TB-Profiler result

Run: ERR2517514
Summary

Run ID: ERR2517514

Sample name:

Date: 31-03-2023 22:15:36

Number of reads: 4910288

Percentage reads mapped: 85.4

Strain: lineage4.8

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.97
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
rpoB 760223 c.417T>C synonymous_variant 0.16
rpoB 760235 c.429T>C synonymous_variant 0.16
rpoB 760283 c.477G>C synonymous_variant 0.16
rpoB 760886 c.1080A>G synonymous_variant 0.15
rpoB 760925 c.1119T>C synonymous_variant 0.16
rpoB 760946 c.1140A>G synonymous_variant 0.14
rpoB 760982 c.1176G>C synonymous_variant 0.16
rpoB 761132 c.1326G>T synonymous_variant 0.19
rpoB 761133 c.1327T>C synonymous_variant 0.19
rpoB 761150 c.1344A>C synonymous_variant 0.18
rpoB 761165 c.1359G>C synonymous_variant 0.18
rpoB 761180 c.1374A>C synonymous_variant 0.19
rpoB 761189 c.1383T>C synonymous_variant 0.18
rpoB 761195 c.1389G>C synonymous_variant 0.16
rpoB 761570 c.1764T>C synonymous_variant 0.14
rpoB 761573 c.1767C>G synonymous_variant 0.14
rpoB 762167 c.2361T>C synonymous_variant 0.14
rpoB 762176 c.2370T>C synonymous_variant 0.14
rpoB 762185 c.2379G>C synonymous_variant 0.15
rpoB 762233 c.2427G>C synonymous_variant 0.17
rpoB 762284 c.2478G>C synonymous_variant 0.15
rpoC 762995 c.-375G>T upstream_gene_variant 0.16
rpoC 763040 c.-330C>G upstream_gene_variant 0.15
rpoC 763070 c.-300T>C upstream_gene_variant 0.14
rpoC 763085 c.-285C>G upstream_gene_variant 0.15
rpoC 763444 c.75T>C synonymous_variant 0.15
rpoC 763456 c.87A>G synonymous_variant 0.17
rpoC 763528 c.159G>A synonymous_variant 0.16
rpoC 763546 c.177A>G synonymous_variant 0.16
rpoC 763570 c.201G>C synonymous_variant 0.16
rpoC 763573 c.204G>C synonymous_variant 0.15
rpoC 763636 c.267T>C synonymous_variant 0.17
rpoC 763660 c.291T>G synonymous_variant 0.19
rpoC 763675 c.306C>G synonymous_variant 0.19
rpoC 763702 c.333C>G synonymous_variant 0.16
rpoC 763717 c.348T>C synonymous_variant 0.17
rpoC 763723 c.354G>C synonymous_variant 0.16
rpoC 763741 c.372C>T synonymous_variant 0.15
rpoC 763744 c.375G>C synonymous_variant 0.15
rpoC 763807 c.438T>C synonymous_variant 0.17
rpoC 763835 p.Ala156Met missense_variant 0.15
rpoC 763858 c.489A>G synonymous_variant 0.17
rpoC 763872 p.Gly168Ala missense_variant 0.16
rpoC 763879 c.510A>G synonymous_variant 0.15
rpoC 764521 c.1152T>C synonymous_variant 0.14
rpoC 764575 c.1206T>G synonymous_variant 0.15
rpoC 764752 c.1383G>C synonymous_variant 0.17
rpoC 764764 c.1395T>C synonymous_variant 0.18
rpoC 764809 c.1440C>T synonymous_variant 0.16
rpoC 764815 c.1446A>G synonymous_variant 0.17
rpoC 764858 c.1489T>C synonymous_variant 0.19
rpoC 764888 c.1519T>C synonymous_variant 0.18
rpoC 764911 c.1542A>G synonymous_variant 0.2
rpoC 764932 c.1563C>A synonymous_variant 0.19
rpoC 764935 c.1566T>C synonymous_variant 0.17
rpoC 764948 c.1579T>C synonymous_variant 0.15
rpoC 764968 c.1599T>C synonymous_variant 0.17
rpoC 765019 c.1650A>G synonymous_variant 0.19
rpoC 765034 c.1665T>C synonymous_variant 0.19
rpoC 765040 c.1671T>C synonymous_variant 0.18
rpoC 765041 c.1672T>C synonymous_variant 0.18
rpoC 765076 c.1707A>G synonymous_variant 0.15
rpoC 765079 c.1710T>G synonymous_variant 0.15
rpoC 765082 c.1713G>C synonymous_variant 0.15
rpoC 765089 c.1720T>C synonymous_variant 0.15
rpoC 765499 c.2130C>G synonymous_variant 0.14
rpoC 765541 c.2172C>G synonymous_variant 0.18
rpoC 765553 c.2184C>T synonymous_variant 0.15
rpoC 765556 c.2187G>C synonymous_variant 0.15
rpoC 765613 p.His748Gln missense_variant 0.14
rpoC 765937 c.2568T>C synonymous_variant 0.15
rpoC 766082 p.Ala905Gln missense_variant 0.16
rpoC 766657 c.3288A>G synonymous_variant 0.14
rpoC 766726 c.3357T>C synonymous_variant 0.14
rpoC 766738 c.3369G>C synonymous_variant 0.17
rpoC 766765 c.3396A>C synonymous_variant 0.18
rpoC 766774 c.3405T>C synonymous_variant 0.17
rpoC 766804 c.3435A>G synonymous_variant 0.22
rpoC 766861 c.3492G>C synonymous_variant 0.17
rpoC 766864 c.3495G>C synonymous_variant 0.18
rpoC 766894 c.3525T>C synonymous_variant 0.15
rpoC 766895 c.3526T>C synonymous_variant 0.16
rpoC 766900 c.3531T>C synonymous_variant 0.18
rpoC 766933 c.3564A>G synonymous_variant 0.15
rpoC 766945 c.3576A>G synonymous_variant 0.15
rpoC 766963 c.3594T>C synonymous_variant 0.15
rpoC 766972 c.3603G>C synonymous_variant 0.14
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.15
rpoC 767014 c.3645G>C synonymous_variant 0.15
rpoC 767059 c.3690T>G synonymous_variant 0.14
rpoC 767134 c.3765C>A synonymous_variant 0.14
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781649 c.90T>C synonymous_variant 0.15
rpsL 781655 c.96T>C synonymous_variant 0.14
rpsL 781715 c.156T>C synonymous_variant 0.15
rpsL 781728 c.169T>C synonymous_variant 0.16
rpsL 781736 c.177T>C synonymous_variant 0.16
rplC 800747 c.-62C>G upstream_gene_variant 0.13
fbiC 1304808 c.1878C>G synonymous_variant 0.16
fbiC 1304811 c.1881C>G synonymous_variant 0.16
fbiC 1304817 c.1887T>C synonymous_variant 0.26
fbiC 1304829 c.1899T>C synonymous_variant 0.2
fbiC 1304832 c.1902C>T synonymous_variant 0.23
fbiC 1304856 c.1926C>G synonymous_variant 0.34
fbiC 1304862 c.1932G>A synonymous_variant 0.17
fbiC 1304869 c.1939C>T synonymous_variant 0.22
fbiC 1304875 p.Ile649Val missense_variant 0.14
fbiC 1304883 p.Glu651Asp missense_variant 0.14
fbiC 1304893 p.Gly655Ser missense_variant 0.18
fbiC 1304907 c.1977C>G synonymous_variant 0.18
fbiC 1304910 c.1980G>C synonymous_variant 0.17
fbiC 1304916 c.1986T>C synonymous_variant 0.18
fbiC 1304928 c.1998T>C synonymous_variant 0.19
fbiC 1304937 c.2007G>C synonymous_variant 0.2
fbiC 1304958 c.2028T>G synonymous_variant 0.17
fbiC 1304983 c.2053C>T synonymous_variant 0.15
fbiC 1304994 c.2064A>G synonymous_variant 0.17
fbiC 1304995 p.Leu689Met missense_variant 0.17
fbiC 1305006 c.2076A>G synonymous_variant 0.16
fbiC 1305012 c.2082G>C synonymous_variant 0.14
fbiC 1305015 c.2085G>C synonymous_variant 0.14
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.15
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.14
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.14
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.14
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.22
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.17
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.18
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.21
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.16
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.18
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.15
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.14
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.18
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.18
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.17
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.14
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.15
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.16
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.17
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.19
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.15
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.15
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.16
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.17
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.18
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.18
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.18
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.2
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.21
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.21
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.21
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.18
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.15
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.17
rpsA 1834528 c.987T>C synonymous_variant 0.14
rpsA 1834609 c.1068T>C synonymous_variant 0.15
rpsA 1834639 c.1098T>C synonymous_variant 0.14
rpsA 1834690 c.1149T>C synonymous_variant 0.15
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2168149 p.Pro822Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pncA 2289680 c.-439T>C upstream_gene_variant 1.0
kasA 2517950 c.-165C>G upstream_gene_variant 0.14
thyX 3067545 p.Glu134Ala missense_variant 0.14
thyX 3067549 p.Thr133Ala missense_variant 0.13
thyX 3067565 p.Asp127Glu missense_variant 0.15
thyX 3067570 p.Ala126Pro missense_variant 0.15
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
Rv3083 3448500 c.-4A>G upstream_gene_variant 1.0
Rv3083 3448501 c.-3G>T upstream_gene_variant 1.0
rpoA 3877704 c.804G>C synonymous_variant 0.14
rpoA 3878271 c.237T>C synonymous_variant 0.15
rpoA 3878292 c.216T>C synonymous_variant 0.14
rpoA 3878322 c.186A>G synonymous_variant 0.15
rpoA 3878331 c.177A>G synonymous_variant 0.14
rpoA 3878385 c.123C>G synonymous_variant 0.14
rpoA 3878415 c.93C>T synonymous_variant 0.16
rpoA 3878578 c.-71C>A upstream_gene_variant 0.14
clpC1 4038623 c.2082A>G synonymous_variant 0.16
clpC1 4038653 c.2052C>T synonymous_variant 0.17
clpC1 4038658 p.Lys683Gln missense_variant 0.16
clpC1 4038661 p.Ser682Thr missense_variant 0.16
clpC1 4038662 c.2043T>C synonymous_variant 0.16
clpC1 4038671 c.2034T>C synonymous_variant 0.17
clpC1 4038683 c.2022T>C synonymous_variant 0.15
clpC1 4038704 c.2001T>C synonymous_variant 0.16
clpC1 4038707 c.1998C>G synonymous_variant 0.16
clpC1 4038713 c.1992T>C synonymous_variant 0.17
clpC1 4038773 c.1932T>C synonymous_variant 0.16
clpC1 4038782 c.1923G>C synonymous_variant 0.15
clpC1 4038812 c.1893T>C synonymous_variant 0.13
clpC1 4038914 c.1791G>C synonymous_variant 0.16
clpC1 4038923 c.1782A>G synonymous_variant 0.16
clpC1 4038953 c.1752A>G synonymous_variant 0.15
clpC1 4038956 c.1749T>C synonymous_variant 0.15
clpC1 4038965 c.1740T>C synonymous_variant 0.14
clpC1 4038971 c.1734T>C synonymous_variant 0.14
clpC1 4038974 c.1731T>C synonymous_variant 0.15
clpC1 4038989 c.1716T>C synonymous_variant 0.14
clpC1 4039022 c.1683A>G synonymous_variant 0.15
clpC1 4039364 c.1341C>G synonymous_variant 0.16
clpC1 4039724 c.981A>G synonymous_variant 0.14
clpC1 4039729 p.Asp326Asn missense_variant 0.87
embA 4242643 c.-590C>T upstream_gene_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0