TB-Profiler

Lineage	Family	RDs	Frequency
La1.2	M.bovis	None	1.0
La1	M.bovis	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
pncA	2289073	p.His57Asp	missense_variant	1.0	pyrazinamide	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	467	p.His156Arg	missense_variant	1.0	isoniazid	Not assoc w R
gyrB	5752	c.513G>A	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	5752	c.513G>A	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	0.96	levofloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	0.96	moxifloxacin	Not assoc w R - Interim
gyrB	6446	p.Ala403Ser	missense_variant	0.97	levofloxacin	Not assoc w R
gyrB	6446	p.Ala403Ser	missense_variant	0.97	moxifloxacin	Uncertain significance
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	0.99	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	0.99	moxifloxacin	Not assoc w R
gyrA	7821	c.520C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	7821	c.520C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8285	c.984C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8285	c.984C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	8741	c.1440C>T	synonymous_variant	0.96	levofloxacin	Not assoc w R - Interim
gyrA	8741	c.1440C>T	synonymous_variant	0.96	moxifloxacin	Not assoc w R - Interim
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9419	c.2118T>C	synonymous_variant	0.13	levofloxacin
gyrA	9419	c.2118T>C	synonymous_variant	0.13	moxifloxacin
gyrA	9420	p.Ile707Ala	missense_variant	0.13	levofloxacin
gyrA	9420	p.Ile707Ala	missense_variant	0.13	moxifloxacin
Rv0010c	13197	p.Thr121Ser	missense_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13228	c.330delG	frameshift_variant	1.0	isoniazid	Uncertain significance
Rv0010c	13280	c.279C>A	synonymous_variant	1.0	isoniazid	Not assoc w R - Interim
Rv0010c	13460	c.99T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
fgd1	491742	c.960T>C	synonymous_variant	1.0	clofazimine	Not assoc w R
					pretomanid
					delamanid	Not assoc w R - Interim
Rv0565c	657578	c.-108T>C	upstream_gene_variant	1.0	ethionamide
rpoB	763031	c.3225T>C	synonymous_variant	0.81	rifampicin	Not assoc w R
rpoB	763031	c.3225T>G	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoB	763034	c.3228C>G	synonymous_variant	0.19	rifampicin	Not assoc w R - Interim
rpoB	763040	c.3234C>G	synonymous_variant	0.21	rifampicin	Not assoc w R - Interim
rpoB	763070	c.3264T>C	synonymous_variant	0.18	rifampicin	Not assoc w R - Interim
rpoC	764431	c.1062G>C	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoC	764434	c.1065A>G	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoC	764452	c.1083T>C	synonymous_variant	0.13	rifampicin
rpoC	764458	c.1089G>C	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoC	764461	c.1092A>G	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoC	764485	c.1116G>C	synonymous_variant	0.14	rifampicin
rpoC	764491	c.1122G>T	synonymous_variant	0.13	rifampicin
rpoC	764497	c.1128A>G	synonymous_variant	0.13	rifampicin	Not assoc w R - Interim
rpoC	764500	c.1131C>G	synonymous_variant	0.13	rifampicin
rpoC	764521	c.1152T>C	synonymous_variant	0.16	rifampicin	Not assoc w R - Interim
rpoC	764527	c.1158C>T	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoC	764539	c.1170C>G	synonymous_variant	0.12	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>T	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoC	764791	c.1422C>G	synonymous_variant	0.15	rifampicin	Not assoc w R - Interim
rpoC	764815	c.1446A>G	synonymous_variant	0.13	rifampicin	Not assoc w R - Interim
rpoC	764824	c.1455T>C	synonymous_variant	0.13	rifampicin	Not assoc w R - Interim
rpoC	766804	c.3435A>G	synonymous_variant	0.12	rifampicin	Not assoc w R - Interim
rpoC	766996	c.3627C>T	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
Rv1129c	1254562	c.-28T>C	upstream_gene_variant	0.99	moxifloxacin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
Rv1129c	1254582	c.-48A>G	upstream_gene_variant	0.99	moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
fbiC	1302899	c.-32A>G	upstream_gene_variant	1.0	clofazimine	Uncertain significance
					pretomanid
					delamanid	Uncertain significance
sigE	1364961	c.549A>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
embR	1417554	c.-207C>G	upstream_gene_variant	1.0	ethambutol
rrs	1471659	n.-187C>T	upstream_gene_variant	0.99	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472446	n.601T>A	non_coding_transcript_exon_variant	0.15	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472452	n.607G>A	non_coding_transcript_exon_variant	0.17	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472464	n.619A>G	non_coding_transcript_exon_variant	0.18	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472489	n.644A>G	non_coding_transcript_exon_variant	0.21	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472973	n.1128A>G	non_coding_transcript_exon_variant	0.17	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	0.15	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473123	n.1278delAinsTC	non_coding_transcript_exon_variant	0.15	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473276	n.1431A>G	non_coding_transcript_exon_variant	0.15	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	0.14	linezolid	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	0.15	linezolid	Uncertain significance
rrl	1474174	n.517A>G	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1474174	n.517A>G	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1474282	n.625G>A	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1474282	n.625G>A	non_coding_transcript_exon_variant	0.15	linezolid
rrl	1474287	n.630delTinsCCC	non_coding_transcript_exon_variant	0.16	capreomycin
rrl	1474287	n.630delTinsCCC	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1474293	n.637_644delCCTCTCCG	non_coding_transcript_exon_variant	0.17	capreomycin
rrl	1474293	n.637_644delCCTCTCCG	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1474303	n.646A>T	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1474303	n.646A>T	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1474306	n.649A>T	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1474306	n.649A>T	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1474308	n.653_654delTG	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1474308	n.653_654delTG	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1474350	n.693G>C	non_coding_transcript_exon_variant	0.17	capreomycin
rrl	1474350	n.693G>C	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1474351	n.694G>C	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1474351	n.694G>C	non_coding_transcript_exon_variant	0.18	linezolid
rrl	1474362	n.705A>G	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1474362	n.705A>G	non_coding_transcript_exon_variant	0.16	linezolid	Uncertain significance
rrl	1474374	n.717T>G	non_coding_transcript_exon_variant	0.12	capreomycin	Uncertain significance
rrl	1474374	n.717T>G	non_coding_transcript_exon_variant	0.12	linezolid
rrl	1474753	n.1096A>G	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1474753	n.1096A>G	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1474794	n.1137C>T	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1475061	n.1404C>T	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1475452	n.1795C>A	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1475452	n.1795C>A	non_coding_transcript_exon_variant	0.18	linezolid	Uncertain significance
rrl	1475460	n.1803A>G	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1475460	n.1803A>G	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1475884	n.2227A>G	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1475884	n.2227A>G	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1475916	n.2259C>T	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.12	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	0.12	linezolid	Uncertain significance
rrl	1475995	n.2338G>A	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1475995	n.2338G>A	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1476035	n.2378G>C	non_coding_transcript_exon_variant	0.12	capreomycin	Uncertain significance
rrl	1476035	n.2378G>C	non_coding_transcript_exon_variant	0.12	linezolid
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1476044	n.2387T>G	non_coding_transcript_exon_variant	0.13	linezolid
rrl	1476088	n.2431A>C	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1476088	n.2431A>C	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1476115	n.2458T>C	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1476214	n.2557G>T	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1476215	n.2558C>T	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1476251	n.2594T>G	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1476251	n.2594T>G	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1476252	n.2595T>A	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1476252	n.2595T>A	non_coding_transcript_exon_variant	0.17	linezolid
rrl	1476256	n.2599A>T	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1476256	n.2599A>T	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1476529	n.2872A>G	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1476529	n.2872A>G	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.25	linezolid
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1476674	n.3017T>C	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1476674	n.3017T>C	non_coding_transcript_exon_variant	0.15	linezolid	Uncertain significance
rpsA	1833841	c.300C>G	synonymous_variant	0.12	pyrazinamide
rpsA	1833874	c.333T>C	synonymous_variant	0.13	pyrazinamide
rpsA	1833892	c.351G>A	synonymous_variant	0.13	pyrazinamide
rpsA	1834859	p.Ala440Thr	missense_variant	0.99	pyrazinamide	Uncertain significance
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2062922	p.Ile603Val	missense_variant	1.0	streptomycin	Not assoc w R
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
bacA	2062946	p.Ser595Gly	missense_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
ndh	2102106	p.Gly313Arg	missense_variant	1.0	ethionamide	Uncertain significance
					delamanid	Uncertain significance
					isoniazid	Not assoc w R - Interim
ndh	2103173	c.-132delG	upstream_gene_variant	1.0	ethionamide
					delamanid
					isoniazid
katG	2154724	p.Arg463Leu	missense_variant	0.98	isoniazid	Not assoc w R
katG	2155503	c.609C>T	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156025	c.87C>A	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156465	c.-354C>T	upstream_gene_variant	1.0	isoniazid	Not assoc w R - Interim
PPE35	2167926	p.Leu896Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
PPE35	2168011	p.Ser868Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2168814	c.1798dupA	frameshift_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2222308	p.Asp286Gly	missense_variant	0.99	clofazimine	Not assoc w R
Rv1979c	2222308	p.Asp286Gly	missense_variant	0.99	bedaquiline	Not assoc w R - Interim
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
kasA	2518132	c.18C>T	synonymous_variant	1.0	isoniazid
Rv2477c	2782927	c.1116A>G	synonymous_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					amikacin	Not assoc w R - Interim
Rv2681	2997325	p.Ala196Val	missense_variant	1.0	capreomycin	Uncertain significance
Rv2752c	3065888	p.Val102Ile	missense_variant	1.0	ethambutol	Uncertain significance
					moxifloxacin
					levofloxacin
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
thyX	3067786	p.Thr54Ala	missense_variant	0.97	para-aminosalicylic_acid
ald	3086728	c.-92C>T	upstream_gene_variant	1.0	cycloserine
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
ald	3087084	c.266delA	frameshift_variant	1.0	cycloserine
fbiD	3339154	p.Ile13Leu	missense_variant	1.0	clofazimine	Uncertain significance
					pretomanid
					delamanid	Uncertain significance
Rv3083	3448745	p.Ile81Ser	missense_variant	1.0	ethionamide	Uncertain significance
Rv3083	3448783	p.Val94Ile	missense_variant	1.0	ethionamide	Uncertain significance
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624350	c.561G>T	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624350	c.561G>T	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624593	c.318G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624593	c.318G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624710	c.201G>A	synonymous_variant	0.96	bedaquiline	Not assoc w R - Interim
lpqB	3624710	c.201G>A	synonymous_variant	0.96	rifampicin	Not assoc w R
mtrB	3625065	p.Met517Leu	missense_variant	1.0	bedaquiline	Uncertain significance
mtrB	3625065	p.Met517Leu	missense_variant	1.0	rifampicin	Not assoc w R
rpoA	3877856	c.652T>C	synonymous_variant	0.13	rifampicin	Not assoc w R - Interim
rpoA	3877866	c.642G>C	synonymous_variant	0.13	rifampicin
rpoA	3877875	c.633T>C	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoA	3877971	p.Asp179Glu	missense_variant	0.13	rifampicin	Uncertain significance
rpoA	3878630	c.-124delC	upstream_gene_variant	1.0	rifampicin	Not assoc w R
clpC1	4038403	c.2302T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
glpK	4138377	p.Val460Ala	missense_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
embC	4239487	c.-376T>C	upstream_gene_variant	1.0	ethambutol	Uncertain significance
embC	4240671	p.Thr270Ile	missense_variant	1.0	ethambutol	Not assoc w R
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embC	4242970	c.3108C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4244220	c.988C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4246551	p.Asn13Ser	missense_variant	1.0	ethambutol	Not assoc w R
embB	4246864	c.351C>T	synonymous_variant	0.99	ethambutol	Not assoc w R
embB	4247173	c.660G>A	synonymous_variant	0.99	ethambutol	Not assoc w R - Interim
embB	4247646	p.Glu378Ala	missense_variant	0.99	ethambutol	Not assoc w R
aftB	4267858	p.Ile327Val	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269351	c.483C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
ubiA	4269387	p.Glu149Asp	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269606	c.228T>C	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R
gid	4407743	p.Arg154Trp	missense_variant	1.0	streptomycin	Uncertain significance

TB-Profiler result