TB-Profiler

Lineage	Family	RDs	Frequency
La1.8	M.bovis	None	1.0
La1.8.1	M.bovis	None	1.0
La1	M.bovis	None	0.99

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
pncA	2289073	p.His57Asp	missense_variant	1.0	pyrazinamide	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	467	p.His156Arg	missense_variant	1.0	isoniazid	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	8285	c.984C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8285	c.984C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8741	c.1440C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8741	c.1440C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9217	p.Asp639Ala	missense_variant	1.0	levofloxacin	Uncertain significance
gyrA	9217	p.Asp639Ala	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	9304	p.Gly668Asp	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	moxifloxacin	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
fbiC	1302899	c.-32A>G	upstream_gene_variant	1.0	clofazimine	Uncertain significance
					pretomanid
					delamanid	Uncertain significance
rrs	1472127	n.282C>T	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472129	n.284G>C	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472137	n.292G>A	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.9	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472151	n.306C>A	non_coding_transcript_exon_variant	0.9	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.91	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472203	n.358G>A	non_coding_transcript_exon_variant	0.91	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472210	n.365A>C	non_coding_transcript_exon_variant	0.87	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472213	n.368G>C	non_coding_transcript_exon_variant	0.83	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472215	n.370A>G	non_coding_transcript_exon_variant	0.87	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>A	non_coding_transcript_exon_variant	0.86	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Uncertain significance
rrs	1472234	n.389T>C	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472236	n.391C>G	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472240	n.395G>A	non_coding_transcript_exon_variant	0.82	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472251	n.406G>A	non_coding_transcript_exon_variant	0.6	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472507	n.662C>G	non_coding_transcript_exon_variant	0.64	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472517	n.672T>A	non_coding_transcript_exon_variant	0.84	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472518	n.673G>C	non_coding_transcript_exon_variant	0.84	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472537	n.692C>T	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472541	n.696T>G	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472544	n.699C>G	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472545	n.700A>T	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472570	n.725G>A	non_coding_transcript_exon_variant	0.85	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>C	non_coding_transcript_exon_variant	0.85	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472573	n.728C>T	non_coding_transcript_exon_variant	0.85	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>T	non_coding_transcript_exon_variant	0.85	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472598	n.753A>C	non_coding_transcript_exon_variant	0.9	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472616	n.771G>A	non_coding_transcript_exon_variant	0.91	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472655	n.810G>A	non_coding_transcript_exon_variant	0.96	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472658	n.813G>A	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472659	n.814G>A	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472661	n.816A>G	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472669	n.824_825insTAG	non_coding_transcript_exon_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472677	n.832C>G	non_coding_transcript_exon_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472678	n.833T>A	non_coding_transcript_exon_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472679	n.834_835insAC	non_coding_transcript_exon_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472684	n.841_846delGATCCG	non_coding_transcript_exon_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472697	n.852T>A	non_coding_transcript_exon_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472700	n.855C>T	non_coding_transcript_exon_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472705	n.860G>A	non_coding_transcript_exon_variant	0.91	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472713	n.868T>C	non_coding_transcript_exon_variant	0.91	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472715	n.870C>T	non_coding_transcript_exon_variant	0.93	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472716	n.871C>T	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472734	n.889C>T	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472741	n.896G>A	non_coding_transcript_exon_variant	0.96	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472744	n.899A>G	non_coding_transcript_exon_variant	0.94	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472767	n.922G>A	non_coding_transcript_exon_variant	0.91	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472895	n.1050C>T	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472953	n.1109_1112delTCTC	non_coding_transcript_exon_variant	0.98	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472959	n.1114_1115insTTTA	non_coding_transcript_exon_variant	0.98	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472971	n.1126G>A	non_coding_transcript_exon_variant	0.38	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472971	n.1126G>T	non_coding_transcript_exon_variant	0.6	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472975	n.1130T>A	non_coding_transcript_exon_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472982	n.1137G>C	non_coding_transcript_exon_variant	1.0	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472987	n.1142G>T	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472988	n.1143T>A	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472991	n.1146G>A	non_coding_transcript_exon_variant	0.97	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472992	n.1147A>T	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473002	n.1157G>T	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473004	n.1159T>A	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473008	n.1163C>A	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473009	n.1164T>C	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473020	n.1175T>C	non_coding_transcript_exon_variant	0.97	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	0.95	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473053	n.1208T>A	non_coding_transcript_exon_variant	0.89	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.87	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473062	n.1217T>A	non_coding_transcript_exon_variant	0.83	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473068	n.1223A>G	non_coding_transcript_exon_variant	0.78	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrl	1474777	n.1120T>C	non_coding_transcript_exon_variant	0.97	capreomycin	Not assoc w R
rrl	1474777	n.1120T>C	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.94	capreomycin	Not assoc w R
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1474790	n.1133C>T	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1474790	n.1133C>T	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1474804	n.1147C>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1474804	n.1147C>T	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1474831	n.1174A>C	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474831	n.1174A>C	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1474866	n.1209C>A	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474866	n.1209C>A	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1474869	n.1212G>T	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474869	n.1212G>T	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1474896	n.1239A>G	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1474896	n.1239A>G	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1474902	n.1245T>C	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1474902	n.1245T>C	non_coding_transcript_exon_variant	0.91	linezolid	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.91	linezolid	Uncertain significance
rrl	1474913	n.1256T>A	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1474913	n.1256T>A	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1474920	n.1263G>A	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1474920	n.1263G>A	non_coding_transcript_exon_variant	0.85	linezolid	Uncertain significance
rrl	1476225	n.2568T>G	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1476225	n.2568T>G	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1476229	n.2572C>G	non_coding_transcript_exon_variant	0.87	capreomycin	Uncertain significance
rrl	1476229	n.2572C>G	non_coding_transcript_exon_variant	0.87	linezolid
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476280	n.2623A>C	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476280	n.2623A>C	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476293	n.2636C>T	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476293	n.2636C>T	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476301	n.2644A>C	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476301	n.2644A>C	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.92	capreomycin	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476313	n.2656G>A	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476313	n.2656G>A	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.99	capreomycin	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.99	linezolid	Uncertain significance
rrl	1476425	n.2768G>A	non_coding_transcript_exon_variant	0.97	capreomycin	Uncertain significance
rrl	1476425	n.2768G>A	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.97	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.97	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.97	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.97	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.92	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.92	linezolid	Uncertain significance
rrl	1476512	n.2855C>T	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1476512	n.2855C>T	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1476514	n.2857C>T	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476514	n.2857C>T	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476517	n.2860C>T	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476517	n.2860C>T	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476523	n.2866T>C	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476523	n.2866T>C	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476530	n.2873C>T	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476530	n.2873C>T	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476537	n.2880A>G	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476537	n.2880A>G	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	0.89	capreomycin	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	0.89	linezolid	Uncertain significance
rrl	1476547	n.2890C>T	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1476547	n.2890C>T	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1476567	n.2910C>T	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1476567	n.2910C>T	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1476573	n.2916A>T	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1476573	n.2916A>T	non_coding_transcript_exon_variant	0.94	linezolid
rrl	1476577	n.2920T>G	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1476577	n.2920T>G	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	0.95	capreomycin	Not assoc w R
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2062922	p.Ile603Val	missense_variant	1.0	streptomycin	Not assoc w R
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
ndh	2103173	c.-132delG	upstream_gene_variant	1.0	ethionamide
					delamanid
					isoniazid
katG	2154724	p.Arg463Leu	missense_variant	1.0	isoniazid	Not assoc w R
katG	2155503	c.609C>T	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156025	c.87C>A	synonymous_variant	1.0	isoniazid	Not assoc w R
PPE35	2167926	p.Leu896Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
PPE35	2168011	p.Ser868Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
eis	2715125	p.Thr70Ala	missense_variant	1.0	amikacin	Uncertain significance
eis	2715125	p.Thr70Ala	missense_variant	1.0	kanamycin	Uncertain significance
Rv2477c	2782927	c.1116A>G	synonymous_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					amikacin	Not assoc w R - Interim
Rv2681	2997325	p.Ala196Val	missense_variant	1.0	capreomycin	Uncertain significance
Rv2752c	3065988	p.Glu68Asp	missense_variant	1.0	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
lpqB	3623372	c.1539G>C	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3623372	c.1539G>C	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624350	c.561G>T	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624350	c.561G>T	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624593	c.318G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624593	c.318G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
mtrB	3625065	p.Met517Leu	missense_variant	1.0	bedaquiline	Uncertain significance
mtrB	3625065	p.Met517Leu	missense_variant	1.0	rifampicin	Not assoc w R
glpK	4138377	p.Val460Ala	missense_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
embC	4240671	p.Thr270Ile	missense_variant	1.0	ethambutol	Not assoc w R
embC	4242970	c.3108C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4244220	c.988C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4246551	p.Asn13Ser	missense_variant	1.0	ethambutol	Not assoc w R
embB	4246864	c.351C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4247646	p.Glu378Ala	missense_variant	1.0	ethambutol	Not assoc w R
aftB	4267858	p.Ile327Val	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269351	c.483C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
ubiA	4269387	p.Glu149Asp	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269606	c.228T>C	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R

TB-Profiler result