TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	0.96

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
rpoB	760244	c.438G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760253	c.447T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760263	p.Met153Leu	missense_variant	1.0	rifampicin
rpoB	760266	p.Met154Gln	missense_variant	1.0	rifampicin
rpoB	760274	p.Glu156Asp	missense_variant	1.0	rifampicin	Uncertain significance
rpoB	762879	p.Met1025Leu	missense_variant	0.89	rifampicin	Uncertain significance
rpoC	762896	c.-474G>C	upstream_gene_variant	0.94	rifampicin
rpoB	762917	c.3111C>G	synonymous_variant	0.98	rifampicin	Not assoc w R - Interim
rpoB	762929	c.3123G>T	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	762947	c.-423C>G	upstream_gene_variant	0.95	rifampicin
rpoB	762962	c.3156C>T	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	762980	c.-390T>C	upstream_gene_variant	0.93	rifampicin
rpoC	762989	c.-381G>C	upstream_gene_variant	0.9	rifampicin
rpoB	762995	c.3189G>T	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoB	763028	c.3222T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	763031	c.3225T>C	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoB	763038	p.Thr1078Ala	missense_variant	1.0	rifampicin
rpoC	763052	c.-318G>C	upstream_gene_variant	1.0	rifampicin
rpoC	763053	c.-317_-315delTTGinsCTC	upstream_gene_variant	1.0	rifampicin
rpoC	763058	c.-312C>G	upstream_gene_variant	1.0	rifampicin
rpoB	763070	c.3264T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	763075	p.Thr1090Ile	missense_variant	1.0	rifampicin
rpoB	763077	p.Val1091Leu	missense_variant	1.0	rifampicin
rpoB	763115	c.3309T>C	synonymous_variant	0.97	rifampicin	Not assoc w R - Interim
rpoB	763126	p.Pro1107Gln	missense_variant	0.96	rifampicin
rpoC	763133	c.-237G>C	upstream_gene_variant	0.95	rifampicin
rpoB	763136	c.3330C>T	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	763148	c.-222G>C	upstream_gene_variant	0.93	rifampicin
rpoC	763462	c.93G>C	synonymous_variant	1.0	rifampicin
rpoC	763483	c.114G>C	synonymous_variant	1.0	rifampicin
rpoC	763486	c.117T>G	synonymous_variant	0.95	rifampicin
rpoC	763492	c.123G>C	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	763504	c.135C>T	synonymous_variant	0.96	rifampicin
rpoC	763511	p.Cys48Gly	missense_variant	0.95	rifampicin
rpoC	763517	p.Lys50Gln	missense_variant	0.96	rifampicin
rpoC	763528	c.159G>A	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	763531	c.162G>C	synonymous_variant	0.96	rifampicin	Not assoc w R
rpoC	763532	p.Thr55Ser	missense_variant	0.96	rifampicin
rpoC	763546	c.177A>G	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	763550	p.Tyr61Ala	missense_variant	0.93	rifampicin
rpoC	763570	c.201G>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	763573	c.204G>C	synonymous_variant	0.88	rifampicin	Not assoc w R - Interim
rpoC	763589	p.Ile74Val	missense_variant	0.94	rifampicin
rpoC	763609	c.240C>G	synonymous_variant	0.88	rifampicin
rpoC	763660	c.291T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	763696	c.327T>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	763699	c.330G>C	synonymous_variant	0.93	rifampicin
rpoC	763708	c.339G>C	synonymous_variant	0.93	rifampicin
rpoC	763709	c.340C>T	synonymous_variant	0.93	rifampicin
rpoC	763714	c.345G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	763717	c.348T>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoC	763723	c.354G>C	synonymous_variant	0.93	rifampicin
rpoC	763727	p.Leu120Met	missense_variant	0.93	rifampicin
rpoC	763732	c.363C>G	synonymous_variant	0.93	rifampicin
rpoC	763744	c.375G>C	synonymous_variant	0.89	rifampicin
rpoC	763751	p.Ile128Val	missense_variant	0.91	rifampicin
rpoC	763765	c.396T>C	synonymous_variant	0.79	rifampicin
rpoC	764593	c.1224C>T	synonymous_variant	0.95	rifampicin
rpoC	764602	c.1233C>T	synonymous_variant	0.97	rifampicin
rpoC	764611	c.1242G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764632	c.1263T>C	synonymous_variant	0.98	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>T	synonymous_variant	0.99	rifampicin	Not assoc w R - Interim
rpoC	764660	p.Val431Ile	missense_variant	0.99	rifampicin
rpoC	764692	c.1323C>T	synonymous_variant	0.96	rifampicin	Not assoc w R - Interim
rpoC	764706	p.Leu446Gln	missense_variant	0.95	rifampicin	Uncertain significance
rpoC	764713	c.1344G>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpsL	781751	c.192G>C	synonymous_variant	0.83	streptomycin
rpsL	781754	c.195G>C	synonymous_variant	0.92	streptomycin
rpsL	781760	c.201T>C	synonymous_variant	0.89	streptomycin
rpsL	781794	p.Met79Leu	missense_variant	0.9	streptomycin
rpsL	781814	c.255C>T	synonymous_variant	0.96	streptomycin
rpsL	781817	c.258G>T	synonymous_variant	0.96	streptomycin
rpsL	781829	c.270G>C	synonymous_variant	0.96	streptomycin
rpsL	781832	c.273T>C	synonymous_variant	0.96	streptomycin
rpsL	781841	c.282C>T	synonymous_variant	0.95	streptomycin
rrs	1472982	n.1137G>A	non_coding_transcript_exon_variant	1.0	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473226	n.1381C>T	non_coding_transcript_exon_variant	0.8	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result