TB-Profiler result

Run: ERR4814683
Summary

Run ID: ERR4814683

Sample name:

Date: 2024-10-04T14:48:00.074481

Number of reads: 2101136

Percentage reads mapped: 79.33

Median coverage: 47.0

Strain: lineage1.1.2;lineage4.1.2.1;lineage4.1.3

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1.3 Euro-American None 0.54
lineage1.1.2 Indo-Oceanic RD239 0.27
lineage4.1 Euro-American None 0.74
lineage4.1.2 Euro-American None 0.26
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.21
lineage1.1 Indo-Oceanic RD239 0.2
lineage4 Euro-American None 0.75
lineage1 Indo-Oceanic RD239 0.25
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrB 6112 p.Met291Ile missense_variant 0.18 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6124 c.885C>T synonymous_variant 0.2 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrB 6798 p.Gly520Ala missense_variant 0.15 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 6841 c.1602T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7475 c.174A>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7480 p.Phe60Tyr missense_variant 0.18 levofloxacin
moxifloxacin
gyrA 7484 c.183T>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7523 c.222C>G synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7526 c.225G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7532 c.231T>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7793 c.492G>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7799 c.498A>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7814 c.513C>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8435 c.1134C>G synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8452 p.Ala384Val missense_variant 0.16 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8897 c.1596T>C synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9143 c.1842T>C synonymous_variant 0.32 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 0.24 isoniazid Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 0.2 pretomanid
delamanid Uncertain significance
clofazimine Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 0.23 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R
mshA 575376 p.Ser10Leu missense_variant 0.24 isoniazid Uncertain significance
ethionamide Uncertain significance
Rv0565c 657269 p.Ser68Pro missense_variant 0.82 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 0.3 ethionamide
nusG 734116 c.-138T>C upstream_gene_variant 0.31 rifampicin Not assoc w R
nusG 734475 c.222T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760115 c.309C>T synonymous_variant 0.26 rifampicin Not assoc w R
rpoB 760184 c.378A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.2 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760406 c.600G>C synonymous_variant 0.16 rifampicin
rpoB 760591 p.Val262Ala missense_variant 0.18 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760646 c.840C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760655 c.849A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760661 c.855A>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760674 c.868T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760679 c.873A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760683 c.877T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760946 c.1140A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761006 c.1200C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761015 c.1209G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.15 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761219 c.1413G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 761570 c.1764T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761573 c.1767C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761579 c.1773G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761615 c.1809A>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 761636 c.1830G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762176 c.2370T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762233 c.2427G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762929 c.3123G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 0.28 rifampicin Not assoc w R
rpoB 763040 c.3234C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763166 c.3360A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763618 c.249C>T synonymous_variant 0.14 rifampicin
rpoC 763884 p.Ala172Val missense_variant 0.26 rifampicin Not assoc w R
rpoC 763886 c.517C>A synonymous_variant 0.27 rifampicin Not assoc w R
rpoC 764497 c.1128A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764539 c.1170C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764554 c.1185C>T synonymous_variant 0.21 rifampicin
rpoC 764566 c.1197C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.15 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764815 c.1446A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764858 c.1489T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764888 c.1519T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764911 c.1542A>G synonymous_variant 0.16 rifampicin
rpoC 764932 c.1563C>A synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 0.76 rifampicin Not assoc w R
rpoC 765171 p.Pro601Leu missense_variant 0.3 rifampicin Not assoc w R
rpoC 765478 c.2109T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765529 c.2160C>T synonymous_variant 0.25 rifampicin
rpoC 765541 c.2172C>G synonymous_variant 0.26 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.18 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.17 rifampicin
rpoC 765826 c.2457T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765886 c.2517C>G synonymous_variant 0.19 rifampicin
rpoC 765937 c.2568T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>G synonymous_variant 0.16 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781276 c.-284A>C upstream_gene_variant 0.26 streptomycin
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781421 c.-139C>A upstream_gene_variant 0.41 streptomycin Uncertain significance
rpsL 781700 c.141G>C synonymous_variant 0.16 streptomycin
rpsL 781703 c.144G>T synonymous_variant 0.17 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.17 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.18 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.18 streptomycin
rpsL 781742 c.183C>T synonymous_variant 0.18 streptomycin
rpsL 781748 c.189C>G synonymous_variant 0.18 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.17 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.18 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.14 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.14 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.13 streptomycin
rplC 800357 c.-452C>A upstream_gene_variant 0.18 linezolid Not assoc w R
Rv1129c 1254562 c.-28T>C upstream_gene_variant 0.21 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
rifampicin Not assoc w R
fbiC 1304568 c.1638T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304580 c.1650T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304610 c.1680C>T synonymous_variant 0.43 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304613 c.1683T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304829 c.1899T>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304832 c.1902C>T synonymous_variant 0.21 pretomanid
delamanid Not assoc w R - Interim
clofazimine Not assoc w R - Interim
fbiC 1304856 c.1926C>G synonymous_variant 0.4 pretomanid
delamanid
clofazimine
fbiC 1304869 c.1939C>T synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304875 p.Ile649Val missense_variant 0.17 pretomanid
delamanid
clofazimine
embR 1417554 c.-207C>G upstream_gene_variant 0.23 ethambutol
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrl 1475475 n.1818C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1475479 n.1822C>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475480 n.1823A>T non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.27 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674903 c.702T>C synonymous_variant 0.16 isoniazid
ethionamide
inhA 1674904 p.Ala235Pro missense_variant 0.15 isoniazid
ethionamide
inhA 1674942 c.741T>G synonymous_variant 0.13 isoniazid
ethionamide
rpsA 1833856 c.315A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833886 c.345C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833928 c.387G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833970 c.429G>C synonymous_variant 0.13 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.18 pyrazinamide
rpsA 1833991 c.450C>G synonymous_variant 0.13 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.2 pyrazinamide
rpsA 1834021 c.480C>T synonymous_variant 0.19 pyrazinamide
rpsA 1834030 c.489C>G synonymous_variant 0.21 pyrazinamide
rpsA 1834081 c.540C>T synonymous_variant 0.14 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834639 c.1098T>C synonymous_variant 0.15 pyrazinamide
tsnR 1854045 p.Tyr147Cys missense_variant 0.31 linezolid Not assoc w R
tsnR 1854300 p.Leu232Pro missense_variant 0.96 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.3 pyrazinamide Not assoc w R
Rv1979c 2222308 p.Asp286Gly missense_variant 0.18 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518076 c.-39C>T upstream_gene_variant 0.22 isoniazid
kasA 2518132 c.18C>T synonymous_variant 0.33 isoniazid
ahpC 2726051 c.-142G>A upstream_gene_variant 0.26 isoniazid
Rv2752c 3066376 c.-185C>T upstream_gene_variant 0.2 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
ald 3086788 c.-32T>C upstream_gene_variant 0.98 cycloserine
lpqB 3624236 c.675C>A synonymous_variant 0.27 rifampicin Not assoc w R - Interim
bedaquiline
lpqB 3624486 p.Asp142Gly missense_variant 0.27 rifampicin Not assoc w R
bedaquiline Uncertain significance
lpqB 3624660 p.Ala84Gly missense_variant 0.45 rifampicin Uncertain significance
bedaquiline Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 0.97 rifampicin Not assoc w R
bedaquiline Uncertain significance
mtrB 3625572 p.Thr348Ser missense_variant 0.13 rifampicin
bedaquiline
lpqB 3625579 c.-669A>G upstream_gene_variant 0.14 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625755 p.Ala287Thr missense_variant 0.15 rifampicin Uncertain significance
bedaquiline
mtrB 3625774 c.840G>A synonymous_variant 0.15 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627181 c.-568T>C upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrA 3627188 c.162A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
bedaquiline
mtrA 3627242 c.108C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3627254 c.-641C>T upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3627263 c.-650C>T upstream_gene_variant 0.13 rifampicin
bedaquiline
mtrB 3627266 c.-653A>G upstream_gene_variant 0.14 rifampicin
bedaquiline
mtrB 3627275 c.-662G>T upstream_gene_variant 0.12 rifampicin
bedaquiline
rpoA 3877553 p.Glu319Gln missense_variant 0.14 rifampicin
rpoA 3877571 p.Pro313Ala missense_variant 0.14 rifampicin
rpoA 3877587 c.921A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.13 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.17 rifampicin
rpoA 3877686 c.822A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877743 c.765T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877905 c.603A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
clpC1 4038782 c.1923G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.19 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039589 c.1116G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039622 c.1083C>T synonymous_variant 0.2 pyrazinamide
clpC1 4039649 c.1056G>T synonymous_variant 0.16 pyrazinamide
clpC1 4039652 c.1053G>T synonymous_variant 0.18 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.29 pyrazinamide
clpC1 4039724 c.981A>G synonymous_variant 0.23 pyrazinamide
clpC1 4039820 c.885T>G synonymous_variant 0.13 pyrazinamide
clpC1 4039826 c.879C>G synonymous_variant 0.13 pyrazinamide
clpC1 4039831 c.874T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039865 c.840T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039898 c.807C>G synonymous_variant 0.16 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040517 p.Val63Ala missense_variant 0.13 pyrazinamide Not assoc w R - Interim
glpK 4138377 p.Val460Ala missense_variant 0.25 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
isoniazid Not assoc w R
streptomycin Not assoc w R
rifampicin Not assoc w R
ethambutol Not assoc w R
embC 4239298 c.-565C>T upstream_gene_variant 0.19 ethambutol Not assoc w R
embC 4240671 p.Thr270Ile missense_variant 0.27 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.61 ethambutol Not assoc w R
embA 4243848 p.Val206Met missense_variant 0.29 ethambutol Not assoc w R
embA 4245969 p.Pro913Ser missense_variant 0.27 ethambutol Not assoc w R
embB 4247050 c.537C>T synonymous_variant 0.27 ethambutol Not assoc w R - Interim
embB 4247356 c.843C>T synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embB 4247646 p.Glu378Ala missense_variant 0.32 ethambutol Not assoc w R
aftB 4268683 p.Gly52Ser missense_variant 0.49 ethambutol Uncertain significance
ubiA 4269606 c.228T>C synonymous_variant 0.33 ethambutol Not assoc w R
whiB6 4338441 p.Tyr27* stop_gained 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
whiB6 4338449 p.Ala25Pro missense_variant 0.22 kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338603 c.-82C>T upstream_gene_variant 0.27 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin
gid 4407588 c.615A>G synonymous_variant 0.26 streptomycin Not assoc w R
gid 4407873 c.330G>T synonymous_variant 0.21 streptomycin Not assoc w R