TB-Profiler result

Run: ERR9787061
Summary

Run ID: ERR9787061

Sample name:

Date: 2024-04-15T16:48:52.298302

Number of reads: 1545530

Percentage reads mapped: 86.63

Median coverage: 69.0

Strain: lineage6.2.3

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage6.2 West-Africa 2 RD702 0.97
lineage6.2.3 West-Africa 2 RD702 0.99
lineage6 West-Africa 2 RD702 0.98
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1110 c.1110T>C synonymous_variant 0.15 isoniazid
dnaA 1113 c.1113A>G synonymous_variant 0.15 isoniazid
gyrB 5072 c.-168G>T upstream_gene_variant 1.0 levofloxacin
moxifloxacin
gyrB 6446 p.Ala403Ser missense_variant 0.96 levofloxacin Not assoc w R
moxifloxacin Uncertain significance
gyrB 7121 p.Pro628Ser missense_variant 0.94 levofloxacin
moxifloxacin
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7480 p.Phe60Tyr missense_variant 0.14 levofloxacin
moxifloxacin
gyrA 7547 c.246C>T synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7562 c.261C>T synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7625 c.324G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8493 p.Leu398Phe missense_variant 0.95 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8672 c.1371A>G synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8678 c.1377G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8693 c.1392T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8711 c.1410A>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8714 c.1413A>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8740 p.Arg480His missense_variant 0.13 levofloxacin
moxifloxacin
gyrA 9143 c.1842T>C synonymous_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
Rv0010c 13460 c.99T>C synonymous_variant 1.0 isoniazid Not assoc w R
Rv0010c 13482 p.Ala26Val missense_variant 1.0 isoniazid Not assoc w R
fgd1 491668 p.Lys296Glu missense_variant 0.93 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
Rv0565c 656298 c.1173G>C synonymous_variant 1.0 ethionamide
Rv0565c 656432 p.Gly347Ser missense_variant 0.99 ethionamide Uncertain significance
Rv0565c 657578 c.-108T>C upstream_gene_variant 1.0 ethionamide
rpoB 760340 c.534G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760370 c.564C>G synonymous_variant 0.18 rifampicin
rpoB 760376 p.Asp190Glu missense_variant 0.18 rifampicin Uncertain significance
rpoB 760380 p.Thr192Leu missense_variant 0.18 rifampicin
rpoB 760406 c.600G>C synonymous_variant 0.21 rifampicin
rpoB 760412 c.606C>G synonymous_variant 0.23 rifampicin
rpoB 760424 c.618C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 760430 c.624T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 760475 c.669A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 760522 p.Ser239Asn missense_variant 0.18 rifampicin Uncertain significance
rpoB 760532 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760533 p.Val243Thr missense_variant 0.18 rifampicin
rpoB 760541 c.735G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760547 c.741G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760563 p.Arg253Met missense_variant 0.19 rifampicin Uncertain significance
rpoB 760591 p.Val262Ala missense_variant 0.21 rifampicin
rpoB 760611 c.805T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760969 p.Ser388Leu missense_variant 0.94 rifampicin Not assoc w R
rpoB 761723 p.Glu639Asp missense_variant 0.92 rifampicin Not assoc w R
rpoB 761906 c.2100C>G synonymous_variant 0.15 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.14 rifampicin
rpoB 762014 c.2208C>T synonymous_variant 0.16 rifampicin
rpoB 762017 c.2211A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762101 c.2295C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.16 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763013 c.-357C>G upstream_gene_variant 0.23 rifampicin
rpoC 763025 c.-345C>T upstream_gene_variant 0.22 rifampicin
rpoB 763028 c.3222T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 763034 c.3228C>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoB 763085 c.3279C>G synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.18 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.17 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763441 c.72C>T synonymous_variant 0.15 rifampicin
rpoC 763444 c.75T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.15 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.15 rifampicin
rpoC 763741 c.372C>T synonymous_variant 0.14 rifampicin
rpoC 763853 p.Val162Ile missense_variant 0.16 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764764 c.1395T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764809 c.1440C>T synonymous_variant 0.17 rifampicin Not assoc w R
rpoC 764815 c.1446A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764827 c.1458G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>T synonymous_variant 0.15 rifampicin
rpoC 765751 c.2382C>G synonymous_variant 0.16 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.16 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.18 rifampicin
rpoC 765787 c.2418C>T synonymous_variant 0.15 rifampicin
rpoC 765793 c.2424C>G synonymous_variant 0.17 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.16 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765850 c.2481G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781868 c.309T>C synonymous_variant 0.15 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.15 streptomycin
rpsL 781877 c.318T>C synonymous_variant 0.15 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.15 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.15 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.16 streptomycin Uncertain significance
rplC 800298 c.-511T>G upstream_gene_variant 1.0 linezolid
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
fbiC 1302899 c.-32A>G upstream_gene_variant 1.0 clofazimine Uncertain significance
pretomanid
delamanid Uncertain significance
fbiC 1303948 p.Gly340Arg missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303961 p.Arg344Leu missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303980 c.1050G>A synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304928 c.1998T>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304937 c.2007G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304958 c.2028T>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304983 c.2053C>T synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304995 p.Leu689Met missense_variant 0.14 clofazimine
pretomanid
delamanid
Rv1258c 1406685 p.Val219Ala missense_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
embR 1416633 p.Leu239Val missense_variant 1.0 ethambutol Uncertain significance
embR 1417554 c.-207C>G upstream_gene_variant 1.0 ethambutol
atpE 1461251 c.207G>T synonymous_variant 1.0 bedaquiline Not assoc w R - Interim
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472108 n.263C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1473877 n.220G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473899 n.242A>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473943 n.286G>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.17 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.25 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.18 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674414 c.213G>A synonymous_variant 1.0 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
inhA 1674434 p.Val78Ala missense_variant 0.98 ethionamide Uncertain significance
isoniazid Not assoc w R
rpsA 1833787 c.246C>G synonymous_variant 0.15 pyrazinamide
rpsA 1833790 c.249T>C synonymous_variant 0.15 pyrazinamide
rpsA 1833802 c.261A>G synonymous_variant 0.17 pyrazinamide
rpsA 1833811 c.270G>T synonymous_variant 0.15 pyrazinamide
rpsA 1834306 c.765T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834348 c.807T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
rpsA 1834366 c.825A>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
rpsA 1834396 c.855G>C synonymous_variant 0.21 pyrazinamide
rpsA 1834411 c.870T>C synonymous_variant 0.23 pyrazinamide
rpsA 1834417 c.876G>C synonymous_variant 0.24 pyrazinamide
rpsA 1834423 c.882G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834435 c.894G>C synonymous_variant 0.22 pyrazinamide
rpsA 1834451 c.910T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834465 c.924T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834468 c.927A>G synonymous_variant 0.16 pyrazinamide
rpsA 1834489 c.948T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834775 p.Ala412Thr missense_variant 0.14 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2062922 p.Ile603Val missense_variant 1.0 streptomycin Not assoc w R
kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R
bacA 2063121 c.1608A>T synonymous_variant 1.0 streptomycin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
ndh 2103181 c.-148_-139delTGTGTAGCCAinsC upstream_gene_variant 1.0 ethionamide
delamanid
isoniazid
katG 2154724 p.Arg463Leu missense_variant 1.0 isoniazid Not assoc w R
katG 2155503 c.609C>T synonymous_variant 1.0 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 1.0 pyrazinamide Not assoc w R
PPE35 2169269 c.1340_1344delGCCAAinsT frameshift_variant&missense_variant 1.0 pyrazinamide Uncertain significance
Rv1979c 2222308 p.Asp286Gly missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518132 c.18C>T synonymous_variant 1.0 isoniazid
kasA 2518744 c.630C>T synonymous_variant 0.16 isoniazid
kasA 2518747 c.633C>G synonymous_variant 0.15 isoniazid
kasA 2518768 c.654C>T synonymous_variant 0.18 isoniazid
kasA 2518777 c.663C>T synonymous_variant 0.19 isoniazid
kasA 2518783 c.669T>C synonymous_variant 0.19 isoniazid
kasA 2518789 c.675G>C synonymous_variant 0.19 isoniazid
kasA 2518792 c.678C>A synonymous_variant 0.19 isoniazid
kasA 2518795 c.681C>G synonymous_variant 0.19 isoniazid
kasA 2518825 c.711T>C synonymous_variant 0.19 isoniazid
kasA 2518864 c.750G>C synonymous_variant 0.16 isoniazid
Rv2477c 2783007 p.Arg346Cys missense_variant 0.98 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783512 c.531A>G synonymous_variant 0.18 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783520 c.523T>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin Not assoc w R - Interim
amikacin
Rv2477c 2783521 c.522G>C synonymous_variant 0.2 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783527 c.516A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783539 c.504G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783542 c.501G>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783548 c.495T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.23 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783557 c.486T>C synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783563 c.480A>G synonymous_variant 0.23 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783572 c.471A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783586 p.Ala153Pro missense_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783593 c.450T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783605 c.438T>C synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783620 c.423C>G synonymous_variant 0.26 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783665 c.378A>G synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.25 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.24 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
thyX 3067445 c.501C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.2 para-aminosalicylic_acid
thyX 3067475 c.471A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067490 c.456C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067493 c.453A>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.17 para-aminosalicylic_acid
thyX 3067530 p.Ala139Ser missense_variant 0.18 para-aminosalicylic_acid
thyX 3067545 p.Glu134Ala missense_variant 0.18 para-aminosalicylic_acid
thyX 3067549 p.Thr133Ala missense_variant 0.18 para-aminosalicylic_acid
thyX 3067556 p.His130Gln missense_variant 0.19 para-aminosalicylic_acid
thyX 3067559 c.387C>G synonymous_variant 0.16 para-aminosalicylic_acid
thyX 3067565 p.Asp127Glu missense_variant 0.17 para-aminosalicylic_acid
thyX 3067570 p.Ala126Pro missense_variant 0.17 para-aminosalicylic_acid
thyX 3067577 c.369G>A synonymous_variant 0.17 para-aminosalicylic_acid
ald 3086728 c.-92C>T upstream_gene_variant 1.0 cycloserine
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
ald 3087084 c.266delA frameshift_variant 1.0 cycloserine
Rv3236c 3612800 p.Val106Ala missense_variant 1.0 pyrazinamide Uncertain significance
lpqB 3624350 c.561G>T synonymous_variant 0.96 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R
lpqB 3624486 p.Asp142Gly missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625065 p.Met517Leu missense_variant 0.98 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3625750 c.864G>A synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625755 p.Ala287Thr missense_variant 0.15 bedaquiline
rifampicin Uncertain significance
mtrB 3625765 c.849C>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625774 c.840G>A synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625797 p.Val273Met missense_variant 0.17 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3625806 c.808A>C synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625807 c.807C>G synonymous_variant 0.16 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3625837 c.777C>G synonymous_variant 0.14 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626795 c.-182C>T upstream_gene_variant 0.17 bedaquiline
rifampicin
mtrB 3626798 c.-185T>C upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrA 3626804 c.546A>G synonymous_variant 0.15 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3626840 c.-227C>G upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627301 c.-688T>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627314 c.-701C>T upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrA 3627347 p.Met1? start_lost 0.9 bedaquiline
rifampicin
alr 3840559 p.Arg288Ser missense_variant 1.0 cycloserine
alr 3840618 p.Asp268Gly missense_variant 1.0 cycloserine
rpoA 3877613 p.Ile299Val missense_variant 0.15 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.15 rifampicin
rpoA 3877782 c.726T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877791 c.717C>G synonymous_variant 0.15 rifampicin
rpoA 3877890 c.618C>T synonymous_variant 0.14 rifampicin
rpoA 3877896 c.612G>C synonymous_variant 0.14 rifampicin
rpoA 3877909 p.Asn200Ser missense_variant 0.15 rifampicin
rpoA 3877920 c.588G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877923 c.585C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877926 c.582G>C synonymous_variant 0.15 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.2 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878022 c.486T>C synonymous_variant 0.19 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878043 c.465G>A synonymous_variant 0.16 rifampicin
rpoA 3878058 c.450G>T synonymous_variant 0.14 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.15 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.15 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.14 rifampicin
rpoA 3878163 c.345C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878232 c.276G>C synonymous_variant 0.15 rifampicin
rpoA 3878292 c.216T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.15 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>T synonymous_variant 0.16 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.16 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.19 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.2 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.2 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.18 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.16 rifampicin
rpoA 3878838 c.-331A>T upstream_gene_variant 0.14 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.15 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.19 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.17 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.15 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.15 rifampicin
clpC1 4038878 c.1827A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4038923 c.1782A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.14 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.15 pyrazinamide
glpK 4138377 p.Val460Ala missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Not assoc w R
streptomycin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
glpK 4139183 c.572dupG frameshift_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4241843 p.Leu661Ile missense_variant 1.0 ethambutol Not assoc w R
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243541 c.309C>T synonymous_variant 1.0 ethambutol Not assoc w R - Interim
embA 4244220 c.988C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4244379 p.Pro383Ser missense_variant 1.0 ethambutol Not assoc w R
embB 4246864 c.351C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4247646 p.Glu378Ala missense_variant 1.0 ethambutol Not assoc w R
embB 4247716 c.1203C>T synonymous_variant 0.14 ethambutol
ubiA 4269351 c.483C>T synonymous_variant 0.96 ethambutol Not assoc w R
ubiA 4269387 p.Glu149Asp missense_variant 0.98 ethambutol Not assoc w R
ubiA 4269522 c.312C>T synonymous_variant 1.0 ethambutol Not assoc w R
ubiA 4269606 c.228T>C synonymous_variant 0.98 ethambutol Not assoc w R
ethA 4326465 p.Ile337Val missense_variant 1.0 ethionamide Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R