Run ID: ERR3283010
Sample name:
Date: 2024-04-15T13:48:17.481930
Number of reads: 223076
Percentage reads mapped: 6.64
Median coverage: 6.0
Strain: La1.8.1
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
La1.8.1 | M.bovis | None | 0.22 |
La1 | M.bovis | None | 0.89 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 6286 | c.1047T>C | synonymous_variant | 0.67 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6703 | c.-599G>C | upstream_gene_variant | 0.8 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6709 | c.-593A>G | upstream_gene_variant | 0.8 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 6760 | c.-542G>C | upstream_gene_variant | 0.6 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9304 | p.Gly668Glu | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
fgd1 | 490905 | c.123T>C | synonymous_variant | 0.5 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 490921 | p.Gln47Glu | missense_variant | 0.44 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 490948 | p.Ser56Ala | missense_variant | 0.54 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491144 | p.Ala121Glu | missense_variant | 0.54 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
mshA | 575884 | c.537G>C | synonymous_variant | 0.64 | ethionamide | |
isoniazid | ||||||
mshA | 575944 | c.597T>C | synonymous_variant | 0.64 | ethionamide | |
isoniazid | ||||||
mshA | 575950 | c.603C>G | synonymous_variant | 0.73 | ethionamide | |
isoniazid | ||||||
hadA | 732378 | c.450_452dupAGA | disruptive_inframe_insertion | 0.6 | isoniazid | |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.75 | rifampicin | Not assoc w R - Interim |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.8 | rifampicin | Not assoc w R - Interim |
rpoB | 760298 | c.492G>C | synonymous_variant | 0.64 | rifampicin | Not assoc w R - Interim |
rpoB | 760310 | c.504G>C | synonymous_variant | 0.55 | rifampicin | |
rpoB | 760328 | c.522G>C | synonymous_variant | 0.67 | rifampicin | |
rpoB | 760331 | c.525G>C | synonymous_variant | 0.7 | rifampicin | |
rpoB | 761015 | c.1209G>C | synonymous_variant | 0.7 | rifampicin | Not assoc w R - Interim |
rpoB | 761027 | c.1221A>G | synonymous_variant | 0.7 | rifampicin | Not assoc w R - Interim |
rpoB | 761036 | c.1230G>C | synonymous_variant | 0.7 | rifampicin | Not assoc w R - Interim |
rpoB | 761037 | c.1231T>C | synonymous_variant | 0.6 | rifampicin | Not assoc w R - Interim |
rpoB | 761180 | c.1374A>C | synonymous_variant | 0.82 | rifampicin | Not assoc w R - Interim |
rpoB | 761249 | c.1443A>G | synonymous_variant | 0.62 | rifampicin | Not assoc w R - Interim |
rpoB | 761261 | c.1455G>T | synonymous_variant | 0.53 | rifampicin | Not assoc w R - Interim |
rpoB | 762062 | c.2256T>C | synonymous_variant | 0.64 | rifampicin | Not assoc w R - Interim |
rpoB | 762065 | c.2259T>C | synonymous_variant | 0.79 | rifampicin | Not assoc w R - Interim |
rpoB | 762083 | c.2277T>C | synonymous_variant | 0.77 | rifampicin | Not assoc w R - Interim |
rpoB | 762086 | c.2280G>C | synonymous_variant | 0.83 | rifampicin | Not assoc w R - Interim |
rpoB | 762101 | c.2295C>G | synonymous_variant | 0.73 | rifampicin | Not assoc w R - Interim |
rpoB | 762114 | p.Ile770Val | missense_variant | 0.71 | rifampicin | Uncertain significance |
rpoB | 762131 | c.2325C>G | synonymous_variant | 0.75 | rifampicin | |
rpoB | 762140 | c.2334G>C | synonymous_variant | 0.59 | rifampicin | |
rpoB | 762143 | c.2337T>C | synonymous_variant | 0.73 | rifampicin | |
rpoB | 762149 | c.2343G>C | synonymous_variant | 0.69 | rifampicin | Not assoc w R - Interim |
rpoB | 762167 | c.2361T>C | synonymous_variant | 0.67 | rifampicin | Not assoc w R - Interim |
rpoB | 762185 | c.2379G>C | synonymous_variant | 0.58 | rifampicin | Not assoc w R - Interim |
rpoB | 762929 | c.3123G>C | synonymous_variant | 0.64 | rifampicin | Not assoc w R - Interim |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.8 | rifampicin | Not assoc w R - Interim |
rpoC | 763528 | c.159G>A | synonymous_variant | 0.69 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.62 | rifampicin | Not assoc w R - Interim |
rpoC | 764098 | c.729A>G | synonymous_variant | 0.73 | rifampicin | Not assoc w R - Interim |
rpoC | 764101 | c.732C>G | synonymous_variant | 0.73 | rifampicin | Not assoc w R - Interim |
rpoC | 764257 | c.888G>C | synonymous_variant | 0.55 | rifampicin | |
rpoC | 764858 | c.1489T>C | synonymous_variant | 0.71 | rifampicin | Not assoc w R - Interim |
rpoC | 764888 | c.1519T>C | synonymous_variant | 0.6 | rifampicin | Not assoc w R - Interim |
rpoC | 764911 | c.1542A>G | synonymous_variant | 0.64 | rifampicin | |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoC | 765478 | c.2109T>C | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.62 | rifampicin | Not assoc w R - Interim |
rpoC | 765814 | c.2445A>G | synonymous_variant | 0.55 | rifampicin | Not assoc w R - Interim |
rpoC | 765826 | c.2457T>C | synonymous_variant | 0.67 | rifampicin | Not assoc w R - Interim |
rpoC | 765835 | c.2466C>T | synonymous_variant | 0.67 | rifampicin | Not assoc w R - Interim |
rpoC | 765883 | c.2514C>G | synonymous_variant | 0.38 | rifampicin | |
rpoC | 765886 | c.2517C>G | synonymous_variant | 0.62 | rifampicin | |
rpoC | 765892 | c.2523T>C | synonymous_variant | 0.67 | rifampicin | Not assoc w R - Interim |
rpoC | 765967 | c.2598C>T | synonymous_variant | 0.47 | rifampicin | Not assoc w R - Interim |
rpoC | 765979 | c.2610C>G | synonymous_variant | 0.43 | rifampicin | Not assoc w R - Interim |
rpoC | 765982 | c.2613C>T | synonymous_variant | 0.46 | rifampicin | Not assoc w R - Interim |
rpoC | 765994 | c.2625A>T | synonymous_variant | 0.54 | rifampicin | Not assoc w R - Interim |
rpoC | 766996 | c.3627C>T | synonymous_variant | 0.82 | rifampicin | Not assoc w R - Interim |
rpoC | 767119 | c.3750A>G | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
rpoC | 767180 | p.Ala1271Gln | missense_variant | 0.8 | rifampicin | |
mmpL5 | 775966 | p.Ala839Ser | missense_variant | 0.58 | clofazimine | |
bedaquiline | ||||||
mmpL5 | 775981 | p.Leu834Met | missense_variant | 0.64 | clofazimine | |
bedaquiline | ||||||
rpsL | 781715 | c.156T>C | synonymous_variant | 0.64 | streptomycin | |
rpsL | 781728 | c.169T>C | synonymous_variant | 0.8 | streptomycin | |
rpsL | 781736 | c.177T>C | synonymous_variant | 0.8 | streptomycin | |
rpsL | 781751 | c.192G>C | synonymous_variant | 0.56 | streptomycin | |
rpsL | 781754 | c.195G>C | synonymous_variant | 0.7 | streptomycin | |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.76 | streptomycin | |
rrs | 1471986 | n.141C>T | non_coding_transcript_exon_variant | 0.58 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472019 | n.174G>A | non_coding_transcript_exon_variant | 0.64 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1472029 | n.184C>T | non_coding_transcript_exon_variant | 0.64 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472061 | n.216A>T | non_coding_transcript_exon_variant | 0.7 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472075 | n.230A>G | non_coding_transcript_exon_variant | 0.7 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472150 | n.305T>A | non_coding_transcript_exon_variant | 0.47 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1472953 | n.1108G>A | non_coding_transcript_exon_variant | 0.38 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472957 | n.1112C>T | non_coding_transcript_exon_variant | 0.46 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.59 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.59 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.68 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473110 | n.1265T>G | non_coding_transcript_exon_variant | 0.44 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473111 | n.1266A>G | non_coding_transcript_exon_variant | 0.44 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.42 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.39 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473276 | n.1431A>G | non_coding_transcript_exon_variant | 0.53 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473301 | n.1456T>C | non_coding_transcript_exon_variant | 0.45 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1474760 | n.1103A>G | non_coding_transcript_exon_variant | 0.39 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.62 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.59 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475315 | n.1658A>T | non_coding_transcript_exon_variant | 0.8 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.83 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475369 | n.1712G>T | non_coding_transcript_exon_variant | 0.8 | capreomycin | |
linezolid | ||||||
rrl | 1475402 | n.1745C>T | non_coding_transcript_exon_variant | 0.7 | capreomycin | |
linezolid | ||||||
rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.92 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475429 | n.1772G>A | non_coding_transcript_exon_variant | 0.64 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475452 | n.1795C>A | non_coding_transcript_exon_variant | 0.73 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475458 | n.1801C>T | non_coding_transcript_exon_variant | 0.75 | capreomycin | |
linezolid | ||||||
rrl | 1475460 | n.1803A>G | non_coding_transcript_exon_variant | 0.73 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475483 | n.1826C>T | non_coding_transcript_exon_variant | 0.75 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.73 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.79 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475544 | n.1887A>T | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475545 | n.1888T>G | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476332 | n.2675G>C | non_coding_transcript_exon_variant | 0.52 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476338 | n.2681C>T | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476353 | n.2696G>T | non_coding_transcript_exon_variant | 0.44 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476358 | n.2701T>C | non_coding_transcript_exon_variant | 0.57 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476369 | n.2712C>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476372 | n.2715T>C | non_coding_transcript_exon_variant | 0.46 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476381 | n.2724G>A | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1476382 | n.2725A>G | non_coding_transcript_exon_variant | 0.56 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476383 | n.2726T>A | non_coding_transcript_exon_variant | 0.32 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476408 | n.2751G>A | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476425 | n.2768G>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476428 | n.2771C>T | non_coding_transcript_exon_variant | 0.39 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476466 | n.2809C>T | non_coding_transcript_exon_variant | 0.29 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476481 | n.2824T>C | non_coding_transcript_exon_variant | 0.46 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476506 | n.2849T>C | non_coding_transcript_exon_variant | 0.25 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476529 | n.2872A>G | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.6 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.69 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.85 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.73 | pyrazinamide | |
rpsA | 1833787 | c.246C>G | synonymous_variant | 0.73 | pyrazinamide | |
rpsA | 1833790 | c.249T>C | synonymous_variant | 0.73 | pyrazinamide | |
rpsA | 1833829 | c.288A>G | synonymous_variant | 0.5 | pyrazinamide | |
rpsA | 1833841 | c.300C>G | synonymous_variant | 0.83 | pyrazinamide | |
rpsA | 1833847 | c.306C>G | synonymous_variant | 0.83 | pyrazinamide | |
rpsA | 1833856 | c.315A>G | synonymous_variant | 0.82 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.75 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.73 | pyrazinamide | |
rpsA | 1834609 | c.1068T>C | synonymous_variant | 0.56 | pyrazinamide | |
rpsA | 1834633 | c.1092A>G | synonymous_variant | 0.61 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.61 | pyrazinamide | |
tsnR | 1853420 | c.-186T>G | upstream_gene_variant | 0.73 | linezolid | |
tsnR | 1853423 | c.-183C>T | upstream_gene_variant | 0.64 | linezolid | |
tsnR | 1853429 | c.-177G>C | upstream_gene_variant | 0.73 | linezolid | |
kasA | 2519072 | p.Ala320Thr | missense_variant | 0.75 | isoniazid | |
Rv2477c | 2783563 | c.480A>G | synonymous_variant | 0.8 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783586 | p.Ala153Pro | missense_variant | 0.73 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783593 | c.450T>C | synonymous_variant | 0.73 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783605 | c.438T>C | synonymous_variant | 0.67 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783920 | c.123G>C | synonymous_variant | 0.7 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
thyA | 3073977 | c.495A>G | synonymous_variant | 0.7 | para-aminosalicylic_acid | |
lpqB | 3625195 | c.-285A>G | upstream_gene_variant | 0.55 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625201 | c.-291T>C | upstream_gene_variant | 0.54 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625206 | p.Ser470Ala | missense_variant | 0.5 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625222 | c.1392T>C | synonymous_variant | 0.75 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625225 | c.-315G>C | upstream_gene_variant | 0.5 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625240 | c.-330T>C | upstream_gene_variant | 0.67 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625750 | c.864G>A | synonymous_variant | 0.55 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625755 | p.Ala287Thr | missense_variant | 0.67 | bedaquiline | |
rifampicin | Uncertain significance | |||||
mtrB | 3625762 | c.852A>G | synonymous_variant | 0.64 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625765 | c.849C>G | synonymous_variant | 0.54 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625797 | p.Val273Met | missense_variant | 0.6 | bedaquiline | Uncertain significance |
rifampicin | Uncertain significance | |||||
mtrB | 3625806 | c.808A>C | synonymous_variant | 0.62 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625837 | c.777C>G | synonymous_variant | 0.64 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625840 | c.-930A>G | upstream_gene_variant | 0.64 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625852 | c.762A>G | synonymous_variant | 0.64 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627236 | c.-623T>C | upstream_gene_variant | 0.9 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627266 | c.-653A>G | upstream_gene_variant | 0.7 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627317 | c.-704T>C | upstream_gene_variant | 0.7 | bedaquiline | |
rifampicin | ||||||
rpoA | 3877900 | p.Ser203Thr | missense_variant | 0.7 | rifampicin | |
rpoA | 3877905 | c.603A>G | synonymous_variant | 0.83 | rifampicin | Not assoc w R - Interim |
rpoA | 3877908 | p.Asn200Ser | missense_variant | 0.64 | rifampicin | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.75 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.67 | pyrazinamide | |
clpC1 | 4038956 | c.1749T>C | synonymous_variant | 0.8 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.8 | pyrazinamide | |
clpC1 | 4038971 | c.1734T>C | synonymous_variant | 0.8 | pyrazinamide | |
clpC1 | 4038974 | c.1731T>C | synonymous_variant | 0.8 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.82 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.75 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.73 | pyrazinamide | |
clpC1 | 4039121 | c.1584T>C | synonymous_variant | 0.83 | pyrazinamide | |
clpC1 | 4039142 | c.1563A>G | synonymous_variant | 0.82 | pyrazinamide | |
clpC1 | 4039145 | c.1560G>C | synonymous_variant | 0.9 | pyrazinamide | |
clpC1 | 4039169 | p.Glu512Asp | missense_variant | 0.73 | pyrazinamide | |
clpC1 | 4039172 | c.1533A>G | synonymous_variant | 0.69 | pyrazinamide | |
clpC1 | 4039178 | c.1527G>C | synonymous_variant | 0.83 | pyrazinamide | |
clpC1 | 4039226 | c.1479T>C | synonymous_variant | 0.8 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039559 | c.1146C>G | synonymous_variant | 0.62 | pyrazinamide | |
clpC1 | 4039577 | c.1128T>C | synonymous_variant | 0.83 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039616 | c.1089G>C | synonymous_variant | 0.73 | pyrazinamide | |
clpC1 | 4039979 | c.726C>G | synonymous_variant | 0.7 | pyrazinamide | |
glpK | 4138574 | c.1182G>C | synonymous_variant | 0.64 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138631 | c.1125C>G | synonymous_variant | 0.8 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138643 | c.1113A>G | synonymous_variant | 0.82 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
glpK | 4138661 | c.1095T>C | synonymous_variant | 0.5 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138664 | c.1092G>C | synonymous_variant | 0.38 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138676 | c.1080T>C | synonymous_variant | 0.47 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138682 | c.1074C>G | synonymous_variant | 0.47 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138695 | p.Pro354Asp | missense_variant | 0.53 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138718 | c.1038T>C | synonymous_variant | 0.69 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138724 | c.1032A>G | synonymous_variant | 0.85 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138745 | c.1011G>C | synonymous_variant | 0.35 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138751 | c.1005T>C | synonymous_variant | 0.41 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138757 | c.999A>G | synonymous_variant | 0.72 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138763 | c.993G>A | synonymous_variant | 0.39 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138769 | c.987G>C | synonymous_variant | 0.47 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138774 | p.Ser328Ala | missense_variant | 0.5 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
glpK | 4138778 | c.978C>G | synonymous_variant | 0.38 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
embC | 4241657 | p.Ser599Pro | missense_variant | 0.46 | ethambutol |