Run ID: ERR1035312
Sample name:
Date: 20-10-2023 21:38:58
Number of reads: 5848725
Percentage reads mapped: 98.7
Strain: lineage4.3.3
Drug-resistance: Pre-XDR-TB
Drug | Resistance | Supporting mutations |
---|---|---|
Rifampicin | R | rpoB p.Ser450Trp (1.00) |
Isoniazid | ||
Ethambutol | R | embA c.-12C>T (1.00) |
Pyrazinamide | R | pncA p.Trp68Arg (1.00) |
Streptomycin | ||
Fluoroquinolones | R | gyrA p.Ala90Val (1.00) |
Moxifloxacin | R | gyrA p.Ala90Val (1.00) |
Ofloxacin | R | gyrA p.Ala90Val (1.00) |
Levofloxacin | R | gyrA p.Ala90Val (1.00) |
Ciprofloxacin | R | gyrA p.Ala90Val (1.00) |
Aminoglycosides | ||
Amikacin | ||
Capreomycin | ||
Kanamycin | ||
Cycloserine | R | ald c.436_437dupGC (0.96) |
Ethionamide | ||
Clofazimine | ||
Para-aminosalicylic_acid | ||
Delamanid | ||
Bedaquiline | ||
Linezolid |
Lineage | Family | Main Spoligotype | RDs | Frequency |
---|---|---|---|---|
lineage4 | Euro-American | LAM;T;S;X;H | None | 1.0 |
lineage4.3 | Euro-American (LAM) | mainly-LAM | None | 1.0 |
lineage4.3.3 | Euro-American (LAM) | LAM;T | RD115 | 1.0 |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs |
---|---|---|---|---|---|
gyrA | 7570 | p.Ala90Val | missense_variant | 1.0 | ofloxacin, moxifloxacin, levofloxacin, fluoroquinolones, ciprofloxacin |
rpoB | 761155 | p.Ser450Trp | missense_variant | 1.0 | rifampicin |
pncA | 2289040 | p.Trp68Arg | missense_variant | 1.0 | pyrazinamide |
ald | 3087252 | c.436_437dupGC | frameshift_variant | 0.96 | cycloserine |
embA | 4243221 | c.-12C>T | upstream_gene_variant | 1.0 | ethambutol |
Gene | Chromosome position | Mutation | Type | Estimated fraction |
---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 |
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 |
gyrA | 8040 | p.Gly247Ser | missense_variant | 1.0 |
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 |
rpoC | 764582 | c.1213C>T | synonymous_variant | 1.0 |
rpoC | 764995 | c.1626C>G | synonymous_variant | 1.0 |
rpoC | 765804 | p.Thr812Ile | missense_variant | 0.33 |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 |
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 |
rrs | 1471969 | n.124T>C | non_coding_transcript_exon_variant | 0.47 |
rrl | 1473752 | n.95G>T | non_coding_transcript_exon_variant | 0.46 |
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.53 |
rrl | 1473815 | n.158T>C | non_coding_transcript_exon_variant | 0.59 |
rrl | 1473836 | n.179A>G | non_coding_transcript_exon_variant | 0.61 |
rrl | 1473876 | n.219G>A | non_coding_transcript_exon_variant | 0.34 |
rrl | 1473877 | n.220G>A | non_coding_transcript_exon_variant | 0.34 |
rrl | 1473898 | n.241C>T | non_coding_transcript_exon_variant | 0.39 |
rrl | 1473943 | n.286G>T | non_coding_transcript_exon_variant | 0.32 |
rrl | 1473944 | n.287G>T | non_coding_transcript_exon_variant | 0.32 |
rrl | 1473981 | n.324delGinsAT | non_coding_transcript_exon_variant | 0.21 |
rrl | 1473995 | n.338G>T | non_coding_transcript_exon_variant | 0.3 |
rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 0.36 |
rrl | 1474028 | n.371T>C | non_coding_transcript_exon_variant | 0.34 |
rrl | 1474029 | n.372G>A | non_coding_transcript_exon_variant | 0.34 |
rrl | 1474034 | n.377G>A | non_coding_transcript_exon_variant | 0.36 |
rrl | 1474040 | n.383G>A | non_coding_transcript_exon_variant | 0.42 |
rrl | 1474083 | n.426C>T | non_coding_transcript_exon_variant | 0.29 |
rrl | 1474111 | n.454T>C | non_coding_transcript_exon_variant | 0.31 |
rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 0.33 |
rrl | 1474151 | n.494C>T | non_coding_transcript_exon_variant | 0.38 |
rrl | 1474181 | n.524C>A | non_coding_transcript_exon_variant | 0.41 |
rrl | 1474632 | n.975G>T | non_coding_transcript_exon_variant | 0.21 |
rrl | 1474639 | n.982G>A | non_coding_transcript_exon_variant | 0.28 |
rrl | 1474716 | n.1059A>G | non_coding_transcript_exon_variant | 0.31 |
rrl | 1474760 | n.1103A>G | non_coding_transcript_exon_variant | 0.29 |
rrl | 1474794 | n.1137C>A | non_coding_transcript_exon_variant | 0.29 |
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.29 |
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.36 |
rrl | 1475202 | n.1545G>C | non_coding_transcript_exon_variant | 0.31 |
rrl | 1475213 | n.1556C>T | non_coding_transcript_exon_variant | 0.31 |
rrl | 1475252 | n.1595C>T | non_coding_transcript_exon_variant | 0.38 |
rrl | 1475266 | n.1609T>C | non_coding_transcript_exon_variant | 0.38 |
rrl | 1475276 | n.1619T>C | non_coding_transcript_exon_variant | 0.28 |
rrl | 1475333 | n.1676T>C | non_coding_transcript_exon_variant | 0.27 |
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.28 |
rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.19 |
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.37 |
rrl | 1476629 | n.2972C>A | non_coding_transcript_exon_variant | 0.37 |
rrl | 1476716 | n.3059A>C | non_coding_transcript_exon_variant | 0.21 |
rrl | 1476726 | n.3069A>G | non_coding_transcript_exon_variant | 0.19 |
rpsA | 1833678 | p.Val46Ala | missense_variant | 1.0 |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 0.97 |
kasA | 2518919 | p.Gly269Ser | missense_variant | 1.0 |
Rv2752c | 3066014 | c.177dupG | frameshift_variant | 1.0 |
thyA | 3073868 | p.Thr202Ala | missense_variant | 1.0 |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 0.97 |
fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 |
clpC1 | 4038287 | c.2418C>T | synonymous_variant | 1.0 |
embC | 4242182 | p.Ala774Ser | missense_variant | 1.0 |
embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 |
embA | 4245187 | p.Thr652Lys | missense_variant | 1.0 |
ubiA | 4268987 | p.Val283Leu | missense_variant | 1.0 |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 |
gid | 4408105 | p.Arg33Pro | missense_variant | 1.0 |
gid | 4408156 | p.Leu16Arg | missense_variant | 1.0 |