TB-Profiler result

Run: ERR11465830
Summary

Run ID: ERR11465830

Sample name:

Date: 07-01-2024 23:44:29

Number of reads: 1656433

Percentage reads mapped: 99.62

Strain: lineage4.9

Drug-resistance: Sensitive

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Rifampicin
Isoniazid
Ethambutol
Pyrazinamide
Streptomycin
Fluoroquinolones
Moxifloxacin
Ofloxacin
Levofloxacin
Ciprofloxacin
Aminoglycosides
Amikacin
Capreomycin
Kanamycin
Cycloserine
Ethionamide
Clofazimine
Para-aminosalicylic_acid
Delamanid
Bedaquiline
Linezolid
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage4 Euro-American LAM;T;S;X;H None 1.0
lineage4.9 Euro-American (H37Rv-like) T1 None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
mshA 575761 c.414C>T synonymous_variant 1.0
rpoB 759814 p.Asp3Gly missense_variant 1.0
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.19
rpoB 761102 c.1296A>G synonymous_variant 0.19
rpoB 761579 c.1773G>C synonymous_variant 0.26
rpoC 763483 c.114G>C synonymous_variant 0.17
rpoC 763486 c.117T>C synonymous_variant 0.15
rpoC 763495 c.126G>A synonymous_variant 0.18
rpoC 763504 c.135C>G synonymous_variant 0.14
rpoC 763507 c.138G>C synonymous_variant 0.14
rpoC 763573 c.204G>C synonymous_variant 0.13
rpoC 763594 c.225C>T synonymous_variant 0.16
rpoC 763621 c.252C>T synonymous_variant 0.15
rpoC 763633 c.264T>C synonymous_variant 0.2
mmpL5 775639 p.Ile948Val missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781502 c.-58G>T upstream_gene_variant 1.0
rpsL 781793 c.234G>C synonymous_variant 0.18
rpsL 781796 p.Met79Ile missense_variant 0.17
rpsL 781802 c.243G>C synonymous_variant 0.15
rpsL 781808 c.249C>T synonymous_variant 0.14
rpsL 781811 c.252C>T synonymous_variant 0.14
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1472148 n.303T>C non_coding_transcript_exon_variant 0.18
rrs 1472150 n.305T>A non_coding_transcript_exon_variant 0.17
rrs 1472172 n.327T>C non_coding_transcript_exon_variant 0.22
rrs 1472225 n.380C>A non_coding_transcript_exon_variant 0.19
rrs 1472379 n.534T>C non_coding_transcript_exon_variant 0.15
rrs 1472382 n.537G>A non_coding_transcript_exon_variant 0.15
rrs 1472400 n.555C>T non_coding_transcript_exon_variant 0.16
rrs 1472530 n.685G>A non_coding_transcript_exon_variant 0.13
rrs 1472571 n.726G>A non_coding_transcript_exon_variant 0.13
rrs 1472581 n.736A>C non_coding_transcript_exon_variant 0.11
rrs 1472583 n.738T>A non_coding_transcript_exon_variant 0.12
rrs 1472956 n.1111T>C non_coding_transcript_exon_variant 0.19
rrs 1472958 n.1113A>G non_coding_transcript_exon_variant 0.14
rrs 1473026 n.1181T>C non_coding_transcript_exon_variant 0.17
rrs 1473055 n.1210C>T non_coding_transcript_exon_variant 0.17
rrs 1473056 n.1211A>T non_coding_transcript_exon_variant 0.18
rrs 1473062 n.1217T>G non_coding_transcript_exon_variant 0.29
rrs 1473068 n.1223A>G non_coding_transcript_exon_variant 0.18
rrs 1473089 n.1244A>T non_coding_transcript_exon_variant 0.17
rrs 1473091 n.1246G>A non_coding_transcript_exon_variant 0.17
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.13
rrs 1473201 n.1356A>T non_coding_transcript_exon_variant 0.19
rrs 1473202 n.1357C>T non_coding_transcript_exon_variant 0.2
rrs 1473252 n.1407T>C non_coding_transcript_exon_variant 0.15
rrs 1473315 n.1470T>C non_coding_transcript_exon_variant 0.14
rrs 1473316 n.1471C>T non_coding_transcript_exon_variant 0.14
rrl 1474200 n.545delT non_coding_transcript_exon_variant 0.16
rrl 1474232 n.575C>G non_coding_transcript_exon_variant 0.12
rrl 1474239 n.582G>C non_coding_transcript_exon_variant 0.13
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.17
rrl 1474558 n.901G>T non_coding_transcript_exon_variant 0.23
rrl 1474676 n.1019T>C non_coding_transcript_exon_variant 0.18
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.17
rrl 1474688 n.1031G>C non_coding_transcript_exon_variant 0.17
rrl 1474690 n.1033C>T non_coding_transcript_exon_variant 0.17
rrl 1474722 n.1065T>C non_coding_transcript_exon_variant 0.11
rrl 1474734 n.1077G>T non_coding_transcript_exon_variant 0.23
rrl 1474736 n.1079C>T non_coding_transcript_exon_variant 0.23
rrl 1474777 n.1120T>G non_coding_transcript_exon_variant 0.11
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.18
rrl 1474801 n.1144G>A non_coding_transcript_exon_variant 0.16
rrl 1474802 n.1145T>C non_coding_transcript_exon_variant 0.16
rrl 1474823 n.1166C>G non_coding_transcript_exon_variant 0.17
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.17
rrl 1474896 n.1239A>T non_coding_transcript_exon_variant 0.19
rrl 1474904 n.1247G>C non_coding_transcript_exon_variant 0.16
rrl 1474905 n.1248T>C non_coding_transcript_exon_variant 0.16
rrl 1474913 n.1256T>C non_coding_transcript_exon_variant 0.18
rrl 1475508 n.1851A>T non_coding_transcript_exon_variant 0.24
rrl 1475696 n.2039T>C non_coding_transcript_exon_variant 0.11
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 0.25
rrl 1475900 n.2243A>G non_coding_transcript_exon_variant 0.14
rrl 1475902 n.2245T>C non_coding_transcript_exon_variant 0.16
rrl 1475906 n.2249C>T non_coding_transcript_exon_variant 0.16
rrl 1475916 n.2259C>T non_coding_transcript_exon_variant 0.15
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.23
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.23
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.25
rrl 1476428 n.2771C>T non_coding_transcript_exon_variant 0.24
rrl 1476429 n.2772A>C non_coding_transcript_exon_variant 0.24
rrl 1476466 n.2809C>T non_coding_transcript_exon_variant 0.15
tlyA 1917972 c.33A>G synonymous_variant 1.0
PPE35 2169902 p.Leu237Phe missense_variant 0.25
PPE35 2169910 p.Asn235Tyr missense_variant 0.26
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
Rv2752c 3065873 p.Phe107Val missense_variant 1.0
clpC1 4039865 c.840T>C synonymous_variant 0.13
clpC1 4039875 p.Asn277Arg missense_variant 0.16
clpC1 4039889 c.816G>C synonymous_variant 0.15
clpC1 4040063 c.642G>C synonymous_variant 0.17
clpC1 4040066 c.639G>C synonymous_variant 0.17
clpC1 4040644 c.61A>C synonymous_variant 0.21
clpC1 4040648 c.57G>A synonymous_variant 0.2
whiB6 4338595 c.-75delG upstream_gene_variant 1.0