TB-Profiler result

Run: SRR1159158
Summary

Run ID: SRR1159158

Sample name:

Date: 02-04-2023 21:49:18

Number of reads: 2891132

Percentage reads mapped: 75.63

Strain: lineage2.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.73 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
mshA 576450 c.1109_1111dupTGG disruptive_inframe_insertion 0.12
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 766645 p.Glu1092Asp missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472112 n.267C>T non_coding_transcript_exon_variant 0.16
rrs 1472122 n.277G>A non_coding_transcript_exon_variant 0.24
rrs 1472127 n.282C>T non_coding_transcript_exon_variant 0.24
rrs 1472128 n.283G>A non_coding_transcript_exon_variant 0.24
rrs 1472129 n.284G>C non_coding_transcript_exon_variant 0.23
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.36
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.43
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.43
rrs 1472164 n.319G>A non_coding_transcript_exon_variant 0.43
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.43
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.44
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.32
rrs 1472378 n.533G>T non_coding_transcript_exon_variant 0.19
rrs 1472379 n.534T>G non_coding_transcript_exon_variant 0.2
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.2
rrs 1472389 n.544G>A non_coding_transcript_exon_variant 0.2
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.18
rrs 1472415 n.570T>G non_coding_transcript_exon_variant 0.12
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.22
rrs 1472541 n.696T>G non_coding_transcript_exon_variant 0.24
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.55
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.58
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.59
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.59
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.58
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.57
rrs 1472596 n.751G>T non_coding_transcript_exon_variant 0.56
rrs 1472598 n.753A>T non_coding_transcript_exon_variant 0.57
rrs 1472614 n.769G>T non_coding_transcript_exon_variant 0.57
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.57
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.2
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.17
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.6
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.65
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.77
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.76
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.77
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.73
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.68
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.59
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.17
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.41
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.41
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.41
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.46
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.46
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.46
rrs 1473172 n.1327T>C non_coding_transcript_exon_variant 0.43
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.44
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.5
rrs 1473191 n.1346C>T non_coding_transcript_exon_variant 0.57
rrs 1473206 n.1361G>A non_coding_transcript_exon_variant 0.58
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.58
rrs 1473248 n.1403G>A non_coding_transcript_exon_variant 0.33
rrs 1473249 n.1404T>C non_coding_transcript_exon_variant 0.33
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.33
rrs 1473255 n.1410A>G non_coding_transcript_exon_variant 0.34
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.33
rrs 1473260 n.1415G>T non_coding_transcript_exon_variant 0.34
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.19
rrs 1473352 n.1507C>T non_coding_transcript_exon_variant 0.22
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.35
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.36
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.41
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.41
rrl 1475858 n.2201T>C non_coding_transcript_exon_variant 0.39
rrl 1475866 n.2209T>A non_coding_transcript_exon_variant 0.36
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.15
rrl 1476268 n.2611A>T non_coding_transcript_exon_variant 0.15
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.53
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.7
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.71
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.73
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.75
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.77
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.76
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.84
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.84
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.84
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.85
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.76
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.66
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.36
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2169221 c.1392T>C synonymous_variant 1.0
PPE35 2170623 c.-11G>A upstream_gene_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714955 c.378C>T synonymous_variant 1.0
eis 2715123 c.210G>T synonymous_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
whiB6 4338711 c.-190C>A upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 0.98