.870C>T	non_coding_transcript_exon_variant	0.53	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472716	n.871C>T	non_coding_transcript_exon_variant	0.76	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472719	n.874G>A	non_coding_transcript_exon_variant	0.74	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472733	n.888G>T	non_coding_transcript_exon_variant	0.79	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472734	n.889C>T	non_coding_transcript_exon_variant	0.65	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472741	n.896G>A	non_coding_transcript_exon_variant	0.48	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472742	n.897C>A	non_coding_transcript_exon_variant	0.82	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472744	n.899A>G	non_coding_transcript_exon_variant	0.94	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472767	n.922G>A	non_coding_transcript_exon_variant	0.57	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472781	n.936C>T	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472793	n.948A>T	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472803	n.958T>A	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472895	n.1050C>T	non_coding_transcript_exon_variant	0.96	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473005	n.1160C>T	non_coding_transcript_exon_variant	0.7	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473020	n.1175T>C	non_coding_transcript_exon_variant	0.36	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	0.85	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473053	n.1208T>A	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473054	n.1209C>T	non_coding_transcript_exon_variant	0.37	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.61	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473062	n.1217T>A	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473068	n.1223A>G	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473205	n.1360T>C	non_coding_transcript_exon_variant	0.91	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1474199	n.542G>C	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1474199	n.542G>C	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1474200	n.545delT	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474200	n.545delT	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474208	n.551C>T	non_coding_transcript_exon_variant	0.76	capreomycin
rrl	1474208	n.551C>T	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1474213	n.556G>A	non_coding_transcript_exon_variant	0.76	capreomycin
rrl	1474213	n.556G>A	non_coding_transcript_exon_variant	0.76	linezolid
rrl	1474218	n.561T>A	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1474218	n.561T>A	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1474228	n.571T>A	non_coding_transcript_exon_variant	0.57	capreomycin	Uncertain significance
rrl	1474228	n.571T>A	non_coding_transcript_exon_variant	0.57	linezolid	Uncertain significance
rrl	1474228	n.571T>G	non_coding_transcript_exon_variant	0.43	capreomycin
rrl	1474228	n.571T>G	non_coding_transcript_exon_variant	0.43	linezolid
rrl	1474252	n.595T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474252	n.595T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.52	capreomycin	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	0.52	linezolid
rrl	1474565	n.908T>A	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1474565	n.908T>A	non_coding_transcript_exon_variant	0.64	linezolid
rrl	1474570	n.913G>T	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1474570	n.913G>T	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1474571	n.914G>T	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1474571	n.914G>T	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1474578	n.921A>G	non_coding_transcript_exon_variant	0.77	capreomycin	Uncertain significance
rrl	1474578	n.921A>G	non_coding_transcript_exon_variant	0.77	linezolid	Uncertain significance
rrl	1474584	n.927C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474584	n.927C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474586	n.929T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474586	n.929T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474777	n.1120T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1474777	n.1120T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474804	n.1147C>T	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1474804	n.1147C>T	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.53	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.53	linezolid	Uncertain significance
rrl	1474839	n.1182C>T	non_coding_transcript_exon_variant	0.43	capreomycin	Uncertain significance
rrl	1474839	n.1182C>T	non_coding_transcript_exon_variant	0.43	linezolid	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474852	n.1195T>C	non_coding_transcript_exon_variant	0.5	capreomycin
rrl	1474852	n.1195T>C	non_coding_transcript_exon_variant	0.5	linezolid
rrl	1475129	n.1472G>A	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1475129	n.1472G>A	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1475150	n.1493C>T	non_coding_transcript_exon_variant	0.82	capreomycin
rrl	1475150	n.1493C>T	non_coding_transcript_exon_variant	0.82	linezolid
rrl	1475154	n.1497C>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475154	n.1497C>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475157	n.1500G>A	non_coding_transcript_exon_variant	0.73	capreomycin
rrl	1475157	n.1500G>A	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1475175	n.1518G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475175	n.1518G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.57	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.57	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result