TB-Profiler result

Run: ERR4821981
Summary

Run ID: ERR4821981

Sample name:

Date: 01-04-2023 17:34:07

Number of reads: 2139436

Percentage reads mapped: 87.27

Strain: lineage4.1.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.2 Euro-American T;H None 1.0
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.57 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 575679 p.Asn111Ser missense_variant 1.0
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoB 762080 c.2274G>C synonymous_variant 0.11
rpoB 762085 p.Ala760Glu missense_variant 0.11
rpoB 762110 c.2304G>C synonymous_variant 0.13
rpoB 762114 p.Ile770Val missense_variant 0.14
rpoB 762212 c.2406G>C synonymous_variant 0.12
rpoB 762218 c.2412T>C synonymous_variant 0.11
rpoB 762245 c.2439G>C synonymous_variant 0.11
rpoB 762254 c.2448T>C synonymous_variant 0.11
rpoC 764503 c.1134G>T synonymous_variant 0.14
rpoC 764512 c.1143G>C synonymous_variant 0.15
rpoC 764521 c.1152T>C synonymous_variant 0.18
rpoC 764530 c.1161C>T synonymous_variant 0.17
rpoC 764536 c.1167G>C synonymous_variant 0.17
rpoC 764543 p.Thr392Ala missense_variant 0.18
rpoC 764548 c.1179G>C synonymous_variant 0.19
rpoC 764626 c.1257C>T synonymous_variant 0.11
rpoC 764632 c.1263T>C synonymous_variant 0.12
rpoC 764647 c.1278C>T synonymous_variant 0.14
rpoC 764650 c.1281G>T synonymous_variant 0.13
rpoC 764653 c.1284G>C synonymous_variant 0.12
rpoC 764656 c.1287C>T synonymous_variant 0.14
rpoC 764662 c.1293G>C synonymous_variant 0.15
rpoC 764677 c.1308C>G synonymous_variant 0.16
rpoC 764678 p.Lys437Gln missense_variant 0.16
rpoC 764692 c.1323C>T synonymous_variant 0.13
rpoC 764706 p.Leu446Gln missense_variant 0.14
rpoC 764713 c.1344G>C synonymous_variant 0.12
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.22
rrs 1472078 n.233C>T non_coding_transcript_exon_variant 0.3
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.64
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.61
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.61
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.62
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.74
rrs 1472155 n.310C>T non_coding_transcript_exon_variant 0.72
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.67
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.8
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.76
rrs 1472258 n.413A>G non_coding_transcript_exon_variant 0.6
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.6
rrs 1472338 n.493A>G non_coding_transcript_exon_variant 0.22
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.22
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.33
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.4
rrs 1472412 n.567A>G non_coding_transcript_exon_variant 0.5
rrs 1472416 n.571C>T non_coding_transcript_exon_variant 0.5
rrs 1472422 n.577T>C non_coding_transcript_exon_variant 0.5
rrs 1472462 n.617T>G non_coding_transcript_exon_variant 0.5
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.5
rrs 1472473 n.628G>T non_coding_transcript_exon_variant 0.5
rrs 1472474 n.629C>G non_coding_transcript_exon_variant 0.5
rrs 1472476 n.631A>G non_coding_transcript_exon_variant 0.5
rrs 1472484 n.639A>T non_coding_transcript_exon_variant 0.67
rrs 1472489 n.644A>T non_coding_transcript_exon_variant 0.67
rrs 1472494 n.649A>G non_coding_transcript_exon_variant 0.67
rrs 1472496 n.651T>G non_coding_transcript_exon_variant 0.67
rrs 1472498 n.653C>T non_coding_transcript_exon_variant 0.75
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.67
rrs 1472513 n.668T>C non_coding_transcript_exon_variant 0.2
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.67
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.67
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.68
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.74
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.72
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.72
rrs 1472549 n.704G>A non_coding_transcript_exon_variant 0.23
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.71
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.76
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.63
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.25
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.81
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.93
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.23
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.72
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.72
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.27
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.3
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.92
rrs 1472655 n.810G>T non_coding_transcript_exon_variant 0.86
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.53
rrs 1472660 n.815T>C non_coding_transcript_exon_variant 0.33
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.53
rrs 1472670 n.825G>T non_coding_transcript_exon_variant 0.5
rrs 1472673 n.828T>A non_coding_transcript_exon_variant 0.6
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.57
rrs 1472677 n.832C>T non_coding_transcript_exon_variant 0.57
rrs 1472681 n.837_838delTT non_coding_transcript_exon_variant 0.5
rrs 1472687 n.843dupT non_coding_transcript_exon_variant 0.43
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.56
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.36
rrs 1472707 n.862A>T non_coding_transcript_exon_variant 0.24
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.54
rrs 1472714 n.869A>G non_coding_transcript_exon_variant 0.31
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.52
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.56
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.56
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.59
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.37
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.57
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.59
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.95
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.29
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.33
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.82
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.84
rrs 1472954 n.1109T>C non_coding_transcript_exon_variant 0.71
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.84
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.75
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.12
rrs 1472973 n.1128A>G non_coding_transcript_exon_variant 0.87
rrs 1472974 n.1129A>G non_coding_transcript_exon_variant 0.14
rrs 1472988 n.1143T>C non_coding_transcript_exon_variant 0.12
rrs 1472990 n.1145A>G non_coding_transcript_exon_variant 0.88
rrs 1472992 n.1147A>G non_coding_transcript_exon_variant 0.68
rrs 1473005 n.1160C>T non_coding_transcript_exon_variant 0.74
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.76
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.76
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.76
rrs 1473066 n.1221A>G non_coding_transcript_exon_variant 0.79
rrs 1473080 n.1235C>T non_coding_transcript_exon_variant 0.65
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.65
rrs 1473088 n.1243A>G non_coding_transcript_exon_variant 0.78
rrs 1473093 n.1248C>T non_coding_transcript_exon_variant 0.73
rrs 1473100 n.1255G>A non_coding_transcript_exon_variant 0.73
rrs 1473101 n.1256C>T non_coding_transcript_exon_variant 0.16
rrs 1473102 n.1257C>T non_coding_transcript_exon_variant 0.5
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.72
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.68
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.68
rrs 1473121 n.1276T>C non_coding_transcript_exon_variant 0.62
rrs 1473123 n.1278A>T non_coding_transcript_exon_variant 0.79
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.73
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.85
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.85
rrs 1473172 n.1327T>G non_coding_transcript_exon_variant 0.86
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.93
rrs 1473221 n.1376C>T non_coding_transcript_exon_variant 0.93
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.83
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.83
rrs 1473276 n.1431A>C non_coding_transcript_exon_variant 0.79
rrs 1473277 n.1432G>A non_coding_transcript_exon_variant 0.74
rrs 1473293 n.1449delA non_coding_transcript_exon_variant 0.58
rrs 1473300 n.1455C>T non_coding_transcript_exon_variant 0.62
rrs 1473301 n.1456T>G non_coding_transcript_exon_variant 0.62
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.69
rrl 1474181 n.524C>A non_coding_transcript_exon_variant 1.0
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 1.0
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 1.0
rrl 1474199 n.542G>C non_coding_transcript_exon_variant 1.0
rrl 1474200 n.545delT non_coding_transcript_exon_variant 1.0
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 1.0
rrl 1474488 n.831G>T non_coding_transcript_exon_variant 1.0
rrl 1474495 n.838G>A non_coding_transcript_exon_variant 1.0
rrl 1474498 n.841G>T non_coding_transcript_exon_variant 1.0
rrl 1474505 n.848C>G non_coding_transcript_exon_variant 1.0
rrl 1474508 n.851C>T non_coding_transcript_exon_variant 1.0
rrl 1474516 n.859C>A non_coding_transcript_exon_variant 1.0
rrl 1474527 n.870T>C non_coding_transcript_exon_variant 1.0
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 1.0
rrl 1474542 n.885A>G non_coding_transcript_exon_variant 1.0
rrl 1474626 n.969T>C non_coding_transcript_exon_variant 1.0
rrl 1474632 n.975G>T non_coding_transcript_exon_variant 1.0
rrl 1474634 n.977T>G non_coding_transcript_exon_variant 1.0
rrl 1474636 n.979A>C non_coding_transcript_exon_variant 1.0
rrl 1474638 n.981C>G non_coding_transcript_exon_variant 1.0
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 1.0
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 1.0
rrl 1474824 n.1167A>G non_coding_transcript_exon_variant 1.0
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 1.0
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 1.0
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 1.0
rrl 1474832 n.1175A>T non_coding_transcript_exon_variant 0.33
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 1.0
rrl 1475715 n.2058G>C non_coding_transcript_exon_variant 0.75
rrl 1475751 n.2094C>A non_coding_transcript_exon_variant 0.87
rrl 1475756 n.2099T>C non_coding_transcript_exon_variant 0.87
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.87
rrl 1475767 n.2110_2111insT non_coding_transcript_exon_variant 0.93
rrl 1475777 n.2120A>T non_coding_transcript_exon_variant 0.93
rrl 1475883 n.2226A>C non_coding_transcript_exon_variant 0.9
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.75
rrl 1475884 n.2227A>G non_coding_transcript_exon_variant 0.69
rrl 1475892 n.2235A>G non_coding_transcript_exon_variant 0.29
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.64
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.9
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.91
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.42
rrl 1475916 n.2259C>G non_coding_transcript_exon_variant 0.8
rrl 1475937 n.2280A>T non_coding_transcript_exon_variant 0.71
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.57
rrl 1475945 n.2288C>A non_coding_transcript_exon_variant 0.43
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.57
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.43
rrl 1475975 n.2318C>T non_coding_transcript_exon_variant 0.43
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.33
rrl 1476164 n.2507A>T non_coding_transcript_exon_variant 0.25
rrl 1476179 n.2522C>T non_coding_transcript_exon_variant 0.33
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.29
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.44
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.22
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.3
rrl 1476207 n.2550T>C non_coding_transcript_exon_variant 0.2
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.3
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.3
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.3
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.2
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.2
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.22
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.25
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.29
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.11
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.75
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.13
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.78
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.11
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.68
rrl 1476429 n.2772A>T non_coding_transcript_exon_variant 0.65
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.74
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.48
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.32
rrl 1476513 n.2856G>T non_coding_transcript_exon_variant 0.22
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.1
rrl 1476585 n.2928A>G non_coding_transcript_exon_variant 0.11
rrl 1476594 n.2937C>A non_coding_transcript_exon_variant 0.11
rrl 1476603 n.2946G>T non_coding_transcript_exon_variant 0.11
rrl 1476607 n.2950C>T non_coding_transcript_exon_variant 0.1
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.1
rpsA 1834234 c.693G>C synonymous_variant 0.1
rpsA 1834249 c.708T>C synonymous_variant 0.12
rpsA 1834261 c.720A>G synonymous_variant 0.15
rpsA 1834264 c.723G>C synonymous_variant 0.15
rpsA 1834294 c.753G>C synonymous_variant 0.11
rpsA 1834298 p.Gln253Glu missense_variant 0.11
rpsA 1834417 c.876G>C synonymous_variant 0.12
rpsA 1834451 c.910T>C synonymous_variant 0.12
rpsA 1834459 c.918G>C synonymous_variant 0.11
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
Rv2752c 3064984 p.Leu403Arg missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0