TB-Profiler result

Run: ERR9787061
Summary

Run ID: ERR9787061

Sample name:

Date: 2025-09-15T16:50:33.084546

Number of reads: 1545530

Percentage reads mapped: 86.63

Median coverage: 69.0

Strain: lineage6.2.3

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage6 West-Africa 2 RD702 100.0
lineage6.2 West-Africa 2 RD702 100.0
lineage6.2.3 West-Africa 2 RD702 100.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1110 c.1110T>C synonymous_variant 0.15 isoniazid Uncertain significance
dnaA 1113 c.1113A>G synonymous_variant 0.15 isoniazid Uncertain significance
gyrB 5072 c.-168G>T upstream_gene_variant 1.0 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6446 p.Ala403Ser missense_variant 0.96 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 7121 p.Pro628Ser missense_variant 0.94 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7480 p.Phe60Tyr missense_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7547 c.246C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7625 c.324G>C synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7631 c.330G>C synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7637 c.336C>G synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8493 p.Leu398Phe missense_variant 0.95 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8672 c.1371A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8693 c.1392T>C synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8711 c.1410A>C synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8714 c.1413A>G synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8740 p.Arg480His missense_variant 0.13 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
fgd1 491668 p.Lys296Glu missense_variant 0.93 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
Rv0565c 656298 c.1173G>C synonymous_variant 1.0 ethionamide Uncertain significance
Rv0565c 656432 p.Gly347Ser missense_variant 0.99 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide Uncertain significance
rpoB 760340 c.534G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 760376 p.Asp190Glu missense_variant 0.18 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.18 rifampicin Uncertain significance
rpoB 760406 c.600G>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoB 760412 c.606C>G synonymous_variant 0.23 rifampicin Uncertain significance
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.18 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.18 rifampicin Uncertain significance
rpoB 760541 c.735G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.21 rifampicin Uncertain significance
rpoB 760611 c.805T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760969 p.Ser388Leu missense_variant 0.94 rifampicin Not assoc w R
rpoB 761723 p.Glu639Asp missense_variant 0.92 rifampicin Not assoc w R
rpoB 761906 c.2100C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 761916 p.Asp704Asn missense_variant 0.14 rifampicin Uncertain significance
rpoB 762014 c.2208C>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 762017 c.2211A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoB 762995 c.3189G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoC 763025 c.-345C>T upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoB 763028 c.3222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoC 763158 c.-212C>T upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoB 763166 c.3360A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 763444 c.75T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 763732 c.363C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 763741 c.372C>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 763853 p.Val162Ile missense_variant 0.16 rifampicin Uncertain significance
rpoC 764365 c.996C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.17 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 765751 c.2382C>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 765753 p.Asp795Ala missense_variant 0.16 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 765787 c.2418C>T synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 765793 c.2424C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 765796 c.2427C>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 765811 c.2442T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
mmpL5 776100 p.Thr794Ile missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781868 c.309T>C synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781871 c.312G>C synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781877 c.318T>C synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781898 c.339A>T synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781916 c.357T>C synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781929 p.Gly124Ser missense_variant 0.16 streptomycin Uncertain significance
rplC 800298 c.-511T>G upstream_gene_variant 1.0 linezolid Uncertain significance
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303948 p.Gly340Arg missense_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303961 p.Arg344Leu missense_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303980 c.1050G>A synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304928 c.1998T>C synonymous_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304937 c.2007G>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304958 c.2028T>G synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304983 c.2053C>T synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304995 p.Leu689Met missense_variant 0.14 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
Rv1258c 1406685 p.Val219Ala missense_variant 1.0 isoniazid Uncertain significance
pyrazinamide Uncertain significance
streptomycin Uncertain significance
embR 1416633 p.Leu239Val missense_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol Uncertain significance
atpE 1461251 c.207G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.25 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674414 c.213G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674434 p.Val78Ala missense_variant 0.98 ethionamide Uncertain significance
isoniazid Not assoc w R
rpsA 1833787 c.246C>G synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833790 c.249T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1833802 c.261A>G synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1833811 c.270G>T synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834306 c.765T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.21 pyrazinamide Uncertain significance
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide Uncertain significance
rpsA 1834417 c.876G>C synonymous_variant 0.24 pyrazinamide Uncertain significance
rpsA 1834423 c.882G>C synonymous_variant 0.23 pyrazinamide Uncertain significance
rpsA 1834435 c.894G>C synonymous_variant 0.22 pyrazinamide Uncertain significance
rpsA 1834451 c.910T>C synonymous_variant 0.19 pyrazinamide Uncertain significance
rpsA 1834465 c.924T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834468 c.927A>G synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834775 p.Ala412Thr missense_variant 0.14 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
streptomycin Not assoc w R
bacA 2063121 c.1608A>T synonymous_variant 1.0 amikacin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
ndh 2103181 c.-148_-139delTGTGTAGCCAinsC upstream_gene_variant 1.0 delamanid Uncertain significance
ethionamide Uncertain significance
isoniazid Uncertain significance
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2169269 c.1340_1344delGCCAAinsT frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid Uncertain significance
kasA 2518744 c.630C>T synonymous_variant 0.16 isoniazid Uncertain significance
kasA 2518747 c.633C>G synonymous_variant 0.15 isoniazid Uncertain significance
kasA 2518768 c.654C>T synonymous_variant 0.18 isoniazid Uncertain significance
kasA 2518777 c.663C>T synonymous_variant 0.19 isoniazid Uncertain significance
kasA 2518783 c.669T>C synonymous_variant 0.19 isoniazid Uncertain significance
kasA 2518789 c.675G>C synonymous_variant 0.19 isoniazid Uncertain significance
kasA 2518792 c.678C>A synonymous_variant 0.19 isoniazid Uncertain significance
kasA 2518795 c.681C>G synonymous_variant 0.19 isoniazid Uncertain significance
kasA 2518825 c.711T>C synonymous_variant 0.19 isoniazid Uncertain significance
kasA 2518864 c.750G>C synonymous_variant 0.16 isoniazid Uncertain significance
Rv2477c 2783007 p.Arg346Cys missense_variant 0.98 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783512 c.531A>G synonymous_variant 0.18 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783520 c.523T>C synonymous_variant 0.17 amikacin Uncertain significance
ethambutol Not assoc w R - Interim
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Not assoc w R - Interim
streptomycin Uncertain significance
Rv2477c 2783521 c.522G>C synonymous_variant 0.2 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783527 c.516A>G synonymous_variant 0.25 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783539 c.504G>C synonymous_variant 0.23 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783542 c.501G>C synonymous_variant 0.23 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783548 c.495T>C synonymous_variant 0.23 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783554 c.489C>T synonymous_variant 0.23 amikacin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Uncertain significance
Rv2477c 2783557 c.486T>C synonymous_variant 0.23 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783563 c.480A>G synonymous_variant 0.23 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783572 c.471A>G synonymous_variant 0.24 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783586 p.Ala153Pro missense_variant 0.24 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783593 c.450T>C synonymous_variant 0.24 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783605 c.438T>C synonymous_variant 0.24 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783620 c.423C>G synonymous_variant 0.26 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783628 p.Ala139Ser missense_variant 0.25 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783656 c.387G>C synonymous_variant 0.25 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783665 c.378A>G synonymous_variant 0.25 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783674 c.369T>C synonymous_variant 0.25 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783683 c.360A>G synonymous_variant 0.24 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783700 p.Thr115Ser missense_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
thyX 3067445 c.501C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067457 c.489C>G synonymous_variant 0.19 para-aminosalicylic_acid Uncertain significance
thyX 3067465 p.Ile161Val missense_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyX 3067475 c.471A>G synonymous_variant 0.19 para-aminosalicylic_acid Uncertain significance
thyX 3067490 c.456C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067493 c.453A>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067515 p.Ser144Thr missense_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067530 p.Ala139Ser missense_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067545 p.Glu134Ala missense_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067549 p.Thr133Ala missense_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067556 p.His130Gln missense_variant 0.19 para-aminosalicylic_acid Uncertain significance
thyX 3067559 c.387C>G synonymous_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyX 3067565 p.Asp127Glu missense_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067570 p.Ala126Pro missense_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067577 c.369G>A synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine Uncertain significance
Rv3236c 3612800 p.Val106Ala missense_variant 1.0 pyrazinamide Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 0.96 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 0.98 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625750 c.864G>A synonymous_variant 0.15 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.15 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.15 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.15 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.16 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.16 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.14 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3626798 c.-185T>C upstream_gene_variant 0.16 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3626804 c.546A>G synonymous_variant 0.15 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.15 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627301 c.-688T>C upstream_gene_variant 0.15 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627314 c.-701C>T upstream_gene_variant 0.15 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627347 p.Met1? start_lost 0.9 bedaquiline Uncertain significance
rifampicin Uncertain significance
alr 3840559 p.Arg264Ser missense_variant 1.0 cycloserine Uncertain significance
alr 3840618 p.Asp244Gly missense_variant 1.0 cycloserine Uncertain significance
rpoA 3877613 p.Ile299Val missense_variant 0.15 rifampicin Uncertain significance
rpoA 3877656 c.852T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3877782 c.726T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3877890 c.618C>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoA 3877896 c.612G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoA 3877909 p.Asn200Ser missense_variant 0.15 rifampicin Uncertain significance
rpoA 3877920 c.588G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3877962 c.546G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.2 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878040 c.468T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878058 c.450G>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoA 3878094 c.414C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878106 c.402G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878118 c.390T>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoA 3878163 c.345C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878232 c.276G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878313 c.195G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878415 c.93C>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878424 c.84G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoA 3878436 c.72A>G synonymous_variant 0.2 rifampicin Uncertain significance
rpoA 3878442 c.66G>C synonymous_variant 0.2 rifampicin Uncertain significance
rpoA 3878454 c.54A>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoA 3878824 c.-317G>C upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3878838 c.-331A>T upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3879079 c.-572A>G upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3879088 c.-581A>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3879094 c.-587T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3879121 c.-614T>G upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3879127 c.-620T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
clpC1 4038878 c.1827A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038923 c.1782A>G synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038953 c.1752A>G synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4038956 c.1749T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039064 c.1641C>T synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039103 c.1602T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4040021 c.684A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.15 pyrazinamide Uncertain significance
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
isoniazid Not assoc w R
levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rifampicin Not assoc w R
streptomycin Not assoc w R
glpK 4139183 c.572dupG frameshift_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241843 p.Leu661Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243541 c.309C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244379 p.Pro383Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247716 c.1203C>T synonymous_variant 0.14 ethambutol Uncertain significance
ubiA 4269351 c.483C>T synonymous_variant 0.96 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 0.98 ethambutol Not assoc w R
ubiA 4269522 c.312C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 0.98 ethambutol Not assoc w R
ethA 4326465 p.Ile337Val missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R