TB-Profiler result

Run: SRR13861153
Summary

Run ID: SRR13861153

Sample name:

Date: 2025-09-15T16:15:54.874882

Number of reads: 1123950

Percentage reads mapped: 37.5

Median coverage: 39.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 100.0
lineage4.9 Euro-American (H37Rv-like) None 100.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.His312Arg Mutation from literature
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
embB 4247448 p.His312Arg missense_variant 0.15 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1317 c.1317A>G synonymous_variant 0.15 isoniazid Uncertain significance
gyrB 6280 c.1041T>C synonymous_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6286 c.1047T>C synonymous_variant 0.24 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6292 c.1053G>C synonymous_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6295 c.1056A>G synonymous_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6298 c.1059C>T synonymous_variant 0.21 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6299 c.1060C>T synonymous_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrB 6307 c.1068T>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrB 6319 c.1080G>C synonymous_variant 0.2 levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
gyrA 6325 c.-977C>G upstream_gene_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8111 c.810G>C synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8156 c.855T>C synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8168 c.867A>G synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8174 c.873C>G synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8177 c.876A>C synonymous_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8198 c.897T>C synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8204 c.903C>T synonymous_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8207 c.906T>C synonymous_variant 0.22 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8253 p.Ile318Leu missense_variant 0.2 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8264 c.963T>C synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8267 c.966G>C synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8270 c.969G>C synonymous_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8283 p.Ile328Leu missense_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8288 c.987T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8294 c.993T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8324 c.1023T>C synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8987 c.1686C>G synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8990 c.1689C>G synonymous_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
fgd1 491121 c.339A>G synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491137 p.Glu119Gln missense_variant 0.2 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491144 p.Ala121Glu missense_variant 0.2 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fgd1 491166 c.384G>C synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
mshA 575623 c.276C>G synonymous_variant 0.16 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575638 c.291T>C synonymous_variant 0.15 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575641 c.294A>G synonymous_variant 0.15 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575648 p.Val101Gln missense_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575659 c.312A>G synonymous_variant 0.22 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575665 c.318G>C synonymous_variant 0.26 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575689 c.342G>C synonymous_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575695 c.348C>G synonymous_variant 0.19 ethionamide Uncertain significance
isoniazid Not assoc w R - Interim
mshA 575704 c.357T>C synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575705 c.358T>C synonymous_variant 0.17 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575713 c.366G>A synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575719 c.372C>T synonymous_variant 0.19 ethionamide Not assoc w R - Interim
isoniazid Not assoc w R - Interim
mshA 575734 c.387T>G synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575737 c.390T>C synonymous_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575746 c.399C>G synonymous_variant 0.22 ethionamide Uncertain significance
isoniazid Uncertain significance
mshA 575752 c.405G>A synonymous_variant 0.21 ethionamide Uncertain significance
isoniazid Not assoc w R - Interim
ccsA 620661 c.771C>G synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620703 c.813G>C synonymous_variant 0.21 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620710 p.Val274Ile missense_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620718 c.828G>C synonymous_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620721 c.831G>C synonymous_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620730 c.840C>T synonymous_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620733 c.843G>C synonymous_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620734 c.844C>A synonymous_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620739 c.849A>G synonymous_variant 0.2 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620745 c.855G>C synonymous_variant 0.19 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620748 c.858T>A synonymous_variant 0.18 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
Rv0565c 657052 p.Phe140Cys missense_variant 0.97 ethionamide Uncertain significance
nusG 734424 c.171G>A synonymous_variant 0.16 rifampicin Uncertain significance
nusG 734442 c.189G>A synonymous_variant 0.17 rifampicin Uncertain significance
nusG 734457 c.204C>G synonymous_variant 0.21 rifampicin Uncertain significance
nusG 734472 c.219T>C synonymous_variant 0.22 rifampicin Uncertain significance
nusG 734475 c.222T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.2 rifampicin Uncertain significance
nusG 734499 c.246G>C synonymous_variant 0.2 rifampicin Uncertain significance
nusG 734532 c.279A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734559 c.306T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 760181 c.375T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760223 c.417T>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 760235 c.429T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 760328 c.522G>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 760331 c.525G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 760337 c.531C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 760340 c.534G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 760475 c.669A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760481 c.675G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760484 c.678A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760919 c.1113C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 760925 c.1119T>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 761657 c.1851C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762218 c.2412T>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 762470 c.2664G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762989 c.-381G>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoB 762995 c.3189G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763136 c.3330C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 763732 c.363C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 763735 c.366G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 763744 c.375G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 764431 c.1062G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764434 c.1065A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764446 c.1077T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 764449 c.1080G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 764455 c.1086G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 764458 c.1089G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765508 c.2139C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765541 c.2172C>G synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 765553 c.2184C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 765613 p.His748Gln missense_variant 0.17 rifampicin Uncertain significance
rpoC 765625 c.2256C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765631 p.Asp754Glu missense_variant 0.18 rifampicin Uncertain significance
rpoC 765739 c.2370G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.22 rifampicin Uncertain significance
rpoC 765886 c.2517C>G synonymous_variant 0.2 rifampicin Uncertain significance
rpoC 765892 c.2523T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766645 c.3276A>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 766738 c.3369G>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 767059 c.3690T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 767074 c.3705T>C synonymous_variant 0.14 rifampicin Uncertain significance
rpsL 781682 c.123T>C synonymous_variant 0.19 streptomycin Uncertain significance
rpsL 781751 c.192G>C synonymous_variant 0.17 streptomycin Uncertain significance
rpsL 781754 c.195G>C synonymous_variant 0.18 streptomycin Uncertain significance
rpsL 781760 c.201T>C synonymous_variant 0.18 streptomycin Uncertain significance
rpsL 781793 c.234G>C synonymous_variant 0.17 streptomycin Uncertain significance
rpsL 781898 c.339A>T synonymous_variant 0.15 streptomycin Uncertain significance
rpsL 781929 p.Gly124Ser missense_variant 0.15 streptomycin Uncertain significance
rplC 800867 p.Ser20Asn missense_variant 0.23 linezolid Uncertain significance
rplC 800889 c.81C>G synonymous_variant 0.2 linezolid Uncertain significance
rplC 800907 c.99C>G synonymous_variant 0.16 linezolid Uncertain significance
rplC 800916 c.108A>G synonymous_variant 0.16 linezolid Uncertain significance
rplC 800937 c.129A>G synonymous_variant 0.15 linezolid Uncertain significance
rplC 800939 p.Arg44His missense_variant 0.14 linezolid Uncertain significance
rplC 800946 c.138T>C synonymous_variant 0.15 linezolid Uncertain significance
rplC 800949 c.141T>C synonymous_variant 0.15 linezolid Uncertain significance
rplC 800955 c.147C>G synonymous_variant 0.15 linezolid Uncertain significance
rplC 800967 c.159C>G synonymous_variant 0.15 linezolid Uncertain significance
rplC 800970 c.162T>C synonymous_variant 0.15 linezolid Not assoc w R - Interim
fbiC 1303632 c.702T>G synonymous_variant 0.16 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303638 c.708A>G synonymous_variant 0.16 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303686 c.756C>G synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303695 c.765T>C synonymous_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303818 c.888C>G synonymous_variant 0.13 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303911 c.981G>C synonymous_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303914 c.984C>G synonymous_variant 0.22 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303920 c.990C>G synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303923 c.993C>T synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303929 c.999G>C synonymous_variant 0.21 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303947 c.1017T>C synonymous_variant 0.19 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303948 p.Gly340Arg missense_variant 0.19 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303969 p.Val347Ile missense_variant 0.19 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1303973 p.Gly348Ala missense_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305311 p.Arg794Gln missense_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305331 p.Glu801Asn missense_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305336 c.2406T>C synonymous_variant 0.16 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
sigE 1364478 c.66C>T synonymous_variant 1.0 pyrazinamide Uncertain significance
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.24 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.24 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.25 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.26 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474151 n.494C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475199 n.1542G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475206 n.1549C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475249 n.1592T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833851 p.Lys104Gln missense_variant 0.95 pyrazinamide Uncertain significance
rpsA 1834498 c.957C>T synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834528 c.987T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
rpsA 1834546 c.1005T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834555 c.1014T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834558 c.1017C>G synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.15 pyrazinamide Uncertain significance
Rv1979c 2223241 c.-77C>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
pncA 2289811 c.-570C>T upstream_gene_variant 1.0 pyrazinamide Uncertain significance
pncA 2289994 c.-753A>C upstream_gene_variant 1.0 pyrazinamide Uncertain significance
kasA 2518301 p.His63Asp missense_variant 1.0 isoniazid Uncertain significance
Rv2477c 2783611 c.432C>G synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784357 c.-316_-315delTTinsAC upstream_gene_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784366 c.-324G>C upstream_gene_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784375 c.-333T>C upstream_gene_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784381 c.-339T>C upstream_gene_variant 0.19 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784390 c.-348G>C upstream_gene_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784396 c.-354A>C upstream_gene_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2784405 c.-363T>C upstream_gene_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
pepQ 2859859 p.Ala187Glu missense_variant 1.0 bedaquiline Uncertain significance
clofazimine Uncertain significance
Rv2752c 3064886 p.Ala436Pro missense_variant 0.97 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3065258 p.Met312Val missense_variant 1.0 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
Rv2752c 3066561 c.-370A>C upstream_gene_variant 0.98 ethambutol Uncertain significance
isoniazid Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
thyX 3067445 c.501C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067515 p.Ser144Thr missense_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067531 p.Ala139Thr missense_variant 0.12 para-aminosalicylic_acid Uncertain significance
thyX 3067619 c.327A>C synonymous_variant 0.15 para-aminosalicylic_acid Uncertain significance
thyX 3067718 c.228C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067721 c.225T>C synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067724 c.222G>A synonymous_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067727 c.219A>C synonymous_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067739 c.207T>C synonymous_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067742 c.204A>C synonymous_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067761 p.Arg62Lys missense_variant 0.15 para-aminosalicylic_acid Uncertain significance
thyX 3067765 p.Leu61Ile missense_variant 0.15 para-aminosalicylic_acid Uncertain significance
thyX 3067781 c.165C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067787 c.159G>A synonymous_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067793 c.153T>C synonymous_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyX 3067799 c.147G>A synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067802 c.144C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067814 c.132T>C synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyX 3067826 c.120C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyA 3073925 c.547T>C synonymous_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyA 3073926 c.546G>C synonymous_variant 0.19 para-aminosalicylic_acid Uncertain significance
thyA 3073929 c.543T>C synonymous_variant 0.19 para-aminosalicylic_acid Uncertain significance
thyA 3073977 c.495A>G synonymous_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyA 3073989 c.483T>C synonymous_variant 0.19 para-aminosalicylic_acid Uncertain significance
thyA 3074001 c.471C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyA 3074004 c.468T>C synonymous_variant 0.18 para-aminosalicylic_acid Uncertain significance
thyA 3074010 c.462C>G synonymous_variant 0.19 para-aminosalicylic_acid Uncertain significance
thyA 3074031 c.441T>C synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyA 3074037 c.435C>G synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyA 3074056 p.Glu139Ala missense_variant 0.16 para-aminosalicylic_acid Uncertain significance
Rv3083 3449104 p.Pro201Ala missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3612337 c.779delG frameshift_variant 1.0 pyrazinamide Uncertain significance
Rv3236c 3613541 c.-425C>A upstream_gene_variant 1.0 pyrazinamide Uncertain significance
lpqB 3624082 c.829A>C synonymous_variant 0.14 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624086 c.825C>T synonymous_variant 0.16 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
lpqB 3624094 c.817A>C synonymous_variant 0.16 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624100 c.811T>C synonymous_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624107 c.804C>T synonymous_variant 0.18 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3624119 c.792C>G synonymous_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624124 p.Leu263Val missense_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624125 c.786A>G synonymous_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624166 p.Met249Leu missense_variant 0.22 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624172 p.Val247Ile missense_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624173 c.738A>C synonymous_variant 0.2 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
lpqB 3624188 c.723G>C synonymous_variant 0.22 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624191 c.720C>G synonymous_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624194 c.717C>A synonymous_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624200 c.711A>G synonymous_variant 0.19 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624209 c.702A>C synonymous_variant 0.19 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624346 p.Ser189Pro missense_variant 0.15 bedaquiline Uncertain significance
rifampicin Uncertain significance
lpqB 3624371 c.540T>G synonymous_variant 0.16 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627008 c.-395G>C upstream_gene_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627011 c.-398T>G upstream_gene_variant 0.22 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627065 c.-452G>C upstream_gene_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627068 c.282T>C synonymous_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3627074 c.-461G>C upstream_gene_variant 0.18 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627080 c.270T>C synonymous_variant 0.2 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3627083 c.-470G>C upstream_gene_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627086 c.-473C>G upstream_gene_variant 0.2 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627098 c.252A>C synonymous_variant 0.23 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3627104 c.-491C>G upstream_gene_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627119 c.231T>G synonymous_variant 0.21 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
mtrB 3627122 c.-509T>C upstream_gene_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627128 c.-515T>C upstream_gene_variant 0.21 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrB 3627139 c.-526T>C upstream_gene_variant 0.24 bedaquiline Uncertain significance
rifampicin Uncertain significance
mtrA 3627882 c.-533C>G upstream_gene_variant 1.0 bedaquiline Uncertain significance
rifampicin Uncertain significance
fbiB 3641723 c.189T>C synonymous_variant 1.0 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
rpoA 3877740 c.768G>T synonymous_variant 0.87 rifampicin Uncertain significance
rpoA 3877743 c.765T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877839 c.669G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3877857 c.651G>A synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3877866 c.642G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3877872 c.636C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878025 c.483C>T synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878028 c.480G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878031 c.477T>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878040 c.468T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878049 c.459G>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoA 3878055 c.453A>G synonymous_variant 0.22 rifampicin Uncertain significance
rpoA 3878061 c.447G>C synonymous_variant 0.24 rifampicin Uncertain significance
rpoA 3878067 c.441C>G synonymous_variant 0.22 rifampicin Uncertain significance
rpoA 3878070 c.438T>C synonymous_variant 0.22 rifampicin Uncertain significance
rpoA 3878082 c.426T>C synonymous_variant 0.24 rifampicin Uncertain significance
rpoA 3878094 c.414C>G synonymous_variant 0.24 rifampicin Uncertain significance
rpoA 3878100 c.408C>G synonymous_variant 0.26 rifampicin Uncertain significance
rpoA 3878103 c.405A>G synonymous_variant 0.23 rifampicin Uncertain significance
rpoA 3878106 c.402G>C synonymous_variant 0.23 rifampicin Uncertain significance
rpoA 3878118 c.390T>C synonymous_variant 0.23 rifampicin Uncertain significance
rpoA 3878141 p.Met123Leu missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878169 c.339G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.19 rifampicin Uncertain significance
rpoA 3878193 c.315T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878202 c.306G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878217 c.291A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878220 c.288C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.14 rifampicin Uncertain significance
rpoA 3879088 c.-581A>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3879094 c.-587T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
clpC1 4038419 c.2286T>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4038434 c.2271G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4038596 c.2109A>G synonymous_variant 0.23 pyrazinamide Uncertain significance
clpC1 4038611 c.2094C>T synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4038623 c.2082A>G synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4038815 c.1890G>T synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4038932 c.1773G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4038953 c.1752A>G synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038956 c.1749T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4038965 c.1740T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038971 c.1734T>C synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4038974 c.1731T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039319 c.1386T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039328 c.1377A>G synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039334 c.1371G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039481 c.1224T>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039547 c.1158C>G synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039553 c.1152C>G synonymous_variant 0.26 pyrazinamide Uncertain significance
clpC1 4039562 c.1143C>G synonymous_variant 0.25 pyrazinamide Uncertain significance
clpC1 4039565 c.1140G>C synonymous_variant 0.24 pyrazinamide Uncertain significance
clpC1 4039904 c.801A>G synonymous_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039928 c.775_777delAGCinsTCG synonymous_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039931 c.774T>C synonymous_variant 0.19 pyrazinamide Uncertain significance
clpC1 4039946 c.759A>T synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4039952 c.753T>C synonymous_variant 0.23 pyrazinamide Uncertain significance
clpC1 4039958 c.747G>C synonymous_variant 0.25 pyrazinamide Uncertain significance
clpC1 4039979 c.726C>G synonymous_variant 0.27 pyrazinamide Uncertain significance
clpC1 4039996 p.Glu237Gln missense_variant 0.24 pyrazinamide Uncertain significance
clpC1 4040021 c.684A>C synonymous_variant 0.27 pyrazinamide Not assoc w R - Interim
clpC1 4040024 c.681A>G synonymous_variant 0.27 pyrazinamide Uncertain significance
clpC1 4040033 c.672G>C synonymous_variant 0.24 pyrazinamide Uncertain significance
clpC1 4040036 c.669C>G synonymous_variant 0.26 pyrazinamide Uncertain significance
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.2 pyrazinamide Uncertain significance
clpC1 4040093 c.612C>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4040105 c.600C>G synonymous_variant 0.23 pyrazinamide Uncertain significance
clpC1 4040369 c.336C>G synonymous_variant 0.16 pyrazinamide Uncertain significance
embC 4239546 c.-317C>T upstream_gene_variant 1.0 ethambutol Uncertain significance
embC 4240216 c.354T>C synonymous_variant 0.15 ethambutol Uncertain significance
embC 4240229 p.Leu123Met missense_variant 0.14 ethambutol Uncertain significance
embC 4240233 p.Gln124Leu missense_variant 0.14 ethambutol Uncertain significance
embC 4240632 p.Met257Thr missense_variant 0.15 ethambutol Uncertain significance
embC 4240645 c.783G>C synonymous_variant 0.17 ethambutol Uncertain significance
embC 4240654 c.792C>T synonymous_variant 0.18 ethambutol Uncertain significance
embC 4240657 c.795G>C synonymous_variant 0.18 ethambutol Uncertain significance
embC 4240671 p.Thr270Ile missense_variant 0.15 ethambutol Not assoc w R
embC 4241005 c.1143G>T synonymous_variant 0.93 ethambutol Uncertain significance
embC 4241081 c.1220delT frameshift_variant 0.88 ethambutol Uncertain significance
embC 4242746 p.Pro962Ser missense_variant 1.0 ethambutol Uncertain significance
embA 4243969 p.Val246Ala missense_variant 1.0 ethambutol Uncertain significance
embB 4247437 c.924A>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embB 4248118 c.1605T>C synonymous_variant 0.22 ethambutol Uncertain significance
embB 4248127 c.1614G>C synonymous_variant 0.2 ethambutol Uncertain significance
embB 4248133 c.1620C>G synonymous_variant 0.17 ethambutol Uncertain significance
embB 4248142 c.1629T>C synonymous_variant 0.16 ethambutol Uncertain significance
embB 4248143 c.1630T>C synonymous_variant 0.16 ethambutol Uncertain significance
embB 4248157 c.1644A>G synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4248220 c.1707A>G synonymous_variant 0.19 ethambutol Not assoc w R - Interim
embB 4248241 c.1728C>T synonymous_variant 0.21 ethambutol Uncertain significance
aftB 4269183 c.-347T>C upstream_gene_variant 0.15 ethambutol Uncertain significance