Run ID: SRR13861153
Sample name:
Date: 2024-04-15T02:58:34.341224
Number of reads: 1123950
Percentage reads mapped: 37.5
Median coverage: 39.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 1.0 |
lineage4.9 | Euro-American (H37Rv-like) | None | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | embB | p.His312Arg | Mutation from literature | |
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | fbiC | c.1039_1041delGTTinsAC | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
c.2401_2403delGAAinsAC | Assoc w R - Interim | Confers DLM-PMD cross-resistance | ||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
fbiC | 1303969 | c.1039_1041delGTTinsAC | frameshift_variant&missense_variant | 0.19 | delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
fbiC | 1305331 | c.2401_2403delGAAinsAC | frameshift_variant&missense_variant | 0.17 | delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
embB | 4247448 | p.His312Arg | missense_variant | 0.15 | ethambutol | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 1317 | c.1317A>G | synonymous_variant | 0.15 | isoniazid | |
gyrB | 6280 | c.1041T>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6286 | c.1047T>C | synonymous_variant | 0.24 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6292 | c.1053G>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6295 | c.1056A>G | synonymous_variant | 0.21 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6298 | c.1059C>T | synonymous_variant | 0.21 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6299 | c.1060C>T | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrB | 6307 | c.1068T>G | synonymous_variant | 0.22 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6319 | c.1080G>C | synonymous_variant | 0.2 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 6325 | c.-977C>G | upstream_gene_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8111 | c.810G>C | synonymous_variant | 0.17 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8156 | c.855T>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8168 | c.867A>G | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8174 | c.873C>G | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8177 | c.876A>C | synonymous_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8198 | c.897T>C | synonymous_variant | 0.22 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8204 | c.903C>T | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8207 | c.906T>C | synonymous_variant | 0.22 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8253 | p.Ile318Leu | missense_variant | 0.2 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8264 | c.963T>C | synonymous_variant | 0.18 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8267 | c.966G>C | synonymous_variant | 0.18 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8270 | c.969G>C | synonymous_variant | 0.19 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8283 | p.Ile328Leu | missense_variant | 0.16 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 8288 | c.987T>C | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8294 | c.993T>C | synonymous_variant | 0.16 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8324 | c.1023T>C | synonymous_variant | 0.16 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8987 | c.1686C>G | synonymous_variant | 0.15 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8990 | c.1689C>G | synonymous_variant | 0.14 | levofloxacin | |
moxifloxacin | ||||||
fgd1 | 491121 | c.339A>G | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491137 | p.Glu119Gln | missense_variant | 0.2 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491144 | p.Ala121Glu | missense_variant | 0.2 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491166 | c.384G>C | synonymous_variant | 0.17 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
mshA | 575623 | c.276C>G | synonymous_variant | 0.16 | ethionamide | |
isoniazid | ||||||
mshA | 575638 | c.291T>C | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
mshA | 575641 | c.294A>G | synonymous_variant | 0.15 | ethionamide | |
isoniazid | ||||||
mshA | 575648 | p.Val101Gln | missense_variant | 0.17 | ethionamide | |
isoniazid | ||||||
mshA | 575659 | c.312A>G | synonymous_variant | 0.22 | ethionamide | |
isoniazid | ||||||
mshA | 575665 | c.318G>C | synonymous_variant | 0.26 | ethionamide | Not assoc w R - Interim |
isoniazid | Not assoc w R - Interim | |||||
mshA | 575689 | c.342G>C | synonymous_variant | 0.19 | ethionamide | |
isoniazid | ||||||
mshA | 575695 | c.348C>G | synonymous_variant | 0.19 | ethionamide | |
isoniazid | Not assoc w R - Interim | |||||
mshA | 575704 | c.357T>C | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
mshA | 575705 | c.358T>C | synonymous_variant | 0.17 | ethionamide | |
isoniazid | ||||||
mshA | 575713 | c.366G>A | synonymous_variant | 0.18 | ethionamide | |
isoniazid | ||||||
mshA | 575719 | c.372C>T | synonymous_variant | 0.19 | ethionamide | Not assoc w R - Interim |
isoniazid | Not assoc w R - Interim | |||||
mshA | 575734 | c.387T>G | synonymous_variant | 0.18 | ethionamide | |
isoniazid | ||||||
mshA | 575737 | c.390T>C | synonymous_variant | 0.19 | ethionamide | |
isoniazid | ||||||
mshA | 575746 | c.399C>G | synonymous_variant | 0.22 | ethionamide | |
isoniazid | ||||||
mshA | 575752 | c.405G>A | synonymous_variant | 0.21 | ethionamide | |
isoniazid | Not assoc w R - Interim | |||||
ccsA | 620661 | c.771C>G | synonymous_variant | 0.16 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620703 | c.813G>C | synonymous_variant | 0.21 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620710 | c.820_822delGTGinsAC | frameshift_variant&missense_variant | 0.2 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620718 | c.828G>C | synonymous_variant | 0.2 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620721 | c.831G>C | synonymous_variant | 0.2 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620730 | c.840C>T | synonymous_variant | 0.2 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620733 | c.843G>C | synonymous_variant | 0.2 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620734 | c.844C>A | synonymous_variant | 0.2 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620739 | c.849A>G | synonymous_variant | 0.2 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620745 | c.855G>C | synonymous_variant | 0.19 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
ccsA | 620748 | c.858T>A | synonymous_variant | 0.18 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
Rv0565c | 657052 | p.Phe140Cys | missense_variant | 0.97 | ethionamide | |
nusG | 734424 | c.171G>A | synonymous_variant | 0.16 | rifampicin | |
nusG | 734442 | c.189G>A | synonymous_variant | 0.17 | rifampicin | |
nusG | 734457 | c.204C>G | synonymous_variant | 0.21 | rifampicin | |
nusG | 734472 | c.219T>C | synonymous_variant | 0.22 | rifampicin | |
nusG | 734475 | c.222T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
nusG | 734481 | c.228C>G | synonymous_variant | 0.2 | rifampicin | |
nusG | 734499 | c.246G>C | synonymous_variant | 0.2 | rifampicin | |
nusG | 734532 | c.279A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
nusG | 734559 | c.306T>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760181 | c.375T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760184 | c.378A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 760196 | c.390C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoB | 760223 | c.417T>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760235 | c.429T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760283 | c.477G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760307 | c.501T>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760328 | c.522G>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760331 | c.525G>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760337 | c.531C>G | synonymous_variant | 0.18 | rifampicin | |
rpoB | 760340 | c.534G>C | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760475 | c.669A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760481 | c.675G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 760484 | c.678A>G | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760919 | c.1113C>G | synonymous_variant | 0.17 | rifampicin | |
rpoB | 760925 | c.1119T>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761657 | c.1851C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 762218 | c.2412T>G | synonymous_variant | 0.16 | rifampicin | |
rpoB | 762470 | c.2664G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 762989 | c.-381G>C | upstream_gene_variant | 0.17 | rifampicin | |
rpoB | 762995 | c.3189G>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 763136 | c.3330C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 763570 | c.201G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 763594 | c.225C>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763633 | c.264T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 763636 | c.267T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 763732 | c.363C>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 763735 | c.366G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 763744 | c.375G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764431 | c.1062G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764434 | c.1065A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764446 | c.1077T>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764449 | c.1080G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764455 | c.1086G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764458 | c.1089G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765508 | c.2139C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765541 | c.2172C>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 765553 | c.2184C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 765556 | c.2187G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 765613 | p.His748Gln | missense_variant | 0.17 | rifampicin | |
rpoC | 765625 | c.2256C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765628 | c.2259G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765631 | p.Asp754Glu | missense_variant | 0.18 | rifampicin | |
rpoC | 765739 | c.2370G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 765826 | c.2457T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 765835 | c.2466C>T | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 765883 | c.2514C>G | synonymous_variant | 0.22 | rifampicin | |
rpoC | 765886 | c.2517C>G | synonymous_variant | 0.2 | rifampicin | |
rpoC | 765892 | c.2523T>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 765928 | c.2559C>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 766645 | c.3276A>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766738 | c.3369G>T | synonymous_variant | 0.14 | rifampicin | |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 767062 | c.3693C>A | synonymous_variant | 0.15 | rifampicin | |
rpoC | 767074 | c.3705T>C | synonymous_variant | 0.14 | rifampicin | |
rpsL | 781682 | c.123T>C | synonymous_variant | 0.19 | streptomycin | |
rpsL | 781751 | c.192G>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781754 | c.195G>C | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.18 | streptomycin | |
rpsL | 781793 | c.234G>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.15 | streptomycin | |
rpsL | 781929 | p.Gly124Ser | missense_variant | 0.15 | streptomycin | Uncertain significance |
rplC | 800867 | p.Ser20Asn | missense_variant | 0.23 | linezolid | |
rplC | 800889 | c.81C>G | synonymous_variant | 0.2 | linezolid | |
rplC | 800907 | c.99C>G | synonymous_variant | 0.16 | linezolid | |
rplC | 800916 | c.108A>G | synonymous_variant | 0.16 | linezolid | |
rplC | 800937 | c.129A>G | synonymous_variant | 0.15 | linezolid | |
rplC | 800939 | p.Arg44His | missense_variant | 0.14 | linezolid | |
rplC | 800946 | c.138T>C | synonymous_variant | 0.15 | linezolid | |
rplC | 800949 | c.141T>C | synonymous_variant | 0.15 | linezolid | |
rplC | 800955 | c.147C>G | synonymous_variant | 0.15 | linezolid | |
rplC | 800967 | c.159C>G | synonymous_variant | 0.15 | linezolid | |
rplC | 800970 | c.162T>C | synonymous_variant | 0.15 | linezolid | Not assoc w R - Interim |
fbiC | 1303632 | c.702T>G | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303638 | c.708A>G | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303686 | c.756C>G | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303695 | c.765T>C | synonymous_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303818 | c.888C>G | synonymous_variant | 0.13 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303911 | c.981G>C | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303914 | c.984C>G | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303920 | c.990C>G | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303923 | c.993C>T | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303929 | c.999G>C | synonymous_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303947 | c.1017T>C | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303948 | p.Gly340Arg | missense_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303973 | p.Gly348Ala | missense_variant | 0.17 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1305311 | p.Arg794Gln | missense_variant | 0.17 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1305336 | c.2406T>C | synonymous_variant | 0.16 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
sigE | 1364478 | c.66C>T | synonymous_variant | 1.0 | pyrazinamide | |
rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.24 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472970 | n.1125C>G | non_coding_transcript_exon_variant | 0.24 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472977 | n.1132G>C | non_coding_transcript_exon_variant | 0.25 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.26 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.16 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.16 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.15 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1474009 | n.352A>G | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | ||||||
rrl | 1474012 | n.355C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1474140 | n.483C>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474151 | n.494C>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474181 | n.524C>T | non_coding_transcript_exon_variant | 0.13 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474249 | n.592G>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475199 | n.1542G>A | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1475206 | n.1549C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475213 | n.1556C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475249 | n.1592T>C | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475276 | n.1619T>C | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | ||||||
rrl | 1475291 | n.1634A>C | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rpsA | 1833851 | p.Lys104Gln | missense_variant | 0.95 | pyrazinamide | |
rpsA | 1834498 | c.957C>T | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834528 | c.987T>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1834546 | c.1005T>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834555 | c.1014T>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834558 | c.1017C>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1834688 | c.1147_1149delAGTinsTCC | synonymous_variant | 0.15 | pyrazinamide | |
Rv1979c | 2223241 | c.-77C>G | upstream_gene_variant | 1.0 | clofazimine | |
bedaquiline | ||||||
pncA | 2289811 | c.-570C>T | upstream_gene_variant | 1.0 | pyrazinamide | |
pncA | 2289994 | c.-753A>C | upstream_gene_variant | 1.0 | pyrazinamide | |
kasA | 2518301 | p.His63Asp | missense_variant | 1.0 | isoniazid | |
Rv2477c | 2783611 | c.432C>G | synonymous_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2784357 | c.-316_-315delTTinsAC | upstream_gene_variant | 0.14 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2784366 | c.-324G>C | upstream_gene_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2784375 | c.-333T>C | upstream_gene_variant | 0.16 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2784381 | c.-339T>C | upstream_gene_variant | 0.19 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2784390 | c.-348G>C | upstream_gene_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2784396 | c.-354A>C | upstream_gene_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
Rv2477c | 2784405 | c.-363T>C | upstream_gene_variant | 0.17 | ethambutol | |
moxifloxacin | ||||||
streptomycin | ||||||
levofloxacin | ||||||
kanamycin | ||||||
rifampicin | ||||||
amikacin | ||||||
pepQ | 2859859 | p.Ala187Glu | missense_variant | 1.0 | clofazimine | Uncertain significance |
bedaquiline | Uncertain significance | |||||
Rv2752c | 3064886 | p.Ala436Pro | missense_variant | 0.97 | ethambutol | |
moxifloxacin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
Rv2752c | 3065258 | p.Met312Val | missense_variant | 1.0 | ethambutol | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
levofloxacin | Uncertain significance | |||||
rifampicin | Uncertain significance | |||||
isoniazid | Uncertain significance | |||||
Rv2752c | 3066561 | c.-370A>C | upstream_gene_variant | 0.98 | ethambutol | |
moxifloxacin | ||||||
levofloxacin | ||||||
rifampicin | ||||||
isoniazid | ||||||
thyX | 3067445 | c.501C>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067515 | p.Ser144Thr | missense_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067531 | p.Ala139Thr | missense_variant | 0.12 | para-aminosalicylic_acid | |
thyX | 3067619 | c.327A>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyX | 3067718 | c.228C>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067721 | c.225T>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067724 | c.222G>A | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
thyX | 3067727 | c.219A>C | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
thyX | 3067739 | c.207T>C | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
thyX | 3067742 | c.204A>C | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
thyX | 3067761 | p.Arg62Lys | missense_variant | 0.15 | para-aminosalicylic_acid | |
thyX | 3067765 | p.Leu61Ile | missense_variant | 0.15 | para-aminosalicylic_acid | |
thyX | 3067781 | c.165C>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067787 | c.159G>A | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
thyX | 3067793 | c.153T>C | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
thyX | 3067799 | c.147G>A | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067802 | c.144C>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067814 | c.132T>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyX | 3067826 | c.120C>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyA | 3073925 | c.547T>C | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyA | 3073926 | c.546G>C | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyA | 3073929 | c.543T>C | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyA | 3073977 | c.495A>G | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyA | 3073989 | c.483T>C | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyA | 3074001 | c.471C>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyA | 3074004 | c.468T>C | synonymous_variant | 0.18 | para-aminosalicylic_acid | |
thyA | 3074010 | c.462C>G | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyA | 3074031 | c.441T>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyA | 3074037 | c.435C>G | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyA | 3074056 | p.Glu139Ala | missense_variant | 0.16 | para-aminosalicylic_acid | |
Rv3083 | 3449104 | p.Pro201Ala | missense_variant | 1.0 | ethionamide | |
Rv3236c | 3612337 | c.779delG | frameshift_variant | 1.0 | pyrazinamide | Uncertain significance |
Rv3236c | 3613541 | c.-425C>A | upstream_gene_variant | 1.0 | pyrazinamide | |
lpqB | 3624082 | c.829A>C | synonymous_variant | 0.14 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624086 | c.825C>T | synonymous_variant | 0.16 | bedaquiline | Not assoc w R - Interim |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3624094 | c.817A>C | synonymous_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624100 | c.811T>C | synonymous_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624107 | c.804C>T | synonymous_variant | 0.18 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3624119 | c.792C>G | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624124 | p.Leu263Val | missense_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624125 | c.786A>G | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624166 | p.Met249Leu | missense_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624172 | p.Val247Ile | missense_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624173 | c.738A>C | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
lpqB | 3624188 | c.723G>C | synonymous_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624191 | c.720C>G | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624194 | c.717C>A | synonymous_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624200 | c.711A>G | synonymous_variant | 0.19 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624209 | c.702A>C | synonymous_variant | 0.19 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624346 | p.Ser189Pro | missense_variant | 0.15 | bedaquiline | |
rifampicin | ||||||
lpqB | 3624371 | c.540T>G | synonymous_variant | 0.16 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627008 | c.-395G>C | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627011 | c.-398T>G | upstream_gene_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627065 | c.-452G>C | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627068 | c.282T>C | synonymous_variant | 0.17 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627074 | c.-461G>C | upstream_gene_variant | 0.18 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627080 | c.270T>C | synonymous_variant | 0.2 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627083 | c.-470G>C | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627086 | c.-473C>G | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627098 | c.252A>C | synonymous_variant | 0.23 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627104 | c.-491C>G | upstream_gene_variant | 0.24 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627119 | c.231T>G | synonymous_variant | 0.21 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627122 | c.-509T>C | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627128 | c.-515T>C | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627139 | c.-526T>C | upstream_gene_variant | 0.24 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627882 | c.-533C>G | upstream_gene_variant | 1.0 | bedaquiline | |
rifampicin | ||||||
fbiB | 3641723 | c.189T>C | synonymous_variant | 1.0 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
rpoA | 3877740 | c.768G>T | synonymous_variant | 0.87 | rifampicin | |
rpoA | 3877743 | c.765T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3877839 | c.669G>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3877857 | c.651G>A | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3877866 | c.642G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3877872 | c.636C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3877986 | c.522G>C | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3877989 | c.519A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878001 | c.507A>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878025 | c.483C>T | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878028 | c.480G>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878031 | c.477T>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878040 | c.468T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoA | 3878046 | c.462T>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878049 | c.459G>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878055 | c.453A>G | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878061 | c.447G>C | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3878067 | c.441C>G | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878070 | c.438T>C | synonymous_variant | 0.22 | rifampicin | |
rpoA | 3878082 | c.426T>C | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3878094 | c.414C>G | synonymous_variant | 0.24 | rifampicin | |
rpoA | 3878100 | c.408C>G | synonymous_variant | 0.26 | rifampicin | |
rpoA | 3878103 | c.405A>G | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878106 | c.402G>C | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878118 | c.390T>C | synonymous_variant | 0.23 | rifampicin | |
rpoA | 3878141 | p.Met123Leu | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoA | 3878142 | p.Gly122Glu | missense_variant | 0.2 | rifampicin | |
rpoA | 3878169 | c.339G>C | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3878184 | c.324C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoA | 3878187 | c.321C>G | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878193 | c.315T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878202 | c.306G>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878217 | c.291A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878220 | c.288C>T | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3878284 | p.Glu75Ala | missense_variant | 0.14 | rifampicin | |
rpoA | 3879088 | c.-581A>C | upstream_gene_variant | 0.17 | rifampicin | |
rpoA | 3879094 | c.-587T>C | upstream_gene_variant | 0.15 | rifampicin | |
clpC1 | 4038419 | c.2286T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038434 | c.2271G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038596 | c.2109A>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038611 | c.2094C>T | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038623 | c.2082A>G | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038815 | c.1890G>T | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038932 | c.1773G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038956 | c.1749T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038971 | c.1734T>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038974 | c.1731T>C | synonymous_variant | 0.14 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039319 | c.1386T>C | synonymous_variant | 0.19 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039322 | c.1383T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039328 | c.1377A>G | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039334 | c.1371G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039481 | c.1224T>G | synonymous_variant | 0.23 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039484 | c.1221T>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039547 | c.1158C>G | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039553 | c.1152C>G | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4039562 | c.1143C>G | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039565 | c.1140G>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039904 | c.801A>G | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039928 | c.775_777delAGCinsTCG | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039931 | c.774T>C | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039946 | c.759A>T | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039952 | c.753T>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4039958 | c.747G>C | synonymous_variant | 0.25 | pyrazinamide | |
clpC1 | 4039979 | c.726C>G | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4039996 | p.Glu237Gln | missense_variant | 0.24 | pyrazinamide | |
clpC1 | 4040021 | c.684A>C | synonymous_variant | 0.27 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040024 | c.681A>G | synonymous_variant | 0.27 | pyrazinamide | |
clpC1 | 4040033 | c.672G>C | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4040036 | c.669C>G | synonymous_variant | 0.26 | pyrazinamide | |
clpC1 | 4040090 | c.613_615delTCTinsAGC | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4040093 | c.612C>G | synonymous_variant | 0.21 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4040105 | c.600C>G | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4040369 | c.336C>G | synonymous_variant | 0.16 | pyrazinamide | |
embC | 4239546 | c.-317C>T | upstream_gene_variant | 1.0 | ethambutol | |
embC | 4240216 | c.354T>C | synonymous_variant | 0.15 | ethambutol | |
embC | 4240229 | p.Leu123Met | missense_variant | 0.14 | ethambutol | |
embC | 4240233 | p.Gln124Leu | missense_variant | 0.14 | ethambutol | |
embC | 4240632 | p.Met257Thr | missense_variant | 0.15 | ethambutol | |
embC | 4240645 | c.783G>C | synonymous_variant | 0.17 | ethambutol | |
embC | 4240654 | c.792C>T | synonymous_variant | 0.18 | ethambutol | |
embC | 4240657 | c.795G>C | synonymous_variant | 0.18 | ethambutol | |
embC | 4240671 | p.Thr270Ile | missense_variant | 0.15 | ethambutol | Not assoc w R |
embC | 4241005 | c.1143G>T | synonymous_variant | 0.93 | ethambutol | |
embC | 4241081 | c.1220delT | frameshift_variant | 0.88 | ethambutol | |
embC | 4242746 | p.Pro962Ser | missense_variant | 1.0 | ethambutol | Uncertain significance |
embA | 4243969 | p.Val246Ala | missense_variant | 1.0 | ethambutol | |
embB | 4247437 | c.924A>G | synonymous_variant | 0.15 | ethambutol | Not assoc w R - Interim |
embB | 4248118 | c.1605T>C | synonymous_variant | 0.22 | ethambutol | |
embB | 4248127 | c.1614G>C | synonymous_variant | 0.2 | ethambutol | |
embB | 4248133 | c.1620C>G | synonymous_variant | 0.17 | ethambutol | |
embB | 4248142 | c.1629T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248143 | c.1630T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248157 | c.1644A>G | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
embB | 4248220 | c.1707A>G | synonymous_variant | 0.19 | ethambutol | Not assoc w R - Interim |
embB | 4248241 | c.1728C>T | synonymous_variant | 0.21 | ethambutol | |
aftB | 4269183 | c.-347T>C | upstream_gene_variant | 0.15 | ethambutol |