Run ID: SRR25827345
Sample name:
Date: 2024-04-16T06:39:49.651028
Number of reads: 7957714
Percentage reads mapped: 98.71
Median coverage: 272.0
Strain: lineage1.1.2;lineage2.2.1;lineage3.1.2;lineage4.8
Spoligotype:
Drug-resistance: XDR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage3 | East-African-Indian | RD750 | 0.33 |
lineage1.1.2 | Indo-Oceanic | RD239 | 0.17 |
lineage3.1.2 | East-African-Indian | RD750 | 0.26 |
lineage2 | East-Asian | RD105 | 0.28 |
lineage1.1 | Indo-Oceanic | RD239 | 0.18 |
lineage2.2.1 | East-Asian (Beijing) | RD105;RD207;RD181 | 0.3 |
lineage2.2 | East-Asian (Beijing) | RD105;RD207 | 0.29 |
lineage4 | Euro-American | None | 0.18 |
lineage4.8 | Euro-American (mainly T) | RD219 | 0.16 |
lineage1 | Indo-Oceanic | RD239 | 0.22 |
lineage3.1 | East-African-Indian | RD750 | 0.26 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | rpoB | p.Ser450Leu | Assoc w R | |
isoniazid | inhA | c.-777C>T | Assoc w R | Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
katG | p.Ser315Thr | Assoc w R | High-level resistance | |
ethambutol | ||||
pyrazinamide | pncA | p.Gly132Ala | Assoc w R | |
p.Asp63Gly | Assoc w R - Interim | |||
streptomycin | rpsL | p.Lys43Arg | Assoc w R | |
gid | p.Tyr22* | Assoc w R | ||
fluoroquinolones | ||||
moxifloxacin | gyrA | p.Ala90Val | Assoc w R | Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
p.Asp94Gly | Assoc w R | High-level resistance | ||
ofloxacin | ||||
levofloxacin | gyrA | p.Ala90Val | Assoc w R | |
p.Asp94Gly | Assoc w R | |||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | eis | c.-37G>T | Assoc w R | |
cycloserine | ||||
ethionamide | inhA | c.-777C>T | Assoc w R | Alias fabG1_c.-15C>T |
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid | rplC | p.Cys154Arg | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
gyrA | 7570 | p.Ala90Val | missense_variant | 0.24 | levofloxacin | Assoc w R | |
moxifloxacin | Assoc w R | Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) | |||||
gyrA | 7582 | p.Asp94Gly | missense_variant | 0.18 | levofloxacin | Assoc w R | |
moxifloxacin | Assoc w R | High-level resistance | |||||
rpoB | 761155 | p.Ser450Leu | missense_variant | 0.92 | rifampicin | Assoc w R | |
rpsL | 781687 | p.Lys43Arg | missense_variant | 0.45 | streptomycin | Assoc w R | |
rplC | 801268 | p.Cys154Arg | missense_variant | 0.19 | linezolid | Assoc w R | |
inhA | 1673425 | c.-777C>T | upstream_gene_variant | 0.41 | ethionamide | Assoc w R | Alias fabG1_c.-15C>T |
isoniazid | Assoc w R | Alias fabG1_c.-15C>T. Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) | |||||
katG | 2155168 | p.Ser315Thr | missense_variant | 0.68 | isoniazid | Assoc w R | High-level resistance |
pncA | 2288847 | p.Gly132Ala | missense_variant | 0.13 | pyrazinamide | Assoc w R | |
pncA | 2289054 | p.Asp63Gly | missense_variant | 0.21 | pyrazinamide | Assoc w R - Interim | |
eis | 2715369 | c.-37G>T | upstream_gene_variant | 0.15 | kanamycin | Assoc w R | |
gid | 4408137 | p.Tyr22* | stop_gained | 0.15 | streptomycin | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 5332 | c.93C>T | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6112 | p.Met291Ile | missense_variant | 0.17 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrB | 6124 | c.885C>T | synonymous_variant | 0.14 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 0.81 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8168 | p.Glu289Asp | missense_variant | 0.13 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8452 | p.Ala384Val | missense_variant | 0.17 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9143 | c.1842T>C | synonymous_variant | 0.21 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 0.8 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
Rv0010c | 13298 | p.Ile87Met | missense_variant | 0.2 | isoniazid | Not assoc w R |
fgd1 | 491290 | p.Val170Met | missense_variant | 0.18 | clofazimine | Not assoc w R |
pretomanid | ||||||
delamanid | Uncertain significance | |||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 0.78 | clofazimine | Not assoc w R |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
mshA | 575907 | p.Ala187Val | missense_variant | 0.31 | ethionamide | Not assoc w R |
isoniazid | Not assoc w R | |||||
ccsA | 620553 | c.663T>C | synonymous_variant | 0.12 | capreomycin | Not assoc w R |
amikacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
ccsA | 620625 | p.Ile245Met | missense_variant | 0.29 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Uncertain significance | |||||
Rv0565c | 656265 | c.1204_1205delAC | frameshift_variant | 0.2 | ethionamide | Uncertain significance |
Rv0565c | 657081 | c.390G>A | synonymous_variant | 0.66 | ethionamide | Not assoc w R - Interim |
Rv0565c | 657142 | p.Arg110His | missense_variant | 0.31 | ethionamide | Uncertain significance |
Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 0.17 | ethionamide | |
nusG | 734116 | c.-138T>C | upstream_gene_variant | 0.24 | rifampicin | Not assoc w R |
nusG | 734658 | c.405A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R |
rpoB | 759546 | c.-261A>G | upstream_gene_variant | 0.2 | rifampicin | Not assoc w R |
rpoB | 759746 | c.-61C>T | upstream_gene_variant | 0.34 | rifampicin | Not assoc w R |
rpoB | 760490 | c.684C>T | synonymous_variant | 0.22 | rifampicin | Not assoc w R |
rpoB | 762434 | c.2628T>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.76 | rifampicin | Not assoc w R |
rpoC | 763884 | p.Ala172Val | missense_variant | 0.17 | rifampicin | Not assoc w R |
rpoC | 763886 | c.517C>A | synonymous_variant | 0.17 | rifampicin | Not assoc w R |
rpoC | 764363 | p.Gly332Ser | missense_variant | 0.13 | rifampicin | Uncertain significance |
rpoC | 764817 | p.Val483Gly | missense_variant | 0.21 | rifampicin | Uncertain significance |
rpoC | 764840 | p.Ile491Val | missense_variant | 0.13 | rifampicin | Uncertain significance |
rpoC | 765171 | p.Pro601Leu | missense_variant | 0.19 | rifampicin | Not assoc w R |
rpoC | 765862 | p.Phe831Leu | missense_variant | 0.19 | rifampicin | Uncertain significance |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 775964 | c.2517G>C | synonymous_variant | 0.24 | clofazimine | |
bedaquiline | ||||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 0.86 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 776182 | p.Asp767Asn | missense_variant | 0.25 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R | |||||
mmpL5 | 776395 | p.Phe696Leu | missense_variant | 0.21 | clofazimine | Not assoc w R |
bedaquiline | Uncertain significance | |||||
mmpR5 | 779243 | p.Val85Gly | missense_variant | 0.14 | clofazimine | |
bedaquiline | ||||||
mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 0.35 | clofazimine | |
bedaquiline | ||||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rplC | 800357 | c.-452C>A | upstream_gene_variant | 0.23 | linezolid | Not assoc w R |
rplC | 801267 | c.459A>G | synonymous_variant | 0.19 | linezolid | Not assoc w R - Interim |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 0.83 | moxifloxacin | Not assoc w R |
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
Rv1129c | 1254591 | c.-57C>T | upstream_gene_variant | 0.19 | moxifloxacin | |
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
Rv1258c | 1406760 | c.580_581insC | frameshift_variant | 0.29 | streptomycin | Uncertain significance |
isoniazid | Uncertain significance | |||||
pyrazinamide | Uncertain significance | |||||
embR | 1417019 | p.Cys110Tyr | missense_variant | 0.21 | ethambutol | Not assoc w R |
embR | 1417554 | c.-207C>G | upstream_gene_variant | 0.21 | ethambutol | |
embR | 1417793 | c.-446C>T | upstream_gene_variant | 0.18 | ethambutol | |
atpE | 1460890 | c.-155G>T | upstream_gene_variant | 0.19 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
inhA | 1673406 | c.-796C>G | upstream_gene_variant | 0.18 | ethionamide | Uncertain significance |
isoniazid | Uncertain significance | |||||
rpsA | 1834177 | c.636A>C | synonymous_variant | 0.3 | pyrazinamide | Not assoc w R - Interim |
tsnR | 1853843 | p.Ser80Pro | missense_variant | 0.16 | linezolid | Uncertain significance |
tsnR | 1853974 | c.369C>T | synonymous_variant | 0.19 | linezolid | Not assoc w R |
tsnR | 1854045 | p.Tyr147Cys | missense_variant | 0.21 | linezolid | Not assoc w R |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 0.84 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
bacA | 2062922 | p.Ile603Val | missense_variant | 0.19 | streptomycin | Not assoc w R |
kanamycin | Not assoc w R | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
ndh | 2102791 | c.252A>C | synonymous_variant | 0.2 | ethionamide | Not assoc w R - Interim |
delamanid | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
katG | 2153931 | c.2181C>T | synonymous_variant | 0.26 | isoniazid | |
katG | 2154724 | p.Arg463Leu | missense_variant | 0.87 | isoniazid | Not assoc w R |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 0.86 | pyrazinamide | Not assoc w R |
PPE35 | 2167983 | p.Gly877Asp | missense_variant | 0.22 | pyrazinamide | Uncertain significance |
PPE35 | 2168604 | p.Pro670Leu | missense_variant | 0.24 | pyrazinamide | Not assoc w R |
PPE35 | 2170785 | c.-173T>C | upstream_gene_variant | 0.17 | pyrazinamide | |
Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 0.23 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
pncA | 2289047 | c.195C>T | synonymous_variant | 0.31 | pyrazinamide | Not assoc w R |
pncA | 2289365 | c.-125delC | upstream_gene_variant | 0.33 | pyrazinamide | |
pncA | 2289604 | c.-363T>A | upstream_gene_variant | 0.25 | pyrazinamide | |
kasA | 2518132 | c.18C>T | synonymous_variant | 0.2 | isoniazid | |
eis | 2715016 | p.Arg106His | missense_variant | 0.17 | amikacin | Uncertain significance |
kanamycin | Uncertain significance | |||||
ahpC | 2726051 | c.-142G>A | upstream_gene_variant | 0.21 | isoniazid | |
ahpC | 2726105 | c.-88G>A | upstream_gene_variant | 0.38 | isoniazid | Not assoc w R |
Rv2477c | 2782498 | c.1545C>T | synonymous_variant | 0.34 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
Rv2477c | 2784204 | c.-162A>C | upstream_gene_variant | 0.3 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2680 | 2995848 | c.-257G>A | upstream_gene_variant | 0.22 | capreomycin | |
Rv2681 | 2996912 | c.174C>T | synonymous_variant | 0.2 | capreomycin | Not assoc w R |
Rv2752c | 3064632 | c.1560C>T | synonymous_variant | 0.23 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
Rv2752c | 3065419 | p.Arg258Leu | missense_variant | 0.17 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
Rv2752c | 3065773 | p.Glu140Gly | missense_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
ald | 3086788 | c.-32T>C | upstream_gene_variant | 0.84 | cycloserine | |
ald | 3086821 | p.Met1? | start_lost | 0.16 | cycloserine | |
Rv3083 | 3448714 | p.Asp71His | missense_variant | 0.29 | ethionamide | Uncertain significance |
Rv3083 | 3448936 | p.Tyr145Asp | missense_variant | 0.21 | ethionamide | Uncertain significance |
Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 0.27 | pyrazinamide | Not assoc w R - Interim |
Rv3236c | 3613636 | c.-520A>G | upstream_gene_variant | 0.17 | pyrazinamide | Not assoc w R |
lpqB | 3624486 | p.Asp142Gly | missense_variant | 0.21 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
mtrB | 3625065 | p.Met517Leu | missense_variant | 0.81 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
mtrB | 3626467 | c.147G>A | synonymous_variant | 0.17 | bedaquiline | Not assoc w R - Interim |
rifampicin | Not assoc w R | |||||
mtrB | 3626562 | p.Pro18Ser | missense_variant | 0.28 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
fbiA | 3640211 | c.-332T>G | upstream_gene_variant | 0.12 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
rpoA | 3878575 | c.-68C>A | upstream_gene_variant | 0.31 | rifampicin | Uncertain significance |
rpoA | 3878641 | c.-135delG | upstream_gene_variant | 0.16 | rifampicin | Uncertain significance |
clpC1 | 4040517 | p.Val63Ala | missense_variant | 0.22 | pyrazinamide | Not assoc w R - Interim |
panD | 4044740 | c.-459C>T | upstream_gene_variant | 0.22 | pyrazinamide | |
panD | 4044872 | c.-591C>T | upstream_gene_variant | 0.37 | pyrazinamide | |
glpK | 4138377 | p.Val460Ala | missense_variant | 0.2 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
streptomycin | Not assoc w R | |||||
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
glpK | 4138622 | c.1134C>T | synonymous_variant | 0.36 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
embC | 4240671 | p.Thr270Ile | missense_variant | 0.27 | ethambutol | Not assoc w R |
embC | 4241042 | p.Asn394Asp | missense_variant | 0.24 | ethambutol | Not assoc w R |
embC | 4242075 | p.Arg738Gln | missense_variant | 0.33 | ethambutol | Not assoc w R |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embA | 4243460 | c.228C>T | synonymous_variant | 0.27 | ethambutol | Not assoc w R |
embA | 4243848 | p.Val206Met | missense_variant | 0.21 | ethambutol | Not assoc w R |
embA | 4245417 | p.Gly729Arg | missense_variant | 0.23 | ethambutol | Uncertain significance |
embA | 4245969 | p.Pro913Ser | missense_variant | 0.22 | ethambutol | Not assoc w R |
embB | 4247028 | p.Leu172Arg | missense_variant | 0.23 | ethambutol | |
embB | 4247429 | c.916_918delATGinsGC | frameshift_variant&missense_variant | 0.32 | ethambutol | |
embB | 4247646 | p.Glu378Ala | missense_variant | 0.29 | ethambutol | Not assoc w R |
embB | 4249485 | p.Gly991Val | missense_variant | 0.22 | ethambutol | |
aftB | 4267647 | p.Asp397Gly | missense_variant | 0.28 | ethambutol | Not assoc w R |
ubiA | 4269102 | c.732C>T | synonymous_variant | 0.2 | ethambutol | Not assoc w R - Interim |
ubiA | 4269296 | p.Met180Val | missense_variant | 0.16 | ethambutol | Uncertain significance |
ubiA | 4269387 | p.Glu149Asp | missense_variant | 0.21 | ethambutol | Not assoc w R |
ubiA | 4269606 | c.228T>C | synonymous_variant | 0.21 | ethambutol | Not assoc w R |
ethA | 4326878 | p.Ala199Asp | missense_variant | 0.19 | ethionamide | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338603 | c.-82C>T | upstream_gene_variant | 0.23 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 0.86 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 0.87 | streptomycin | Not assoc w R |
gid | 4407873 | c.330G>T | synonymous_variant | 0.21 | streptomycin | Not assoc w R |
gid | 4407927 | p.Glu92Asp | missense_variant | 0.27 | streptomycin | Not assoc w R |