TB-Profiler result

Run: SRR28351488
Summary

Run ID: SRR28351488

Sample name:

Date: 2024-05-22T15:04:49.996735

Number of reads: 4416039

Percentage reads mapped: 99.74

Median coverage: 121.0

Strain: lineage2.2.1

Spoligotype:

Drug-resistance: MDR-TB

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage2 East-Asian RD105 0.99
lineage2.2.1 East-Asian (Beijing) RD105;RD207;RD181 0.99
lineage2.2 East-Asian (Beijing) RD105;RD207 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin rpoB p.Asp435Tyr Assoc w R
isoniazid katG p.Ser315Thr Assoc w R High-level resistance
ethambutol embB p.Met306Val Assoc w R
pyrazinamide
streptomycin rpsL p.Lys43Arg Assoc w R
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rpoB 761109 p.Asp435Tyr missense_variant 0.7 rifampicin Assoc w R
rpsL 781687 p.Lys43Arg missense_variant 0.99 streptomycin Assoc w R
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid Assoc w R High-level resistance
embB 4247429 p.Met306Val missense_variant 0.98 ethambutol Assoc w R
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1448 p.Glu483Gly missense_variant 0.15 isoniazid Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491742 c.960T>C synonymous_variant 1.0 clofazimine Not assoc w R
pretomanid
delamanid Not assoc w R - Interim
mshA 575907 p.Ala187Val missense_variant 0.25 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620625 p.Ile245Met missense_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Uncertain significance
Rv0565c 656324 p.Asn383Asp missense_variant 0.79 ethionamide Uncertain significance
Rv0565c 656460 c.1011C>A synonymous_variant 0.77 ethionamide Not assoc w R - Interim
Rv0565c 657081 c.390G>A synonymous_variant 0.99 ethionamide Not assoc w R - Interim
Rv0565c 657142 p.Arg110His missense_variant 0.99 ethionamide Uncertain significance
nusG 734475 c.222T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761097 c.1291_1293delAGCinsTCG synonymous_variant 0.2 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.2 rifampicin
rpoB 761180 c.1374A>G synonymous_variant 0.15 rifampicin
rpoB 763031 c.3225T>C synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 764071 c.702G>C synonymous_variant 0.16 rifampicin
rpoC 764075 p.Val236Ile missense_variant 0.15 rifampicin Uncertain significance
rpoC 764083 c.714A>G synonymous_variant 0.17 rifampicin
rpoC 764085 p.Asn239Ser missense_variant 0.18 rifampicin Uncertain significance
rpoC 764087 p.Leu240Ile missense_variant 0.18 rifampicin
rpoC 764098 c.729A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764131 c.762T>C synonymous_variant 0.22 rifampicin
rpoC 764134 c.765C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764191 c.822C>G synonymous_variant 0.15 rifampicin
rpoC 764203 c.834G>C synonymous_variant 0.16 rifampicin
rpoC 764206 c.837T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764817 p.Val483Ala missense_variant 0.27 rifampicin Uncertain significance
rpoC 765478 c.2109T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765493 c.2124G>C synonymous_variant 0.27 rifampicin
rpoC 765520 c.2151G>A synonymous_variant 0.31 rifampicin
rpoC 765529 c.2160C>G synonymous_variant 0.32 rifampicin
rpoC 765550 c.2181C>T synonymous_variant 0.32 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.31 rifampicin
rpoC 765559 c.2190G>C synonymous_variant 0.31 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.31 rifampicin
rpoC 765565 c.2196G>C synonymous_variant 0.32 rifampicin
rpoC 765580 c.2211G>C synonymous_variant 0.33 rifampicin
rpoC 765611 p.His748Ala missense_variant 0.27 rifampicin
rpoC 765625 c.2256C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765628 c.2259G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>G synonymous_variant 0.14 rifampicin
rpoC 765661 c.2292T>G synonymous_variant 0.14 rifampicin
rpoC 765662 c.2293_2295delTTGinsCC frameshift_variant&missense_variant 0.14 rifampicin
rpoC 765669 p.His767Arg missense_variant 0.14 rifampicin
rpoC 765700 c.2331T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765712 c.2343C>G synonymous_variant 0.14 rifampicin
rpoC 765772 c.2403C>G synonymous_variant 0.13 rifampicin
rpoC 765778 c.2409C>G synonymous_variant 0.14 rifampicin
rpoC 765781 p.Asp804Glu missense_variant 0.13 rifampicin
rpoC 766381 c.3012C>T synonymous_variant 0.21 rifampicin
rpoC 766384 c.3015A>G synonymous_variant 0.22 rifampicin
rpoC 766387 c.3018C>G synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.2 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.2 rifampicin
rpoC 766459 c.3090G>C synonymous_variant 0.2 rifampicin
rpoC 766486 c.3117A>G synonymous_variant 0.21 rifampicin
rpoC 766492 c.3123T>C synonymous_variant 0.21 rifampicin
rpoC 766517 p.Thr1050Ala missense_variant 0.15 rifampicin
rpoC 766703 p.Met1112Leu missense_variant 0.15 rifampicin
rpoC 766708 c.3339A>G synonymous_variant 0.2 rifampicin
rpoC 766714 c.3345G>C synonymous_variant 0.22 rifampicin
rpoC 766726 c.3357T>C synonymous_variant 0.28 rifampicin
rpoC 766738 c.3369G>C synonymous_variant 0.28 rifampicin
rpoC 766750 c.3381C>G synonymous_variant 0.29 rifampicin
rpoC 766753 c.3384C>G synonymous_variant 0.27 rifampicin
rpoC 766763 c.3394_3396delATAinsGC frameshift_variant&missense_variant 0.28 rifampicin
rpoC 766774 c.3405T>C synonymous_variant 0.26 rifampicin
rpoC 766775 p.Arg1136Lys missense_variant 0.25 rifampicin
rpoC 766783 c.3414C>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 766804 c.3435A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 766843 c.3474T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpL5 776100 p.Thr794Ile missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpS5 779615 c.-710C>G upstream_gene_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781832 c.273T>C synonymous_variant 0.25 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.27 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.28 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.28 streptomycin
rpsL 781880 c.321C>G synonymous_variant 0.27 streptomycin
rpsL 781898 c.339A>C synonymous_variant 0.24 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.18 streptomycin
Rv1129c 1254562 c.-28T>C upstream_gene_variant 1.0 moxifloxacin Not assoc w R
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R
Rv1258c 1406760 c.580_581insC frameshift_variant 1.0 streptomycin Uncertain significance
isoniazid Uncertain significance
pyrazinamide Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrl 1475202 n.1545G>A non_coding_transcript_exon_variant 0.3 capreomycin
linezolid
rrl 1475209 n.1552G>C non_coding_transcript_exon_variant 0.28 capreomycin Uncertain significance
linezolid
rrl 1475217 n.1560T>A non_coding_transcript_exon_variant 0.28 capreomycin
linezolid
rrl 1475243 n.1586G>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475247 n.1590_1593delGATCinsA non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475273 n.1616T>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475275 n.1618C>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.26 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.46 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.53 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475375 n.1718G>A non_coding_transcript_exon_variant 0.52 capreomycin Uncertain significance
linezolid
rrl 1475378 n.1723_1724delCG non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475383 n.1726_1727insCC non_coding_transcript_exon_variant 0.53 capreomycin
linezolid
rrl 1475395 n.1738T>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475407 n.1750C>T non_coding_transcript_exon_variant 0.5 capreomycin
linezolid
rrl 1475409 n.1752T>C non_coding_transcript_exon_variant 0.51 capreomycin
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.47 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475460 n.1803A>G non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475477 n.1820_1821insT non_coding_transcript_exon_variant 0.33 capreomycin
linezolid
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.43 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.51 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.57 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.56 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475586 n.1929C>A non_coding_transcript_exon_variant 0.69 capreomycin
linezolid
rrl 1475606 n.1949T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.7 capreomycin Uncertain significance
linezolid
rrl 1475621 n.1964T>C non_coding_transcript_exon_variant 0.67 capreomycin Uncertain significance
linezolid
rrl 1475629 n.1973dupA non_coding_transcript_exon_variant 0.65 capreomycin Uncertain significance
linezolid
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.61 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475997 n.2340A>G non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1476025 n.2368G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid Uncertain significance
rrl 1476033 n.2376T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476034 n.2377C>G non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.23 capreomycin Uncertain significance
linezolid
rrl 1476045 n.2388G>T non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid
rpsA 1834150 c.609G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834153 c.612T>C synonymous_variant 0.14 pyrazinamide
rpsA 1834154 p.Asn205His missense_variant 0.14 pyrazinamide
rpsA 1834177 c.636A>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
rpsA 1834189 c.648G>C synonymous_variant 0.14 pyrazinamide
rpsA 1834222 c.681T>C synonymous_variant 0.15 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 0.98 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2154724 p.Arg463Leu missense_variant 0.98 isoniazid Not assoc w R
PPE35 2167926 p.Leu896Ser missense_variant 0.99 pyrazinamide Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
Rv2477c 2783656 c.387G>C synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783737 c.306C>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783746 c.297G>A synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
whiB7 3569220 c.-541C>T upstream_gene_variant 0.66 streptomycin
amikacin
kanamycin
Rv3236c 3612813 p.Thr102Ala missense_variant 1.0 pyrazinamide Not assoc w R - Interim
mtrB 3625065 p.Met517Leu missense_variant 0.98 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3626562 p.Pro18Ser missense_variant 0.99 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrB 3627209 c.-596G>A upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627215 c.-602G>T upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627218 c.-605G>C upstream_gene_variant 0.15 bedaquiline
rifampicin
mtrB 3627227 c.-614T>G upstream_gene_variant 0.16 bedaquiline
rifampicin
mtrB 3627233 c.-620T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrB 3627236 c.-623T>C upstream_gene_variant 0.14 bedaquiline
rifampicin
mtrA 3627239 c.111C>T synonymous_variant 0.13 bedaquiline Not assoc w R - Interim
rifampicin Not assoc w R - Interim
fbiA 3640211 c.-332T>G upstream_gene_variant 0.26 clofazimine
pretomanid
delamanid
rpoA 3877557 c.951C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877569 c.937_939delCCGinsGC frameshift_variant&missense_variant 0.16 rifampicin
rpoA 3877587 c.919_921delTCAinsGG frameshift_variant&missense_variant 0.24 rifampicin
rpoA 3877613 p.Ile299Val missense_variant 0.29 rifampicin
rpoA 3877656 c.852T>C synonymous_variant 0.33 rifampicin Not assoc w R - Interim
rpoA 3877668 c.840A>G synonymous_variant 0.34 rifampicin
rpoA 3877680 c.828G>C synonymous_variant 0.36 rifampicin Not assoc w R - Interim
rpoA 3877686 c.822A>G synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877689 c.819C>G synonymous_variant 0.34 rifampicin
rpoA 3877692 c.816G>C synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>C synonymous_variant 0.35 rifampicin
rpoA 3877707 c.801G>A synonymous_variant 0.35 rifampicin Not assoc w R - Interim
rpoA 3877710 c.798C>T synonymous_variant 0.34 rifampicin Not assoc w R - Interim
rpoA 3877731 c.777G>C synonymous_variant 0.29 rifampicin
rpoA 3877737 c.771G>C synonymous_variant 0.26 rifampicin
rpoA 3877743 c.765T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoA 3877764 c.744C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877770 c.738A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3877776 c.732T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3877782 c.726T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3877803 c.705G>A synonymous_variant 0.15 rifampicin
clpC1 4038671 c.2034T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038679 p.Pro676Ala missense_variant 0.16 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4038698 c.2007C>G synonymous_variant 0.29 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.3 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.31 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.33 pyrazinamide
clpC1 4038721 c.1984C>T synonymous_variant 0.38 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.46 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.53 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.51 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.53 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.53 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.31 pyrazinamide Not assoc w R - Interim
clpC1 4038905 c.1800A>C synonymous_variant 0.14 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.15 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.15 pyrazinamide
clpC1 4039064 c.1641C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039076 c.1629G>A synonymous_variant 0.15 pyrazinamide
clpC1 4039079 c.1626C>G synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4039085 c.1620A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.2 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039121 c.1584T>G synonymous_variant 0.27 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.26 pyrazinamide
clpC1 4039127 p.Lys526Asn missense_variant 0.29 pyrazinamide
clpC1 4039133 c.1572C>G synonymous_variant 0.3 pyrazinamide
clpC1 4039139 p.Glu522Asp missense_variant 0.34 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.36 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.46 pyrazinamide
clpC1 4039199 c.1506C>G synonymous_variant 0.44 pyrazinamide
clpC1 4039211 c.1494G>A synonymous_variant 0.43 pyrazinamide Not assoc w R - Interim
clpC1 4039226 c.1479T>G synonymous_variant 0.42 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.34 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.33 pyrazinamide
clpC1 4039292 c.1413C>G synonymous_variant 0.31 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.29 pyrazinamide
clpC1 4039304 c.1401G>A synonymous_variant 0.29 pyrazinamide
clpC1 4039320 p.Ala462Ser missense_variant 0.27 pyrazinamide
clpC1 4039322 c.1383T>C synonymous_variant 0.26 pyrazinamide
clpC1 4039328 c.1377A>C synonymous_variant 0.27 pyrazinamide
clpC1 4039338 p.Thr456Gln missense_variant 0.28 pyrazinamide
clpC1 4039347 p.Arg453Gln missense_variant 0.3 pyrazinamide Uncertain significance
clpC1 4039352 c.1353C>T synonymous_variant 0.26 pyrazinamide Not assoc w R - Interim
clpC1 4039361 c.1344C>T synonymous_variant 0.56 pyrazinamide Not assoc w R - Interim
clpC1 4039391 c.1314T>G synonymous_variant 0.21 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039412 p.Ala431Val missense_variant 0.17 pyrazinamide
clpC1 4039415 p.Glu430Asp missense_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039430 c.1275T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.16 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
embC 4241107 c.1245G>C synonymous_variant 0.17 ethambutol
embC 4241140 c.1278A>G synonymous_variant 0.18 ethambutol Not assoc w R - Interim
embC 4241141 p.Ile427Val missense_variant 0.19 ethambutol Uncertain significance
embC 4241158 c.1296T>C synonymous_variant 0.16 ethambutol
embC 4241161 c.1299C>G synonymous_variant 0.15 ethambutol Not assoc w R - Interim
embC 4241162 c.1300T>C synonymous_variant 0.15 ethambutol
embC 4241167 c.1305C>G synonymous_variant 0.16 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4243460 c.228C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4248256 c.1743C>G synonymous_variant 0.13 ethambutol
embB 4249757 p.Thr1082Ala missense_variant 0.14 ethambutol Not assoc w R
aftB 4267647 p.Asp397Gly missense_variant 1.0 ethambutol Not assoc w R
ethA 4326676 p.Ser266Arg missense_variant 0.73 ethionamide Uncertain significance
whiB6 4338537 c.-16T>C upstream_gene_variant 0.69 capreomycin Uncertain significance
amikacin Uncertain significance
kanamycin Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407588 c.615A>G synonymous_variant 1.0 streptomycin Not assoc w R
gid 4407927 p.Glu92Asp missense_variant 1.0 streptomycin Not assoc w R