TB-Profiler result

Run: SRR1013527
Summary

Run ID: SRR1013527

Sample name:

Date: 02-04-2023 15:42:44

Number of reads: 252732

Percentage reads mapped: 3.54

Strain: lineage2.2

Drug-resistance: RR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2.2 East-Asian (Beijing) Beijing-RD207 RD105;RD207 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761155 p.Ser450Leu missense_variant 1.0 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 1.0 streptomycin
pncA 2289080 c.161delC frameshift_variant 1.0 pyrazinamide, pyrazinamide
embB 4248003 p.Gln497Arg missense_variant 1.0 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491742 c.960T>C synonymous_variant 1.0
mshA 575907 p.Ala187Val missense_variant 0.75
ccsA 620625 p.Ile245Met missense_variant 1.0
rpoB 762030 p.Thr742Ala missense_variant 1.0
rpoB 762879 p.Met1025Leu missense_variant 0.4
rpoC 762894 c.-476C>T upstream_gene_variant 0.84
rpoC 762899 c.-471G>C upstream_gene_variant 0.89
rpoB 762911 p.Ile1035Met missense_variant 0.92
rpoC 762917 c.-453C>G upstream_gene_variant 0.92
rpoC 762920 c.-450C>T upstream_gene_variant 0.88
rpoC 762923 c.-447C>G upstream_gene_variant 0.88
rpoC 762929 c.-441G>T upstream_gene_variant 0.92
rpoB 762939 p.Met1045Leu missense_variant 0.88
rpoB 762942 p.Ile1046Val missense_variant 0.88
rpoC 762947 c.-423C>G upstream_gene_variant 0.88
rpoC 762971 c.-399G>C upstream_gene_variant 0.92
rpoC 762989 c.-381G>T upstream_gene_variant 0.85
rpoC 762995 c.-375G>T upstream_gene_variant 0.75
rpoC 762998 c.-372G>A upstream_gene_variant 0.75
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 764611 c.1242G>C synonymous_variant 0.33
rpoC 764616 p.Asn416Ser missense_variant 0.44
rpoC 764623 c.1254C>G synonymous_variant 0.67
rpoC 764632 c.1263T>C synonymous_variant 0.67
rpoC 764635 c.1266C>G synonymous_variant 0.53
rpoC 764647 c.1278C>T synonymous_variant 0.27
rpoC 764650 c.1281G>T synonymous_variant 0.87
rpoC 764658 c.1289_1290insTAC disruptive_inframe_insertion 0.27
rpoC 764665 c.1296C>G synonymous_variant 0.82
rpoC 764671 c.1302G>A synonymous_variant 0.27
rpoC 764672 p.Gln435Thr missense_variant 0.87
rpoC 764686 c.1317C>T synonymous_variant 0.6
rpoC 764695 c.1326T>C synonymous_variant 0.6
rpoC 764716 c.1347G>C synonymous_variant 0.64
rpoC 764719 c.1350G>A synonymous_variant 0.62
rpoC 764722 c.1353G>C synonymous_variant 0.62
rpoC 764731 c.1362G>C synonymous_variant 0.43
rpoC 764890 p.Leu507Phe missense_variant 0.18
rpoC 764902 c.1533C>G synonymous_variant 0.5
rpoC 764911 c.1542A>G synonymous_variant 0.53
rpoC 764912 p.Met515Val missense_variant 0.5
rpoC 764918 p.Val517Ile missense_variant 0.56
rpoC 764935 c.1566T>C synonymous_variant 0.62
rpoC 764948 c.1579T>C synonymous_variant 0.62
rpoC 764953 c.1584G>C synonymous_variant 0.57
rpoC 764956 c.1587T>C synonymous_variant 0.57
rpoC 764958 p.Glu530Ala missense_variant 0.57
rpoC 764968 c.1599T>C synonymous_variant 0.57
rpoC 764995 c.1626C>T synonymous_variant 0.33
rpoC 764998 c.1629G>T synonymous_variant 0.25
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 776100 p.Thr794Ile missense_variant 1.0
mmpL5 776182 p.Asp767Asn missense_variant 0.9
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.25
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.25
rrs 1472153 n.308G>A non_coding_transcript_exon_variant 0.14
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.76
rrs 1472210 n.365A>T non_coding_transcript_exon_variant 0.83
rrs 1472214 n.369C>G non_coding_transcript_exon_variant 0.83
rrs 1472223 n.378C>G non_coding_transcript_exon_variant 0.49
rrs 1472228 n.383G>C non_coding_transcript_exon_variant 0.5
rrs 1472235 n.390G>C non_coding_transcript_exon_variant 0.95
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.95
rrs 1472242 n.397C>T non_coding_transcript_exon_variant 0.95
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.87
rrs 1472251 n.406G>T non_coding_transcript_exon_variant 0.89
rrs 1472252 n.407G>A non_coding_transcript_exon_variant 0.4
rrs 1472253 n.408G>T non_coding_transcript_exon_variant 0.54
rrs 1472256 n.411T>A non_coding_transcript_exon_variant 0.52
rrs 1472259 n.414C>A non_coding_transcript_exon_variant 0.92
rrs 1472277 n.432C>G non_coding_transcript_exon_variant 0.46
rrs 1472278 n.433C>T non_coding_transcript_exon_variant 0.18
rrs 1472279 n.434T>A non_coding_transcript_exon_variant 0.56
rrs 1472558 n.713G>A non_coding_transcript_exon_variant 0.57
rrs 1472569 n.724G>A non_coding_transcript_exon_variant 0.43
rrs 1472571 n.726G>A non_coding_transcript_exon_variant 0.33
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.33
rrs 1472606 n.761C>G non_coding_transcript_exon_variant 0.29
rrs 1472616 n.771G>A non_coding_transcript_exon_variant 0.29
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.25
rrs 1472716 n.871C>A non_coding_transcript_exon_variant 0.4
rrs 1472734 n.889C>T non_coding_transcript_exon_variant 0.42
rrs 1472741 n.896G>A non_coding_transcript_exon_variant 0.42
rrs 1472742 n.897C>T non_coding_transcript_exon_variant 0.82
rrs 1472744 n.899A>G non_coding_transcript_exon_variant 0.38
rrs 1472767 n.922G>A non_coding_transcript_exon_variant 0.89
rrs 1472781 n.936C>T non_coding_transcript_exon_variant 0.83
rrs 1472785 n.940G>T non_coding_transcript_exon_variant 0.8
rrs 1472786 n.941C>G non_coding_transcript_exon_variant 0.8
rrs 1472793 n.948A>T non_coding_transcript_exon_variant 0.37
rrs 1472814 n.969G>A non_coding_transcript_exon_variant 0.82
rrs 1473139 n.1294T>C non_coding_transcript_exon_variant 0.29
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.12
rrs 1473147 n.1302G>T non_coding_transcript_exon_variant 0.4
rrs 1473148 n.1303G>A non_coding_transcript_exon_variant 0.39
rrs 1473163 n.1318C>T non_coding_transcript_exon_variant 0.64
rrs 1473164 n.1319C>A non_coding_transcript_exon_variant 0.62
rrs 1473172 n.1327T>C non_coding_transcript_exon_variant 0.56
rrs 1473173 n.1328C>T non_coding_transcript_exon_variant 0.56
rrs 1473177 n.1332G>A non_coding_transcript_exon_variant 0.67
rrs 1473192 n.1347A>G non_coding_transcript_exon_variant 0.64
rrs 1473205 n.1360T>C non_coding_transcript_exon_variant 0.62
rrs 1473226 n.1381C>T non_coding_transcript_exon_variant 0.77
rrs 1473248 n.1403G>A non_coding_transcript_exon_variant 0.4
rrl 1474218 n.561T>A non_coding_transcript_exon_variant 0.5
rrl 1474228 n.571T>A non_coding_transcript_exon_variant 0.4
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.4
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.25
rrl 1475783 n.2126T>G non_coding_transcript_exon_variant 0.6
rrl 1475787 n.2130C>T non_coding_transcript_exon_variant 0.71
rrl 1475791 n.2134A>G non_coding_transcript_exon_variant 0.62
rrl 1475803 n.2146T>C non_coding_transcript_exon_variant 0.75
rrl 1475804 n.2147G>C non_coding_transcript_exon_variant 0.82
rrl 1475816 n.2159C>G non_coding_transcript_exon_variant 0.8
rrl 1475817 n.2160A>G non_coding_transcript_exon_variant 0.8
rrl 1475896 n.2239A>G non_coding_transcript_exon_variant 0.29
rrl 1475897 n.2240T>C non_coding_transcript_exon_variant 0.29
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.29
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.33
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.5
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.4
rrl 1475963 n.2306G>T non_coding_transcript_exon_variant 0.5
rrl 1475970 n.2313C>T non_coding_transcript_exon_variant 0.67
rrl 1475977 n.2320A>G non_coding_transcript_exon_variant 0.5
rrl 1476313 n.2656G>A non_coding_transcript_exon_variant 0.33
rrl 1476336 n.2679C>T non_coding_transcript_exon_variant 0.91
rrl 1476338 n.2681C>T non_coding_transcript_exon_variant 0.89
rrl 1476356 n.2699C>A non_coding_transcript_exon_variant 0.9
rrl 1476357 n.2700T>C non_coding_transcript_exon_variant 0.91
rrl 1476358 n.2701T>C non_coding_transcript_exon_variant 0.91
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.92
rrl 1476369 n.2712C>T non_coding_transcript_exon_variant 0.92
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.92
rrl 1476382 n.2725A>G non_coding_transcript_exon_variant 0.92
rrl 1476383 n.2726T>G non_coding_transcript_exon_variant 0.94
rrl 1476384 n.2727G>T non_coding_transcript_exon_variant 0.94
rrl 1476408 n.2751G>A non_coding_transcript_exon_variant 0.91
rrl 1476411 n.2754G>T non_coding_transcript_exon_variant 0.91
rrl 1476425 n.2768G>T non_coding_transcript_exon_variant 0.89
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.21
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.86
rrl 1476442 n.2785T>A non_coding_transcript_exon_variant 0.83
rrl 1476443 n.2786G>T non_coding_transcript_exon_variant 0.82
rrl 1476455 n.2798C>A non_coding_transcript_exon_variant 0.81
rrl 1476456 n.2799A>T non_coding_transcript_exon_variant 0.81
rrl 1476463 n.2806C>A non_coding_transcript_exon_variant 0.79
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.86
rrl 1476470 n.2813C>T non_coding_transcript_exon_variant 0.79
rrl 1476483 n.2826G>A non_coding_transcript_exon_variant 0.7
rrl 1476501 n.2844C>T non_coding_transcript_exon_variant 0.43
rrl 1476506 n.2849T>C non_coding_transcript_exon_variant 0.5
rpsA 1834177 c.636A>C synonymous_variant 1.0
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
PPE35 2167926 p.Leu896Ser missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
thyA 3074010 c.462C>G synonymous_variant 0.25
ald 3086739 c.-81G>A upstream_gene_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
Rv3083 3448670 p.Asp56Ala missense_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0
fbiB 3641589 p.Gly19Trp missense_variant 0.2
rpoA 3878252 c.253_255dupGTG conservative_inframe_insertion 0.4
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embA 4243460 c.228C>T synonymous_variant 1.0
aftB 4267647 p.Asp397Gly missense_variant 1.0
ubiA 4269391 p.Val148Ala missense_variant 0.8
ethA 4326743 p.Leu244Pro missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0
gid 4407927 p.Glu92Asp missense_variant 1.0