Run ID: SRR6831950
Sample name:
Date: 2024-10-04T15:32:30.726482
Number of reads: 2394279
Percentage reads mapped: 89.65
Median coverage: 48.0
Strain: lineage4.3.3
Spoligotype:
Drug-resistance: Sensitive
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4.3 | Euro-American (LAM) | None | 0.99 |
lineage4 | Euro-American | None | 0.99 |
lineage4.3.3 | Euro-American (LAM) | RD115 | 1.0 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | ||||
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 805 | c.805T>C | synonymous_variant | 0.17 | isoniazid | |
dnaA | 813 | c.813C>T | synonymous_variant | 0.17 | isoniazid | |
dnaA | 822 | c.822A>G | synonymous_variant | 0.17 | isoniazid | |
dnaA | 828 | c.828T>C | synonymous_variant | 0.17 | isoniazid | Not assoc w R - Interim |
dnaA | 831 | c.831A>G | synonymous_variant | 0.17 | isoniazid | |
dnaA | 837 | c.837A>G | synonymous_variant | 0.18 | isoniazid | |
dnaA | 840 | c.840G>A | synonymous_variant | 0.19 | isoniazid | |
dnaA | 843 | c.843T>C | synonymous_variant | 0.19 | isoniazid | Not assoc w R - Interim |
dnaA | 846 | c.846T>C | synonymous_variant | 0.19 | isoniazid | |
dnaA | 849 | c.849A>G | synonymous_variant | 0.18 | isoniazid | |
dnaA | 885 | c.885T>C | synonymous_variant | 0.18 | isoniazid | |
dnaA | 1104 | c.1104T>C | synonymous_variant | 0.14 | isoniazid | |
dnaA | 1110 | c.1110T>C | synonymous_variant | 0.14 | isoniazid | |
dnaA | 1122 | c.1122C>A | synonymous_variant | 0.14 | isoniazid | Not assoc w R - Interim |
dnaA | 1125 | c.1125G>C | synonymous_variant | 0.15 | isoniazid | |
dnaA | 1152 | c.1152A>G | synonymous_variant | 0.15 | isoniazid | |
dnaA | 1153 | c.1153T>C | synonymous_variant | 0.15 | isoniazid | |
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8040 | p.Gly247Ser | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 8366 | c.1065G>C | synonymous_variant | 0.25 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8375 | c.1074G>C | synonymous_variant | 0.25 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | ||||||
gyrA | 8391 | p.Tyr364His | missense_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8399 | c.1098T>C | synonymous_variant | 0.31 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8420 | c.1119T>C | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8423 | c.1122G>C | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8442 | c.1141C>T | synonymous_variant | 0.34 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8453 | c.1152A>C | synonymous_variant | 0.37 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8504 | c.1203G>C | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8516 | c.1215T>C | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8519 | c.1218A>C | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8537 | c.1236G>A | synonymous_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8546 | c.1245T>C | synonymous_variant | 0.3 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8552 | c.1251C>G | synonymous_variant | 0.29 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8556 | p.Ala419Gln | missense_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8561 | c.1260A>C | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8562 | c.1261C>T | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8576 | c.1275C>G | synonymous_variant | 0.28 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8998 | p.Leu566Trp | missense_variant | 0.18 | levofloxacin | Uncertain significance |
moxifloxacin | Uncertain significance | |||||
gyrA | 9304 | p.Gly668Asp | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
hadA | 731741 | c.-189G>A | upstream_gene_variant | 0.2 | isoniazid | |
hadA | 731747 | c.-183T>C | upstream_gene_variant | 0.21 | isoniazid | |
hadA | 731753 | c.-177A>G | upstream_gene_variant | 0.23 | isoniazid | |
hadA | 731774 | c.-156T>C | upstream_gene_variant | 0.22 | isoniazid | |
hadA | 731789 | c.-141A>G | upstream_gene_variant | 0.23 | isoniazid | |
hadA | 731792 | c.-138G>A | upstream_gene_variant | 0.23 | isoniazid | |
hadA | 731801 | c.-129C>G | upstream_gene_variant | 0.21 | isoniazid | |
hadA | 731816 | c.-114G>A | upstream_gene_variant | 0.17 | isoniazid | |
nusG | 734457 | c.204C>G | synonymous_variant | 0.15 | rifampicin | |
nusG | 734472 | c.219T>C | synonymous_variant | 0.15 | rifampicin | |
nusG | 734475 | c.222T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
nusG | 734481 | c.228C>G | synonymous_variant | 0.16 | rifampicin | |
nusG | 734499 | c.246G>C | synonymous_variant | 0.13 | rifampicin | |
rpoB | 760886 | c.1080A>G | synonymous_variant | 0.21 | rifampicin | |
rpoB | 760919 | c.1113C>G | synonymous_variant | 0.2 | rifampicin | |
rpoB | 760925 | c.1119T>C | synonymous_variant | 0.21 | rifampicin | |
rpoB | 760928 | c.1122G>C | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoB | 760934 | c.1128C>T | synonymous_variant | 0.19 | rifampicin | |
rpoB | 760946 | c.1140A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 761327 | c.1521A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 763034 | c.3228C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 763076 | c.-294C>G | upstream_gene_variant | 0.27 | rifampicin | |
rpoB | 763085 | c.3279C>G | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoB | 763115 | c.3309T>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 763148 | c.-222G>C | upstream_gene_variant | 0.19 | rifampicin | |
rpoC | 763158 | c.-212C>T | upstream_gene_variant | 0.16 | rifampicin | |
rpoC | 763402 | c.33C>G | synonymous_variant | 0.25 | rifampicin | |
rpoC | 763411 | c.42T>G | synonymous_variant | 0.27 | rifampicin | Not assoc w R - Interim |
rpoC | 763414 | c.45T>C | synonymous_variant | 0.27 | rifampicin | |
rpoC | 763441 | c.72C>G | synonymous_variant | 0.32 | rifampicin | |
rpoC | 763444 | c.75T>C | synonymous_variant | 0.32 | rifampicin | Not assoc w R - Interim |
rpoC | 763696 | c.327T>C | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 763702 | c.333C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 763708 | c.339G>A | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
rpoC | 763709 | c.340C>T | synonymous_variant | 0.23 | rifampicin | |
rpoC | 763714 | c.345G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 763717 | c.348T>C | synonymous_variant | 0.26 | rifampicin | Not assoc w R - Interim |
rpoC | 763723 | c.354G>C | synonymous_variant | 0.3 | rifampicin | |
rpoC | 763732 | c.363C>G | synonymous_variant | 0.37 | rifampicin | |
rpoC | 763735 | c.366G>C | synonymous_variant | 0.35 | rifampicin | |
rpoC | 763744 | c.375G>C | synonymous_variant | 0.35 | rifampicin | |
rpoC | 763765 | c.396T>C | synonymous_variant | 0.37 | rifampicin | |
rpoC | 763768 | c.399C>G | synonymous_variant | 0.35 | rifampicin | |
rpoC | 763780 | c.411C>G | synonymous_variant | 0.31 | rifampicin | |
rpoC | 763783 | c.414G>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 764083 | c.714A>G | synonymous_variant | 0.21 | rifampicin | |
rpoC | 764098 | c.729A>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 764188 | c.819A>G | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 764195 | p.Ser276Gln | missense_variant | 0.16 | rifampicin | |
rpoC | 764203 | c.834G>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764257 | c.888G>C | synonymous_variant | 0.38 | rifampicin | |
rpoC | 764893 | c.1524T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764911 | c.1542A>G | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764923 | c.1554A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 764932 | c.1563C>A | synonymous_variant | 0.21 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 764995 | c.1626C>G | synonymous_variant | 0.93 | rifampicin | Not assoc w R |
rpoC | 765007 | c.1638T>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 765928 | c.2559C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 765967 | c.2598C>T | synonymous_variant | 0.2 | rifampicin | Not assoc w R - Interim |
rpoC | 765979 | c.2610C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 765985 | c.2616C>T | synonymous_variant | 0.19 | rifampicin | |
rpoC | 765994 | c.2625A>T | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoC | 766726 | c.3357T>C | synonymous_variant | 0.13 | rifampicin | |
rpoC | 766738 | c.3369G>T | synonymous_variant | 0.15 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781760 | c.201T>C | synonymous_variant | 0.14 | streptomycin | |
rpsL | 781793 | c.234G>C | synonymous_variant | 0.14 | streptomycin | |
rpsL | 781832 | c.273T>C | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781841 | c.282C>G | synonymous_variant | 0.2 | streptomycin | |
rpsL | 781859 | c.300T>C | synonymous_variant | 0.15 | streptomycin | Not assoc w R - Interim |
rpsL | 781868 | c.309T>C | synonymous_variant | 0.16 | streptomycin | |
rpsL | 781892 | c.333A>G | synonymous_variant | 0.17 | streptomycin | |
rpsL | 781898 | c.339A>T | synonymous_variant | 0.2 | streptomycin | |
rpsL | 781916 | c.357T>C | synonymous_variant | 0.21 | streptomycin | |
rplC | 800582 | c.-227C>G | upstream_gene_variant | 0.12 | linezolid | |
rplC | 800814 | c.6A>G | synonymous_variant | 0.2 | linezolid | |
rplC | 800817 | c.9A>T | synonymous_variant | 0.2 | linezolid | |
rplC | 800844 | c.36T>C | synonymous_variant | 0.15 | linezolid | |
fbiC | 1303095 | c.165G>A | synonymous_variant | 0.96 | pretomanid | |
delamanid | Not assoc w R - Interim | |||||
clofazimine | Not assoc w R - Interim | |||||
atpE | 1461185 | c.141G>C | synonymous_variant | 0.22 | bedaquiline | |
atpE | 1461189 | c.145C>T | synonymous_variant | 0.21 | bedaquiline | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1471969 | n.124T>C | non_coding_transcript_exon_variant | 0.16 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1471970 | n.125G>A | non_coding_transcript_exon_variant | 0.16 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473104 | n.1259C>T | non_coding_transcript_exon_variant | 0.28 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473105 | n.1260G>A | non_coding_transcript_exon_variant | 0.28 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1473123 | n.1278delAinsTT | non_coding_transcript_exon_variant | 0.26 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.18 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473166 | n.1321G>A | non_coding_transcript_exon_variant | 0.18 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473756 | n.99G>A | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473813 | n.156C>T | non_coding_transcript_exon_variant | 0.35 | capreomycin | |
linezolid | ||||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475599 | n.1942A>G | non_coding_transcript_exon_variant | 0.16 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476583 | n.2926G>A | non_coding_transcript_exon_variant | 0.21 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476584 | n.2927C>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | Not assoc w R |
linezolid | Uncertain significance | |||||
rrl | 1476597 | n.2940G>A | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476608 | n.2951C>G | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.2 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
inhA | 1674315 | c.114C>G | synonymous_variant | 0.26 | isoniazid | |
ethionamide | ||||||
inhA | 1674321 | c.120G>C | synonymous_variant | 0.3 | isoniazid | |
ethionamide | ||||||
inhA | 1674342 | c.141T>C | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674537 | c.336C>G | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674542 | p.Ala114Glu | missense_variant | 0.22 | isoniazid | |
ethionamide | ||||||
inhA | 1674585 | c.384T>C | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674589 | p.Met130Leu | missense_variant | 0.19 | isoniazid | |
ethionamide | ||||||
inhA | 1674624 | c.423A>C | synonymous_variant | 0.18 | isoniazid | |
ethionamide | ||||||
inhA | 1674627 | c.426T>G | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
inhA | 1674630 | c.429C>G | synonymous_variant | 0.21 | isoniazid | |
ethionamide | ||||||
rpsA | 1834836 | p.Met432Thr | missense_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
tsnR | 1854300 | p.Leu232Pro | missense_variant | 1.0 | linezolid | Not assoc w R |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
katG | 2156196 | c.-85C>T | upstream_gene_variant | 1.0 | isoniazid | Not assoc w R |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
kasA | 2518919 | p.Gly269Ser | missense_variant | 0.94 | isoniazid | |
folC | 2746340 | p.Ala420Val | missense_variant | 1.0 | para-aminosalicylic_acid | |
Rv2477c | 2783365 | c.678C>T | synonymous_variant | 0.22 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783373 | p.Glu224Gln | missense_variant | 0.26 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783395 | c.648T>C | synonymous_variant | 0.27 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
thyA | 3073824 | c.648A>C | synonymous_variant | 0.12 | para-aminosalicylic_acid | |
thyA | 3073839 | c.633T>C | synonymous_variant | 0.14 | para-aminosalicylic_acid | |
thyA | 3073863 | c.609T>C | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
thyA | 3073868 | p.Thr202Ala | missense_variant | 0.8 | para-aminosalicylic_acid | |
thyA | 3073872 | p.Ile200Val | missense_variant | 0.2 | para-aminosalicylic_acid | |
thyA | 3073878 | c.594G>A | synonymous_variant | 0.22 | para-aminosalicylic_acid | |
thyA | 3074172 | c.300G>C | synonymous_variant | 0.15 | para-aminosalicylic_acid | |
thyA | 3074175 | c.297A>G | synonymous_variant | 0.13 | para-aminosalicylic_acid | |
thyA | 3074199 | c.273G>A | synonymous_variant | 0.16 | para-aminosalicylic_acid | |
thyA | 3074205 | p.Glu89Asp | missense_variant | 0.17 | para-aminosalicylic_acid | |
thyA | 3074214 | c.258T>C | synonymous_variant | 0.17 | para-aminosalicylic_acid | |
thyA | 3074217 | c.255T>C | synonymous_variant | 0.21 | para-aminosalicylic_acid | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | rifampicin | Not assoc w R |
bedaquiline | Uncertain significance | |||||
mtrA | 3627242 | c.108C>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
rpoA | 3877692 | c.816G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3877704 | c.804G>T | synonymous_variant | 0.12 | rifampicin | Not assoc w R - Interim |
rpoA | 3878082 | c.426T>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878141 | p.Met123Leu | missense_variant | 0.2 | rifampicin | Uncertain significance |
rpoA | 3878142 | p.Gly122Glu | missense_variant | 0.21 | rifampicin | |
rpoA | 3878193 | c.315T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878199 | c.309T>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878202 | c.306G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878271 | c.237T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoA | 3878284 | p.Glu75Ala | missense_variant | 0.15 | rifampicin | |
clpC1 | 4038287 | c.2418C>T | synonymous_variant | 0.87 | pyrazinamide | Not assoc w R |
clpC1 | 4038293 | c.2412G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.23 | pyrazinamide | |
clpC1 | 4038790 | c.1915C>T | synonymous_variant | 0.2 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038815 | c.1890G>T | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4038968 | c.1737G>A | synonymous_variant | 0.92 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039586 | c.1119G>C | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039610 | c.1095G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039616 | c.1089G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4039622 | c.1083C>G | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039817 | c.888A>T | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039820 | c.885T>G | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4039831 | c.874T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039832 | c.873C>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4040354 | c.351A>G | synonymous_variant | 0.21 | pyrazinamide | |
panD | 4045034 | c.-753A>T | upstream_gene_variant | 0.13 | pyrazinamide | |
embC | 4241086 | c.1224G>C | synonymous_variant | 0.22 | ethambutol | |
embC | 4241104 | c.1242G>A | synonymous_variant | 0.24 | ethambutol | Not assoc w R - Interim |
embC | 4241509 | c.1647A>G | synonymous_variant | 1.0 | ethambutol | |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4248064 | c.1551G>C | synonymous_variant | 0.17 | ethambutol | Not assoc w R - Interim |
embB | 4248070 | c.1557T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248085 | c.1572T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248097 | c.1584C>G | synonymous_variant | 0.14 | ethambutol | |
embB | 4248127 | c.1614G>C | synonymous_variant | 0.13 | ethambutol | |
embB | 4248133 | c.1620C>G | synonymous_variant | 0.16 | ethambutol | |
embB | 4248142 | c.1629T>C | synonymous_variant | 0.16 | ethambutol | |
embB | 4248143 | c.1630T>C | synonymous_variant | 0.15 | ethambutol | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
gid | 4408156 | p.Leu16Arg | missense_variant | 1.0 | streptomycin | Not assoc w R |