TB-Profiler result

Run: SRR9971369
Summary

Run ID: SRR9971369

Sample name:

Date: 04-04-2023 23:25:33

Number of reads: 4736908

Percentage reads mapped: 81.85

Strain: lineage4.1.1.3

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 1.0
lineage4.1.1 Euro-American (X-type) X1;X2;X3 None 1.0
lineage4.1.1.3 Euro-American (X-type) X1;X3 RD193 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 0.99 rifampicin
rrs 1472723 n.878G>A non_coding_transcript_exon_variant 0.48 streptomycin
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.48 streptomycin
fabG1 1673425 c.-15C>T upstream_gene_variant 1.0 isoniazid, ethionamide
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
pncA 2288782 p.Arg154Gly missense_variant 1.0 pyrazinamide
ald 3087278 c.464delG frameshift_variant 1.0 cycloserine
embA 4243217 c.-16C>G upstream_gene_variant 1.0 ethambutol
embB 4247431 p.Met306Ile missense_variant 0.99 ethambutol
ethA 4326279 c.1192_1194dupGTG conservative_inframe_insertion 0.91 ethionamide
ethA 4326604 c.869dupA frameshift_variant 0.99 ethionamide, ethionamide
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7581 p.Asp94Cys missense_variant 0.19
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.22
rpoB 762285 p.Arg827Cys missense_variant 0.98
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 0.99
rpsL 781435 c.-125G>C upstream_gene_variant 0.99
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.12
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.15
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.13
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.13
rrs 1472507 n.662C>G non_coding_transcript_exon_variant 0.33
rrs 1472517 n.672T>A non_coding_transcript_exon_variant 0.42
rrs 1472518 n.673G>T non_coding_transcript_exon_variant 0.48
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.58
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.61
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.62
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.61
rrs 1472566 n.721G>A non_coding_transcript_exon_variant 0.62
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.6
rrs 1472579 n.734G>C non_coding_transcript_exon_variant 0.59
rrs 1472580 n.735C>T non_coding_transcript_exon_variant 0.57
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.57
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.58
rrs 1472599 n.754G>T non_coding_transcript_exon_variant 0.58
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.58
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.42
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.4
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.38
rrs 1472668 n.825_829delGGGTT non_coding_transcript_exon_variant 0.39
rrs 1472675 n.830_831insAGAC non_coding_transcript_exon_variant 0.35
rrs 1472680 n.835C>T non_coding_transcript_exon_variant 0.35
rrs 1472682 n.837T>C non_coding_transcript_exon_variant 0.35
rrs 1472683 n.838T>G non_coding_transcript_exon_variant 0.35
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.34
rrs 1472689 n.844C>T non_coding_transcript_exon_variant 0.34
rrs 1472690 n.845C>A non_coding_transcript_exon_variant 0.39
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.38
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.47
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.45
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.45
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.45
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.32
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.3
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.23
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.12
rrs 1473199 n.1356delA non_coding_transcript_exon_variant 0.16
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.15
rrl 1473999 n.342C>A non_coding_transcript_exon_variant 0.15
rrl 1474139 n.482C>A non_coding_transcript_exon_variant 0.29
rrl 1474228 n.571T>C non_coding_transcript_exon_variant 0.22
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.5
rrl 1474252 n.595T>A non_coding_transcript_exon_variant 0.25
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.33
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.29
rrl 1474292 n.635T>G non_coding_transcript_exon_variant 0.33
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.4
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.25
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.25
rrl 1474362 n.705A>G non_coding_transcript_exon_variant 0.17
rrl 1474401 n.744C>A non_coding_transcript_exon_variant 0.17
rrl 1474458 n.801C>A non_coding_transcript_exon_variant 0.17
rrl 1474514 n.857G>T non_coding_transcript_exon_variant 0.17
rrl 1474700 n.1043C>A non_coding_transcript_exon_variant 0.12
rrl 1475175 n.1518G>T non_coding_transcript_exon_variant 0.21
rrl 1475595 n.1938G>T non_coding_transcript_exon_variant 0.13
rrl 1475981 n.2324G>C non_coding_transcript_exon_variant 0.14
rrl 1476014 n.2357G>T non_coding_transcript_exon_variant 0.23
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.12
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.12
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.25
rrl 1476227 n.2570C>T non_coding_transcript_exon_variant 0.24
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.32
rrl 1476250 n.2593C>G non_coding_transcript_exon_variant 0.33
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.4
rrl 1476252 n.2595T>A non_coding_transcript_exon_variant 0.33
rrl 1476257 n.2600G>C non_coding_transcript_exon_variant 0.33
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.35
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.41
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.38
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.38
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.38
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.36
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.45
rrl 1476301 n.2644A>C non_coding_transcript_exon_variant 0.41
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.41
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.4
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.41
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.43
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.6
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.62
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.63
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.65
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.67
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.67
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.71
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.71
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.69
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.69
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.68
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.65
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.43
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.28
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.18
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
alr 3841418 c.-18_2delAGGCCGGAATACTGCTCAGT frameshift_variant 0.52
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 0.99
embB 4249408 c.2895G>A synonymous_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407798 c.405G>T synonymous_variant 1.0