TB-Profiler result

Run: SRR13861153
Summary

Run ID: SRR13861153

Sample name:

Date: 2024-04-15T02:58:34.341224

Number of reads: 1123950

Percentage reads mapped: 37.5

Median coverage: 39.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
c.2401_2403delGAAinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.19 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
fbiC 1305331 c.2401_2403delGAAinsAC frameshift_variant&missense_variant 0.17 delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
embB 4247448 p.His312Arg missense_variant 0.15 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1317 c.1317A>G synonymous_variant 0.15 isoniazid
gyrB 6280 c.1041T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6286 c.1047T>C synonymous_variant 0.24 levofloxacin
moxifloxacin
gyrB 6292 c.1053G>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6295 c.1056A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrB 6298 c.1059C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrB 6307 c.1068T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin
gyrA 6325 c.-977C>G upstream_gene_variant 0.2 levofloxacin
moxifloxacin
gyrA 8111 c.810G>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 8156 c.855T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8168 c.867A>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8174 c.873C>G synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8177 c.876A>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 8198 c.897T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8204 c.903C>T synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8207 c.906T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 8253 p.Ile318Leu missense_variant 0.2 levofloxacin
moxifloxacin
gyrA 8264 c.963T>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 8267 c.966G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 8283 p.Ile328Leu missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 8987 c.1686C>G synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8990 c.1689C>G synonymous_variant 0.14 levofloxacin
moxifloxacin
fgd1 491121 c.339A>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fgd1 491137 p.Glu119Gln missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491144 p.Ala121Glu missense_variant 0.2 clofazimine
pretomanid
delamanid
fgd1 491166 c.384G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
mshA 575623 c.276C>G synonymous_variant 0.16 ethionamide
isoniazid
mshA 575638 c.291T>C synonymous_variant 0.15 ethionamide
isoniazid
mshA 575641 c.294A>G synonymous_variant 0.15 ethionamide
isoniazid
mshA 575648 p.Val101Gln missense_variant 0.17 ethionamide
isoniazid
mshA 575659 c.312A>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575665 c.318G>C synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575695 c.348C>G synonymous_variant 0.19 ethionamide
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575705 c.358T>C synonymous_variant 0.17 ethionamide
isoniazid
mshA 575713 c.366G>A synonymous_variant 0.18 ethionamide
isoniazid
mshA 575719 c.372C>T synonymous_variant 0.19 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.18 ethionamide
isoniazid
mshA 575737 c.390T>C synonymous_variant 0.19 ethionamide
isoniazid
mshA 575746 c.399C>G synonymous_variant 0.22 ethionamide
isoniazid
mshA 575752 c.405G>A synonymous_variant 0.21 ethionamide
isoniazid Not assoc w R - Interim
ccsA 620661 c.771C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620703 c.813G>C synonymous_variant 0.21 capreomycin
amikacin
kanamycin
ccsA 620710 c.820_822delGTGinsAC frameshift_variant&missense_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620718 c.828G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620721 c.831G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620730 c.840C>T synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620733 c.843G>C synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620734 c.844C>A synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620739 c.849A>G synonymous_variant 0.2 capreomycin
amikacin
kanamycin
ccsA 620745 c.855G>C synonymous_variant 0.19 capreomycin
amikacin
kanamycin
ccsA 620748 c.858T>A synonymous_variant 0.18 capreomycin
amikacin
kanamycin
Rv0565c 657052 p.Phe140Cys missense_variant 0.97 ethionamide
nusG 734424 c.171G>A synonymous_variant 0.16 rifampicin
nusG 734442 c.189G>A synonymous_variant 0.17 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.21 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.22 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.2 rifampicin
nusG 734499 c.246G>C synonymous_variant 0.2 rifampicin
nusG 734532 c.279A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.17 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.18 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.18 rifampicin
rpoB 760328 c.522G>C synonymous_variant 0.18 rifampicin
rpoB 760331 c.525G>C synonymous_variant 0.17 rifampicin
rpoB 760337 c.531C>G synonymous_variant 0.18 rifampicin
rpoB 760340 c.534G>C synonymous_variant 0.17 rifampicin
rpoB 760475 c.669A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>G synonymous_variant 0.17 rifampicin
rpoB 760925 c.1119T>C synonymous_variant 0.18 rifampicin
rpoB 761657 c.1851C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.16 rifampicin
rpoB 762470 c.2664G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.17 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.17 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.15 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.14 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.14 rifampicin
rpoC 764431 c.1062G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.16 rifampicin
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin
rpoC 764455 c.1086G>C synonymous_variant 0.15 rifampicin
rpoC 764458 c.1089G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.15 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.14 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.17 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.18 rifampicin
rpoC 765739 c.2370G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.22 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.2 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766645 c.3276A>G synonymous_variant 0.16 rifampicin
rpoC 766738 c.3369G>T synonymous_variant 0.14 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.15 rifampicin
rpoC 767074 c.3705T>C synonymous_variant 0.14 rifampicin
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.17 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.18 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.18 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.17 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.15 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.15 streptomycin Uncertain significance
rplC 800867 p.Ser20Asn missense_variant 0.23 linezolid
rplC 800889 c.81C>G synonymous_variant 0.2 linezolid
rplC 800907 c.99C>G synonymous_variant 0.16 linezolid
rplC 800916 c.108A>G synonymous_variant 0.16 linezolid
rplC 800937 c.129A>G synonymous_variant 0.15 linezolid
rplC 800939 p.Arg44His missense_variant 0.14 linezolid
rplC 800946 c.138T>C synonymous_variant 0.15 linezolid
rplC 800949 c.141T>C synonymous_variant 0.15 linezolid
rplC 800955 c.147C>G synonymous_variant 0.15 linezolid
rplC 800967 c.159C>G synonymous_variant 0.15 linezolid
rplC 800970 c.162T>C synonymous_variant 0.15 linezolid Not assoc w R - Interim
fbiC 1303632 c.702T>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303638 c.708A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1303686 c.756C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303695 c.765T>C synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1303818 c.888C>G synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1303911 c.981G>C synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303914 c.984C>G synonymous_variant 0.22 clofazimine
pretomanid
delamanid
fbiC 1303920 c.990C>G synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303923 c.993C>T synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303929 c.999G>C synonymous_variant 0.21 clofazimine
pretomanid
delamanid
fbiC 1303947 c.1017T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305311 p.Arg794Gln missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1305336 c.2406T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
sigE 1364478 c.66C>T synonymous_variant 1.0 pyrazinamide
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.24 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.24 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.25 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.26 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833851 p.Lys104Gln missense_variant 0.95 pyrazinamide
rpsA 1834498 c.957C>T synonymous_variant 0.16 pyrazinamide
rpsA 1834528 c.987T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834558 c.1017C>G synonymous_variant 0.17 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.15 pyrazinamide
Rv1979c 2223241 c.-77C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
pncA 2289811 c.-570C>T upstream_gene_variant 1.0 pyrazinamide
pncA 2289994 c.-753A>C upstream_gene_variant 1.0 pyrazinamide
kasA 2518301 p.His63Asp missense_variant 1.0 isoniazid
Rv2477c 2783611 c.432C>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784357 c.-316_-315delTTinsAC upstream_gene_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784366 c.-324G>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784375 c.-333T>C upstream_gene_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784381 c.-339T>C upstream_gene_variant 0.19 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
pepQ 2859859 p.Ala187Glu missense_variant 1.0 clofazimine Uncertain significance
bedaquiline Uncertain significance
Rv2752c 3064886 p.Ala436Pro missense_variant 0.97 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
Rv2752c 3065258 p.Met312Val missense_variant 1.0 ethambutol Uncertain significance
moxifloxacin Uncertain significance
levofloxacin Uncertain significance
rifampicin Uncertain significance
isoniazid Uncertain significance
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.98 ethambutol
moxifloxacin
levofloxacin
rifampicin
isoniazid
thyX 3067445 c.501C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067515 p.Ser144Thr missense_variant 0.17 para-aminosalicylic_acid
thyX 3067531 p.Ala139Thr missense_variant 0.12 para-aminosalicylic_acid
thyX 3067619 c.327A>C synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067718 c.228C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067721 c.225T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067724 c.222G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067727 c.219A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067739 c.207T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067742 c.204A>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067761 p.Arg62Lys missense_variant 0.15 para-aminosalicylic_acid
thyX 3067765 p.Leu61Ile missense_variant 0.15 para-aminosalicylic_acid
thyX 3067781 c.165C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067787 c.159G>A synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067793 c.153T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067799 c.147G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067802 c.144C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067814 c.132T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067826 c.120C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073977 c.495A>G synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074001 c.471C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074004 c.468T>C synonymous_variant 0.18 para-aminosalicylic_acid
thyA 3074010 c.462C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3074031 c.441T>C synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074037 c.435C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3074056 p.Glu139Ala missense_variant 0.16 para-aminosalicylic_acid
Rv3083 3449104 p.Pro201Ala missense_variant 1.0 ethionamide
Rv3236c 3612337 c.779delG frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv3236c 3613541 c.-425C>A upstream_gene_variant 1.0 pyrazinamide
lpqB 3624082 c.829A>C synonymous_variant 0.14 bedaquiline
rifampicin
lpqB 3624086 c.825C>T synonymous_variant 0.16 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624094 c.817A>C synonymous_variant 0.16 bedaquiline
rifampicin
lpqB 3624100 c.811T>C synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624107 c.804C>T synonymous_variant 0.18 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624119 c.792C>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624124 p.Leu263Val missense_variant 0.2 bedaquiline
rifampicin
lpqB 3624125 c.786A>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624166 p.Met249Leu missense_variant 0.22 bedaquiline
rifampicin
lpqB 3624172 p.Val247Ile missense_variant 0.21 bedaquiline
rifampicin
lpqB 3624173 c.738A>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
lpqB 3624188 c.723G>C synonymous_variant 0.22 bedaquiline
rifampicin
lpqB 3624191 c.720C>G synonymous_variant 0.2 bedaquiline
rifampicin
lpqB 3624194 c.717C>A synonymous_variant 0.18 bedaquiline
rifampicin
lpqB 3624200 c.711A>G synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624209 c.702A>C synonymous_variant 0.19 bedaquiline
rifampicin
lpqB 3624346 p.Ser189Pro missense_variant 0.15 bedaquiline
rifampicin
lpqB 3624371 c.540T>G synonymous_variant 0.16 bedaquiline
rifampicin
mtrB 3627008 c.-395G>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627011 c.-398T>G upstream_gene_variant 0.22 bedaquiline
rifampicin
mtrB 3627065 c.-452G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627068 c.282T>C synonymous_variant 0.17 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.18 bedaquiline
rifampicin
mtrA 3627080 c.270T>C synonymous_variant 0.2 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrB 3627086 c.-473C>G upstream_gene_variant 0.2 bedaquiline
rifampicin
mtrA 3627098 c.252A>C synonymous_variant 0.23 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627119 c.231T>G synonymous_variant 0.21 bedaquiline
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627128 c.-515T>C upstream_gene_variant 0.21 bedaquiline
rifampicin
mtrB 3627139 c.-526T>C upstream_gene_variant 0.24 bedaquiline
rifampicin
mtrA 3627882 c.-533C>G upstream_gene_variant 1.0 bedaquiline
rifampicin
fbiB 3641723 c.189T>C synonymous_variant 1.0 clofazimine
pretomanid
delamanid
rpoA 3877740 c.768G>T synonymous_variant 0.87 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.17 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.16 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.17 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878025 c.483C>T synonymous_variant 0.15 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.15 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.15 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.16 rifampicin
rpoA 3878049 c.459G>C synonymous_variant 0.22 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.22 rifampicin
rpoA 3878061 c.447G>C synonymous_variant 0.24 rifampicin
rpoA 3878067 c.441C>G synonymous_variant 0.22 rifampicin
rpoA 3878070 c.438T>C synonymous_variant 0.22 rifampicin
rpoA 3878082 c.426T>C synonymous_variant 0.24 rifampicin
rpoA 3878094 c.414C>G synonymous_variant 0.24 rifampicin
rpoA 3878100 c.408C>G synonymous_variant 0.26 rifampicin
rpoA 3878103 c.405A>G synonymous_variant 0.23 rifampicin
rpoA 3878106 c.402G>C synonymous_variant 0.23 rifampicin
rpoA 3878118 c.390T>C synonymous_variant 0.23 rifampicin
rpoA 3878141 p.Met123Leu missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.2 rifampicin
rpoA 3878169 c.339G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.19 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.15 rifampicin
rpoA 3878217 c.291A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.14 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.17 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.15 rifampicin
clpC1 4038419 c.2286T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038596 c.2109A>G synonymous_variant 0.23 pyrazinamide
clpC1 4038611 c.2094C>T synonymous_variant 0.2 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.2 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.18 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039328 c.1377A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.22 pyrazinamide
clpC1 4039547 c.1158C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039553 c.1152C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039562 c.1143C>G synonymous_variant 0.25 pyrazinamide
clpC1 4039565 c.1140G>C synonymous_variant 0.24 pyrazinamide
clpC1 4039904 c.801A>G synonymous_variant 0.19 pyrazinamide
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.19 pyrazinamide
clpC1 4039931 c.774T>C synonymous_variant 0.19 pyrazinamide
clpC1 4039946 c.759A>T synonymous_variant 0.22 pyrazinamide
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide
clpC1 4039958 c.747G>C synonymous_variant 0.25 pyrazinamide
clpC1 4039979 c.726C>G synonymous_variant 0.27 pyrazinamide
clpC1 4039996 p.Glu237Gln missense_variant 0.24 pyrazinamide
clpC1 4040021 c.684A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.27 pyrazinamide
clpC1 4040033 c.672G>C synonymous_variant 0.24 pyrazinamide
clpC1 4040036 c.669C>G synonymous_variant 0.26 pyrazinamide
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.2 pyrazinamide
clpC1 4040093 c.612C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.23 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.16 pyrazinamide
embC 4239546 c.-317C>T upstream_gene_variant 1.0 ethambutol
embC 4240216 c.354T>C synonymous_variant 0.15 ethambutol
embC 4240229 p.Leu123Met missense_variant 0.14 ethambutol
embC 4240233 p.Gln124Leu missense_variant 0.14 ethambutol
embC 4240632 p.Met257Thr missense_variant 0.15 ethambutol
embC 4240645 c.783G>C synonymous_variant 0.17 ethambutol
embC 4240654 c.792C>T synonymous_variant 0.18 ethambutol
embC 4240657 c.795G>C synonymous_variant 0.18 ethambutol
embC 4240671 p.Thr270Ile missense_variant 0.15 ethambutol Not assoc w R
embC 4241005 c.1143G>T synonymous_variant 0.93 ethambutol
embC 4241081 c.1220delT frameshift_variant 0.88 ethambutol
embC 4242746 p.Pro962Ser missense_variant 1.0 ethambutol Uncertain significance
embA 4243969 p.Val246Ala missense_variant 1.0 ethambutol
embB 4247437 c.924A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248118 c.1605T>C synonymous_variant 0.22 ethambutol
embB 4248127 c.1614G>C synonymous_variant 0.2 ethambutol
embB 4248133 c.1620C>G synonymous_variant 0.17 ethambutol
embB 4248142 c.1629T>C synonymous_variant 0.16 ethambutol
embB 4248143 c.1630T>C synonymous_variant 0.16 ethambutol
embB 4248157 c.1644A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248220 c.1707A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.21 ethambutol
aftB 4269183 c.-347T>C upstream_gene_variant 0.15 ethambutol