Run ID: ERR9787223
Sample name:
Date: 2024-04-15T14:26:53.383968
Number of reads: 3996827
Percentage reads mapped: 88.85
Median coverage: 194.0
Strain: lineage6.3.1
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage6.3 | West-Africa 2 | RD702 | 0.99 |
lineage6.3.1 | West-Africa 2 | RD702 | 0.99 |
lineage6 | West-Africa 2 | RD702 | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 6446 | p.Ala403Ser | missense_variant | 0.93 | levofloxacin | Not assoc w R |
moxifloxacin | Uncertain significance | |||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
Rv0010c | 13460 | c.99T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
Rv0010c | 13482 | p.Ala26Val | missense_variant | 1.0 | isoniazid | Not assoc w R |
fgd1 | 491668 | p.Lys296Glu | missense_variant | 0.98 | clofazimine | Uncertain significance |
pretomanid | ||||||
delamanid | Uncertain significance | |||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
ccsA | 619628 | c.-263G>A | upstream_gene_variant | 0.93 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 619862 | c.-29G>A | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
Rv0565c | 656432 | p.Gly347Ser | missense_variant | 0.95 | ethionamide | Uncertain significance |
Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 1.0 | ethionamide | |
nusG | 734151 | c.-103G>C | upstream_gene_variant | 0.99 | rifampicin | Uncertain significance |
rpoB | 760424 | c.618C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760430 | c.624T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760475 | c.669A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760481 | c.675G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760484 | c.678A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760969 | p.Ser388Leu | missense_variant | 0.94 | rifampicin | Not assoc w R |
rpoB | 761723 | p.Glu639Asp | missense_variant | 0.91 | rifampicin | Not assoc w R |
rpoB | 762338 | c.2532T>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 762410 | c.-960T>C | upstream_gene_variant | 0.14 | rifampicin | |
rpoB | 762929 | c.3123G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 762989 | c.-381G>C | upstream_gene_variant | 0.17 | rifampicin | |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763013 | c.-357C>G | upstream_gene_variant | 0.15 | rifampicin | |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.99 | rifampicin | Not assoc w R |
rpoC | 763675 | c.306C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763774 | c.405G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764554 | c.1185C>T | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764827 | c.1458G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765739 | c.2370G>T | synonymous_variant | 0.14 | rifampicin | |
rpoC | 765850 | c.2481G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765892 | c.2523T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765967 | c.2598C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 766549 | c.3180G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766573 | c.3204T>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766582 | c.3213C>G | synonymous_variant | 0.14 | rifampicin | |
rpoC | 766583 | c.3214_3216delGGTinsAC | frameshift_variant&missense_variant | 0.14 | rifampicin | |
rpoC | 766588 | p.Glu1073Asp | missense_variant | 0.15 | rifampicin | Uncertain significance |
rpoC | 766594 | c.3225G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766597 | c.3228C>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 766607 | p.Ile1080Leu | missense_variant | 0.16 | rifampicin | |
rpoC | 766630 | c.3261G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766657 | c.3288A>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766660 | c.3291G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766672 | c.3303T>C | synonymous_variant | 0.18 | rifampicin | |
rpoC | 766673 | p.Gly1102Asn | missense_variant | 0.18 | rifampicin | |
rpoC | 766726 | c.3357T>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766738 | c.3369G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766861 | c.3492G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766876 | c.3507C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 766882 | c.3513C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 766900 | c.3531T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766933 | c.3564A>G | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766945 | c.3576A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 766963 | c.3594T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 766972 | c.3603G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766996 | c.3627C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 767009 | c.3640_3642delTCGinsAGC | synonymous_variant | 0.16 | rifampicin | |
rpoC | 767014 | c.3645G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 767033 | c.3664_3666delTCGinsAGT | synonymous_variant | 0.18 | rifampicin | |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 767062 | c.3693C>A | synonymous_variant | 0.16 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 767134 | c.3765C>A | synonymous_variant | 0.14 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | moxifloxacin | Not assoc w R |
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
fbiC | 1302899 | c.-32A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
pretomanid | ||||||
delamanid | Uncertain significance | |||||
embR | 1417554 | c.-207C>G | upstream_gene_variant | 1.0 | ethambutol | |
atpE | 1461251 | c.207G>T | synonymous_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474904 | n.1247G>A | non_coding_transcript_exon_variant | 0.13 | capreomycin | |
linezolid | ||||||
rrl | 1474970 | n.1313G>A | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1475006 | n.1349A>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1475088 | n.1431A>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
inhA | 1674434 | p.Val78Ala | missense_variant | 0.96 | ethionamide | Uncertain significance |
isoniazid | Not assoc w R | |||||
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
bacA | 2062922 | p.Ile603Val | missense_variant | 1.0 | streptomycin | Not assoc w R |
kanamycin | Not assoc w R | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
bacA | 2063121 | c.1608A>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
kanamycin | Not assoc w R - Interim | |||||
capreomycin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
ndh | 2102694 | p.Val117Ile | missense_variant | 0.98 | ethionamide | Uncertain significance |
delamanid | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
katG | 2155503 | c.609C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
Rv1979c | 2222852 | p.Ala105Thr | missense_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
Rv2477c | 2783040 | p.Ala335Thr | missense_variant | 0.16 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
kanamycin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
Rv2477c | 2783044 | c.999G>C | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783048 | p.Asp332Gly | missense_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783059 | c.984T>C | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783068 | p.Asp325Glu | missense_variant | 0.18 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783077 | c.966T>C | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783092 | c.951A>G | synonymous_variant | 0.15 | ethambutol | Not assoc w R - Interim |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | ||||||
Rv2477c | 2783095 | c.948C>G | synonymous_variant | 0.14 | ethambutol | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783098 | c.945C>G | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783101 | c.942G>T | synonymous_variant | 0.14 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783116 | c.927T>C | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783140 | c.903C>G | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783146 | c.897G>A | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | ||||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783149 | c.894G>C | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
thyX | 3067490 | c.456C>G | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
ald | 3086728 | c.-92C>T | upstream_gene_variant | 1.0 | cycloserine | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
ald | 3087084 | c.266delA | frameshift_variant | 1.0 | cycloserine | |
Rv3083 | 3449781 | c.1278G>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
Rv3236c | 3613354 | c.-238G>T | upstream_gene_variant | 1.0 | pyrazinamide | |
lpqB | 3624350 | c.561G>T | synonymous_variant | 0.96 | bedaquiline | Not assoc w R - Interim |
rifampicin | Not assoc w R | |||||
lpqB | 3624486 | p.Asp142Gly | missense_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
mtrA | 3627071 | c.279G>T | synonymous_variant | 0.14 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3627098 | c.252A>C | synonymous_variant | 0.14 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627104 | c.-491C>G | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627119 | c.231T>G | synonymous_variant | 0.15 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627122 | c.-509T>C | upstream_gene_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627167 | c.-554T>C | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
alr | 3841377 | p.Thr15Ile | missense_variant | 1.0 | cycloserine | |
rpoA | 3877679 | p.Ala277Ser | missense_variant | 0.15 | rifampicin | |
rpoA | 3877696 | p.Thr271Ile | missense_variant | 0.85 | rifampicin | Uncertain significance |
rpoA | 3877704 | c.804G>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878292 | c.216T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878304 | c.204G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878310 | c.198G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878364 | c.144A>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878367 | c.141C>G | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878376 | c.132G>C | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878385 | c.123C>G | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878388 | c.120C>G | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878391 | c.117T>C | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878415 | c.93C>T | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878424 | c.84G>C | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878436 | c.72A>G | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878442 | c.66G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878454 | c.54A>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878785 | c.-278T>G | upstream_gene_variant | 0.14 | rifampicin | |
rpoA | 3878788 | c.-281G>C | upstream_gene_variant | 0.14 | rifampicin | Uncertain significance |
rpoA | 3878806 | c.-299C>G | upstream_gene_variant | 0.16 | rifampicin | |
rpoA | 3878809 | c.-302T>C | upstream_gene_variant | 0.16 | rifampicin | |
rpoA | 3878818 | c.-311G>A | upstream_gene_variant | 0.14 | rifampicin | |
rpoA | 3878878 | c.-371T>C | upstream_gene_variant | 0.19 | rifampicin | Uncertain significance |
rpoA | 3878890 | c.-383C>G | upstream_gene_variant | 0.2 | rifampicin | |
rpoA | 3878896 | c.-389G>C | upstream_gene_variant | 0.2 | rifampicin | |
rpoA | 3878909 | c.-402A>G | upstream_gene_variant | 0.19 | rifampicin | |
rpoA | 3878914 | c.-407T>C | upstream_gene_variant | 0.19 | rifampicin | Uncertain significance |
rpoA | 3878917 | c.-410G>A | upstream_gene_variant | 0.2 | rifampicin | Uncertain significance |
rpoA | 3878932 | c.-425G>A | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3878938 | c.-431T>C | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878947 | c.-440G>C | upstream_gene_variant | 0.21 | rifampicin | Uncertain significance |
rpoA | 3878968 | c.-461T>C | upstream_gene_variant | 0.23 | rifampicin | Uncertain significance |
rpoA | 3878976 | c.-469A>G | upstream_gene_variant | 0.22 | rifampicin | Uncertain significance |
rpoA | 3878986 | c.-479G>C | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3878998 | c.-491C>G | upstream_gene_variant | 0.22 | rifampicin | Uncertain significance |
rpoA | 3879005 | c.-499_-498delAAinsCG | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3879013 | c.-506A>G | upstream_gene_variant | 0.19 | rifampicin | |
rpoA | 3879079 | c.-572A>G | upstream_gene_variant | 0.17 | rifampicin | |
rpoA | 3879088 | c.-581A>C | upstream_gene_variant | 0.17 | rifampicin | |
rpoA | 3879094 | c.-587T>C | upstream_gene_variant | 0.16 | rifampicin | |
clpC1 | 4040926 | c.-222C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
glpK | 4138377 | p.Val460Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
streptomycin | Not assoc w R | |||||
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
glpK | 4139183 | c.572dupG | frameshift_variant | 0.9 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4241843 | p.Leu661Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242643 | c.2781C>T | synonymous_variant | 0.99 | ethambutol | Not assoc w R |
embA | 4244220 | c.988C>T | synonymous_variant | 0.96 | ethambutol | Not assoc w R |
embA | 4244379 | p.Pro383Ser | missense_variant | 0.96 | ethambutol | Not assoc w R |
embB | 4246864 | c.351C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
aftB | 4268477 | c.360C>T | synonymous_variant | 0.98 | ethambutol | Not assoc w R - Interim |
ubiA | 4268953 | p.Thr294Met | missense_variant | 1.0 | ethambutol | |
ubiA | 4269351 | c.483C>T | synonymous_variant | 0.91 | ethambutol | Not assoc w R |
ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
ubiA | 4269522 | c.312C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
ubiA | 4269606 | c.228T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
ethA | 4326465 | p.Ile337Val | missense_variant | 1.0 | ethionamide | Uncertain significance |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |