Run ID: SRR22251329
Sample name:
Date: 2024-04-15T20:40:12.839162
Number of reads: 2156394
Percentage reads mapped: 97.72
Median coverage: 65.0
Strain: lineage2.1
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage2 | East-Asian | RD105 | 1.0 |
lineage2.1 | East-Asian (non-Beijing) | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | gid | c.102delG | Assoc w R | |
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
gid | 4408100 | c.102delG | frameshift_variant | 1.0 | streptomycin | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7963 | p.Gly221Glu | missense_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7970 | c.669T>C | synonymous_variant | 0.14 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
fgd1 | 491232 | c.450T>C | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491259 | c.477T>C | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491268 | c.486C>T | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491286 | c.504G>C | synonymous_variant | 0.15 | clofazimine | Not assoc w R - Interim |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
Rv0565c | 657081 | c.390G>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
Rv0565c | 657142 | p.Arg110His | missense_variant | 1.0 | ethionamide | Uncertain significance |
rpoB | 760718 | c.912C>T | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760724 | c.918T>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 762813 | p.Met1003Val | missense_variant | 0.15 | rifampicin | |
rpoB | 762818 | c.3012C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 762857 | c.3051C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
rpoC | 763900 | c.531G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 764716 | c.1347G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764752 | c.1383G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764764 | c.1395T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764803 | c.1434C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 764809 | c.1440C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R |
rpoC | 764812 | c.1443C>G | synonymous_variant | 0.23 | rifampicin | |
rpoC | 764815 | c.1446A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764824 | c.1455T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764833 | c.1464A>G | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764836 | c.1467G>A | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764842 | c.1473C>T | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764869 | c.1500C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765121 | c.1752G>A | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
rpoC | 767033 | c.3664_3666delTCGinsAGT | synonymous_variant | 0.24 | rifampicin | |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 767062 | c.3693C>A | synonymous_variant | 0.22 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 767119 | c.3750A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 767134 | c.3765C>A | synonymous_variant | 0.14 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpS5 | 778706 | p.Val67Gly | missense_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781865 | c.306G>C | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781871 | c.312G>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781904 | c.345C>T | synonymous_variant | 0.17 | streptomycin | Not assoc w R - Interim |
rpsL | 781907 | c.348T>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781916 | c.357T>G | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781929 | p.Gly124Ser | missense_variant | 0.21 | streptomycin | Uncertain significance |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | moxifloxacin | Not assoc w R |
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
fbiC | 1304443 | p.Ala505Thr | missense_variant | 1.0 | clofazimine | Uncertain significance |
pretomanid | ||||||
delamanid | Uncertain significance | |||||
embR | 1417272 | p.Thr26Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rpsA | 1833802 | c.261A>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833811 | c.270G>T | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833817 | c.276C>G | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833820 | c.279G>A | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833856 | c.315A>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833859 | c.318C>T | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833874 | c.333T>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833894 | p.Ala118Glu | missense_variant | 0.17 | pyrazinamide | |
rpsA | 1834177 | c.636A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834297 | c.756C>G | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834303 | c.762T>G | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834369 | c.828C>G | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1834396 | c.855G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834451 | c.910T>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834456 | c.915T>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834459 | c.918G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834468 | c.927A>G | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834499 | c.958C>T | synonymous_variant | 0.14 | pyrazinamide | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
tlyA | 1918306 | p.Arg123Ser | missense_variant | 1.0 | capreomycin | |
katG | 2153961 | c.2151G>A | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
kasA | 2518902 | p.Ala263Val | missense_variant | 0.97 | isoniazid | |
folC | 2747026 | c.573C>G | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
Rv2477c | 2783374 | c.669G>C | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783377 | c.666C>G | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783395 | c.648T>C | synonymous_variant | 0.2 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783422 | c.621T>G | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783427 | p.Pro206Ala | missense_variant | 0.2 | ethambutol | Uncertain significance |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | Uncertain significance | |||||
amikacin | ||||||
Rv2477c | 2783428 | c.615C>T | synonymous_variant | 0.2 | ethambutol | |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | ||||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783440 | c.603T>C | synonymous_variant | 0.22 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783461 | c.582T>C | synonymous_variant | 0.24 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783467 | c.576G>C | synonymous_variant | 0.23 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783473 | c.570A>G | synonymous_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783499 | c.544T>C | synonymous_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783502 | c.541T>C | synonymous_variant | 0.17 | ethambutol | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2477c | 2783512 | c.531A>G | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783605 | c.438T>C | synonymous_variant | 0.15 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783659 | p.Glu128Asp | missense_variant | 0.2 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
kanamycin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
Rv2477c | 2783665 | c.378A>G | synonymous_variant | 0.2 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2783790 | p.Val85Ile | missense_variant | 0.89 | ethambutol | Not assoc w R |
moxifloxacin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
kanamycin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
lpqB | 3625537 | c.-627T>C | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625579 | c.-669A>C | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625588 | c.-678G>A | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625612 | c.-702G>C | upstream_gene_variant | 0.19 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625623 | p.Thr331Ala | missense_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625627 | c.-717C>T | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625630 | c.-720C>G | upstream_gene_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625638 | p.Ala326Ser | missense_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625648 | c.-738T>C | upstream_gene_variant | 0.19 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625656 | c.958T>C | synonymous_variant | 0.21 | bedaquiline | Not assoc w R - Interim |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625663 | c.-753G>C | upstream_gene_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625675 | c.-765G>C | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625690 | c.-780T>C | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625696 | c.-786A>G | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625699 | c.915C>T | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625720 | c.894G>C | synonymous_variant | 0.22 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625723 | c.-813C>T | upstream_gene_variant | 0.23 | bedaquiline | |
rifampicin | ||||||
lpqB | 3625731 | c.-821C>T | upstream_gene_variant | 0.24 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625744 | c.870G>A | synonymous_variant | 0.26 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625747 | c.867G>C | synonymous_variant | 0.26 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625753 | c.859_861delGCCinsAT | frameshift_variant&missense_variant | 0.25 | bedaquiline | Uncertain significance |
rifampicin | Uncertain significance | |||||
mtrB | 3625765 | c.849C>G | synonymous_variant | 0.24 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625774 | c.840G>A | synonymous_variant | 0.27 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625806 | c.808A>C | synonymous_variant | 0.24 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625807 | c.807C>G | synonymous_variant | 0.23 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3625828 | c.-918G>C | upstream_gene_variant | 0.23 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625852 | c.762A>G | synonymous_variant | 0.22 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625867 | c.747A>G | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625912 | c.702G>C | synonymous_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625915 | c.699G>T | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625927 | c.687T>C | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625936 | c.678C>G | synonymous_variant | 0.16 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625942 | c.672C>T | synonymous_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625945 | c.669A>G | synonymous_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625950 | c.664C>T | synonymous_variant | 0.15 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3625951 | c.663A>G | synonymous_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625977 | p.Gly213Ser | missense_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625978 | c.636T>C | synonymous_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
mtrB | 3625987 | c.627G>T | synonymous_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626029 | c.585A>G | synonymous_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626035 | c.579G>C | synonymous_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626705 | c.-92G>T | upstream_gene_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626711 | c.-98T>C | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
mtrA | 3626741 | c.609C>G | synonymous_variant | 0.17 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3626744 | c.-131G>C | upstream_gene_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626750 | c.-137T>C | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrA | 3626759 | c.591T>C | synonymous_variant | 0.21 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrA | 3626774 | c.574_576delAGGinsCC | frameshift_variant&missense_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626780 | c.-167T>C | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626783 | c.-170C>G | upstream_gene_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
mtrA | 3626786 | c.564A>G | synonymous_variant | 0.23 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3626798 | c.-185T>A | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626804 | c.-191A>C | upstream_gene_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
mtrA | 3626846 | c.504G>A | synonymous_variant | 0.21 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3626849 | c.-236C>G | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626858 | c.-245A>G | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626866 | c.-253T>C | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626876 | c.-263A>G | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626885 | c.-272A>G | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626890 | c.-277T>C | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626891 | c.-278G>C | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626903 | c.-290T>A | upstream_gene_variant | 0.19 | bedaquiline | |
rifampicin | ||||||
mtrA | 3626912 | c.438T>C | synonymous_variant | 0.16 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3626930 | c.-317A>G | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrA | 3626939 | p.Glu137Asp | missense_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626942 | c.-329A>C | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626969 | c.-356C>G | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626972 | c.-359A>G | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626987 | c.-374C>G | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3626992 | c.-379C>T | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627011 | c.-398T>C | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627026 | c.324G>A | synonymous_variant | 0.18 | bedaquiline | Not assoc w R - Interim |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627059 | c.-446G>C | upstream_gene_variant | 0.19 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627068 | c.282T>C | synonymous_variant | 0.17 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627071 | c.-458G>C | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627080 | c.270T>C | synonymous_variant | 0.17 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627083 | c.-470G>C | upstream_gene_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627098 | c.252A>C | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627104 | c.-491C>G | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627110 | c.-497G>C | upstream_gene_variant | 0.17 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627119 | c.231T>G | synonymous_variant | 0.16 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627122 | c.-509T>C | upstream_gene_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
fbiA | 3641110 | p.Ala190Thr | missense_variant | 1.0 | clofazimine | Uncertain significance |
pretomanid | ||||||
delamanid | Uncertain significance | |||||
rpoA | 3878974 | c.-467C>G | upstream_gene_variant | 0.15 | rifampicin | |
clpC1 | 4040841 | c.-138delG | upstream_gene_variant | 1.0 | pyrazinamide | |
embC | 4240418 | p.Gly186Cys | missense_variant | 0.98 | ethambutol | Uncertain significance |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embA | 4246088 | c.2856A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4247028 | p.Leu172Arg | missense_variant | 0.22 | ethambutol | |
aftB | 4267647 | p.Asp397Gly | missense_variant | 1.0 | ethambutol | Not assoc w R |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |