TB-Profiler result

Run: ERR9787079
Summary

Run ID: ERR9787079

Sample name:

Date: 02-04-2023 12:59:15

Number of reads: 1441065

Percentage reads mapped: 92.89

Strain: lineage6.1.3

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage6 West-Africa 2 AFRI_1 RD702 1.0
lineage6.1.3 West-Africa 2 AFRI_1 RD702 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
embC 4240781 p.Ala307Thr missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6446 p.Ala403Ser missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 8493 p.Leu398Phe missense_variant 1.0
gyrA 8806 p.Asp502Gly missense_variant 1.0
gyrA 9143 c.1842T>C synonymous_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491668 p.Lys296Glu missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 760855 p.Thr350Ile missense_variant 1.0
rpoB 760969 p.Ser388Leu missense_variant 1.0
rpoB 761723 p.Glu639Asp missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 766231 c.2862T>C synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0
fbiC 1304213 p.Val428Ala missense_variant 1.0
Rv1258c 1406685 p.Val219Ala missense_variant 1.0
embR 1416633 p.Leu239Val missense_variant 1.0
atpE 1461251 c.207G>T synonymous_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.13
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.13
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.15
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.19
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.16
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.14
rrs 1472591 n.746G>A non_coding_transcript_exon_variant 0.2
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.22
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.24
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.27
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.27
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.26
rrs 1472669 n.824_825insTAG non_coding_transcript_exon_variant 0.23
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.21
rrs 1472678 n.833T>A non_coding_transcript_exon_variant 0.21
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.21
rrs 1472708 n.863T>A non_coding_transcript_exon_variant 0.22
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.21
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.21
rrs 1472733 n.888G>C non_coding_transcript_exon_variant 0.22
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.22
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.22
rrs 1472742 n.897C>G non_coding_transcript_exon_variant 0.22
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.22
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.19
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.14
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.13
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.17
rrs 1472953 n.1108G>A non_coding_transcript_exon_variant 0.15
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.15
rrs 1472958 n.1113A>T non_coding_transcript_exon_variant 0.15
rrs 1472959 n.1114T>A non_coding_transcript_exon_variant 0.15
rrs 1472969 n.1125_1126delCG non_coding_transcript_exon_variant 0.15
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.15
rrs 1472974 n.1129A>C non_coding_transcript_exon_variant 0.14
rrs 1472975 n.1130T>A non_coding_transcript_exon_variant 0.14
rrs 1472977 n.1132G>T non_coding_transcript_exon_variant 0.14
rrs 1472982 n.1137G>C non_coding_transcript_exon_variant 0.15
rrs 1472987 n.1142G>T non_coding_transcript_exon_variant 0.17
rrs 1472988 n.1143T>A non_coding_transcript_exon_variant 0.17
rrs 1473001 n.1156G>T non_coding_transcript_exon_variant 0.17
rrs 1473002 n.1157G>C non_coding_transcript_exon_variant 0.17
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.14
rrs 1473008 n.1163C>G non_coding_transcript_exon_variant 0.16
rrs 1473009 n.1164T>A non_coding_transcript_exon_variant 0.17
rrs 1473020 n.1175T>C non_coding_transcript_exon_variant 0.17
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.19
rrs 1473053 n.1208T>A non_coding_transcript_exon_variant 0.17
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.16
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.17
rrl 1474869 n.1212G>T non_coding_transcript_exon_variant 0.12
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.17
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.17
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.18
rrl 1476195 n.2538C>A non_coding_transcript_exon_variant 0.19
rrl 1476196 n.2539C>A non_coding_transcript_exon_variant 0.18
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.18
rrl 1476204 n.2547C>A non_coding_transcript_exon_variant 0.16
rrl 1476210 n.2553G>T non_coding_transcript_exon_variant 0.14
rrl 1476211 n.2554G>T non_coding_transcript_exon_variant 0.16
rrl 1476212 n.2555T>C non_coding_transcript_exon_variant 0.16
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.16
rrl 1476215 n.2558C>A non_coding_transcript_exon_variant 0.16
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.3
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.38
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.4
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.38
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.36
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.36
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.36
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.36
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.36
rrl 1476301 n.2644A>C non_coding_transcript_exon_variant 0.35
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.35
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.35
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.36
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.35
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.4
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.43
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.5
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.53
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.54
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.51
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.51
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.52
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.49
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.49
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.47
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.48
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.45
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.42
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.41
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.42
rrl 1476523 n.2866T>C non_coding_transcript_exon_variant 0.41
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.41
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.42
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.42
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.42
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.41
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.4
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.41
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.37
rrl 1476573 n.2916A>C non_coding_transcript_exon_variant 0.33
rrl 1476577 n.2920T>G non_coding_transcript_exon_variant 0.33
rrl 1476595 n.2938C>A non_coding_transcript_exon_variant 0.29
rrl 1476602 n.2945G>T non_coding_transcript_exon_variant 0.31
rrl 1476608 n.2951C>A non_coding_transcript_exon_variant 0.26
rrl 1476614 n.2957A>G non_coding_transcript_exon_variant 0.2
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.2
rrl 1476621 n.2964C>T non_coding_transcript_exon_variant 0.14
rrl 1476624 n.2967T>G non_coding_transcript_exon_variant 0.14
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.14
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.14
rrl 1476637 n.2980C>G non_coding_transcript_exon_variant 0.15
inhA 1674434 p.Val78Ala missense_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155503 c.609C>T synonymous_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289770 c.-529T>G upstream_gene_variant 1.0
kasA 2518132 c.18C>T synonymous_variant 1.0
folC 2746750 c.849C>A synonymous_variant 0.12
ald 3086728 c.-92C>T upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
ald 3087084 c.266delA frameshift_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
fprA 3475159 p.Asn385Asp missense_variant 1.0
Rv3236c 3612143 p.Arg325His missense_variant 1.0
embC 4240671 p.Thr270Ile missense_variant 1.0
embC 4241843 p.Leu661Ile missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4244220 c.988C>T synonymous_variant 1.0
embA 4244379 p.Pro383Ser missense_variant 1.0
embB 4246864 c.351C>T synonymous_variant 1.0
embB 4247646 p.Glu378Ala missense_variant 1.0
aftB 4269351 c.-515C>T upstream_gene_variant 1.0
ubiA 4269387 p.Glu149Asp missense_variant 1.0
aftB 4269522 c.-686C>T upstream_gene_variant 1.0
aftB 4269606 c.-770T>C upstream_gene_variant 1.0
ethA 4326465 p.Ile337Val missense_variant 1.0
ethR 4327779 p.Asp77Glu missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338602 c.-81A>C upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4408034 p.Glu57Lys missense_variant 1.0