TB-Profiler result

Run: ERR2517514
Summary

Run ID: ERR2517514

Sample name:

Date: 2024-04-15T09:03:57.653136

Number of reads: 4910288

Percentage reads mapped: 85.4

Median coverage: 134.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.97
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0565c 656265 c.1204_1205delAC frameshift_variant 1.0 ethionamide Uncertain significance
hadA 732396 p.Gly156Ala missense_variant 0.17 isoniazid
hadA 732398 p.Ala157Thr missense_variant 0.16 isoniazid
nusG 734658 c.405A>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 760223 c.417T>C synonymous_variant 0.16 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760886 c.1080A>G synonymous_variant 0.15 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.16 rifampicin
rpoB 760946 c.1140A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760982 c.1176G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761132 c.1326G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761133 c.1327T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761150 c.1344A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761165 c.1359G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762167 c.2361T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762185 c.2379G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762284 c.2478G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763444 c.75T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763456 c.87A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763573 c.204G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.17 rifampicin
rpoC 763660 c.291T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763675 c.306C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.16 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.15 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.15 rifampicin
rpoC 763807 c.438T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763835 p.Ala156Met missense_variant 0.15 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.17 rifampicin
rpoC 763872 p.Gly168Ala missense_variant 0.16 rifampicin
rpoC 763879 c.510A>G synonymous_variant 0.15 rifampicin
rpoC 764521 c.1152T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764752 c.1383G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.16 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.2 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764935 c.1566T>C synonymous_variant 0.17 rifampicin
rpoC 764948 c.1579T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765034 c.1665T>C synonymous_variant 0.19 rifampicin
rpoC 765040 c.1671T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765041 c.1672T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765076 c.1707A>G synonymous_variant 0.15 rifampicin
rpoC 765079 c.1710T>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765082 c.1713G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765089 c.1720T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.18 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.15 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.14 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766082 p.Ala905Gln missense_variant 0.16 rifampicin
rpoC 766657 c.3288A>G synonymous_variant 0.14 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.14 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.17 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766774 c.3405T>C synonymous_variant 0.17 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.18 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.15 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.16 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.18 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.15 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.15 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.15 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.14 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781649 c.90T>C synonymous_variant 0.15 streptomycin
rpsL 781655 c.96T>C synonymous_variant 0.14 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.15 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.16 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.16 streptomycin
rplC 800747 c.-62C>G upstream_gene_variant 0.13 linezolid
Rv1129c 1253330 p.Gly402Glu missense_variant 1.0 moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
fbiC 1304808 c.1878C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.26 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.23 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.34 clofazimine
pretomanid
delamanid
fbiC 1304862 c.1932G>A synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1304875 p.Ile649Val missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304883 p.Glu651Asp missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304893 p.Gly655Ser missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304907 c.1977C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304994 c.2064A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.14 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.14 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.22 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.19 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rpsA 1834528 c.987T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834690 c.1149T>C synonymous_variant 0.15 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
PPE35 2168149 p.Pro822Ser missense_variant 1.0 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
pncA 2289680 c.-439T>C upstream_gene_variant 1.0 pyrazinamide
kasA 2517950 c.-165C>G upstream_gene_variant 0.14 isoniazid
Rv2477c 2783059 c.984T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783077 c.966T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783092 c.951A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R
amikacin Not assoc w R - Interim
Rv2477c 2783098 c.945C>G synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783101 c.942G>T synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783146 c.897G>A synonymous_variant 0.18 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin
amikacin Not assoc w R - Interim
Rv2477c 2783149 c.894G>C synonymous_variant 0.2 ethambutol
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783158 c.885A>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783914 c.129T>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783920 c.123G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783962 c.81T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783971 c.72G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783980 c.63C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783992 c.51T>C synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin
Rv2680 2995848 c.-257G>A upstream_gene_variant 1.0 capreomycin
thyX 3067545 p.Glu134Ala missense_variant 0.14 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.13 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.15 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.15 para-aminosalicylic_acid
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0 ethionamide Uncertain significance
Rv3236c 3613636 c.-520A>G upstream_gene_variant 1.0 pyrazinamide Not assoc w R
rpoA 3877704 c.804G>C synonymous_variant 0.14 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878292 c.216T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878385 c.123C>G synonymous_variant 0.14 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.16 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.16 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.16 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.16 rifampicin
rpoA 3878968 c.-461T>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878976 c.-469A>G upstream_gene_variant 0.13 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 0.13 rifampicin Uncertain significance
clpC1 4038623 c.2082A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.17 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.16 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.16 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038704 c.2001T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.15 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.14 pyrazinamide
clpC1 4039729 p.Asp326Asn missense_variant 0.87 pyrazinamide Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R