TB-Profiler result

Run: ERR9786619
Summary

Run ID: ERR9786619

Sample name:

Date: 02-04-2023 12:38:54

Number of reads: 5787540

Percentage reads mapped: 91.32

Strain: lineage4.8

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 0.97
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrB 7017 p.Ala593Val missense_variant 0.91
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 0.14
gyrA 7661 c.360C>T synonymous_variant 0.13
rpoC 764497 c.1128A>G synonymous_variant 0.14
rpoC 764521 c.1152T>C synonymous_variant 0.15
rpoC 764527 c.1158C>T synonymous_variant 0.15
rpoC 764536 c.1167G>C synonymous_variant 0.15
rpoC 764539 c.1170C>G synonymous_variant 0.15
rpoC 764554 c.1185C>T synonymous_variant 0.15
rpoC 764560 c.1191T>C synonymous_variant 0.15
rpoC 764566 c.1197C>G synonymous_variant 0.15
rpoC 764576 p.Ser403Thr missense_variant 0.13
rpoC 764611 c.1242G>C synonymous_variant 0.16
rpoC 764618 c.1249C>T synonymous_variant 0.16
rpoC 764626 c.1257C>T synonymous_variant 0.15
rpoC 764632 c.1263T>C synonymous_variant 0.14
rpoC 764809 c.1440C>T synonymous_variant 0.14
rpoC 765796 c.2427C>T synonymous_variant 0.14
rpoC 765835 c.2466C>T synonymous_variant 0.14
rpoC 765886 c.2517C>G synonymous_variant 0.16
rpoC 765928 c.2559C>G synonymous_variant 0.17
rpoC 765967 c.2598C>T synonymous_variant 0.16
rpoC 765979 c.2610C>G synonymous_variant 0.15
rpoC 765982 c.2613C>T synonymous_variant 0.15
rpoC 765994 c.2625A>T synonymous_variant 0.13
rpoC 766085 p.Pro906Ala missense_variant 0.98
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
atpE 1460992 c.-53A>C upstream_gene_variant 0.99
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.16
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.16
rrl 1473839 n.182G>T non_coding_transcript_exon_variant 0.18
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.19
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.21
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.21
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.15
rrl 1473944 n.287G>A non_coding_transcript_exon_variant 0.15
rrl 1473966 n.309T>C non_coding_transcript_exon_variant 0.16
rrl 1473971 n.314G>T non_coding_transcript_exon_variant 0.16
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.16
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 0.98
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.17
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.17
rrl 1474036 n.379G>A non_coding_transcript_exon_variant 0.16
rrl 1474040 n.383G>A non_coding_transcript_exon_variant 0.17
rrl 1474054 n.397T>C non_coding_transcript_exon_variant 0.16
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.15
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.15
rrl 1474103 n.446A>T non_coding_transcript_exon_variant 0.16
rrl 1474111 n.454T>C non_coding_transcript_exon_variant 0.18
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.18
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.19
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.19
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.16
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.15
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.16
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.14
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.15
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.15
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.16
rrl 1475013 n.1356G>A non_coding_transcript_exon_variant 0.13
rrl 1475201 n.1544G>A non_coding_transcript_exon_variant 0.12
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.14
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.14
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.14
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.14
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.14
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.15
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.15
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.14
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.14
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.14
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.13
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.14
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.13
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.14
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.13
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.13
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.13
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.13
rpsA 1834528 c.987T>C synonymous_variant 0.15
rpsA 1834531 c.990C>T synonymous_variant 0.14
tlyA 1917972 c.33A>G synonymous_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv3083 3448497 c.-7T>A upstream_gene_variant 0.56
whiB7 3568503 c.177G>T synonymous_variant 0.98
alr 3840764 c.657G>C synonymous_variant 0.99
rpoA 3878247 c.261G>C synonymous_variant 0.14
rpoA 3878271 c.237T>C synonymous_variant 0.15
rpoA 3878276 c.232C>T synonymous_variant 0.16
rpoA 3878284 p.Glu75Ala missense_variant 0.17
rpoA 3878292 c.216T>C synonymous_variant 0.15
rpoA 3878298 c.210A>G synonymous_variant 0.15
rpoA 3878304 c.204G>T synonymous_variant 0.15
rpoA 3878307 c.201C>G synonymous_variant 0.15
rpoA 3878313 c.195G>C synonymous_variant 0.15
rpoA 3878322 c.186A>G synonymous_variant 0.16
rpoA 3878346 c.162T>C synonymous_variant 0.15
clpC1 4038914 c.1791G>C synonymous_variant 0.14
clpC1 4038917 c.1788C>T synonymous_variant 0.13
clpC1 4038953 c.1752A>G synonymous_variant 0.14
clpC1 4038965 c.1740T>C synonymous_variant 0.14
clpC1 4038989 c.1716T>C synonymous_variant 0.14
clpC1 4039556 c.1149G>C synonymous_variant 0.15
clpC1 4039559 c.1146C>G synonymous_variant 0.15
clpC1 4039574 p.Ala377Gly missense_variant 0.15
clpC1 4039577 c.1128T>C synonymous_variant 0.15
clpC1 4039592 c.1113G>T synonymous_variant 0.16
clpC1 4039610 c.1095G>T synonymous_variant 0.17
clpC1 4039616 c.1089G>C synonymous_variant 0.16
clpC1 4039622 c.1083C>T synonymous_variant 0.14
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4249511 p.Met1000Leu missense_variant 0.97
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0