Run ID: SRR069989
Sample name:
Date: 2024-10-05T07:30:41.377736
Number of reads: 1366546
Percentage reads mapped: 76.26
Median coverage: 22.0
Strain: lineage2.2.2
Spoligotype:
Drug-resistance: HR-TB
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage2 | East-Asian | RD105 | 1.0 |
lineage2.2.2 | East-Asian (Beijing) | RD105;RD207 | 0.74 |
lineage2.2 | East-Asian (Beijing) | RD105;RD207 | 0.81 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | katG | c.1002_1003dupGA | Assoc w R | High-level resistance |
kasA | p.Asp66Asn | Mutation from literature | ||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | gyrA | p.Ala90Val | Assoc w R | Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) |
ofloxacin | ||||
levofloxacin | gyrA | p.Ala90Val | Assoc w R | |
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
gyrA | 7570 | p.Ala90Val | missense_variant | 0.89 | levofloxacin | Assoc w R | |
moxifloxacin | Assoc w R | Low-level resistance (multiple, genetically linked low-level resistance mutations are additive and confer high-level resistance) | |||||
katG | 2155108 | c.1002_1003dupGA | frameshift_variant | 0.86 | isoniazid | Assoc w R | High-level resistance |
kasA | 2518310 | p.Asp66Asn | missense_variant | 1.0 | isoniazid | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 750 | c.750C>G | synonymous_variant | 0.18 | isoniazid | |
dnaA | 756 | c.756T>C | synonymous_variant | 0.18 | isoniazid | |
gyrA | 6778 | c.-524C>T | upstream_gene_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6793 | c.1554T>C | synonymous_variant | 0.19 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6797 | p.Gly520Thr | missense_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8156 | c.855T>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8198 | c.897T>C | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8207 | c.906T>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8219 | c.918T>C | synonymous_variant | 0.17 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8225 | c.924T>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8294 | c.993T>C | synonymous_variant | 0.15 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8420 | c.1119T>C | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8423 | c.1122G>C | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9674 | c.2373T>C | synonymous_variant | 0.32 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9677 | c.2376C>T | synonymous_variant | 0.33 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9701 | c.2400T>C | synonymous_variant | 0.3 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9704 | c.2403T>C | synonymous_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 9708 | c.2407T>C | synonymous_variant | 0.26 | levofloxacin | |
moxifloxacin | ||||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R | |||||
Rv0565c | 657081 | c.390G>A | synonymous_variant | 1.0 | ethionamide | Not assoc w R - Interim |
Rv0565c | 657142 | p.Arg110His | missense_variant | 1.0 | ethionamide | Uncertain significance |
rpoB | 760253 | c.447T>C | synonymous_variant | 0.33 | rifampicin | Not assoc w R - Interim |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 760970 | c.1164G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760991 | c.1185G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 762989 | c.-381G>C | upstream_gene_variant | 0.34 | rifampicin | |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>C | synonymous_variant | 0.75 | rifampicin | Not assoc w R |
rpoB | 763031 | c.3225T>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 763034 | c.3228C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 763136 | c.3330C>T | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 763148 | c.-222G>C | upstream_gene_variant | 0.24 | rifampicin | |
rpoC | 763158 | c.-212C>T | upstream_gene_variant | 0.26 | rifampicin | |
rpoC | 763456 | c.87A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763468 | c.99G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763546 | c.177A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764059 | c.690G>C | synonymous_variant | 0.28 | rifampicin | |
rpoC | 764083 | c.714A>G | synonymous_variant | 0.3 | rifampicin | |
rpoC | 764098 | c.729A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764110 | c.741C>T | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764131 | c.762T>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764161 | c.792G>C | synonymous_variant | 0.19 | rifampicin | |
rpoC | 764188 | c.819A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764365 | c.996C>T | synonymous_variant | 0.44 | rifampicin | Not assoc w R - Interim |
rpoC | 764626 | c.1257C>T | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 764632 | c.1263T>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
rpoC | 764650 | c.1281G>T | synonymous_variant | 0.5 | rifampicin | Not assoc w R - Interim |
rpoC | 764695 | c.1326T>C | synonymous_variant | 0.47 | rifampicin | |
rpoC | 764716 | c.1347G>C | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 764752 | c.1383G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 765508 | c.2139C>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 765541 | c.2172C>G | synonymous_variant | 0.35 | rifampicin | |
rpoC | 765553 | c.2184C>T | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 765556 | c.2187G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 765559 | c.2190G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 765625 | c.2256C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 765628 | c.2259G>C | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 765631 | p.Asp754Glu | missense_variant | 0.27 | rifampicin | |
rpoC | 765658 | c.2289C>T | synonymous_variant | 0.34 | rifampicin | Not assoc w R - Interim |
rpoC | 765700 | c.2331T>C | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoC | 765734 | c.2365T>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 765835 | c.2466C>T | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765892 | c.2523T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 766583 | p.Gly1072Ser | missense_variant | 0.26 | rifampicin | |
rpoC | 766588 | c.3219G>A | synonymous_variant | 0.26 | rifampicin | |
rpoC | 766591 | c.3222A>G | synonymous_variant | 0.24 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
mmpS5 | 779615 | c.-710C>G | upstream_gene_variant | 1.0 | bedaquiline | |
clofazimine | ||||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781682 | c.123T>C | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781715 | c.156T>C | synonymous_variant | 0.26 | streptomycin | |
rpsL | 781728 | c.169T>C | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.27 | streptomycin | |
rpsL | 781793 | c.234G>C | synonymous_variant | 0.24 | streptomycin | |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.24 | streptomycin | |
rplC | 800648 | c.-161A>C | upstream_gene_variant | 0.19 | linezolid | |
rplC | 800654 | c.-155T>C | upstream_gene_variant | 0.16 | linezolid | |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
fbiC | 1303846 | p.Phe306Val | missense_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303854 | c.924T>C | synonymous_variant | 0.24 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1303860 | c.930A>C | synonymous_variant | 0.27 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471923 | n.78T>C | non_coding_transcript_exon_variant | 0.21 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471934 | n.89A>G | non_coding_transcript_exon_variant | 0.19 | kanamycin | |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.21 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473756 | n.99G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | |
linezolid | ||||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473839 | n.182G>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1473877 | n.220G>A | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1473981 | n.324delGinsTT | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1473995 | n.338G>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | |
linezolid | ||||||
rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>T | non_coding_transcript_exon_variant | 0.26 | capreomycin | |
linezolid | ||||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474904 | n.1247G>A | non_coding_transcript_exon_variant | 0.38 | capreomycin | |
linezolid | ||||||
rrl | 1475249 | n.1592T>C | non_coding_transcript_exon_variant | 0.4 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475252 | n.1595C>T | non_coding_transcript_exon_variant | 0.38 | capreomycin | |
linezolid | ||||||
rrl | 1475355 | n.1698C>T | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475369 | n.1712G>C | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1475483 | n.1826C>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rpsA | 1833595 | c.54T>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1833724 | c.183C>G | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.34 | pyrazinamide | |
rpsA | 1833742 | c.201A>G | synonymous_variant | 0.38 | pyrazinamide | |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1833787 | c.246C>G | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1833838 | c.297G>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833841 | c.300C>G | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1833847 | c.306C>G | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1833928 | c.387G>C | synonymous_variant | 0.31 | pyrazinamide | |
rpsA | 1833940 | c.399C>G | synonymous_variant | 0.36 | pyrazinamide | |
rpsA | 1833970 | c.429G>C | synonymous_variant | 0.32 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.28 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834015 | c.474G>C | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834021 | c.480C>T | synonymous_variant | 0.26 | pyrazinamide | |
rpsA | 1834177 | c.636A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834297 | c.756C>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1834303 | c.762T>G | synonymous_variant | 0.19 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834348 | c.807T>C | synonymous_variant | 0.27 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834366 | c.825A>G | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1834606 | c.1065C>G | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1834609 | c.1068T>C | synonymous_variant | 0.23 | pyrazinamide | |
rpsA | 1834622 | c.1081_1083delTCGinsAGC | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1834639 | c.1098T>C | synonymous_variant | 0.21 | pyrazinamide | |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
ndh | 2101924 | c.1119T>G | synonymous_variant | 0.25 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2101939 | c.1104A>C | synonymous_variant | 0.3 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
ndh | 2101960 | c.1083A>G | synonymous_variant | 0.34 | isoniazid | |
delamanid | ||||||
ethionamide | ||||||
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
kasA | 2517947 | c.-168C>T | upstream_gene_variant | 0.18 | isoniazid | |
kasA | 2518702 | c.588C>T | synonymous_variant | 0.35 | isoniazid | |
kasA | 2518711 | c.597A>G | synonymous_variant | 0.32 | isoniazid | |
kasA | 2518714 | c.600A>C | synonymous_variant | 0.29 | isoniazid | |
kasA | 2518717 | c.603C>T | synonymous_variant | 0.27 | isoniazid | |
kasA | 2518747 | c.633C>G | synonymous_variant | 0.26 | isoniazid | |
ahpC | 2726645 | c.453C>G | synonymous_variant | 0.2 | isoniazid | |
ahpC | 2726657 | c.465A>C | synonymous_variant | 0.2 | isoniazid | Not assoc w R - Interim |
ahpC | 2726669 | p.Asp159Glu | missense_variant | 0.21 | isoniazid | |
ahpC | 2726672 | c.480G>A | synonymous_variant | 0.18 | isoniazid | Not assoc w R - Interim |
ahpC | 2726681 | c.489A>G | synonymous_variant | 0.19 | isoniazid | |
thyX | 3067661 | c.285C>G | synonymous_variant | 0.23 | para-aminosalicylic_acid | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
fbiD | 3339040 | c.-78T>C | upstream_gene_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
Rv3236c | 3612813 | p.Thr102Ala | missense_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
mtrB | 3625762 | c.852A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625765 | c.849C>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625797 | p.Val273Met | missense_variant | 0.28 | rifampicin | Uncertain significance |
bedaquiline | Uncertain significance | |||||
mtrB | 3625806 | c.808A>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625852 | c.762A>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
lpqB | 3625864 | c.-954T>G | upstream_gene_variant | 0.36 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625876 | c.738G>C | synonymous_variant | 0.38 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrA | 3627252 | p.Ala33Val | missense_variant | 0.85 | rifampicin | |
bedaquiline | ||||||
rpoA | 3877542 | c.966C>T | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3877553 | p.Glu319Gln | missense_variant | 0.31 | rifampicin | |
rpoA | 3877557 | c.951C>G | synonymous_variant | 0.31 | rifampicin | Not assoc w R - Interim |
rpoA | 3878436 | c.72A>G | synonymous_variant | 0.27 | rifampicin | |
clpC1 | 4038740 | c.1965G>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4038851 | c.1854G>A | synonymous_variant | 0.35 | pyrazinamide | |
clpC1 | 4039025 | c.1680C>T | synonymous_variant | 0.76 | pyrazinamide | |
clpC1 | 4039484 | c.1221T>G | synonymous_variant | 0.37 | pyrazinamide | |
clpC1 | 4039517 | c.1188C>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039524 | p.Phe394Tyr | missense_variant | 0.21 | pyrazinamide | |
glpK | 4138547 | c.1209C>T | synonymous_variant | 0.36 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
isoniazid | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R - Interim | |||||
ethambutol | Not assoc w R - Interim | |||||
glpK | 4138568 | c.1188A>G | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138571 | c.1185C>G | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138583 | c.1173G>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
glpK | 4138586 | c.1170C>T | synonymous_variant | 0.23 | levofloxacin | |
moxifloxacin | ||||||
isoniazid | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
embC | 4240780 | c.918T>C | synonymous_variant | 0.35 | ethambutol | |
embC | 4240783 | c.921G>C | synonymous_variant | 0.34 | ethambutol | |
embC | 4240789 | c.927T>C | synonymous_variant | 0.29 | ethambutol | |
embA | 4243460 | c.228C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4247491 | c.978G>C | synonymous_variant | 0.23 | ethambutol | |
embB | 4248277 | c.1764G>C | synonymous_variant | 0.29 | ethambutol | |
embB | 4248902 | p.Thr797Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
aftB | 4267647 | p.Asp397Gly | missense_variant | 1.0 | ethambutol | Not assoc w R |
aftB | 4269183 | c.-347T>C | upstream_gene_variant | 0.23 | ethambutol | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |
gid | 4407927 | p.Glu92Asp | missense_variant | 1.0 | streptomycin | Not assoc w R |