Run ID: SRR6046737
Sample name:
Date: 2024-04-15T17:40:25.179887
Number of reads: 20605
Percentage reads mapped: 1.89
Median coverage: 0.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 1.0 |
lineage4.9 | Euro-American (H37Rv-like) | None | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | rrs | n.799C>T | Uncertain significance | Mutation from literature |
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
capreomycin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
kanamycin | rrs | n.1402C>A | Uncertain significance | Mutation from literature |
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rrs | 1472644 | n.799C>T | non_coding_transcript_exon_variant | 0.59 | streptomycin | Uncertain significance | Mutation from literature |
rrs | 1473247 | n.1402C>A | non_coding_transcript_exon_variant | 0.42 | capreomycin | Uncertain significance | Mutation from literature |
amikacin | Uncertain significance | Mutation from literature | |||||
kanamycin | Uncertain significance | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
rpoB | 761552 | c.1746G>C | synonymous_variant | 1.0 | rifampicin | |
rpoB | 761558 | c.1752C>T | synonymous_variant | 1.0 | rifampicin | |
rpoB | 761564 | c.1758G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 761573 | c.1767C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 761612 | c.1806G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 761615 | c.1809A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 762200 | c.2394C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 762221 | c.2415G>A | synonymous_variant | 1.0 | rifampicin | |
rpoB | 762239 | c.2433G>A | synonymous_variant | 1.0 | rifampicin | |
rpoB | 762245 | c.2439G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 762248 | c.2442G>C | synonymous_variant | 1.0 | rifampicin | |
rpoB | 762251 | c.2445G>C | synonymous_variant | 1.0 | rifampicin | |
rpoB | 762254 | c.2448T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 762257 | c.2451C>G | synonymous_variant | 1.0 | rifampicin | |
rpoB | 762266 | c.2460T>C | synonymous_variant | 1.0 | rifampicin | |
rpoB | 762281 | c.2475G>A | synonymous_variant | 1.0 | rifampicin | |
rpoB | 762284 | c.2478G>T | synonymous_variant | 1.0 | rifampicin | |
rpoC | 762884 | c.-486G>A | upstream_gene_variant | 1.0 | rifampicin | |
rpoB | 762899 | c.3093G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 762905 | p.Asp1033Glu | missense_variant | 1.0 | rifampicin | |
rpoB | 762917 | c.3111C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 762929 | c.3123G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 762938 | c.-432G>C | upstream_gene_variant | 0.9 | rifampicin | |
rpoB | 762959 | c.3153G>C | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
rpoB | 762962 | c.3156C>T | synonymous_variant | 0.94 | rifampicin | Not assoc w R - Interim |
rpoB | 762971 | c.3165G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 762983 | c.-387C>T | upstream_gene_variant | 0.95 | rifampicin | |
rpoC | 762989 | c.-381G>C | upstream_gene_variant | 1.0 | rifampicin | |
rpoB | 762995 | c.3189G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 763002 | c.3197dupA | frameshift_variant | 1.0 | rifampicin | |
rpoB | 763006 | c.3201delC | frameshift_variant | 1.0 | rifampicin | |
rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
rpoB | 763040 | c.3234C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763049 | c.-321G>A | upstream_gene_variant | 1.0 | rifampicin | |
rpoC | 763052 | c.-318G>C | upstream_gene_variant | 1.0 | rifampicin | |
rpoB | 763053 | c.3247T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763064 | c.-306G>A | upstream_gene_variant | 1.0 | rifampicin | |
rpoB | 763070 | c.3264T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 763074 | p.Thr1090Val | missense_variant | 1.0 | rifampicin | |
rpoB | 763077 | p.Val1091Ile | missense_variant | 1.0 | rifampicin | |
rpoB | 763085 | c.3279C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763100 | c.-270G>A | upstream_gene_variant | 0.88 | rifampicin | |
rpoC | 763103 | c.-267G>C | upstream_gene_variant | 0.87 | rifampicin | |
rpoC | 763109 | c.-261C>G | upstream_gene_variant | 0.86 | rifampicin | |
rpoB | 763115 | c.3309T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoB | 763118 | p.Glu1104Asp | missense_variant | 0.82 | rifampicin | |
rpoC | 763492 | c.123G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763516 | c.147G>A | synonymous_variant | 1.0 | rifampicin | |
rpoC | 763531 | c.162G>A | synonymous_variant | 1.0 | rifampicin | |
rpoC | 763534 | c.165T>C | synonymous_variant | 1.0 | rifampicin | |
rpoC | 763549 | c.180C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763550 | p.Tyr61Ala | missense_variant | 1.0 | rifampicin | |
rpoC | 763558 | c.189C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763561 | c.192G>A | synonymous_variant | 1.0 | rifampicin | |
rpoC | 763570 | c.201G>A | synonymous_variant | 1.0 | rifampicin | |
rpoC | 763573 | c.204G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 763578 | p.Phe70Tyr | missense_variant | 1.0 | rifampicin | |
rpoC | 764680 | c.1311G>A | synonymous_variant | 1.0 | rifampicin | |
rpoC | 764701 | c.1332C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rpoC | 764707 | c.1338G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
rplC | 800672 | c.-137G>T | upstream_gene_variant | 1.0 | linezolid | |
rplC | 800693 | c.-116A>G | upstream_gene_variant | 1.0 | linezolid | |
rplC | 800702 | c.-107G>C | upstream_gene_variant | 0.83 | linezolid | |
rplC | 800703 | c.-106T>C | upstream_gene_variant | 1.0 | linezolid | |
rplC | 800720 | c.-89T>C | upstream_gene_variant | 1.0 | linezolid | |
rplC | 800726 | c.-83G>C | upstream_gene_variant | 0.8 | linezolid | |
rrs | 1472581 | n.736A>T | non_coding_transcript_exon_variant | 0.56 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1472607 | n.762G>A | non_coding_transcript_exon_variant | 0.63 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472612 | n.767G>T | non_coding_transcript_exon_variant | 0.4 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472655 | n.810G>A | non_coding_transcript_exon_variant | 0.41 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472660 | n.815T>C | non_coding_transcript_exon_variant | 0.67 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472661 | n.816A>G | non_coding_transcript_exon_variant | 0.74 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472675 | n.830T>C | non_coding_transcript_exon_variant | 0.35 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472697 | n.852T>C | non_coding_transcript_exon_variant | 0.28 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472713 | n.868T>C | non_coding_transcript_exon_variant | 0.68 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1472714 | n.869A>G | non_coding_transcript_exon_variant | 0.57 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472790 | n.945T>C | non_coding_transcript_exon_variant | 0.5 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472990 | n.1145A>G | non_coding_transcript_exon_variant | 0.92 | streptomycin | Uncertain significance |
kanamycin | Not assoc w R | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1472996 | n.1151T>C | non_coding_transcript_exon_variant | 0.29 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473005 | n.1160C>T | non_coding_transcript_exon_variant | 0.71 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473035 | n.1190G>A | non_coding_transcript_exon_variant | 0.8 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473252 | n.1407T>C | non_coding_transcript_exon_variant | 0.42 | streptomycin | Uncertain significance |
kanamycin | Not assoc w R | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
rrs | 1473259 | n.1414C>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Not assoc w R | |||||
rrs | 1473270 | n.1425G>A | non_coding_transcript_exon_variant | 0.42 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473276 | n.1431A>G | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473286 | n.1441_1442delCCinsA | non_coding_transcript_exon_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473292 | n.1447G>T | non_coding_transcript_exon_variant | 0.62 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473293 | n.1448G>T | non_coding_transcript_exon_variant | 0.62 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1473301 | n.1456T>C | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473316 | n.1471C>T | non_coding_transcript_exon_variant | 1.0 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1474798 | n.1141C>T | non_coding_transcript_exon_variant | 0.6 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474803 | n.1146G>A | non_coding_transcript_exon_variant | 0.58 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.58 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>G | non_coding_transcript_exon_variant | 0.83 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474824 | n.1167A>G | non_coding_transcript_exon_variant | 0.75 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474825 | n.1168G>A | non_coding_transcript_exon_variant | 0.58 | capreomycin | |
linezolid | ||||||
rrl | 1474830 | n.1173A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474864 | n.1207C>T | non_coding_transcript_exon_variant | 0.79 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1475881 | n.2224T>C | non_coding_transcript_exon_variant | 0.64 | capreomycin | |
linezolid | ||||||
rrl | 1475883 | n.2226A>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475884 | n.2227A>G | non_coding_transcript_exon_variant | 0.64 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475897 | n.2240T>C | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475898 | n.2241A>G | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475899 | n.2242G>A | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475900 | n.2243A>G | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475902 | n.2245T>C | non_coding_transcript_exon_variant | 0.47 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475916 | n.2259C>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475937 | n.2280A>T | non_coding_transcript_exon_variant | 0.38 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475943 | n.2286G>A | non_coding_transcript_exon_variant | 0.53 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475952 | n.2295A>G | non_coding_transcript_exon_variant | 0.41 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476194 | n.2537A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476353 | n.2696G>T | non_coding_transcript_exon_variant | 0.72 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476358 | n.2701T>C | non_coding_transcript_exon_variant | 0.72 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476369 | n.2712C>T | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476372 | n.2715T>C | non_coding_transcript_exon_variant | 0.71 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476382 | n.2725A>G | non_coding_transcript_exon_variant | 0.7 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476383 | n.2726T>A | non_coding_transcript_exon_variant | 0.7 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476425 | n.2768G>T | non_coding_transcript_exon_variant | 0.68 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476428 | n.2771C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476429 | n.2772A>C | non_coding_transcript_exon_variant | 0.89 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476481 | n.2824T>C | non_coding_transcript_exon_variant | 0.88 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476506 | n.2849T>C | non_coding_transcript_exon_variant | 0.71 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476536 | n.2879G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476539 | n.2882A>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476540 | n.2883C>G | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rpsA | 1834294 | c.753G>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834298 | p.Gln253Ala | missense_variant | 1.0 | pyrazinamide | |
rpsA | 1834306 | c.765T>C | synonymous_variant | 1.0 | pyrazinamide | |
rpsA | 1834327 | c.786G>C | synonymous_variant | 1.0 | pyrazinamide |