Run ID: cba57d2a-b5a5-4b81-9063-48f802944a86
Sample name:
Date: 17-01-2024 18:04:26
Number of reads: 3709501
Percentage reads mapped: 96.03
Median coverage: 107
Strain:
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| moxifloxacin | ||||
| levofloxacin | ||||
| bedaquiline | ||||
| delamanid | ||||
| pretomanid | ||||
| linezolid | ||||
| streptomycin | ||||
| amikacin | ||||
| kanamycin | ||||
| capreomycin | ||||
| clofazimine | ||||
| ethionamide | ||||
| para-aminosalicylic_acid | ||||
| cycloserine |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrB | 5452 | c.213G>A | synonymous_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 6454 | c.-848C>T | upstream_gene_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 7835 | c.534A>G | synonymous_variant | 0.99 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 8714 | c.1413A>G | synonymous_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | ||||||
| levofloxacin | ||||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | fluoroquinolones | |
| moxifloxacin | Uncertain significance | |||||
| levofloxacin | Uncertain significance | |||||
| ciprofloxacin | ||||||
| ofloxacin | ||||||
| fgd1 | 490598 | c.-185G>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490604 | c.-179A>G | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490607 | c.-176G>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490610 | c.-173G>A | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490613 | c.-170A>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490617 | c.-166T>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490627 | c.-156T>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490629 | c.-154T>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490634 | c.-149A>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490640 | c.-143C>A | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490656 | c.-127C>G | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490666 | c.-117G>T | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490678 | c.-105_-104insG | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490687 | c.-96T>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490690 | c.-93C>G | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490704 | c.-79A>G | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490706 | c.-77G>T | upstream_gene_variant | 0.21 | delamanid | |
| fgd1 | 490707 | c.-76G>A | upstream_gene_variant | 0.76 | delamanid | |
| fgd1 | 490709 | c.-74A>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490710 | c.-73T>G | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490711 | c.-72A>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490712 | c.-71T>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490732 | c.-51C>T | upstream_gene_variant | 0.35 | delamanid | |
| fgd1 | 490738 | c.-45C>G | upstream_gene_variant | 0.38 | delamanid | |
| fgd1 | 490744 | c.-39T>C | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490763 | c.-20C>G | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490777 | c.-6G>A | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490778 | c.-5A>G | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490781 | c.-2T>G | upstream_gene_variant | 1.0 | delamanid | |
| fgd1 | 490800 | c.18A>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490809 | c.27A>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490815 | c.33G>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490818 | c.36C>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490851 | c.69A>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490887 | c.105G>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490896 | c.114C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490905 | c.123T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490911 | c.129T>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490917 | c.135C>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490922 | p.Gln47Arg | missense_variant | 1.0 | delamanid | |
| fgd1 | 490929 | c.147C>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490941 | c.159C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490962 | c.180T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490974 | c.192T>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 490980 | p.Asn66Lys | missense_variant | 1.0 | delamanid | |
| fgd1 | 490998 | c.216T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491013 | c.231C>A | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491016 | c.234C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491022 | c.240C>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491037 | c.255C>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491043 | c.261T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491049 | c.267T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491064 | c.282A>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491073 | c.291C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491076 | c.294G>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491082 | c.300T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491085 | c.303T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491091 | c.309T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491094 | c.312C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491115 | c.333G>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491121 | c.339A>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491133 | c.351A>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491137 | p.Glu119Gln | missense_variant | 1.0 | delamanid | |
| fgd1 | 491145 | c.363C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491181 | c.399T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491191 | p.Gly137Arg | missense_variant | 1.0 | delamanid | |
| fgd1 | 491196 | c.414A>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491206 | c.424C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491212 | p.Ser144Arg | missense_variant | 1.0 | delamanid | |
| fgd1 | 491217 | c.435T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491220 | c.438C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491223 | c.441C>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491226 | c.444C>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491232 | c.450T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491241 | p.Asp153Glu | missense_variant | 1.0 | delamanid | |
| fgd1 | 491244 | c.462T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491283 | p.Asp167Glu | missense_variant | 1.0 | delamanid | |
| fgd1 | 491286 | c.504G>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491295 | c.513C>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491310 | c.528C>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491331 | c.549G>A | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491340 | c.558C>A | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491349 | c.567T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491364 | c.582T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491381 | p.Glu200Ala | missense_variant | 1.0 | delamanid | |
| fgd1 | 491388 | c.606C>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491401 | c.619C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491404 | p.Met208Leu | missense_variant | 1.0 | delamanid | |
| fgd1 | 491409 | c.627G>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491415 | c.633A>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491418 | c.636A>C | synonymous_variant | 0.98 | delamanid | |
| fgd1 | 491421 | c.639A>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491430 | c.648T>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491436 | c.654T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491438 | p.Asp219Gly | missense_variant | 1.0 | delamanid | |
| fgd1 | 491449 | p.Asp223Asn | missense_variant | 1.0 | delamanid | |
| fgd1 | 491453 | p.Gly224Asp | missense_variant | 1.0 | delamanid | |
| fgd1 | 491472 | c.690A>G | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491499 | c.717G>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491508 | c.726A>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491509 | c.727T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491526 | c.744T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491542 | c.760T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491547 | c.765A>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491550 | c.768T>C | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491565 | c.783C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491574 | c.792C>T | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491583 | c.801G>A | synonymous_variant | 1.0 | delamanid | |
| fgd1 | 491590 | p.Lys270Arg | missense_variant | 1.0 | delamanid | |
| fgd1 | 491601 | c.819T>C | synonymous_variant | 1.0 | delamanid | |
| mshA | 575216 | c.-132C>A | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | Uncertain significance | |||||
| mshA | 576108 | p.Ala254Gly | missense_variant | 0.28 | ethionamide | Uncertain significance |
| isoniazid | ||||||
| mshA | 576757 | c.1410C>G | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| ccsA | 619697 | c.-194A>C | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| ccsA | 619766 | c.-125A>G | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| ccsA | 619798 | c.-93G>A | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| ccsA | 620256 | c.366C>G | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| ccsA | 620257 | p.Ile123Ala | missense_variant | 1.0 | capreomycin | |
| amikacin | Uncertain significance | |||||
| ccsA | 620415 | c.525T>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| ccsA | 620490 | c.600A>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| ccsA | 620808 | c.918T>C | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| rpoC | 762689 | c.-681G>A | upstream_gene_variant | 1.0 | rifampicin | |
| rpoC | 763031 | c.-339T>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoC | 763375 | c.6C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763660 | c.291T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764134 | c.765C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764152 | c.783C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764159 | c.790C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764278 | c.909A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764287 | c.918C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764293 | c.924G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764365 | c.996C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764405 | c.1036A>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764497 | c.1128A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764506 | c.1137C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764510 | c.1141C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764521 | c.1152T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764533 | c.1164C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764536 | c.1167G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764539 | c.1170C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764554 | c.1185C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764575 | c.1206T>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764578 | c.1209C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764626 | c.1257C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764632 | c.1263T>G | synonymous_variant | 0.99 | rifampicin | |
| rpoC | 764650 | c.1281G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764651 | c.1282_1284delTCGinsAGC | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764752 | c.1383G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764761 | c.1392C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765082 | c.1713G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765220 | c.1851A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765409 | c.2040T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765478 | c.2109T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765637 | c.2268C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766010 | c.2641_2642delTCinsAG | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766900 | c.3531T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766945 | c.3576A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 767030 | c.3661C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 767062 | c.3693C>A | synonymous_variant | 1.0 | rifampicin | |
| mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| mmpL5 | 776705 | c.1776C>T | synonymous_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 778057 | p.Ser142Gly | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 778573 | c.-93C>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 778747 | c.-267C>T | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779283 | c.-803G>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779295 | c.-815A>G | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpR5 | 779431 | p.Asn148Gln | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpR5 | 779452 | p.Gly155Arg | missense_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpL5 | 779472 | c.-992G>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| mmpS5 | 779523 | c.-618T>A | upstream_gene_variant | 1.0 | clofazimine | |
| bedaquiline | ||||||
| rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| rpsL | 781875 | p.Gly106Ser | missense_variant | 1.0 | streptomycin | |
| rplC | 800618 | c.-191T>C | upstream_gene_variant | 1.0 | linezolid | Uncertain significance |
| rplC | 800946 | c.138T>C | synonymous_variant | 1.0 | linezolid | |
| rplC | 801109 | p.Leu101Val | missense_variant | 1.0 | linezolid | |
| fbiC | 1303695 | c.765T>C | synonymous_variant | 1.0 | delamanid | |
| fbiC | 1304208 | c.1278C>T | synonymous_variant | 1.0 | delamanid | |
| fbiC | 1304745 | c.1815C>T | synonymous_variant | 1.0 | delamanid | |
| Rv1258c | 1406466 | p.Ser292Leu | missense_variant | 1.0 | streptomycin | |
| pyrazinamide | ||||||
| isoniazid | Uncertain significance | |||||
| Rv1258c | 1406492 | c.849C>A | synonymous_variant | 1.0 | streptomycin | |
| pyrazinamide | ||||||
| isoniazid | ||||||
| embR | 1417294 | c.54A>G | synonymous_variant | 1.0 | ethambutol | |
| embR | 1417454 | c.-107C>A | upstream_gene_variant | 1.0 | ethambutol | Uncertain significance |
| embR | 1417474 | c.-127C>T | upstream_gene_variant | 1.0 | ethambutol | |
| rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrs | 1471845 | n.4dupT | non_coding_transcript_exon_variant | 1.0 | linezolid | |
| kanamycin | ||||||
| capreomycin | ||||||
| amikacin | ||||||
| aminoglycosides | ||||||
| streptomycin | ||||||
| rrl | 1473403 | n.-255C>T | upstream_gene_variant | 1.0 | linezolid | |
| rrl | 1473749 | n.92A>G | non_coding_transcript_exon_variant | 1.0 | linezolid | |
| rrl | 1474064 | n.407A>T | non_coding_transcript_exon_variant | 0.11 | linezolid | |
| rrl | 1474777 | n.1120T>C | non_coding_transcript_exon_variant | 1.0 | linezolid | |
| rrl | 1476248 | n.2591G>T | non_coding_transcript_exon_variant | 0.12 | linezolid | |
| fabG1 | 1673257 | c.-183C>G | upstream_gene_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| inhA | 1674816 | c.615T>C | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| rpsA | 1833381 | c.-161T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| rpsA | 1834912 | c.1371A>G | synonymous_variant | 1.0 | pyrazinamide | |
| tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | |
| ndh | 2102875 | c.168C>T | synonymous_variant | 1.0 | ethionamide | |
| isoniazid | ||||||
| katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Uncertain significance |
| katG | 2156055 | c.57C>T | synonymous_variant | 1.0 | isoniazid | |
| PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
| PPE35 | 2169686 | c.927T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2169717 | p.Asn299Ile | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170232 | c.381T>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170394 | c.219G>C | synonymous_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170485 | p.Val43Ala | missense_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170660 | c.-48C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170694 | c.-82T>C | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170713 | c.-101A>G | upstream_gene_variant | 1.0 | pyrazinamide | |
| PPE35 | 2170720 | c.-108A>G | upstream_gene_variant | 1.0 | pyrazinamide | Uncertain significance |
| Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| Rv1979c | 2223318 | c.-154A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
| bedaquiline | Uncertain significance | |||||
| pncA | 2289104 | c.138A>G | synonymous_variant | 1.0 | pyrazinamide | |
| kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
| kasA | 2519287 | c.1173T>C | synonymous_variant | 1.0 | isoniazid | |
| eis | 2714628 | c.705A>C | synonymous_variant | 1.0 | kanamycin | |
| amikacin | ||||||
| folC | 2746174 | c.1425A>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2746425 | p.Ala392Thr | missense_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2746451 | p.Gly383Ala | missense_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747374 | c.225G>A | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747549 | p.Val17Ala | missense_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747572 | c.27T>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747575 | c.24G>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747628 | c.-30G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747631 | c.-33C>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| folC | 2747691 | c.-93A>G | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| ribD | 2986929 | p.Leu31Phe | missense_variant | 1.0 | para-aminosalicylic_acid | |
| Rv2752c | 3064627 | p.Asn522Ser | missense_variant | 1.0 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3065823 | c.369G>C | synonymous_variant | 1.0 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3066354 | c.-163G>C | upstream_gene_variant | 1.0 | rifampicin | |
| isoniazid | ||||||
| Rv2752c | 3066996 | c.-805T>C | upstream_gene_variant | 1.0 | rifampicin | |
| isoniazid | ||||||
| thyX | 3067239 | p.Ala236Asp | missense_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3073782 | c.690A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074160 | c.312A>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074238 | c.234C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074247 | c.225C>T | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyA | 3074529 | c.-58G>C | upstream_gene_variant | 1.0 | para-aminosalicylic_acid | |
| ald | 3086739 | c.-81G>A | upstream_gene_variant | 1.0 | cycloserine | |
| ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
| fbiD | 3339248 | p.Val44Ala | missense_variant | 1.0 | delamanid | |
| fbiD | 3339734 | p.Ala206Gly | missense_variant | 0.32 | delamanid | |
| Rv3083 | 3448349 | c.-155C>T | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448403 | c.-101G>A | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448453 | c.-51G>T | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448474 | c.-30G>T | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448481 | c.-23G>C | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448484 | c.-20T>C | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448487 | c.-17T>G | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448495 | c.-9G>C | upstream_gene_variant | 1.0 | ethionamide | |
| Rv3083 | 3448545 | c.42A>G | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3448588 | p.Asp29Asn | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3448606 | c.103C>T | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3448611 | c.108A>G | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3448686 | c.183C>T | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3448869 | p.His122Gln | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3448905 | c.402T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3448972 | p.His157Asp | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449028 | c.525T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449029 | p.Ser176Ala | missense_variant | 1.0 | ethionamide | |
| Rv3083 | 3449305 | c.802T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449622 | c.1119T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449868 | c.1365C>A | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449877 | c.1374T>C | synonymous_variant | 1.0 | ethionamide | |
| Rv3083 | 3449885 | p.Arg461Lys | missense_variant | 1.0 | ethionamide | |
| fprA | 3473996 | c.-11_-10insA | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| fprA | 3474095 | p.Glu30Ala | missense_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| fprA | 3474309 | c.303C>T | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| fprA | 3475125 | c.1119G>A | synonymous_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| fprA | 3475159 | p.Asn385Asp | missense_variant | 1.0 | capreomycin | Uncertain significance |
| amikacin | Uncertain significance | |||||
| Rv3236c | 3612250 | c.867A>G | synonymous_variant | 1.0 | pyrazinamide | |
| Rv3236c | 3612319 | c.798G>C | synonymous_variant | 1.0 | pyrazinamide | |
| Rv3236c | 3612322 | c.795G>C | synonymous_variant | 1.0 | pyrazinamide | |
| fbiB | 3640935 | c.-600C>G | upstream_gene_variant | 1.0 | delamanid | |
| fbiB | 3642467 | c.933T>C | synonymous_variant | 1.0 | delamanid | |
| alr | 3840527 | c.894A>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841199 | c.222T>C | synonymous_variant | 1.0 | cycloserine | |
| alr | 3841419 | p.Val1Ala | missense_variant | 1.0 | cycloserine | |
| alr | 3841524 | c.-104G>A | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841531 | c.-111A>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841532 | c.-112A>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841539 | c.-119C>T | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841546 | c.-126C>G | upstream_gene_variant | 1.0 | cycloserine | |
| alr | 3841568 | c.-148G>A | upstream_gene_variant | 1.0 | cycloserine | |
| ddn | 3986805 | c.-39G>C | upstream_gene_variant | 1.0 | delamanid | |
| ddn | 3987050 | c.207C>T | synonymous_variant | 1.0 | delamanid | |
| ddn | 3987287 | c.444T>C | synonymous_variant | 1.0 | delamanid | |
| clpC1 | 4038227 | c.2478G>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040534 | c.171A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4040874 | c.-171_-170insT | upstream_gene_variant | 1.0 | pyrazinamide | |
| embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4242643 | c.-590C>T | upstream_gene_variant | 1.0 | ethambutol | |
| embA | 4243377 | p.Ser49Arg | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4243690 | p.Met153Thr | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4243919 | c.687G>A | synonymous_variant | 1.0 | ethambutol | |
| embA | 4244154 | p.Thr308Pro | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embA | 4244312 | c.1080T>G | synonymous_variant | 1.0 | ethambutol | |
| embA | 4245023 | c.1791A>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4245701 | c.-813G>T | upstream_gene_variant | 1.0 | ethambutol | |
| embB | 4246584 | p.Arg24Pro | missense_variant | 0.26 | ethambutol | |
| embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embB | 4248206 | p.Ser565Gly | missense_variant | 1.0 | ethambutol | Uncertain significance |
| ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Uncertain significance |
| aftB | 4269606 | c.-770T>C | upstream_gene_variant | 1.0 | capreomycin | |
| amikacin | ||||||
| ubiA | 4269811 | p.Gln8Arg | missense_variant | 1.0 | ethambutol | Uncertain significance |
| ethA | 4327546 | c.-74_-73insC | upstream_gene_variant | 1.0 | ethionamide | |
| ethA | 4327830 | c.-357G>A | upstream_gene_variant | 1.0 | ethionamide | |
| whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | streptomycin | Uncertain significance |
| capreomycin | Uncertain significance | |||||
| amikacin | Uncertain significance | |||||
| gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | |
| gid | 4408185 | c.18C>T | synonymous_variant | 1.0 | streptomycin |
