Run ID: ERR13265833
Sample name:
Date: 2025-02-11T12:52:22.222453
Number of reads: 52498
Percentage reads mapped: 27.53
Median coverage: 0.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 1.0 |
lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | fgd1 | c.355delG | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
c.361_363delGCCinsAG | Assoc w R - Interim | Confers DLM-PMD cross-resistance | ||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
fgd1 | 491136 | c.355delG | frameshift_variant | 1.0 | delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
fgd1 | 491143 | c.361_363delGCCinsAG | frameshift_variant&missense_variant | 1.0 | delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 1220 | p.Asn407Thr | missense_variant | 1.0 | isoniazid | |
dnaA | 1230 | c.1230A>G | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1236 | c.1236C>T | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1237 | p.Ala413Thr | missense_variant | 1.0 | isoniazid | Uncertain significance |
dnaA | 1243 | p.Thr415Ala | missense_variant | 1.0 | isoniazid | Uncertain significance |
dnaA | 1254 | c.1254T>G | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1266 | c.1266A>G | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1275 | p.Asp425Glu | missense_variant | 1.0 | isoniazid | |
dnaA | 1278 | c.1278T>C | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1281 | c.1281C>G | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1287 | c.1287A>G | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1293 | c.1293T>G | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1314 | c.1314A>T | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1317 | c.1317A>G | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1329 | c.1329A>C | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1332 | c.1332A>T | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1338 | c.1338T>C | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1341 | c.1341G>C | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1347 | c.1347C>T | synonymous_variant | 1.0 | isoniazid | |
dnaA | 1353 | c.1353T>C | synonymous_variant | 1.0 | isoniazid | |
gyrA | 7108 | c.-194G>A | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7123 | c.-179C>G | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7126 | c.-176G>A | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7129 | c.-173T>G | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7132 | c.-170T>G | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7153 | c.-149G>T | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7156 | c.1917C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 7159 | c.1920C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 7162 | c.1923C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7165 | c.-137C>T | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7168 | c.-134C>G | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7178 | c.-124T>C | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7210 | p.Asp657Glu | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7213 | c.-89G>A | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7225 | c.-77T>C | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7234 | c.1995C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7243 | c.-59G>A | upstream_gene_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 7246 | c.2007T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7391 | c.90C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7394 | c.93T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7397 | c.96G>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7406 | c.105G>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7412 | c.111C>G | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7418 | c.117C>T | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7433 | c.132G>A | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7442 | c.141G>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7457 | c.156T>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7463 | c.162G>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7472 | c.171T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 7475 | c.174A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7480 | p.Phe60Tyr | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7484 | c.183T>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7499 | c.198G>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7526 | c.225G>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7532 | c.231T>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7541 | c.240C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7547 | c.246C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7601 | c.300C>T | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7607 | c.306C>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7613 | c.312G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 7622 | c.321C>T | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7631 | c.330G>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7637 | c.336C>T | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7652 | c.351C>T | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7694 | c.393A>G | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7697 | c.396C>G | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7706 | c.405C>T | synonymous_variant | 0.91 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7709 | c.408G>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7710 | c.409T>C | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 7728 | c.427_429delAGGinsCGC | synonymous_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
fgd1 | 491091 | c.309T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491115 | c.333G>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491121 | c.339A>G | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491166 | c.384G>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491508 | c.726A>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491512 | p.Asn244Glu | missense_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491523 | c.741G>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491526 | c.744T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491542 | c.760T>C | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491563 | c.781_783delAGCinsTCG | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491595 | c.813C>T | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491610 | c.828A>G | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491616 | c.834A>G | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491620 | p.Ile280Val | missense_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491649 | c.867C>T | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491652 | c.870C>T | synonymous_variant | 0.82 | pretomanid | |
delamanid | ||||||
clofazimine | Not assoc w R - Interim | |||||
fgd1 | 491655 | c.873C>T | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491658 | c.876A>G | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491661 | c.879C>G | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fgd1 | 491667 | c.885A>G | synonymous_variant | 1.0 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
mshA | 575837 | c.490C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R - Interim |
ethionamide | Not assoc w R - Interim | |||||
mshA | 575842 | c.495G>C | synonymous_variant | 1.0 | isoniazid | |
ethionamide | ||||||
mshA | 575864 | c.517T>C | synonymous_variant | 1.0 | isoniazid | |
ethionamide | ||||||
mshA | 575881 | c.534C>T | synonymous_variant | 1.0 | isoniazid | |
ethionamide | ||||||
mshA | 575884 | c.537G>C | synonymous_variant | 1.0 | isoniazid | |
ethionamide | ||||||
mshA | 575893 | c.546C>A | synonymous_variant | 1.0 | isoniazid | |
ethionamide | ||||||
rpoC | 764932 | c.1563C>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764935 | c.1566T>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764948 | c.1579T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765007 | c.1638T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765008 | c.1639T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765011 | c.1642_1644delAGCinsTCG | synonymous_variant | 1.0 | rifampicin | |
rpoC | 765016 | c.1647C>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765022 | c.1653G>T | synonymous_variant | 1.0 | rifampicin | |
rpoC | 765034 | c.1665T>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 765040 | c.1671T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765041 | c.1672T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765047 | c.1678T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 765055 | c.1686C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
sigE | 1364931 | c.519C>T | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1364950 | p.Ala180Ser | missense_variant | 1.0 | pyrazinamide | |
sigE | 1364956 | c.544C>T | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1364962 | p.Pro184Ala | missense_variant | 1.0 | pyrazinamide | |
sigE | 1364976 | c.564T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
sigE | 1364979 | c.567C>G | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1364980 | c.568T>C | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1364984 | p.Ala191Asp | missense_variant | 1.0 | pyrazinamide | |
sigE | 1364989 | c.577C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
sigE | 1364992 | p.Pro194Ala | missense_variant | 1.0 | pyrazinamide | |
sigE | 1365000 | c.588G>A | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
sigE | 1365003 | c.591T>C | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1365006 | c.594T>C | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1365018 | c.606G>C | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1365042 | c.630G>C | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1365048 | c.636G>A | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1365051 | c.639G>A | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1365063 | c.651A>G | synonymous_variant | 1.0 | pyrazinamide | |
sigE | 1365069 | c.657C>T | synonymous_variant | 1.0 | pyrazinamide | |
katG | 2155691 | c.421T>C | synonymous_variant | 1.0 | isoniazid | |
katG | 2155696 | p.Ala139Val | missense_variant | 1.0 | isoniazid | |
katG | 2155716 | c.396T>G | synonymous_variant | 1.0 | isoniazid | |
katG | 2155722 | c.390G>C | synonymous_variant | 1.0 | isoniazid | |
katG | 2155728 | c.384G>C | synonymous_variant | 1.0 | isoniazid | |
katG | 2155742 | p.Gly124Arg | missense_variant | 1.0 | isoniazid | |
katG | 2155747 | p.Ala122Gly | missense_variant | 1.0 | isoniazid | |
katG | 2155764 | p.His116Glu | missense_variant | 1.0 | isoniazid | |
katG | 2155769 | p.Ile115Val | missense_variant | 1.0 | isoniazid | |
katG | 2155770 | c.342C>G | synonymous_variant | 1.0 | isoniazid | |
katG | 2155782 | c.330C>A | synonymous_variant | 1.0 | isoniazid | |
katG | 2155785 | c.327T>C | synonymous_variant | 1.0 | isoniazid | |
katG | 2155794 | p.Ala106Ser | missense_variant | 1.0 | isoniazid | |
katG | 2155800 | c.312G>C | synonymous_variant | 1.0 | isoniazid | |
katG | 2155805 | p.Ile103Val | missense_variant | 1.0 | isoniazid | Uncertain significance |
katG | 2155806 | c.306T>C | synonymous_variant | 1.0 | isoniazid | |
clpC1 | 4038383 | c.2322G>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038388 | c.2317T>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038398 | c.2307G>T | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038401 | c.2302_2304delTTGinsCTC | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038410 | c.2295C>T | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038419 | c.2286T>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038433 | c.2272C>T | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038434 | c.2271G>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038444 | p.Ala754Lys | missense_variant | 1.0 | pyrazinamide | |
clpC1 | 4038446 | c.2259T>C | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038456 | p.Val750Gln | missense_variant | 1.0 | pyrazinamide | |
clpC1 | 4038460 | p.Leu749Met | missense_variant | 1.0 | pyrazinamide | |
clpC1 | 4038462 | p.Ala748Glu | missense_variant | 1.0 | pyrazinamide | |
clpC1 | 4038474 | p.Ser744Ala | missense_variant | 1.0 | pyrazinamide | |
clpC1 | 4038479 | c.2226C>G | synonymous_variant | 1.0 | pyrazinamide | |
clpC1 | 4038486 | p.Gly740Asn | missense_variant | 1.0 | pyrazinamide | |
clpC1 | 4038489 | p.Ala739Gly | missense_variant | 1.0 | pyrazinamide | |
clpC1 | 4038499 | p.Ser736Gly | missense_variant | 1.0 | pyrazinamide | |
clpC1 | 4038519 | p.Arg729Gln | missense_variant | 1.0 | pyrazinamide | |
embB | 4247491 | c.978G>C | synonymous_variant | 1.0 | ethambutol | |
embB | 4247497 | c.984T>C | synonymous_variant | 1.0 | ethambutol | |
embB | 4247511 | p.Tyr333Phe | missense_variant | 1.0 | ethambutol | |
embB | 4247527 | c.1014G>C | synonymous_variant | 1.0 | ethambutol | |
embB | 4247536 | c.1023C>G | synonymous_variant | 1.0 | ethambutol | |
embB | 4247554 | c.1041T>C | synonymous_variant | 1.0 | ethambutol | |
embB | 4247555 | p.Leu348Ile | missense_variant | 1.0 | ethambutol | |
embB | 4247566 | c.1053C>A | synonymous_variant | 1.0 | ethambutol | |
embB | 4247572 | c.1059A>C | synonymous_variant | 1.0 | ethambutol | |
embB | 4247578 | c.1065_1066insATCTGT | conservative_inframe_insertion | 1.0 | ethambutol | |
embB | 4247581 | c.1069_1074delGCCGGG | conservative_inframe_deletion | 1.0 | ethambutol | |
embB | 4247590 | c.1077A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
embB | 4248112 | c.1599C>G | synonymous_variant | 1.0 | ethambutol |