Run ID: ERR7451300
Sample name:
Date: 2024-10-05T06:07:06.447007
Number of reads: 343730
Percentage reads mapped: 96.99
Median coverage: 10.0
Strain: M.canetti
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
M.canetti | M.canetti | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrB | 5452 | c.213G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6454 | c.1215C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6721 | c.1482C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7835 | c.534A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7937 | c.636A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8039 | c.738T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8054 | c.753T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8198 | c.897T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8219 | c.918T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8399 | c.1098T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8756 | c.1455A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8966 | c.1665C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9817 | c.2517_*53delANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | frameshift_variant&stop_lost&splice_region_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
Rv0010c | 13460 | c.99T>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
fgd1 | 490666 | c.-117G>T | upstream_gene_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 490687 | c.-96T>C | upstream_gene_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491181 | c.399T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491191 | p.Gly137Arg | missense_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491196 | c.414A>G | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491212 | p.Ser144Arg | missense_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R | |||||
mshA | 575665 | c.318G>C | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
ethionamide | Not assoc w R - Interim | |||||
hadA | 731852 | c.-78A>G | upstream_gene_variant | 1.0 | isoniazid | |
hadA | 732379 | c.450A>G | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
mmaA3 | 737397 | c.753G>C | synonymous_variant | 1.0 | isoniazid | |
mmaA3 | 738177 | c.-28G>T | upstream_gene_variant | 1.0 | isoniazid | |
rpoB | 759741 | c.-66C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
rpoC | 764152 | c.783C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 779283 | c.-803G>A | upstream_gene_variant | 1.0 | bedaquiline | |
clofazimine | ||||||
mmpL5 | 779295 | c.-815A>G | upstream_gene_variant | 1.0 | bedaquiline | |
clofazimine | ||||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781456 | c.-104A>G | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
rplC | 800111 | c.-698C>T | upstream_gene_variant | 1.0 | linezolid | |
rplC | 800155 | c.-654_-653insG | upstream_gene_variant | 1.0 | linezolid | |
rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | |
rplC | 801267 | c.459A>G | synonymous_variant | 1.0 | linezolid | Not assoc w R - Interim |
Rv1129c | 1254602 | c.-68C>T | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
fbiC | 1303695 | c.765T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304598 | c.1668C>T | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
sigE | 1364547 | c.135G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
Rv1258c | 1406466 | p.Ser292Leu | missense_variant | 1.0 | streptomycin | Uncertain significance |
pyrazinamide | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
Rv1258c | 1406492 | c.849C>A | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
pyrazinamide | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
embR | 1417454 | c.-107C>A | upstream_gene_variant | 1.0 | ethambutol | |
embR | 1417554 | c.-207C>G | upstream_gene_variant | 1.0 | ethambutol | |
embR | 1418025 | c.-678G>A | upstream_gene_variant | 1.0 | ethambutol | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471850 | n.5_6delGTinsTGG | non_coding_transcript_exon_variant | 1.0 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1474438 | n.781A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
inhA | 1673257 | c.-945C>G | upstream_gene_variant | 1.0 | isoniazid | |
ethionamide | ||||||
rpsA | 1834169 | p.Thr210Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
tlyA | 1917606 | c.-334G>C | upstream_gene_variant | 1.0 | capreomycin | |
bacA | 2064378 | c.351C>T | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
capreomycin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
katG | 2156055 | c.57C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
katG | 2156658 | c.-547A>G | upstream_gene_variant | 1.0 | isoniazid | |
PPE35 | 2169686 | c.927T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
PPE35 | 2169717 | p.Asn299Ile | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
PPE35 | 2170232 | c.381T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
PPE35 | 2170394 | c.219G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
PPE35 | 2170485 | p.Val43Ala | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
PPE35 | 2170694 | c.-82T>C | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
PPE35 | 2170720 | c.-108A>G | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
PPE35 | 2170847 | c.-235T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
PPE35 | 2170860 | c.-248A>C | upstream_gene_variant | 1.0 | pyrazinamide | |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
Rv1979c | 2223318 | c.-154A>G | upstream_gene_variant | 1.0 | bedaquiline | Uncertain significance |
clofazimine | Uncertain significance | |||||
pncA | 2289104 | c.138A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
pncA | 2289700 | c.-459T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
pncA | 2289827 | c.-586A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
Rv2477c | 2783425 | c.618C>T | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
levofloxacin | Not assoc w R - Interim | |||||
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
ribD | 2986929 | p.Leu31Phe | missense_variant | 1.0 | para-aminosalicylic_acid | |
Rv2680 | 2996440 | c.336G>A | synonymous_variant | 1.0 | capreomycin | Not assoc w R - Interim |
Rv2752c | 3064578 | c.1614C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
Rv2752c | 3066687 | c.-496G>C | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
rifampicin | ||||||
ethambutol | ||||||
thyA | 3074238 | c.234C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
thyA | 3074247 | c.225C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
ald | 3087122 | c.303T>C | synonymous_variant | 1.0 | cycloserine | |
ald | 3087140 | c.321G>A | synonymous_variant | 1.0 | cycloserine | |
fbiD | 3339402 | c.285C>T | synonymous_variant | 1.0 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R - Interim | |||||
Rv3083 | 3448349 | c.-155C>T | upstream_gene_variant | 1.0 | ethionamide | |
Rv3083 | 3448453 | c.-51G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
Rv3083 | 3448474 | c.-30G>T | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
Rv3083 | 3448481 | c.-23G>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
Rv3083 | 3448484 | c.-20T>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
Rv3083 | 3448487 | c.-17T>G | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
Rv3083 | 3448495 | c.-9G>C | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
Rv3083 | 3448545 | c.42A>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
Rv3083 | 3448588 | p.Asp29Asn | missense_variant | 1.0 | ethionamide | Uncertain significance |
Rv3083 | 3448606 | c.103C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
Rv3083 | 3448611 | c.108A>G | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
whiB7 | 3568687 | c.-8A>T | upstream_gene_variant | 1.0 | kanamycin | Uncertain significance |
amikacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
Rv3236c | 3612709 | c.408G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
mtrA | 3627190 | c.160T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3627802 | c.-453T>C | upstream_gene_variant | 1.0 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627831 | c.-482T>C | upstream_gene_variant | 1.0 | rifampicin | |
bedaquiline | ||||||
mtrA | 3627839 | c.-490T>C | upstream_gene_variant | 1.0 | rifampicin | |
bedaquiline | ||||||
fbiB | 3642254 | c.720G>A | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiB | 3642467 | c.933T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiB | 3642852 | p.Pro440Ser | missense_variant | 1.0 | pretomanid | |
delamanid | Uncertain significance | |||||
clofazimine | Uncertain significance | |||||
fbiB | 3642874 | p.Leu447Arg | missense_variant | 1.0 | pretomanid | |
delamanid | Uncertain significance | |||||
clofazimine | Uncertain significance | |||||
alr | 3840527 | c.894A>C | synonymous_variant | 1.0 | cycloserine | |
alr | 3840620 | c.801T>C | synonymous_variant | 1.0 | cycloserine | |
alr | 3840719 | c.702A>G | synonymous_variant | 1.0 | cycloserine | |
alr | 3840796 | p.Asp209Asn | missense_variant | 1.0 | cycloserine | |
alr | 3840994 | p.His143Asp | missense_variant | 1.0 | cycloserine | |
alr | 3841172 | c.249A>C | synonymous_variant | 1.0 | cycloserine | |
alr | 3841419 | p.Val1Ala | missense_variant | 1.0 | cycloserine | |
rpoA | 3877527 | c.981C>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoA | 3877740 | c.768G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoA | 3877886 | c.622C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoA | 3877887 | c.621G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoA | 3878848 | c.-341C>T | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
rpoA | 3879193 | c.-686G>A | upstream_gene_variant | 1.0 | rifampicin | |
ddn | 3986910 | c.67C>A | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
ddn | 3987050 | c.207C>T | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clpC1 | 4038443 | c.2262G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038746 | c.1959C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038779 | c.1926C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038848 | c.1857C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038860 | c.1845G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039046 | c.1659C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039058 | c.1647C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039094 | c.1611C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039100 | c.1605C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039336 | c.1369C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039352 | c.1353C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039448 | c.1257A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039454 | c.1251A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039502 | c.1203C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040045 | c.660C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040048 | c.657C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040063 | c.642G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040090 | c.615T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040093 | c.612C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040267 | c.438A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040273 | c.432T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040276 | c.429C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040279 | c.426C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040450 | c.255A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040471 | c.234T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040480 | c.225T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040534 | c.171A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040551 | c.154T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040573 | c.132T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040657 | c.48T>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
panD | 4043932 | p.Met117Thr | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
panD | 4044243 | c.39C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
glpK | 4138377 | p.Val460Ala | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
streptomycin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
ethambutol | Not assoc w R | |||||
glpK | 4139183 | c.572dupG | frameshift_variant | 1.0 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
ethambutol | Uncertain significance | |||||
glpK | 4139813 | c.-58T>G | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
embC | 4239764 | c.-99G>C | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
embA | 4244154 | p.Thr308Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
embA | 4245023 | c.1791A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
embB | 4247590 | c.1077A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4248195 | p.Lys561Met | missense_variant | 1.0 | ethambutol | Uncertain significance |
embB | 4248206 | p.Ser565Gly | missense_variant | 1.0 | ethambutol | Uncertain significance |
embB | 4248439 | c.1926C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
embB | 4248664 | c.2151G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
embB | 4248721 | c.2208C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
embB | 4248744 | p.Val744Ala | missense_variant | 1.0 | ethambutol | Uncertain significance |
embB | 4248853 | c.2340G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
aftB | 4268331 | p.Gln169Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
ethA | 4326463 | c.1011C>T | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
ethA | 4326740 | p.Arg245His | missense_variant | 1.0 | ethionamide | Uncertain significance |
ethR | 4327547 | c.-2_-1insA | upstream_gene_variant | 1.0 | ethionamide | Uncertain significance |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
whiB6 | 4338741 | c.-220A>G | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
whiB6 | 4338785 | c.-266_-264delGGCinsAG | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
gid | 4408185 | c.18C>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |