TB-Profiler result

Run: ERR2229541
Summary

Run ID: ERR2229541

Sample name:

Date: 31-03-2023 17:18:06

Number of reads: 1154149

Percentage reads mapped: 97.44

Strain: lineage4.8

Drug-resistance: Other

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.8 Euro-American (mainly T) T1;T2;T3;T5 RD219 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rrs 1473247 n.1402C>A non_coding_transcript_exon_variant 0.35 kanamycin, capreomycin, aminoglycosides, amikacin
rrs 1473329 n.1484G>T non_coding_transcript_exon_variant 0.15 kanamycin, capreomycin, aminoglycosides, amikacin
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 576108 p.Ala254Gly missense_variant 0.36
mshA 576111 p.Ala255Gly missense_variant 0.22
mshA 576443 p.Gly366Cys missense_variant 0.13
mshA 576615 p.Arg423Gln missense_variant 0.14
rpoC 764546 p.Gly393Arg missense_variant 0.13
rpoC 764605 c.1236G>T synonymous_variant 0.14
rpoC 764611 c.1242G>T synonymous_variant 0.12
rpoC 764617 c.1248C>T synonymous_variant 0.12
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
fbiC 1303747 p.Thr273Ala missense_variant 1.0
embR 1416540 p.Ala270Ser missense_variant 0.12
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472122 n.277G>T non_coding_transcript_exon_variant 0.12
rrs 1472123 n.278A>T non_coding_transcript_exon_variant 0.12
rrs 1472124 n.279C>T non_coding_transcript_exon_variant 0.12
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.16
rrs 1472160 n.315C>T non_coding_transcript_exon_variant 0.13
rrs 1472225 n.380C>G non_coding_transcript_exon_variant 0.34
rrs 1472240 n.395G>A non_coding_transcript_exon_variant 0.12
rrs 1472251 n.406G>C non_coding_transcript_exon_variant 0.12
rrs 1472344 n.499C>T non_coding_transcript_exon_variant 0.16
rrs 1472368 n.523A>G non_coding_transcript_exon_variant 0.27
rrs 1472396 n.551A>T non_coding_transcript_exon_variant 0.32
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.33
rrs 1472522 n.677T>G non_coding_transcript_exon_variant 0.19
rrs 1472557 n.712G>A non_coding_transcript_exon_variant 0.32
rrs 1472571 n.726G>T non_coding_transcript_exon_variant 0.33
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.28
rrs 1472582 n.737G>T non_coding_transcript_exon_variant 0.28
rrs 1472584 n.739A>T non_coding_transcript_exon_variant 0.28
rrs 1472585 n.740A>C non_coding_transcript_exon_variant 0.28
rrs 1472623 n.778A>C non_coding_transcript_exon_variant 0.32
rrs 1472647 n.802C>T non_coding_transcript_exon_variant 0.38
rrs 1472673 n.828T>G non_coding_transcript_exon_variant 0.31
rrs 1472675 n.830T>C non_coding_transcript_exon_variant 0.3
rrs 1472677 n.832C>A non_coding_transcript_exon_variant 0.29
rrs 1472682 n.837T>A non_coding_transcript_exon_variant 0.26
rrs 1472683 n.838T>C non_coding_transcript_exon_variant 0.26
rrs 1472687 n.842A>T non_coding_transcript_exon_variant 0.27
rrs 1472707 n.862A>T non_coding_transcript_exon_variant 0.35
rrs 1472767 n.922G>C non_coding_transcript_exon_variant 0.16
rrs 1472790 n.945T>C non_coding_transcript_exon_variant 0.14
rrs 1472812 n.967A>T non_coding_transcript_exon_variant 0.17
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.15
rrs 1472986 n.1141_1142insA non_coding_transcript_exon_variant 0.15
rrs 1472989 n.1145delA non_coding_transcript_exon_variant 0.18
rrs 1472996 n.1151T>C non_coding_transcript_exon_variant 0.18
rrs 1473081 n.1236C>T non_coding_transcript_exon_variant 0.14
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.13
rrs 1473164 n.1319C>T non_coding_transcript_exon_variant 0.29
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.29
rrs 1473226 n.1381C>G non_coding_transcript_exon_variant 0.34
rrs 1473259 n.1414C>T non_coding_transcript_exon_variant 0.28
rrs 1473276 n.1431A>G non_coding_transcript_exon_variant 0.21
rrs 1473288 n.1443C>G non_coding_transcript_exon_variant 0.12
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.11
rrs 1473294 n.1449A>G non_coding_transcript_exon_variant 0.12
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.12
rrl 1473916 n.259C>A non_coding_transcript_exon_variant 0.38
rrl 1473922 n.265A>G non_coding_transcript_exon_variant 0.35
rrl 1473923 n.266C>G non_coding_transcript_exon_variant 0.35
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0
rrl 1474166 n.509G>T non_coding_transcript_exon_variant 0.19
rrl 1474167 n.510T>C non_coding_transcript_exon_variant 0.19
rrl 1474184 n.527C>T non_coding_transcript_exon_variant 0.17
rrl 1474186 n.529A>G non_coding_transcript_exon_variant 0.17
rrl 1474197 n.540C>T non_coding_transcript_exon_variant 0.15
rrl 1474202 n.545T>G non_coding_transcript_exon_variant 0.18
rrl 1474218 n.561T>G non_coding_transcript_exon_variant 0.18
rrl 1474253 n.596A>T non_coding_transcript_exon_variant 0.19
rrl 1474529 n.872A>C non_coding_transcript_exon_variant 0.15
rrl 1474530 n.873G>A non_coding_transcript_exon_variant 0.14
rrl 1474537 n.880G>A non_coding_transcript_exon_variant 0.15
rrl 1474539 n.882C>T non_coding_transcript_exon_variant 0.15
rrl 1474540 n.883T>G non_coding_transcript_exon_variant 0.15
rrl 1474552 n.895C>T non_coding_transcript_exon_variant 0.15
rrl 1474558 n.901G>A non_coding_transcript_exon_variant 0.17
rrl 1474582 n.925T>A non_coding_transcript_exon_variant 0.18
rrl 1474798 n.1141C>T non_coding_transcript_exon_variant 0.12
rrl 1474799 n.1143delT non_coding_transcript_exon_variant 0.12
rrl 1474803 n.1146_1147insA non_coding_transcript_exon_variant 0.12
rrl 1474806 n.1149A>C non_coding_transcript_exon_variant 0.12
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.19
rrl 1474827 n.1170C>T non_coding_transcript_exon_variant 0.19
rrl 1474830 n.1173A>G non_coding_transcript_exon_variant 0.19
rrl 1474831 n.1174A>T non_coding_transcript_exon_variant 0.19
rrl 1474853 n.1196A>G non_coding_transcript_exon_variant 0.36
rrl 1474864 n.1207C>T non_coding_transcript_exon_variant 0.35
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.19
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.19
rrl 1475781 n.2124T>C non_coding_transcript_exon_variant 0.12
rrl 1475869 n.2212C>A non_coding_transcript_exon_variant 0.3
rrl 1475877 n.2220C>T non_coding_transcript_exon_variant 0.18
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.2
rrl 1475883 n.2226A>T non_coding_transcript_exon_variant 0.2
rrl 1475892 n.2235A>C non_coding_transcript_exon_variant 0.29
rrl 1475898 n.2241A>G non_coding_transcript_exon_variant 0.18
rrl 1475899 n.2242G>A non_coding_transcript_exon_variant 0.17
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.21
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.21
rrl 1475943 n.2286G>A non_coding_transcript_exon_variant 0.19
rrl 1475952 n.2295A>G non_coding_transcript_exon_variant 0.21
rrl 1476141 n.2484A>G non_coding_transcript_exon_variant 0.27
rrl 1476153 n.2496T>C non_coding_transcript_exon_variant 0.26
rrl 1476164 n.2507A>G non_coding_transcript_exon_variant 0.28
rrl 1476165 n.2508T>G non_coding_transcript_exon_variant 0.28
rrl 1476194 n.2537A>G non_coding_transcript_exon_variant 0.31
rrl 1476200 n.2543A>T non_coding_transcript_exon_variant 0.31
rrl 1476201 n.2544C>T non_coding_transcript_exon_variant 0.31
rrl 1476204 n.2547C>T non_coding_transcript_exon_variant 0.3
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.35
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.4
rrl 1476235 n.2578A>G non_coding_transcript_exon_variant 0.24
rrl 1476245 n.2588C>T non_coding_transcript_exon_variant 0.26
rrl 1476252 n.2595T>G non_coding_transcript_exon_variant 0.24
rrl 1476256 n.2599A>G non_coding_transcript_exon_variant 0.24
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.21
rrl 1476359 n.2702C>G non_coding_transcript_exon_variant 0.12
rrl 1476363 n.2706A>G non_coding_transcript_exon_variant 0.12
rrl 1476366 n.2709A>C non_coding_transcript_exon_variant 0.12
rrl 1476368 n.2711T>C non_coding_transcript_exon_variant 0.11
rrl 1476374 n.2717T>G non_coding_transcript_exon_variant 0.11
rrl 1476381 n.2724G>C non_coding_transcript_exon_variant 0.26
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.21
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.21
rrl 1476481 n.2824T>C non_coding_transcript_exon_variant 0.19
rpsA 1834069 c.528G>C synonymous_variant 0.12
tlyA 1917972 c.33A>G synonymous_variant 1.0
ndh 2102604 c.439T>C synonymous_variant 0.11
PPE35 2167865 c.2748G>C synonymous_variant 0.17
PPE35 2167868 c.2745A>C synonymous_variant 0.18
PPE35 2168728 p.Gly629Arg missense_variant 1.0
PPE35 2169278 c.1335T>C synonymous_variant 0.11
PPE35 2169281 c.1332T>G synonymous_variant 0.11
PPE35 2169602 c.1011C>A synonymous_variant 0.19
PPE35 2169902 p.Leu237Phe missense_variant 0.17
PPE35 2169910 p.Asn235Tyr missense_variant 0.17
PPE35 2170048 p.Leu189Val missense_variant 0.38
PPE35 2170053 p.Thr187Ser missense_variant 0.39
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
pepQ 2860008 c.411C>T synonymous_variant 0.12
Rv3083 3448497 c.-7T>A upstream_gene_variant 1.0
Rv3236c 3612193 c.924C>A synonymous_variant 0.2
rpoA 3878400 c.108T>C synonymous_variant 0.11
clpC1 4039466 c.1239T>C synonymous_variant 0.11
embC 4242291 p.Asn810Ser missense_variant 0.22
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4245986 c.-528G>T upstream_gene_variant 0.18
embA 4246102 p.Thr957Asn missense_variant 0.12
embB 4246548 p.Pro12Gln missense_variant 0.38
embB 4246555 c.42G>C synonymous_variant 0.38
embB 4246556 p.Ala15Pro missense_variant 0.38
embB 4246584 p.Arg24Pro missense_variant 0.25
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
Rv3083 3448507 c.5_*1408del frameshift_variant&stop_lost&splice_region_variant 1.0