TB-Profiler

Lineage	Family	RDs	Frequency
La1.8.1	M.bovis	None	0.22
La1	M.bovis	None	0.89

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrB	6286	c.1047T>C	synonymous_variant	0.67	levofloxacin
gyrB	6286	c.1047T>C	synonymous_variant	0.67	moxifloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.8	levofloxacin
gyrA	6703	c.-599G>C	upstream_gene_variant	0.8	moxifloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.8	levofloxacin
gyrA	6709	c.-593A>G	upstream_gene_variant	0.8	moxifloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.6	levofloxacin
gyrA	6760	c.-542G>C	upstream_gene_variant	0.6	moxifloxacin
gyrA	9304	p.Gly668Glu	missense_variant	1.0	levofloxacin
gyrA	9304	p.Gly668Glu	missense_variant	1.0	moxifloxacin
fgd1	490905	c.123T>C	synonymous_variant	0.5	clofazimine
					pretomanid
					delamanid
fgd1	490921	p.Gln47Glu	missense_variant	0.44	clofazimine
					pretomanid
					delamanid
fgd1	490948	p.Ser56Ala	missense_variant	0.54	clofazimine
					pretomanid
					delamanid
fgd1	491144	p.Ala121Glu	missense_variant	0.54	clofazimine
					pretomanid
					delamanid
mshA	575884	c.537G>C	synonymous_variant	0.64	ethionamide
mshA	575884	c.537G>C	synonymous_variant	0.64	isoniazid
mshA	575944	c.597T>C	synonymous_variant	0.64	ethionamide
mshA	575944	c.597T>C	synonymous_variant	0.64	isoniazid
mshA	575950	c.603C>G	synonymous_variant	0.73	ethionamide
mshA	575950	c.603C>G	synonymous_variant	0.73	isoniazid
hadA	732378	c.450_452dupAGA	disruptive_inframe_insertion	0.6	isoniazid
rpoB	760235	c.429T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
rpoB	760283	c.477G>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoB	760298	c.492G>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoB	760310	c.504G>C	synonymous_variant	0.55	rifampicin
rpoB	760328	c.522G>C	synonymous_variant	0.67	rifampicin
rpoB	760331	c.525G>C	synonymous_variant	0.7	rifampicin
rpoB	761015	c.1209G>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	761027	c.1221A>G	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	761036	c.1230G>C	synonymous_variant	0.7	rifampicin	Not assoc w R - Interim
rpoB	761037	c.1231T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoB	761180	c.1374A>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	761249	c.1443A>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoB	761261	c.1455G>T	synonymous_variant	0.53	rifampicin	Not assoc w R - Interim
rpoB	762062	c.2256T>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoB	762065	c.2259T>C	synonymous_variant	0.79	rifampicin	Not assoc w R - Interim
rpoB	762083	c.2277T>C	synonymous_variant	0.77	rifampicin	Not assoc w R - Interim
rpoB	762086	c.2280G>C	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoB	762101	c.2295C>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoB	762114	p.Ile770Val	missense_variant	0.71	rifampicin	Uncertain significance
rpoB	762131	c.2325C>G	synonymous_variant	0.75	rifampicin
rpoB	762140	c.2334G>C	synonymous_variant	0.59	rifampicin
rpoB	762143	c.2337T>C	synonymous_variant	0.73	rifampicin
rpoB	762149	c.2343G>C	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoB	762167	c.2361T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoB	762185	c.2379G>C	synonymous_variant	0.58	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>C	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
rpoB	763028	c.3222T>C	synonymous_variant	0.8	rifampicin	Not assoc w R - Interim
rpoC	763528	c.159G>A	synonymous_variant	0.69	rifampicin	Not assoc w R - Interim
rpoC	763546	c.177A>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	764098	c.729A>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	764101	c.732C>G	synonymous_variant	0.73	rifampicin	Not assoc w R - Interim
rpoC	764257	c.888G>C	synonymous_variant	0.55	rifampicin
rpoC	764858	c.1489T>C	synonymous_variant	0.71	rifampicin	Not assoc w R - Interim
rpoC	764888	c.1519T>C	synonymous_variant	0.6	rifampicin	Not assoc w R - Interim
rpoC	764911	c.1542A>G	synonymous_variant	0.64	rifampicin
rpoC	764948	c.1579T>C	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	765478	c.2109T>C	synonymous_variant	0.5	rifampicin	Not assoc w R - Interim
rpoC	765499	c.2130C>G	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
rpoC	765814	c.2445A>G	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
rpoC	765826	c.2457T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	765835	c.2466C>T	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	765883	c.2514C>G	synonymous_variant	0.38	rifampicin
rpoC	765886	c.2517C>G	synonymous_variant	0.62	rifampicin
rpoC	765892	c.2523T>C	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	765967	c.2598C>T	synonymous_variant	0.47	rifampicin	Not assoc w R - Interim
rpoC	765979	c.2610C>G	synonymous_variant	0.43	rifampicin	Not assoc w R - Interim
rpoC	765982	c.2613C>T	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoC	765994	c.2625A>T	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
rpoC	766996	c.3627C>T	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoC	767119	c.3750A>G	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	767180	p.Ala1271Gln	missense_variant	0.8	rifampicin
mmpL5	775966	p.Ala839Ser	missense_variant	0.58	clofazimine
mmpL5	775966	p.Ala839Ser	missense_variant	0.58	bedaquiline
mmpL5	775981	p.Leu834Met	missense_variant	0.64	clofazimine
mmpL5	775981	p.Leu834Met	missense_variant	0.64	bedaquiline
rpsL	781715	c.156T>C	synonymous_variant	0.64	streptomycin
rpsL	781728	c.169T>C	synonymous_variant	0.8	streptomycin
rpsL	781736	c.177T>C	synonymous_variant	0.8	streptomycin
rpsL	781751	c.192G>C	synonymous_variant	0.56	streptomycin
rpsL	781754	c.195G>C	synonymous_variant	0.7	streptomycin
rpsL	781760	c.201T>C	synonymous_variant	0.76	streptomycin
rrs	1471986	n.141C>T	non_coding_transcript_exon_variant	0.58	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472019	n.174G>A	non_coding_transcript_exon_variant	0.64	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472029	n.184C>T	non_coding_transcript_exon_variant	0.64	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472061	n.216A>T	non_coding_transcript_exon_variant	0.7	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472075	n.230A>G	non_coding_transcript_exon_variant	0.7	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.47	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472953	n.1108G>A	non_coding_transcript_exon_variant	0.38	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472957	n.1112C>T	non_coding_transcript_exon_variant	0.46	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472969	n.1124A>G	non_coding_transcript_exon_variant	0.59	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472978	n.1133T>C	non_coding_transcript_exon_variant	0.59	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.68	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	0.44	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.44	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.42	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.39	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.53	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>C	non_coding_transcript_exon_variant	0.45	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.39	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.39	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.62	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.62	linezolid	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.8	capreomycin	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	0.8	linezolid	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.83	capreomycin	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	0.83	linezolid	Uncertain significance
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.8	capreomycin
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	0.8	linezolid
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.7	capreomycin
rrl	1475402	n.1745C>T	non_coding_transcript_exon_variant	0.7	linezolid
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1475452	n.1795C>A	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1475452	n.1795C>A	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1475458	n.1801C>T	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1475458	n.1801C>T	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1475460	n.1803A>G	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1475460	n.1803A>G	non_coding_transcript_exon_variant	0.73	linezolid	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.73	capreomycin	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	0.73	linezolid
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.79	capreomycin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	0.79	linezolid	Uncertain significance
rrl	1475544	n.1887A>T	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1475544	n.1887A>T	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rrl	1475545	n.1888T>G	non_coding_transcript_exon_variant	0.71	capreomycin	Uncertain significance
rrl	1475545	n.1888T>G	non_coding_transcript_exon_variant	0.71	linezolid	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.52	capreomycin	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.52	linezolid	Uncertain significance
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.47	capreomycin	Uncertain significance
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.47	linezolid	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.44	capreomycin	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.44	linezolid	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.57	capreomycin	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.57	linezolid	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.41	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.41	linezolid	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.46	capreomycin	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.46	linezolid	Uncertain significance
rrl	1476381	n.2724G>A	non_coding_transcript_exon_variant	0.21	capreomycin
rrl	1476381	n.2724G>A	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.56	capreomycin	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.56	linezolid	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.39	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.39	linezolid	Uncertain significance
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.29	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.29	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.46	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.46	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.25	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476529	n.2872A>G	non_coding_transcript_exon_variant	0.47	capreomycin	Uncertain significance
rrl	1476529	n.2872A>G	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.6	capreomycin	Not assoc w R
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.6	linezolid	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.69	linezolid
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rpsA	1833745	c.204G>C	synonymous_variant	0.73	pyrazinamide
rpsA	1833787	c.246C>G	synonymous_variant	0.73	pyrazinamide
rpsA	1833790	c.249T>C	synonymous_variant	0.73	pyrazinamide
rpsA	1833829	c.288A>G	synonymous_variant	0.5	pyrazinamide
rpsA	1833841	c.300C>G	synonymous_variant	0.83	pyrazinamide
rpsA	1833847	c.306C>G	synonymous_variant	0.83	pyrazinamide
rpsA	1833856	c.315A>G	synonymous_variant	0.82	pyrazinamide
rpsA	1833928	c.387G>C	synonymous_variant	0.75	pyrazinamide
rpsA	1834546	c.1005T>C	synonymous_variant	0.73	pyrazinamide
rpsA	1834609	c.1068T>C	synonymous_variant	0.56	pyrazinamide
rpsA	1834633	c.1092A>G	synonymous_variant	0.61	pyrazinamide
rpsA	1834639	c.1098T>C	synonymous_variant	0.61	pyrazinamide
tsnR	1853420	c.-186T>G	upstream_gene_variant	0.73	linezolid
tsnR	1853423	c.-183C>T	upstream_gene_variant	0.64	linezolid
tsnR	1853429	c.-177G>C	upstream_gene_variant	0.73	linezolid
kasA	2519072	p.Ala320Thr	missense_variant	0.75	isoniazid
Rv2477c	2783563	c.480A>G	synonymous_variant	0.8	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783586	p.Ala153Pro	missense_variant	0.73	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783593	c.450T>C	synonymous_variant	0.73	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783605	c.438T>C	synonymous_variant	0.67	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
Rv2477c	2783920	c.123G>C	synonymous_variant	0.7	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					kanamycin
					rifampicin
					amikacin
thyA	3073977	c.495A>G	synonymous_variant	0.7	para-aminosalicylic_acid
lpqB	3625195	c.-285A>G	upstream_gene_variant	0.55	bedaquiline
lpqB	3625195	c.-285A>G	upstream_gene_variant	0.55	rifampicin
lpqB	3625201	c.-291T>C	upstream_gene_variant	0.54	bedaquiline
lpqB	3625201	c.-291T>C	upstream_gene_variant	0.54	rifampicin
mtrB	3625206	p.Ser470Ala	missense_variant	0.5	bedaquiline
mtrB	3625206	p.Ser470Ala	missense_variant	0.5	rifampicin
mtrB	3625222	c.1392T>C	synonymous_variant	0.75	bedaquiline
mtrB	3625222	c.1392T>C	synonymous_variant	0.75	rifampicin	Not assoc w R - Interim
lpqB	3625225	c.-315G>C	upstream_gene_variant	0.5	bedaquiline
lpqB	3625225	c.-315G>C	upstream_gene_variant	0.5	rifampicin
lpqB	3625240	c.-330T>C	upstream_gene_variant	0.67	bedaquiline
lpqB	3625240	c.-330T>C	upstream_gene_variant	0.67	rifampicin
mtrB	3625750	c.864G>A	synonymous_variant	0.55	bedaquiline
mtrB	3625750	c.864G>A	synonymous_variant	0.55	rifampicin	Not assoc w R - Interim
mtrB	3625755	p.Ala287Thr	missense_variant	0.67	bedaquiline
mtrB	3625755	p.Ala287Thr	missense_variant	0.67	rifampicin	Uncertain significance
mtrB	3625762	c.852A>G	synonymous_variant	0.64	bedaquiline
mtrB	3625762	c.852A>G	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
mtrB	3625765	c.849C>G	synonymous_variant	0.54	bedaquiline
mtrB	3625765	c.849C>G	synonymous_variant	0.54	rifampicin	Not assoc w R - Interim
mtrB	3625797	p.Val273Met	missense_variant	0.6	bedaquiline	Uncertain significance
mtrB	3625797	p.Val273Met	missense_variant	0.6	rifampicin	Uncertain significance
mtrB	3625806	c.808A>C	synonymous_variant	0.62	bedaquiline
mtrB	3625806	c.808A>C	synonymous_variant	0.62	rifampicin	Not assoc w R - Interim
mtrB	3625837	c.777C>G	synonymous_variant	0.64	bedaquiline
mtrB	3625837	c.777C>G	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
lpqB	3625840	c.-930A>G	upstream_gene_variant	0.64	bedaquiline
lpqB	3625840	c.-930A>G	upstream_gene_variant	0.64	rifampicin
mtrB	3625852	c.762A>G	synonymous_variant	0.64	bedaquiline
mtrB	3625852	c.762A>G	synonymous_variant	0.64	rifampicin	Not assoc w R - Interim
mtrB	3627236	c.-623T>C	upstream_gene_variant	0.9	bedaquiline
mtrB	3627236	c.-623T>C	upstream_gene_variant	0.9	rifampicin
mtrB	3627266	c.-653A>G	upstream_gene_variant	0.7	bedaquiline
mtrB	3627266	c.-653A>G	upstream_gene_variant	0.7	rifampicin
mtrB	3627317	c.-704T>C	upstream_gene_variant	0.7	bedaquiline
mtrB	3627317	c.-704T>C	upstream_gene_variant	0.7	rifampicin
rpoA	3877900	p.Ser203Thr	missense_variant	0.7	rifampicin
rpoA	3877905	c.603A>G	synonymous_variant	0.83	rifampicin	Not assoc w R - Interim
rpoA	3877908	p.Asn200Ser	missense_variant	0.64	rifampicin
clpC1	4038773	c.1932T>C	synonymous_variant	0.75	pyrazinamide
clpC1	4038782	c.1923G>C	synonymous_variant	0.67	pyrazinamide
clpC1	4038956	c.1749T>C	synonymous_variant	0.8	pyrazinamide
clpC1	4038965	c.1740T>C	synonymous_variant	0.8	pyrazinamide
clpC1	4038971	c.1734T>C	synonymous_variant	0.8	pyrazinamide
clpC1	4038974	c.1731T>C	synonymous_variant	0.8	pyrazinamide	Not assoc w R - Interim
clpC1	4038989	c.1716T>C	synonymous_variant	0.82	pyrazinamide
clpC1	4038997	c.1708T>C	synonymous_variant	0.75	pyrazinamide	Not assoc w R - Interim
clpC1	4039022	c.1683A>G	synonymous_variant	0.73	pyrazinamide
clpC1	4039121	c.1584T>C	synonymous_variant	0.83	pyrazinamide
clpC1	4039142	c.1563A>G	synonymous_variant	0.82	pyrazinamide
clpC1	4039145	c.1560G>C	synonymous_variant	0.9	pyrazinamide
clpC1	4039169	p.Glu512Asp	missense_variant	0.73	pyrazinamide
clpC1	4039172	c.1533A>G	synonymous_variant	0.69	pyrazinamide
clpC1	4039178	c.1527G>C	synonymous_variant	0.83	pyrazinamide
clpC1	4039226	c.1479T>C	synonymous_variant	0.8	pyrazinamide	Not assoc w R - Interim
clpC1	4039559	c.1146C>G	synonymous_variant	0.62	pyrazinamide
clpC1	4039577	c.1128T>C	synonymous_variant	0.83	pyrazinamide	Not assoc w R - Interim
clpC1	4039616	c.1089G>C	synonymous_variant	0.73	pyrazinamide
clpC1	4039979	c.726C>G	synonymous_variant	0.7	pyrazinamide
glpK	4138574	c.1182G>C	synonymous_variant	0.64	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138631	c.1125C>G	synonymous_variant	0.8	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138643	c.1113A>G	synonymous_variant	0.82	ethambutol	Not assoc w R - Interim
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin	Not assoc w R - Interim
					isoniazid	Not assoc w R - Interim
glpK	4138661	c.1095T>C	synonymous_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138664	c.1092G>C	synonymous_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138676	c.1080T>C	synonymous_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138682	c.1074C>G	synonymous_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138695	p.Pro354Asp	missense_variant	0.53	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138718	c.1038T>C	synonymous_variant	0.69	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138724	c.1032A>G	synonymous_variant	0.85	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138745	c.1011G>C	synonymous_variant	0.35	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138751	c.1005T>C	synonymous_variant	0.41	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138757	c.999A>G	synonymous_variant	0.72	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138763	c.993G>A	synonymous_variant	0.39	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138769	c.987G>C	synonymous_variant	0.47	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138774	p.Ser328Ala	missense_variant	0.5	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
glpK	4138778	c.978C>G	synonymous_variant	0.38	ethambutol
					moxifloxacin
					streptomycin
					levofloxacin
					rifampicin
					isoniazid
embC	4241657	p.Ser599Pro	missense_variant	0.46	ethambutol

TB-Profiler result