TB-Profiler

Lineage	Family	RDs	Frequency
La1.8	M.bovis	None	1.0
La1.8.1	M.bovis	None	1.0
La1	M.bovis	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
pncA	2289073	p.His57Asp	missense_variant	1.0	pyrazinamide	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	467	p.His156Arg	missense_variant	1.0	isoniazid	Not assoc w R
gyrB	5752	c.513G>A	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	5752	c.513G>A	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6446	p.Ala403Ser	missense_variant	1.0	levofloxacin	Not assoc w R
gyrB	6446	p.Ala403Ser	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	8285	c.984C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8285	c.984C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9217	p.Asp639Ala	missense_variant	1.0	levofloxacin	Uncertain significance
gyrA	9217	p.Asp639Ala	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	9304	p.Gly668Asp	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	moxifloxacin	Not assoc w R
Rv0010c	13197	p.Thr121Ser	missense_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13228	c.330delG	frameshift_variant	1.0	isoniazid	Uncertain significance
Rv0010c	13460	c.99T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
fgd1	491742	c.960T>C	synonymous_variant	1.0	clofazimine	Not assoc w R
					pretomanid
					delamanid	Not assoc w R - Interim
mshA	576105	p.Arg253Leu	missense_variant	0.99	ethionamide	Uncertain significance
mshA	576105	p.Arg253Leu	missense_variant	0.99	isoniazid	Uncertain significance
Rv0565c	657578	c.-108T>C	upstream_gene_variant	1.0	ethionamide
rpoB	763031	c.3225T>C	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoC	765567	p.Met733Thr	missense_variant	0.61	rifampicin
rpoC	765569	p.Ala734Pro	missense_variant	0.62	rifampicin
mmpL5	775639	p.Ile948Val	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
Rv1129c	1254562	c.-28T>C	upstream_gene_variant	1.0	moxifloxacin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
Rv1129c	1254582	c.-48A>G	upstream_gene_variant	1.0	moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
fbiC	1302899	c.-32A>G	upstream_gene_variant	1.0	clofazimine	Uncertain significance
					pretomanid
					delamanid	Uncertain significance
embR	1417554	c.-207C>G	upstream_gene_variant	1.0	ethambutol
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472655	n.810G>A	non_coding_transcript_exon_variant	0.12	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472661	n.816A>G	non_coding_transcript_exon_variant	0.11	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472708	n.863T>A	non_coding_transcript_exon_variant	0.12	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1472713	n.868T>C	non_coding_transcript_exon_variant	0.12	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472716	n.871C>T	non_coding_transcript_exon_variant	0.12	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472733	n.888G>C	non_coding_transcript_exon_variant	0.12	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472734	n.889C>T	non_coding_transcript_exon_variant	0.12	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472741	n.896G>A	non_coding_transcript_exon_variant	0.12	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472742	n.897C>G	non_coding_transcript_exon_variant	0.12	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472744	n.899A>G	non_coding_transcript_exon_variant	0.12	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472767	n.922G>A	non_coding_transcript_exon_variant	0.12	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472895	n.1050C>T	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472952	n.1107_1108insAG	non_coding_transcript_exon_variant	0.2	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472957	n.1112_1114delCATinsA	non_coding_transcript_exon_variant	0.21	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472973	n.1128A>T	non_coding_transcript_exon_variant	0.21	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472974	n.1129A>G	non_coding_transcript_exon_variant	0.12	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472975	n.1130T>A	non_coding_transcript_exon_variant	0.25	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472977	n.1132G>T	non_coding_transcript_exon_variant	0.21	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472982	n.1137G>C	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472987	n.1142G>T	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472988	n.1143T>A	non_coding_transcript_exon_variant	0.23	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472992	n.1147A>C	non_coding_transcript_exon_variant	0.23	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473002	n.1157G>T	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473004	n.1159T>A	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473008	n.1163C>A	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473009	n.1164T>C	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473035	n.1190G>A	non_coding_transcript_exon_variant	0.32	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473053	n.1208T>A	non_coding_transcript_exon_variant	0.33	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.32	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473062	n.1217T>A	non_coding_transcript_exon_variant	0.32	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473068	n.1223A>G	non_coding_transcript_exon_variant	0.31	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473070	n.1225G>A	non_coding_transcript_exon_variant	0.3	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473088	n.1243A>G	non_coding_transcript_exon_variant	0.28	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473093	n.1248C>A	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473094	n.1249T>A	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473099	n.1254T>A	non_coding_transcript_exon_variant	0.27	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	0.26	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.26	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473122	n.1277T>A	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473127	n.1282G>A	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473128	n.1283C>G	non_coding_transcript_exon_variant	0.22	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473147	n.1302G>C	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473148	n.1303G>A	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473150	n.1305T>G	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473161	n.1316A>C	non_coding_transcript_exon_variant	0.18	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473163	n.1318C>T	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473164	n.1319C>G	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473177	n.1332G>A	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473179	n.1334C>T	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473192	n.1347A>G	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473201	n.1356_1357delACinsT	non_coding_transcript_exon_variant	0.17	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473205	n.1360T>C	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473226	n.1381C>T	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1474804	n.1147C>T	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474804	n.1147C>T	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.12	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.12	linezolid	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.12	capreomycin	Uncertain significance
rrl	1474830	n.1173A>G	non_coding_transcript_exon_variant	0.12	linezolid	Uncertain significance
rrl	1474831	n.1174A>C	non_coding_transcript_exon_variant	0.12	capreomycin	Uncertain significance
rrl	1474831	n.1174A>C	non_coding_transcript_exon_variant	0.12	linezolid	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1474866	n.1209C>A	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474866	n.1209C>A	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1474869	n.1212G>C	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474869	n.1212G>C	non_coding_transcript_exon_variant	0.13	linezolid
rrl	1474896	n.1239A>G	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474896	n.1239A>G	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1474902	n.1245T>C	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474902	n.1245T>C	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1474913	n.1256T>A	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474913	n.1256T>A	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1476229	n.2572C>G	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1476229	n.2572C>G	non_coding_transcript_exon_variant	0.18	linezolid
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1476251	n.2594T>C	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1476252	n.2595T>G	non_coding_transcript_exon_variant	0.23	linezolid	Uncertain significance
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.25	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476280	n.2623A>C	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1476280	n.2623A>C	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1476293	n.2636C>T	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1476293	n.2636C>T	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.26	capreomycin	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.26	linezolid	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476313	n.2656G>A	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476313	n.2656G>A	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1476338	n.2681C>T	non_coding_transcript_exon_variant	0.35	linezolid	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.4	capreomycin	Uncertain significance
rrl	1476353	n.2696G>T	non_coding_transcript_exon_variant	0.4	linezolid	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.42	linezolid	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.43	capreomycin	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.43	linezolid	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.45	capreomycin	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.45	linezolid	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.45	capreomycin	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.45	linezolid	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.48	capreomycin	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.48	linezolid	Uncertain significance
rrl	1476425	n.2768G>A	non_coding_transcript_exon_variant	0.51	capreomycin	Uncertain significance
rrl	1476425	n.2768G>A	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.51	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.5	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.5	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.49	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	0.49	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.46	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.46	linezolid	Uncertain significance
rrl	1476512	n.2855C>T	non_coding_transcript_exon_variant	0.44	capreomycin	Uncertain significance
rrl	1476512	n.2855C>T	non_coding_transcript_exon_variant	0.44	linezolid
rrl	1476514	n.2857C>T	non_coding_transcript_exon_variant	0.44	capreomycin	Uncertain significance
rrl	1476514	n.2857C>T	non_coding_transcript_exon_variant	0.44	linezolid	Uncertain significance
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	0.44	capreomycin	Uncertain significance
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	0.44	linezolid	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	0.42	linezolid	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.42	linezolid	Uncertain significance
rrl	1476530	n.2873C>T	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1476530	n.2873C>T	non_coding_transcript_exon_variant	0.42	linezolid	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.42	linezolid	Uncertain significance
rrl	1476537	n.2880A>G	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1476537	n.2880A>G	non_coding_transcript_exon_variant	0.42	linezolid	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.42	linezolid	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	0.4	capreomycin	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	0.4	linezolid	Uncertain significance
rrl	1476547	n.2890C>T	non_coding_transcript_exon_variant	0.42	capreomycin	Uncertain significance
rrl	1476547	n.2890C>T	non_coding_transcript_exon_variant	0.42	linezolid	Uncertain significance
rrl	1476567	n.2910C>T	non_coding_transcript_exon_variant	0.39	capreomycin	Uncertain significance
rrl	1476567	n.2910C>T	non_coding_transcript_exon_variant	0.39	linezolid	Uncertain significance
rrl	1476573	n.2916A>T	non_coding_transcript_exon_variant	0.35	capreomycin	Uncertain significance
rrl	1476573	n.2916A>T	non_coding_transcript_exon_variant	0.35	linezolid
rrl	1476577	n.2920T>G	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1476577	n.2920T>G	non_coding_transcript_exon_variant	0.34	linezolid	Uncertain significance
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.32	capreomycin	Not assoc w R
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476595	n.2938C>T	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1476595	n.2938C>T	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1476602	n.2945G>A	non_coding_transcript_exon_variant	0.23	capreomycin	Uncertain significance
rrl	1476602	n.2945G>A	non_coding_transcript_exon_variant	0.23	linezolid
rrl	1476607	n.2950C>T	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1476607	n.2950C>T	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	0.21	linezolid	Uncertain significance
rrl	1476621	n.2964C>A	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1476621	n.2964C>A	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rpsA	1834859	p.Ala440Thr	missense_variant	1.0	pyrazinamide	Uncertain significance
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2062922	p.Ile603Val	missense_variant	1.0	streptomycin	Not assoc w R
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
ndh	2103173	c.-132delG	upstream_gene_variant	1.0	ethionamide
					delamanid
					isoniazid
katG	2154724	p.Arg463Leu	missense_variant	1.0	isoniazid	Not assoc w R
katG	2155503	c.609C>T	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156025	c.87C>A	synonymous_variant	1.0	isoniazid	Not assoc w R
PPE35	2167926	p.Leu896Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
PPE35	2168011	p.Ser868Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2168319	p.Thr765Ile	missense_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2168814	c.1798dupA	frameshift_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2170048	p.Leu189Val	missense_variant	0.21	pyrazinamide
PPE35	2170053	p.Thr187Ser	missense_variant	0.22	pyrazinamide
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
kasA	2518132	c.18C>T	synonymous_variant	1.0	isoniazid
eis	2715125	p.Thr70Ala	missense_variant	1.0	amikacin	Uncertain significance
eis	2715125	p.Thr70Ala	missense_variant	1.0	kanamycin	Uncertain significance
eis	2715719	c.-387C>T	upstream_gene_variant	1.0	amikacin
eis	2715719	c.-387C>T	upstream_gene_variant	1.0	kanamycin
Rv2477c	2782927	c.1116A>G	synonymous_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					amikacin	Not assoc w R - Interim
Rv2680	2995832	c.-273G>A	upstream_gene_variant	1.0	capreomycin
Rv2681	2997325	p.Ala196Val	missense_variant	1.0	capreomycin	Uncertain significance
ald	3086728	c.-92C>T	upstream_gene_variant	1.0	cycloserine
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
ald	3087084	c.266delA	frameshift_variant	1.0	cycloserine
Rv3083	3448783	p.Val94Ile	missense_variant	1.0	ethionamide	Uncertain significance
lpqB	3623372	c.1539G>C	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3623372	c.1539G>C	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624350	c.561G>T	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624350	c.561G>T	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624593	c.318G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624593	c.318G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624710	c.201G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624710	c.201G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
mtrB	3625065	p.Met517Leu	missense_variant	1.0	bedaquiline	Uncertain significance
mtrB	3625065	p.Met517Leu	missense_variant	1.0	rifampicin	Not assoc w R
fbiB	3641590	p.Gly19Glu	missense_variant	1.0	clofazimine
					pretomanid
					delamanid	Uncertain significance
clpC1	4038403	c.2302T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
glpK	4138377	p.Val460Ala	missense_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embC	4242970	c.3108C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4244220	c.988C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4246551	p.Asn13Ser	missense_variant	0.99	ethambutol	Not assoc w R
embB	4246864	c.351C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4247646	p.Glu378Ala	missense_variant	1.0	ethambutol	Not assoc w R
aftB	4267858	p.Ile327Val	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269351	c.483C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
ubiA	4269387	p.Glu149Asp	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269606	c.228T>C	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R

TB-Profiler result