TB-Profiler result

Run: ERR2652981
Summary

Run ID: ERR2652981

Sample name:

Date: 31-03-2023 22:25:49

Number of reads: 722721

Percentage reads mapped: 68.86

Strain: lineage4.1.2.1

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.1 Euro-American T;X;H None 0.99
lineage4.1.2 Euro-American T;H None 0.99
lineage4.1.2.1 Euro-American (Haarlem) T1;H1 RD182 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491591 p.Lys270Met missense_variant 1.0
mshA 575679 p.Asn111Ser missense_variant 1.0
mshA 576332 p.Pro329Ser missense_variant 0.12
ccsA 619811 c.-80A>G upstream_gene_variant 0.12
rpoB 760115 c.309C>T synonymous_variant 1.0
rpoC 765150 p.Gly594Glu missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1407021 p.Ala107Gly missense_variant 0.67
Rv1258c 1407489 c.-149G>A upstream_gene_variant 1.0
embR 1416526 c.822C>G synonymous_variant 0.11
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.11
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.17
rrs 1472537 n.692C>T non_coding_transcript_exon_variant 0.2
rrs 1472544 n.699C>G non_coding_transcript_exon_variant 0.2
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.2
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.27
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.32
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.32
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.31
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.31
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.33
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.33
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.32
rrs 1472659 n.814G>A non_coding_transcript_exon_variant 0.32
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.32
rrs 1472669 n.824_825insTAG non_coding_transcript_exon_variant 0.34
rrs 1472677 n.832C>G non_coding_transcript_exon_variant 0.31
rrs 1472678 n.833T>A non_coding_transcript_exon_variant 0.31
rrs 1472679 n.834_835insAC non_coding_transcript_exon_variant 0.31
rrs 1472684 n.841_846delGATCCG non_coding_transcript_exon_variant 0.31
rrs 1472697 n.852T>A non_coding_transcript_exon_variant 0.34
rrs 1472700 n.855C>T non_coding_transcript_exon_variant 0.35
rrs 1472705 n.860G>A non_coding_transcript_exon_variant 0.33
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.32
rrs 1472715 n.870C>T non_coding_transcript_exon_variant 0.31
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.31
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.32
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.31
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.34
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.35
rrs 1472779 n.934G>A non_coding_transcript_exon_variant 0.25
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.25
rrs 1472786 n.941C>T non_coding_transcript_exon_variant 0.22
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.22
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.18
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.17
rrs 1472953 n.1109_1112delTCTC non_coding_transcript_exon_variant 0.18
rrs 1472959 n.1114_1115insTTTA non_coding_transcript_exon_variant 0.17
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.17
rrs 1472975 n.1130T>G non_coding_transcript_exon_variant 0.17
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.17
rrs 1472982 n.1137G>C non_coding_transcript_exon_variant 0.17
rrs 1472987 n.1142G>T non_coding_transcript_exon_variant 0.17
rrs 1472988 n.1143T>A non_coding_transcript_exon_variant 0.17
rrs 1472991 n.1146G>A non_coding_transcript_exon_variant 0.17
rrs 1472992 n.1147A>T non_coding_transcript_exon_variant 0.17
rrs 1473002 n.1157G>T non_coding_transcript_exon_variant 0.17
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.17
rrs 1473008 n.1163C>A non_coding_transcript_exon_variant 0.17
rrs 1473009 n.1164T>C non_coding_transcript_exon_variant 0.17
rrs 1473020 n.1175T>C non_coding_transcript_exon_variant 0.17
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.19
rrs 1473053 n.1208T>A non_coding_transcript_exon_variant 0.19
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.19
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.19
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.19
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.21
rrs 1473070 n.1225G>A non_coding_transcript_exon_variant 0.2
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.21
rrs 1473089 n.1244A>C non_coding_transcript_exon_variant 0.2
rrs 1473093 n.1248C>A non_coding_transcript_exon_variant 0.21
rrs 1473094 n.1249T>A non_coding_transcript_exon_variant 0.21
rrs 1473099 n.1254T>A non_coding_transcript_exon_variant 0.2
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.2
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.2
rrs 1473115 n.1270G>C non_coding_transcript_exon_variant 0.19
rrs 1473121 n.1276_1277insA non_coding_transcript_exon_variant 0.2
rrs 1473130 n.1285G>A non_coding_transcript_exon_variant 0.17
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.13
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.23
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.36
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.34
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.34
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.35
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.33
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.33
rrl 1476297 n.2640C>A non_coding_transcript_exon_variant 0.33
rrl 1476301 n.2644A>C non_coding_transcript_exon_variant 0.33
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.33
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.32
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.32
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.32
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.35
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.39
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.43
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.42
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.38
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.39
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.39
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.43
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.49
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.48
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.47
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.41
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.36
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.33
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.33
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.33
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.33
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.34
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.34
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.33
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.32
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.32
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.32
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.32
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.32
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.33
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.33
rrl 1476577 n.2920T>G non_coding_transcript_exon_variant 0.33
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.23
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.11
rrl 1476614 n.2957A>G non_coding_transcript_exon_variant 0.11
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168758 p.Gln619* stop_gained 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518076 c.-39C>T upstream_gene_variant 1.0
kasA 2518598 p.Ala162Thr missense_variant 0.12
kasA 2518603 c.489G>C synonymous_variant 0.13
kasA 2519057 p.Thr315Ser missense_variant 0.13
kasA 2519062 c.948T>G synonymous_variant 0.15
kasA 2519065 c.951C>A synonymous_variant 0.15
kasA 2519070 p.Asp319Val missense_variant 0.17
kasA 2519076 p.Ala321Val missense_variant 0.15
folC 2747472 p.Ile43Val missense_variant 0.1
pepQ 2859573 c.846C>T synonymous_variant 0.12
pepQ 2860162 p.Arg86Pro missense_variant 0.18
pepQ 2860170 c.249G>C synonymous_variant 0.18
Rv2752c 3066299 c.-108C>T upstream_gene_variant 1.0
thyX 3067230 p.Thr239Ile missense_variant 0.2
thyX 3067401 p.Arg182His missense_variant 0.14
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fbiD 3339655 p.Gly180* stop_gained 0.12
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475339 p.Ala445Thr missense_variant 0.11
fprA 3475352 p.Glu449Gly missense_variant 0.11
alr 3841144 p.Thr93Ser missense_variant 0.18
rpoA 3878508 c.-1C>G upstream_gene_variant 0.11
embA 4242553 c.-680G>C upstream_gene_variant 0.29
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242803 p.Val981Leu missense_variant 1.0
embA 4244626 p.Leu465Pro missense_variant 0.29
embB 4247066 p.Ile185Val missense_variant 0.1
ubiA 4270018 c.-185T>A upstream_gene_variant 0.17
whiB6 4338595 c.-75delG upstream_gene_variant 1.0