TB-Profiler result

Run: ERR3283010

Summary

Run ID: ERR3283010

Sample name:

Date: 2024-04-15T13:48:17.481930

Number of reads: 223076

Percentage reads mapped: 6.64

Median coverage: 6.0

Strain: La1.8.1

Spoligotype:

Drug-resistance: Sensitive


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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
La1.8.1 M.bovis None 0.22
La1 M.bovis None 0.89
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6286 c.1047T>C synonymous_variant 0.67 levofloxacin
moxifloxacin
gyrA 6703 c.-599G>C upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6709 c.-593A>G upstream_gene_variant 0.8 levofloxacin
moxifloxacin
gyrA 6760 c.-542G>C upstream_gene_variant 0.6 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Glu missense_variant 1.0 levofloxacin
moxifloxacin
fgd1 490905 c.123T>C synonymous_variant 0.5 clofazimine
pretomanid
delamanid
fgd1 490921 p.Gln47Glu missense_variant 0.44 clofazimine
pretomanid
delamanid
fgd1 490948 p.Ser56Ala missense_variant 0.54 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.54 clofazimine
pretomanid
delamanid
mshA 575884 c.537G>C synonymous_variant 0.64 ethionamide
isoniazid
mshA 575944 c.597T>C synonymous_variant 0.64 ethionamide
isoniazid
mshA 575950 c.603C>G synonymous_variant 0.73 ethionamide
isoniazid
hadA 732378 c.450_452dupAGA disruptive_inframe_insertion 0.6 isoniazid
rpoB 760235 c.429T>C synonymous_variant 0.75 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoB 760298 c.492G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 760310 c.504G>C synonymous_variant 0.55 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.67 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.7 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761027 c.1221A>G synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761036 c.1230G>C synonymous_variant 0.7 rifampicin Not assoc w R - Interim
rpoB 761037 c.1231T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoB 761249 c.1443A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.53 rifampicin Not assoc w R - Interim
rpoB 762062 c.2256T>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762065 c.2259T>C synonymous_variant 0.79 rifampicin Not assoc w R - Interim
rpoB 762083 c.2277T>C synonymous_variant 0.77 rifampicin Not assoc w R - Interim
rpoB 762086 c.2280G>C synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoB 762114 p.Ile770Val missense_variant 0.71 rifampicin Uncertain significance
rpoB 762131 c.2325C>G synonymous_variant 0.75 rifampicin
rpoB 762140 c.2334G>C synonymous_variant 0.59 rifampicin
rpoB 762143 c.2337T>C synonymous_variant 0.73 rifampicin
rpoB 762149 c.2343G>C synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.58 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.8 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.69 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 764098 c.729A>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764101 c.732C>G synonymous_variant 0.73 rifampicin Not assoc w R - Interim
rpoC 764257 c.888G>C synonymous_variant 0.55 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.71 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.6 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.64 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765478 c.2109T>C synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.62 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.55 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.38 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.62 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.67 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.47 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.43 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.46 rifampicin Not assoc w R - Interim
rpoC 765994 c.2625A>T synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.82 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.92 rifampicin Not assoc w R - Interim
rpoC 767180 p.Ala1271Gln missense_variant 0.8 rifampicin
mmpL5 775966 p.Ala839Ser missense_variant 0.58 clofazimine
bedaquiline
mmpL5 775981 p.Leu834Met missense_variant 0.64 clofazimine
bedaquiline
rpsL 781715 c.156T>C synonymous_variant 0.64 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.8 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.8 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.56 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.7 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.76 streptomycin
rrs 1471986 n.141C>T non_coding_transcript_exon_variant 0.58 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.64 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472029 n.184C>T non_coding_transcript_exon_variant 0.64 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472061 n.216A>T non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.7 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.47 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Not assoc w R
amikacin Not assoc w R
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.38 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.46 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.59 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.68 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.44 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.42 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.39 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.53 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.45 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.39 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.59 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.8 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.83 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.8 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.7 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.92 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475458 n.1801C>T non_coding_transcript_exon_variant 0.75 capreomycin
linezolid
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.75 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.73 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.79 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.71 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.44 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.41 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>A non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.32 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.39 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.29 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.46 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.25 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.6 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.85 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833745 c.204G>C synonymous_variant 0.73 pyrazinamide
rpsA 1833787 c.246C>G synonymous_variant 0.73 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.73 pyrazinamide
rpsA 1833829 c.288A>G synonymous_variant 0.5 pyrazinamide
rpsA 1833841 c.300C>G synonymous_variant 0.83 pyrazinamide
rpsA 1833847 c.306C>G synonymous_variant 0.83 pyrazinamide
rpsA 1833856 c.315A>G synonymous_variant 0.82 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.75 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.73 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.56 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.61 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.61 pyrazinamide
tsnR 1853420 c.-186T>G upstream_gene_variant 0.73 linezolid
tsnR 1853423 c.-183C>T upstream_gene_variant 0.64 linezolid
tsnR 1853429 c.-177G>C upstream_gene_variant 0.73 linezolid
kasA 2519072 p.Ala320Thr missense_variant 0.75 isoniazid
Rv2477c 2783563 c.480A>G synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.73 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.67 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.7 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyA 3073977 c.495A>G synonymous_variant 0.7 para-aminosalicylic_acid
lpqB 3625195 c.-285A>G upstream_gene_variant 0.55 bedaquiline
rifampicin
lpqB 3625201 c.-291T>C upstream_gene_variant 0.54 bedaquiline
rifampicin
mtrB 3625206 p.Ser470Ala missense_variant 0.5 bedaquiline
rifampicin
mtrB 3625222 c.1392T>C synonymous_variant 0.75 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625225 c.-315G>C upstream_gene_variant 0.5 bedaquiline
rifampicin
lpqB 3625240 c.-330T>C upstream_gene_variant 0.67 bedaquiline
rifampicin
mtrB 3625750 c.864G>A synonymous_variant 0.55 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.67 bedaquiline
rifampicin Uncertain significance
mtrB 3625762 c.852A>G synonymous_variant 0.64 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625765 c.849C>G synonymous_variant 0.54 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.6 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.62 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.64 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3625840 c.-930A>G upstream_gene_variant 0.64 bedaquiline
rifampicin
mtrB 3625852 c.762A>G synonymous_variant 0.64 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627236 c.-623T>C upstream_gene_variant 0.9 bedaquiline
rifampicin
mtrB 3627266 c.-653A>G upstream_gene_variant 0.7 bedaquiline
rifampicin
mtrB 3627317 c.-704T>C upstream_gene_variant 0.7 bedaquiline
rifampicin
rpoA 3877900 p.Ser203Thr missense_variant 0.7 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.83 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.64 rifampicin
clpC1 4038773 c.1932T>C synonymous_variant 0.75 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.67 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.8 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.82 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.75 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.73 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.83 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.82 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.9 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.73 pyrazinamide
clpC1 4039172 c.1533A>G synonymous_variant 0.69 pyrazinamide
clpC1 4039178 c.1527G>C synonymous_variant 0.83 pyrazinamide
clpC1 4039226 c.1479T>C synonymous_variant 0.8 pyrazinamide Not assoc w R - Interim
clpC1 4039559 c.1146C>G synonymous_variant 0.62 pyrazinamide
clpC1 4039577 c.1128T>C synonymous_variant 0.83 pyrazinamide Not assoc w R - Interim
clpC1 4039616 c.1089G>C synonymous_variant 0.73 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.7 pyrazinamide
glpK 4138574 c.1182G>C synonymous_variant 0.64 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138631 c.1125C>G synonymous_variant 0.8 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138643 c.1113A>G synonymous_variant 0.82 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
rifampicin Not assoc w R - Interim
isoniazid Not assoc w R - Interim
glpK 4138661 c.1095T>C synonymous_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138664 c.1092G>C synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138676 c.1080T>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138682 c.1074C>G synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138695 p.Pro354Asp missense_variant 0.53 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138718 c.1038T>C synonymous_variant 0.69 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138724 c.1032A>G synonymous_variant 0.85 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138745 c.1011G>C synonymous_variant 0.35 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138751 c.1005T>C synonymous_variant 0.41 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138757 c.999A>G synonymous_variant 0.72 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138763 c.993G>A synonymous_variant 0.39 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138769 c.987G>C synonymous_variant 0.47 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138774 p.Ser328Ala missense_variant 0.5 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
glpK 4138778 c.978C>G synonymous_variant 0.38 ethambutol
moxifloxacin
streptomycin
levofloxacin
rifampicin
isoniazid
embC 4241657 p.Ser599Pro missense_variant 0.46 ethambutol