TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472644	n.799C>T	non_coding_transcript_exon_variant	0.32	streptomycin	Uncertain significance	Mutation from literature
rrs	1472733	n.888G>A	non_coding_transcript_exon_variant	0.79	streptomycin	Uncertain significance	Mutation from literature
rrs	1473247	n.1402C>A	non_coding_transcript_exon_variant	0.36	capreomycin	Uncertain significance	Mutation from literature
amikacin	Uncertain significance	Mutation from literature
kanamycin	Uncertain significance	Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
rrs	1472100	n.255T>C	non_coding_transcript_exon_variant	0.6	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472106	n.261G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472113	n.268T>C	non_coding_transcript_exon_variant	0.73	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472127	n.282C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472128	n.283G>C	non_coding_transcript_exon_variant	0.97	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472129	n.284G>A	non_coding_transcript_exon_variant	0.77	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472151	n.306C>A	non_coding_transcript_exon_variant	0.71	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.91	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472181	n.336G>A	non_coding_transcript_exon_variant	0.6	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472223	n.378C>G	non_coding_transcript_exon_variant	0.6	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472225	n.380C>A	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472228	n.383G>C	non_coding_transcript_exon_variant	0.57	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472235	n.390G>C	non_coding_transcript_exon_variant	0.27	kanamycin
					amikacin
					streptomycin	Uncertain significance
					capreomycin
rrs	1472240	n.395G>A	non_coding_transcript_exon_variant	0.51	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472251	n.406G>A	non_coding_transcript_exon_variant	0.8	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472256	n.411T>A	non_coding_transcript_exon_variant	0.91	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.79	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472537	n.692C>T	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472544	n.699C>T	non_coding_transcript_exon_variant	0.63	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.75	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472571	n.726G>C	non_coding_transcript_exon_variant	0.95	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472573	n.728C>T	non_coding_transcript_exon_variant	0.59	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472574	n.729T>G	non_coding_transcript_exon_variant	0.42	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472579	n.734G>A	non_coding_transcript_exon_variant	0.89	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472581	n.736A>T	non_coding_transcript_exon_variant	0.88	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472583	n.738T>C	non_coding_transcript_exon_variant	0.37	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472592	n.747C>T	non_coding_transcript_exon_variant	0.49	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472598	n.753A>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472599	n.754G>T	non_coding_transcript_exon_variant	0.84	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472612	n.767G>T	non_coding_transcript_exon_variant	0.35	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472616	n.771G>A	non_coding_transcript_exon_variant	0.66	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472647	n.802C>T	non_coding_transcript_exon_variant	0.26	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472655	n.810G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472713	n.868T>C	non_coding_transcript_exon_variant	0.46	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472715	n.870C>A	non_coding_transcript_exon_variant	0.46	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472716	n.871C>T	non_coding_transcript_exon_variant	0.95	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472719	n.874G>A	non_coding_transcript_exon_variant	0.47	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1472734	n.889C>T	non_coding_transcript_exon_variant	0.3	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472742	n.897C>T	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472744	n.899A>G	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472767	n.922G>A	non_coding_transcript_exon_variant	0.37	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472781	n.936C>T	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472793	n.948A>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Not assoc w R
rrs	1472803	n.958T>A	non_coding_transcript_exon_variant	0.79	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1472824	n.979T>A	non_coding_transcript_exon_variant	0.71	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473131	n.1286G>T	non_coding_transcript_exon_variant	0.39	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.46	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473148	n.1303G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473158	n.1313T>C	non_coding_transcript_exon_variant	0.76	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1473163	n.1318C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473172	n.1327T>C	non_coding_transcript_exon_variant	0.95	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Not assoc w R
					capreomycin	Not assoc w R
rrs	1473173	n.1328C>T	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Not assoc w R
					capreomycin	Not assoc w R
rrs	1473177	n.1332G>T	non_coding_transcript_exon_variant	1.0	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1473192	n.1347A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Not assoc w R
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473193	n.1348G>C	non_coding_transcript_exon_variant	0.73	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1473204	n.1359C>G	non_coding_transcript_exon_variant	0.72	kanamycin
					amikacin
					streptomycin
					capreomycin
rrs	1473205	n.1360T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473248	n.1403G>A	non_coding_transcript_exon_variant	0.67	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473249	n.1404T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473255	n.1410A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473260	n.1415G>T	non_coding_transcript_exon_variant	0.87	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin	Uncertain significance
					capreomycin	Uncertain significance
rrs	1473270	n.1425G>A	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					amikacin	Uncertain significance
					streptomycin
					capreomycin
rrl	1474171	n.514C>G	non_coding_transcript_exon_variant	0.6	capreomycin
rrl	1474171	n.514C>G	non_coding_transcript_exon_variant	0.6	linezolid
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1474208	n.551C>T	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474208	n.551C>T	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474213	n.556G>A	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1474213	n.556G>A	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1474218	n.561T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474218	n.561T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474252	n.595T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474252	n.595T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.94	capreomycin	Not assoc w R
rrl	1474782	n.1125G>A	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1474784	n.1127C>T	non_coding_transcript_exon_variant	0.88	capreomycin
rrl	1474784	n.1127C>T	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1474790	n.1133C>T	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1474790	n.1133C>T	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1474797	n.1140G>A	non_coding_transcript_exon_variant	0.79	capreomycin
rrl	1474797	n.1140G>A	non_coding_transcript_exon_variant	0.79	linezolid
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474798	n.1141C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474799	n.1142G>C	non_coding_transcript_exon_variant	0.75	capreomycin
rrl	1474799	n.1142G>C	non_coding_transcript_exon_variant	0.75	linezolid
rrl	1474801	n.1144G>A	non_coding_transcript_exon_variant	0.7	capreomycin	Uncertain significance
rrl	1474801	n.1144G>A	non_coding_transcript_exon_variant	0.7	linezolid	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474825	n.1168G>A	non_coding_transcript_exon_variant	0.39	capreomycin
rrl	1474825	n.1168G>A	non_coding_transcript_exon_variant	0.39	linezolid
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.86	linezolid	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1474839	n.1182C>T	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1474839	n.1182C>T	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474892	n.1235G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474892	n.1235G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474896	n.1239A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474896	n.1239A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475783	n.2126T>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475783	n.2126T>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475791	n.2134A>G	non_coding_transcript_exon_variant	0.47	capreomycin	Uncertain significance
rrl	1475791	n.2134A>G	non_coding_transcript_exon_variant	0.47	linezolid	Uncertain significance
rrl	1475803	n.2146T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475803	n.2146T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475804	n.2147G>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475804	n.2147G>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475816	n.2159C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475816	n.2159C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475817	n.2160A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475817	n.2160A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475869	n.2212C>T	non_coding_transcript_exon_variant	0.69	capreomycin	Uncertain significance
rrl	1475869	n.2212C>T	non_coding_transcript_exon_variant	0.69	linezolid
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.93	capreomycin	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.93	linezolid	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476322	n.2665C>A	non_coding_transcript_exon_variant	0.46	capreomycin
rrl	1476322	n.2665C>A	non_coding_transcript_exon_variant	0.46	linezolid
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1476336	n.2679C>T	non_coding_transcript_exon_variant	0.48	capreomycin
rrl	1476336	n.2679C>T	non_coding_transcript_exon_variant	0.48	linezolid
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.5	capreomycin	Uncertain significance
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.31	capreomycin	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.31	linezolid	Uncertain significance
rrl	1476357	n.2700T>C	non_coding_transcript_exon_variant	0.58	capreomycin
rrl	1476357	n.2700T>C	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1476359	n.2702C>T	non_coding_transcript_exon_variant	0.65	capreomycin
rrl	1476359	n.2702C>T	non_coding_transcript_exon_variant	0.65	linezolid
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.42	linezolid
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.84	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.84	linezolid	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.51	capreomycin	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1476381	n.2724G>A	non_coding_transcript_exon_variant	0.63	capreomycin
rrl	1476381	n.2724G>A	non_coding_transcript_exon_variant	0.63	linezolid
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.98	capreomycin	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.98	linezolid	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.3	capreomycin	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.3	linezolid	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1476411	n.2754G>A	non_coding_transcript_exon_variant	0.43	capreomycin
rrl	1476411	n.2754G>A	non_coding_transcript_exon_variant	0.43	linezolid
rrl	1476417	n.2760T>C	non_coding_transcript_exon_variant	0.38	capreomycin	Uncertain significance
rrl	1476417	n.2760T>C	non_coding_transcript_exon_variant	0.38	linezolid
rrl	1476425	n.2768G>A	non_coding_transcript_exon_variant	0.46	capreomycin	Uncertain significance
rrl	1476425	n.2768G>A	non_coding_transcript_exon_variant	0.46	linezolid	Uncertain significance
rrl	1476428	n.2771C>A	non_coding_transcript_exon_variant	0.37	capreomycin
rrl	1476428	n.2771C>A	non_coding_transcript_exon_variant	0.37	linezolid
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.45	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.45	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1476443	n.2786G>A	non_coding_transcript_exon_variant	0.37	capreomycin
rrl	1476443	n.2786G>A	non_coding_transcript_exon_variant	0.37	linezolid
rrl	1476455	n.2798C>T	non_coding_transcript_exon_variant	0.36	capreomycin
rrl	1476455	n.2798C>T	non_coding_transcript_exon_variant	0.36	linezolid
rrl	1476463	n.2806C>T	non_coding_transcript_exon_variant	0.37	capreomycin
rrl	1476463	n.2806C>T	non_coding_transcript_exon_variant	0.37	linezolid
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.41	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.41	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.81	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476514	n.2857C>T	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1476514	n.2857C>T	non_coding_transcript_exon_variant	0.88	linezolid	Uncertain significance
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin	rrs	n.799C>T	Uncertain significance	Mutation from literature
streptomycin	rrs	n.888G>A	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
capreomycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
kanamycin	rrs	n.1402C>A	Uncertain significance	Mutation from literature
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

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