TB-Profiler result

Run: SRR1048965
Summary

Run ID: SRR1048965

Sample name:

Date: 2024-10-04T04:00:43.471691

Number of reads: 296109

Percentage reads mapped: 8.42

Median coverage: 6.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: HR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 1.0
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 1.0
lineage2.2 East-Asian (Beijing) RD105;RD207 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid katG p.Ser140Asn Uncertain significance Mutation from literature
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
katG 2155693 p.Ser140Asn missense_variant 1.0 isoniazid Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
rpoC 762893 c.-477C>T upstream_gene_variant 0.56 rifampicin
rpoC 762896 c.-474G>C upstream_gene_variant 0.56 rifampicin
rpoB 762909 p.Ile1035Val missense_variant 0.36 rifampicin Uncertain significance
rpoB 762917 c.3111C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762920 c.3114C>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762923 c.3117C>G synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762925 p.Thr1040Ile missense_variant 0.64 rifampicin
rpoB 762929 c.3123G>T synonymous_variant 0.64 rifampicin Not assoc w R - Interim
rpoB 762939 p.Met1045Leu missense_variant 0.64 rifampicin
rpoB 762942 p.Ile1046Val missense_variant 0.64 rifampicin Uncertain significance
rpoC 762965 c.-405T>C upstream_gene_variant 0.74 rifampicin
rpoC 762980 c.-390T>C upstream_gene_variant 0.74 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.6 rifampicin
rpoC 764344 c.975C>T synonymous_variant 0.52 rifampicin
rpoC 764348 p.Met327Leu missense_variant 0.52 rifampicin
rpoC 764355 p.Gln329Pro missense_variant 0.52 rifampicin
rpoC 764377 c.1008C>G synonymous_variant 0.52 rifampicin Not assoc w R - Interim
rpoC 764380 c.1011G>C synonymous_variant 0.54 rifampicin Not assoc w R - Interim
rpoC 764383 c.1014C>G synonymous_variant 0.54 rifampicin
rpoC 764387 c.1018_1020delTTGinsCTC synonymous_variant 0.5 rifampicin Not assoc w R - Interim
rpoC 764398 c.1029G>C synonymous_variant 0.48 rifampicin
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.45 rifampicin Not assoc w R - Interim
rpoC 764410 c.1041G>T synonymous_variant 0.45 rifampicin
rpoC 764428 c.1059G>T synonymous_variant 0.31 rifampicin
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rrs 1472181 n.336G>A non_coding_transcript_exon_variant 0.73 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.72 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472235 n.390G>C non_coding_transcript_exon_variant 0.62 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472240 n.395G>C non_coding_transcript_exon_variant 0.63 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472242 n.397C>T non_coding_transcript_exon_variant 0.63 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472251 n.406G>A non_coding_transcript_exon_variant 0.59 kanamycin Uncertain significance
capreomycin Not assoc w R
streptomycin Uncertain significance
amikacin Not assoc w R
rrs 1472253 n.408G>T non_coding_transcript_exon_variant 0.59 kanamycin
capreomycin
streptomycin Uncertain significance
amikacin
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.71 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1476336 n.2679C>G non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1476356 n.2699C>G non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476357 n.2700T>A non_coding_transcript_exon_variant 0.62 capreomycin
linezolid
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.62 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.64 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.69 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476384 n.2727G>C non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476411 n.2754G>A non_coding_transcript_exon_variant 0.79 capreomycin
linezolid
rrl 1476428 n.2771C>A non_coding_transcript_exon_variant 0.89 capreomycin
linezolid
rrl 1476443 n.2786G>C non_coding_transcript_exon_variant 0.86 capreomycin
linezolid
rrl 1476455 n.2798C>G non_coding_transcript_exon_variant 0.77 capreomycin
linezolid
rrl 1476463 n.2806C>T non_coding_transcript_exon_variant 0.74 capreomycin
linezolid
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.78 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.78 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.75 capreomycin Not assoc w R
linezolid Uncertain significance
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
katG 2155626 c.486G>C synonymous_variant 1.0 isoniazid
katG 2155637 p.Leu159Ile missense_variant 1.0 isoniazid
katG 2155641 p.Lys157Arg missense_variant 1.0 isoniazid
katG 2155650 c.462G>A synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2155655 p.Lys153Gln missense_variant 1.0 isoniazid Uncertain significance
katG 2155661 p.Val151Ile missense_variant 1.0 isoniazid
katG 2155668 c.444G>C synonymous_variant 1.0 isoniazid
katG 2155689 c.421_423delTTGinsCTC synonymous_variant 1.0 isoniazid Not assoc w R - Interim
katG 2155704 c.408C>T synonymous_variant 1.0 isoniazid
katG 2155716 c.396T>C synonymous_variant 1.0 isoniazid
katG 2155722 c.390G>C synonymous_variant 1.0 isoniazid
katG 2155728 c.384G>C synonymous_variant 1.0 isoniazid
katG 2155735 p.Met126Gln missense_variant 1.0 isoniazid
katG 2155737 c.375C>T synonymous_variant 1.0 isoniazid
katG 2155741 p.Gly124Ala missense_variant 1.0 isoniazid Uncertain significance
katG 2155743 c.369G>T synonymous_variant 1.0 isoniazid
embC 4240423 c.561G>A synonymous_variant 1.0 ethambutol Not assoc w R - Interim
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin