TB-Profiler result

Run: SRR6982194
Summary

Run ID: SRR6982194

Sample name:

Date: 04-04-2023 18:30:13

Number of reads: 889845

Percentage reads mapped: 97.16

Strain: lineage2.2.1

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 0.99
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
lineage2.2.1 East-Asian (Beijing) Beijing-RD181 RD105;RD207;RD181 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1472733 n.888G>A non_coding_transcript_exon_variant 0.43 streptomycin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 1.0
ccsA 620067 c.177T>G synonymous_variant 0.11
ccsA 620625 p.Ile245Met missense_variant 1.0
ccsA 620748 c.858T>G synonymous_variant 0.21
rpoB 759615 c.-192A>C upstream_gene_variant 0.19
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 766500 p.Ala1044Val missense_variant 1.0
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 1.0
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472137 n.292G>A non_coding_transcript_exon_variant 0.11
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.12
rrs 1472151 n.306C>T non_coding_transcript_exon_variant 0.12
rrs 1472164 n.319G>A non_coding_transcript_exon_variant 0.19
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.19
rrs 1472177 n.332C>T non_coding_transcript_exon_variant 0.22
rrs 1472203 n.358G>A non_coding_transcript_exon_variant 0.21
rrs 1472210 n.365A>C non_coding_transcript_exon_variant 0.19
rrs 1472213 n.368G>C non_coding_transcript_exon_variant 0.17
rrs 1472215 n.370A>G non_coding_transcript_exon_variant 0.17
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.17
rrs 1472234 n.389T>C non_coding_transcript_exon_variant 0.18
rrs 1472236 n.391C>G non_coding_transcript_exon_variant 0.19
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.18
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.16
rrs 1472541 n.696T>G non_coding_transcript_exon_variant 0.16
rrs 1472544 n.699C>A non_coding_transcript_exon_variant 0.17
rrs 1472545 n.700A>T non_coding_transcript_exon_variant 0.17
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.29
rrs 1472570 n.725G>A non_coding_transcript_exon_variant 0.31
rrs 1472571 n.726G>C non_coding_transcript_exon_variant 0.31
rrs 1472573 n.728C>T non_coding_transcript_exon_variant 0.31
rrs 1472579 n.734G>T non_coding_transcript_exon_variant 0.32
rrs 1472581 n.736A>T non_coding_transcript_exon_variant 0.34
rrs 1472596 n.751G>T non_coding_transcript_exon_variant 0.42
rrs 1472598 n.753A>T non_coding_transcript_exon_variant 0.42
rrs 1472614 n.769G>T non_coding_transcript_exon_variant 0.42
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.42
rrs 1472655 n.810G>A non_coding_transcript_exon_variant 0.38
rrs 1472658 n.813G>A non_coding_transcript_exon_variant 0.38
rrs 1472661 n.816A>G non_coding_transcript_exon_variant 0.35
rrs 1472665 n.820G>A non_coding_transcript_exon_variant 0.36
rrs 1472669 n.824_825insTAGG non_coding_transcript_exon_variant 0.36
rrs 1472695 n.850C>T non_coding_transcript_exon_variant 0.31
rrs 1472697 n.852T>C non_coding_transcript_exon_variant 0.31
rrs 1472713 n.868T>C non_coding_transcript_exon_variant 0.4
rrs 1472716 n.871C>T non_coding_transcript_exon_variant 0.41
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.43
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.43
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.46
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.4
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.39
rrs 1472803 n.958T>A non_coding_transcript_exon_variant 0.37
rrs 1472824 n.979T>A non_coding_transcript_exon_variant 0.18
rrs 1472825 n.980G>A non_coding_transcript_exon_variant 0.14
rrs 1472826 n.981G>A non_coding_transcript_exon_variant 0.14
rrs 1472827 n.982G>T non_coding_transcript_exon_variant 0.14
rrs 1472828 n.983T>C non_coding_transcript_exon_variant 0.14
rrs 1472836 n.991G>C non_coding_transcript_exon_variant 0.14
rrs 1472838 n.993A>T non_coding_transcript_exon_variant 0.14
rrs 1472845 n.1000G>C non_coding_transcript_exon_variant 0.13
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.13
rrs 1472873 n.1028C>A non_coding_transcript_exon_variant 0.17
rrs 1472875 n.1030T>A non_coding_transcript_exon_variant 0.18
rrs 1472877 n.1032T>A non_coding_transcript_exon_variant 0.17
rrs 1472880 n.1035_1036insA non_coding_transcript_exon_variant 0.17
rrs 1472895 n.1050C>T non_coding_transcript_exon_variant 0.26
rrs 1473035 n.1190G>A non_coding_transcript_exon_variant 0.3
rrs 1473053 n.1208T>A non_coding_transcript_exon_variant 0.16
rrs 1473054 n.1209C>T non_coding_transcript_exon_variant 0.12
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.12
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.13
rrs 1473062 n.1217T>A non_coding_transcript_exon_variant 0.12
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.12
rrs 1473080 n.1235C>A non_coding_transcript_exon_variant 0.12
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.12
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.11
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.11
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.12
rrs 1473165 n.1320C>T non_coding_transcript_exon_variant 0.11
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.11
rrs 1473172 n.1327T>C non_coding_transcript_exon_variant 0.11
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.11
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.11
rrs 1473191 n.1346C>T non_coding_transcript_exon_variant 0.15
rrs 1473206 n.1361G>A non_coding_transcript_exon_variant 0.16
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.18
rrs 1473352 n.1507C>T non_coding_transcript_exon_variant 0.16
rrl 1475713 n.2056C>G non_coding_transcript_exon_variant 0.15
rrl 1475716 n.2059A>G non_coding_transcript_exon_variant 0.15
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.14
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.18
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.17
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.17
rrl 1476225 n.2568T>G non_coding_transcript_exon_variant 0.39
rrl 1476229 n.2572C>T non_coding_transcript_exon_variant 0.44
rrl 1476251 n.2594T>C non_coding_transcript_exon_variant 0.52
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.52
rrl 1476268 n.2611A>T non_coding_transcript_exon_variant 0.53
rrl 1476275 n.2618T>A non_coding_transcript_exon_variant 0.54
rrl 1476279 n.2622G>A non_coding_transcript_exon_variant 0.54
rrl 1476280 n.2623A>C non_coding_transcript_exon_variant 0.54
rrl 1476293 n.2636C>T non_coding_transcript_exon_variant 0.54
rrl 1476294 n.2637A>G non_coding_transcript_exon_variant 0.54
rrl 1476295 n.2638C>G non_coding_transcript_exon_variant 0.54
rrl 1476296 n.2639C>T non_coding_transcript_exon_variant 0.54
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.54
rrl 1476301 n.2644A>C non_coding_transcript_exon_variant 0.57
rrl 1476302 n.2645G>A non_coding_transcript_exon_variant 0.56
rrl 1476311 n.2654G>C non_coding_transcript_exon_variant 0.56
rrl 1476312 n.2655T>C non_coding_transcript_exon_variant 0.57
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.57
rrl 1476332 n.2675G>C non_coding_transcript_exon_variant 0.62
rrl 1476353 n.2696G>T non_coding_transcript_exon_variant 0.71
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.72
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.74
rrl 1476372 n.2715T>C non_coding_transcript_exon_variant 0.74
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.72
rrl 1476383 n.2726T>A non_coding_transcript_exon_variant 0.72
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.73
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.64
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.64
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.64
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.66
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.66
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.56
rrl 1476514 n.2857C>T non_coding_transcript_exon_variant 0.54
rrl 1476517 n.2860C>T non_coding_transcript_exon_variant 0.48
rrl 1476519 n.2862C>G non_coding_transcript_exon_variant 0.48
rrl 1476524 n.2867C>A non_coding_transcript_exon_variant 0.48
rrl 1476525 n.2868A>G non_coding_transcript_exon_variant 0.48
rrl 1476530 n.2873C>T non_coding_transcript_exon_variant 0.47
rrl 1476536 n.2879G>A non_coding_transcript_exon_variant 0.47
rrl 1476537 n.2880A>G non_coding_transcript_exon_variant 0.47
rrl 1476538 n.2881A>G non_coding_transcript_exon_variant 0.47
rrl 1476540 n.2883C>G non_coding_transcript_exon_variant 0.46
rrl 1476547 n.2890C>T non_coding_transcript_exon_variant 0.45
rrl 1476567 n.2910C>T non_coding_transcript_exon_variant 0.45
rrl 1476572 n.2915G>A non_coding_transcript_exon_variant 0.39
rrl 1476573 n.2916A>T non_coding_transcript_exon_variant 0.39
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.3
rpsA 1833749 p.Ile70Leu missense_variant 1.0
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
eis 2714526 c.805_806delAC frameshift_variant 1.0
ahpC 2726338 p.Val49Gly missense_variant 0.26
Rv2752c 3065711 p.Gly161Ser missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
embA 4244817 p.Phe529Leu missense_variant 0.13
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0