TB-Profiler result

Run: ERR037501
Summary

Run ID: ERR037501

Sample name:

Date: 31-03-2023 08:34:27

Number of reads: 11306170

Percentage reads mapped: 58.33

Strain: lineage4.3.4.2.1

Drug-resistance: Sensitive

Download CSV Download TXT Download PDF Download JSON
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.3 Euro-American (LAM) mainly-LAM None 1.0
lineage4.3.4 Euro-American (LAM) LAM RD174 1.0
lineage4.3.4.2 Euro-American (LAM) LAM1;LAM4;LAM11 RD174 1.0
lineage4.3.4.2.1 Euro-American (LAM) LAM11 RD174 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 6140 p.Val301Leu missense_variant 1.0
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
rpoC 762836 c.-534C>G upstream_gene_variant 0.26
rpoC 764995 c.1626C>G synonymous_variant 1.0
rpoC 767083 c.3714C>T synonymous_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 777399 p.Thr361Arg missense_variant 0.15
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
atpE 1461019 c.-26C>A upstream_gene_variant 0.19
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472113 n.268T>C non_coding_transcript_exon_variant 0.16
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.27
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.29
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.38
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.41
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.42
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.43
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.27
rrs 1472210 n.365A>C non_coding_transcript_exon_variant 0.18
rrs 1472213 n.368G>C non_coding_transcript_exon_variant 0.11
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.11
rrs 1472215 n.370A>G non_coding_transcript_exon_variant 0.1
rrs 1472333 n.490dupA non_coding_transcript_exon_variant 0.15
rrs 1472338 n.493A>C non_coding_transcript_exon_variant 0.31
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.4
rrs 1472379 n.534T>G non_coding_transcript_exon_variant 0.35
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.35
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.33
rrs 1472412 n.567A>C non_coding_transcript_exon_variant 0.11
rrs 1472598 n.753A>C non_coding_transcript_exon_variant 0.41
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.31
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.13
rrs 1472733 n.888G>C non_coding_transcript_exon_variant 0.29
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.28
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.26
rrs 1472742 n.897C>G non_coding_transcript_exon_variant 0.26
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.3
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.57
rrs 1472779 n.934G>A non_coding_transcript_exon_variant 0.6
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.6
rrs 1472786 n.941C>T non_coding_transcript_exon_variant 0.57
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.54
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.49
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.23
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.31
rrs 1472953 n.1108_1109insA non_coding_transcript_exon_variant 0.21
rrs 1472957 n.1112C>T non_coding_transcript_exon_variant 0.18
rrs 1472958 n.1114delT non_coding_transcript_exon_variant 0.19
rrs 1473002 n.1157G>T non_coding_transcript_exon_variant 0.11
rrs 1473004 n.1159T>A non_coding_transcript_exon_variant 0.12
rrs 1473008 n.1163C>A non_coding_transcript_exon_variant 0.11
rrs 1473009 n.1164T>C non_coding_transcript_exon_variant 0.16
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.39
rrs 1473053 n.1208T>A non_coding_transcript_exon_variant 0.41
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.43
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.42
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.43
rrs 1473070 n.1225G>A non_coding_transcript_exon_variant 0.37
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.29
rrs 1473179 n.1334C>T non_coding_transcript_exon_variant 0.29
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.38
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.4
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.42
rrs 1473343 n.1498G>T non_coding_transcript_exon_variant 0.26
rrs 1473352 n.1507C>T non_coding_transcript_exon_variant 0.25
rrl 1473384 n.-274A>T upstream_gene_variant 0.15
rrl 1474380 n.723G>T non_coding_transcript_exon_variant 0.27
rrl 1474798 n.1141C>T non_coding_transcript_exon_variant 0.14
rrl 1474804 n.1147C>T non_coding_transcript_exon_variant 0.34
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.48
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.48
rrl 1474831 n.1174A>C non_coding_transcript_exon_variant 0.49
rrl 1474844 n.1187G>T non_coding_transcript_exon_variant 0.56
rrl 1474866 n.1209C>A non_coding_transcript_exon_variant 0.57
rrl 1474896 n.1239A>G non_coding_transcript_exon_variant 0.35
rrl 1474902 n.1245T>C non_coding_transcript_exon_variant 0.32
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.29
rrl 1474913 n.1256T>A non_coding_transcript_exon_variant 0.19
rrl 1474920 n.1263G>A non_coding_transcript_exon_variant 0.16
rrl 1475363 n.1706C>A non_coding_transcript_exon_variant 0.17
rrl 1475672 n.2015C>G non_coding_transcript_exon_variant 0.34
rrl 1475673 n.2016T>C non_coding_transcript_exon_variant 0.36
rrl 1475687 n.2030C>T non_coding_transcript_exon_variant 0.53
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.52
rrl 1475703 n.2046A>G non_coding_transcript_exon_variant 0.52
rrl 1475707 n.2050T>A non_coding_transcript_exon_variant 0.53
rrl 1475716 n.2059A>G non_coding_transcript_exon_variant 0.57
rrl 1475747 n.2090A>G non_coding_transcript_exon_variant 0.28
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.42
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.44
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.58
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.58
rrl 1475843 n.2186G>A non_coding_transcript_exon_variant 0.59
rrl 1475849 n.2192G>A non_coding_transcript_exon_variant 0.54
rrl 1475853 n.2196C>T non_coding_transcript_exon_variant 0.53
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.47
rrl 1476135 n.2478T>C non_coding_transcript_exon_variant 0.18
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.17
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.19
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.19
rrl 1476165 n.2508T>A non_coding_transcript_exon_variant 0.19
rrl 1476221 n.2564T>C non_coding_transcript_exon_variant 0.15
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.24
rrl 1476229 n.2572C>A non_coding_transcript_exon_variant 0.23
rrl 1476246 n.2589G>A non_coding_transcript_exon_variant 0.25
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.22
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.19
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.49
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.58
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.68
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.71
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.73
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.75
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.75
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.83
rrl 1476425 n.2768G>A non_coding_transcript_exon_variant 0.81
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.83
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.77
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.71
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.43
rrl 1476512 n.2855C>T non_coding_transcript_exon_variant 0.17
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.42
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.41
rrl 1476573 n.2916A>C non_coding_transcript_exon_variant 0.39
rrl 1476577 n.2920T>G non_coding_transcript_exon_variant 0.39
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.42
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.48
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.46
rrl 1476608 n.2951C>A non_coding_transcript_exon_variant 0.45
rrl 1476614 n.2957A>G non_coding_transcript_exon_variant 0.44
rrl 1476619 n.2962C>T non_coding_transcript_exon_variant 0.33
rrl 1476624 n.2967T>G non_coding_transcript_exon_variant 0.24
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.24
rrl 1476630 n.2973A>G non_coding_transcript_exon_variant 0.23
rrl 1476637 n.2980C>G non_coding_transcript_exon_variant 0.23
rrl 1476657 n.3000G>T non_coding_transcript_exon_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169320 p.Leu431Phe missense_variant 0.2
PPE35 2169866 c.747G>C synonymous_variant 0.33
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714366 p.Val323Leu missense_variant 0.25
eis 2715586 c.-254G>C upstream_gene_variant 0.46
pepQ 2859381 c.1038C>G synonymous_variant 0.2
Rv2752c 3064741 p.Gly484Ala missense_variant 0.32
thyA 3073806 c.666C>G synonymous_variant 0.22
thyA 3073868 p.Thr202Ala missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 0.99
Rv3236c 3612009 p.Ala370Thr missense_variant 1.0
fbiB 3641955 p.Gly141Arg missense_variant 0.26
fbiB 3642772 p.Asp413Ala missense_variant 0.23
alr 3840719 c.702A>G synonymous_variant 1.0
alr 3840869 c.552C>G synonymous_variant 0.99
clpC1 4038287 c.2418C>T synonymous_variant 1.0
clpC1 4038857 c.1848C>A synonymous_variant 0.2
clpC1 4039932 p.Gly258Val missense_variant 0.26
embC 4239842 c.-21C>A upstream_gene_variant 0.19
embC 4242425 p.Arg855Gly missense_variant 0.21
embC 4242476 p.Pro872Ala missense_variant 0.28
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embC 4242822 p.Val987Gly missense_variant 0.33
embA 4245045 c.1813C>T synonymous_variant 1.0
ubiA 4269529 p.Ala102Gly missense_variant 0.19
ethA 4327672 c.-199G>A upstream_gene_variant 0.32
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4408156 p.Leu16Arg missense_variant 1.0