TB-Profiler result

Run: SRR6831950
Summary

Run ID: SRR6831950

Sample name:

Date: 2025-09-15T19:12:16.494359

Number of reads: 2394279

Percentage reads mapped: 89.65

Median coverage: 48.0

Strain: lineage4.3.3

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 100.0
lineage4.3 Euro-American (LAM) None 100.0
lineage4.3.3 Euro-American (LAM) RD115 100.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 805 c.805T>C synonymous_variant 0.17 isoniazid Uncertain significance
dnaA 813 c.813C>T synonymous_variant 0.17 isoniazid Uncertain significance
dnaA 822 c.822A>G synonymous_variant 0.17 isoniazid Uncertain significance
dnaA 828 c.828T>C synonymous_variant 0.17 isoniazid Not assoc w R - Interim
dnaA 831 c.831A>G synonymous_variant 0.17 isoniazid Uncertain significance
dnaA 837 c.837A>G synonymous_variant 0.18 isoniazid Uncertain significance
dnaA 840 c.840G>A synonymous_variant 0.19 isoniazid Uncertain significance
dnaA 843 c.843T>C synonymous_variant 0.19 isoniazid Not assoc w R - Interim
dnaA 846 c.846T>C synonymous_variant 0.19 isoniazid Uncertain significance
dnaA 849 c.849A>G synonymous_variant 0.18 isoniazid Uncertain significance
dnaA 885 c.885T>C synonymous_variant 0.18 isoniazid Uncertain significance
dnaA 1104 c.1104T>C synonymous_variant 0.14 isoniazid Uncertain significance
dnaA 1110 c.1110T>C synonymous_variant 0.14 isoniazid Uncertain significance
dnaA 1122 c.1122C>A synonymous_variant 0.14 isoniazid Not assoc w R - Interim
dnaA 1125 c.1125G>C synonymous_variant 0.15 isoniazid Uncertain significance
dnaA 1152 c.1152A>G synonymous_variant 0.15 isoniazid Uncertain significance
dnaA 1153 c.1153T>C synonymous_variant 0.15 isoniazid Uncertain significance
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8040 p.Gly247Ser missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8366 c.1065G>C synonymous_variant 0.25 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8375 c.1074G>C synonymous_variant 0.25 levofloxacin Not assoc w R - Interim
moxifloxacin Uncertain significance
gyrA 8391 p.Tyr364His missense_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8399 c.1098T>C synonymous_variant 0.31 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8423 c.1122G>C synonymous_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8442 c.1141C>T synonymous_variant 0.34 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8453 c.1152A>C synonymous_variant 0.37 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8504 c.1203G>C synonymous_variant 0.27 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8516 c.1215T>C synonymous_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8519 c.1218A>C synonymous_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8537 c.1236G>A synonymous_variant 0.3 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8546 c.1245T>C synonymous_variant 0.3 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8552 c.1251C>G synonymous_variant 0.29 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8556 p.Ala419Gln missense_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8561 c.1260A>C synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8562 c.1261C>T synonymous_variant 0.28 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8576 c.1275C>G synonymous_variant 0.28 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 8998 p.Leu566Trp missense_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
hadA 731741 c.-189G>A upstream_gene_variant 0.2 isoniazid Uncertain significance
hadA 731747 c.-183T>C upstream_gene_variant 0.21 isoniazid Uncertain significance
hadA 731753 c.-177A>G upstream_gene_variant 0.23 isoniazid Uncertain significance
hadA 731774 c.-156T>C upstream_gene_variant 0.22 isoniazid Uncertain significance
hadA 731789 c.-141A>G upstream_gene_variant 0.23 isoniazid Uncertain significance
hadA 731792 c.-138G>A upstream_gene_variant 0.23 isoniazid Uncertain significance
hadA 731801 c.-129C>G upstream_gene_variant 0.21 isoniazid Uncertain significance
hadA 731816 c.-114G>A upstream_gene_variant 0.17 isoniazid Uncertain significance
nusG 734457 c.204C>G synonymous_variant 0.15 rifampicin Uncertain significance
nusG 734472 c.219T>C synonymous_variant 0.15 rifampicin Uncertain significance
nusG 734475 c.222T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
nusG 734481 c.228C>G synonymous_variant 0.16 rifampicin Uncertain significance
nusG 734499 c.246G>C synonymous_variant 0.13 rifampicin Uncertain significance
rpoB 760886 c.1080A>G synonymous_variant 0.21 rifampicin Uncertain significance
rpoB 760919 c.1113C>G synonymous_variant 0.2 rifampicin Uncertain significance
rpoB 760925 c.1119T>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoB 760928 c.1122G>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoB 760934 c.1128C>T synonymous_variant 0.19 rifampicin Uncertain significance
rpoB 760946 c.1140A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoB 763085 c.3279C>G synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoB 763115 c.3309T>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoC 763158 c.-212C>T upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoC 763402 c.33C>G synonymous_variant 0.25 rifampicin Uncertain significance
rpoC 763411 c.42T>G synonymous_variant 0.27 rifampicin Not assoc w R - Interim
rpoC 763414 c.45T>C synonymous_variant 0.27 rifampicin Uncertain significance
rpoC 763441 c.72C>G synonymous_variant 0.32 rifampicin Uncertain significance
rpoC 763444 c.75T>C synonymous_variant 0.32 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.23 rifampicin Uncertain significance
rpoC 763714 c.345G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.3 rifampicin Uncertain significance
rpoC 763732 c.363C>G synonymous_variant 0.37 rifampicin Uncertain significance
rpoC 763735 c.366G>C synonymous_variant 0.35 rifampicin Uncertain significance
rpoC 763744 c.375G>C synonymous_variant 0.35 rifampicin Uncertain significance
rpoC 763765 c.396T>C synonymous_variant 0.37 rifampicin Uncertain significance
rpoC 763768 c.399C>G synonymous_variant 0.35 rifampicin Uncertain significance
rpoC 763780 c.411C>G synonymous_variant 0.31 rifampicin Uncertain significance
rpoC 763783 c.414G>C synonymous_variant 0.29 rifampicin Uncertain significance
rpoC 764083 c.714A>G synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 764098 c.729A>G synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 764188 c.819A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764195 p.Ser276Gln missense_variant 0.16 rifampicin Uncertain significance
rpoC 764203 c.834G>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 764257 c.888G>C synonymous_variant 0.38 rifampicin Uncertain significance
rpoC 764893 c.1524T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 764911 c.1542A>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 764923 c.1554A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764932 c.1563C>A synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764968 c.1599T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 0.93 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 765979 c.2610C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.19 rifampicin Uncertain significance
rpoC 765994 c.2625A>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766726 c.3357T>C synonymous_variant 0.13 rifampicin Uncertain significance
rpoC 766738 c.3369G>T synonymous_variant 0.15 rifampicin Uncertain significance
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781760 c.201T>C synonymous_variant 0.14 streptomycin Uncertain significance
rpsL 781793 c.234G>C synonymous_variant 0.14 streptomycin Uncertain significance
rpsL 781832 c.273T>C synonymous_variant 0.17 streptomycin Uncertain significance
rpsL 781841 c.282C>G synonymous_variant 0.2 streptomycin Uncertain significance
rpsL 781859 c.300T>C synonymous_variant 0.15 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.16 streptomycin Uncertain significance
rpsL 781892 c.333A>G synonymous_variant 0.17 streptomycin Uncertain significance
rpsL 781898 c.339A>T synonymous_variant 0.2 streptomycin Uncertain significance
rpsL 781916 c.357T>C synonymous_variant 0.21 streptomycin Uncertain significance
rplC 800582 c.-227C>G upstream_gene_variant 0.12 linezolid Uncertain significance
rplC 800814 c.6A>G synonymous_variant 0.2 linezolid Uncertain significance
rplC 800817 c.9A>T synonymous_variant 0.2 linezolid Uncertain significance
rplC 800844 c.36T>C synonymous_variant 0.15 linezolid Uncertain significance
fbiC 1303095 c.165G>A synonymous_variant 0.96 clofazimine Not assoc w R - Interim
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
atpE 1461185 c.141G>C synonymous_variant 0.22 bedaquiline Uncertain significance
atpE 1461189 c.145C>T synonymous_variant 0.21 bedaquiline Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471969 n.124T>C non_coding_transcript_exon_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1471970 n.125G>A non_coding_transcript_exon_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.28 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473105 n.1260G>A non_coding_transcript_exon_variant 0.28 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473123 n.1278delAinsTT non_coding_transcript_exon_variant 0.26 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.18 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.18 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1473756 n.99G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473758 n.101G>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473813 n.156C>T non_coding_transcript_exon_variant 0.35 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.22 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476608 n.2951C>G non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674315 c.114C>G synonymous_variant 0.26 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674321 c.120G>C synonymous_variant 0.3 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674342 c.141T>C synonymous_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674537 c.336C>G synonymous_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674542 p.Ala114Glu missense_variant 0.22 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674585 c.384T>C synonymous_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674589 p.Met130Leu missense_variant 0.19 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674624 c.423A>C synonymous_variant 0.18 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674627 c.426T>G synonymous_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674630 c.429C>G synonymous_variant 0.21 ethionamide Uncertain significance
isoniazid Uncertain significance
rpsA 1834836 p.Met432Thr missense_variant 1.0 pyrazinamide Not assoc w R - Interim
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
katG 2156196 c.-85C>T upstream_gene_variant 1.0 isoniazid Not assoc w R
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518919 p.Gly269Ser missense_variant 0.94 isoniazid Uncertain significance
folC 2746340 p.Ala420Val missense_variant 1.0 para-aminosalicylic_acid Uncertain significance
Rv2477c 2783365 c.678C>T synonymous_variant 0.22 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783373 p.Glu224Gln missense_variant 0.26 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783395 c.648T>C synonymous_variant 0.27 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
thyA 3073824 c.648A>C synonymous_variant 0.12 para-aminosalicylic_acid Uncertain significance
thyA 3073839 c.633T>C synonymous_variant 0.14 para-aminosalicylic_acid Uncertain significance
thyA 3073863 c.609T>C synonymous_variant 0.19 para-aminosalicylic_acid Uncertain significance
thyA 3073868 p.Thr202Ala missense_variant 0.8 para-aminosalicylic_acid Uncertain significance
thyA 3073872 p.Ile200Val missense_variant 0.2 para-aminosalicylic_acid Uncertain significance
thyA 3073878 c.594G>A synonymous_variant 0.22 para-aminosalicylic_acid Uncertain significance
thyA 3074172 c.300G>C synonymous_variant 0.15 para-aminosalicylic_acid Uncertain significance
thyA 3074175 c.297A>G synonymous_variant 0.13 para-aminosalicylic_acid Uncertain significance
thyA 3074199 c.273G>A synonymous_variant 0.16 para-aminosalicylic_acid Uncertain significance
thyA 3074205 p.Glu89Asp missense_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyA 3074214 c.258T>C synonymous_variant 0.17 para-aminosalicylic_acid Uncertain significance
thyA 3074217 c.255T>C synonymous_variant 0.21 para-aminosalicylic_acid Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3627242 c.108C>T synonymous_variant 0.17 bedaquiline Uncertain significance
rifampicin Not assoc w R - Interim
rpoA 3877692 c.816G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877704 c.804G>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoA 3878082 c.426T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878141 p.Met123Leu missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878142 p.Gly122Glu missense_variant 0.21 rifampicin Uncertain significance
rpoA 3878193 c.315T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878199 c.309T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878202 c.306G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3878271 c.237T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878284 p.Glu75Ala missense_variant 0.15 rifampicin Uncertain significance
clpC1 4038287 c.2418C>T synonymous_variant 0.87 pyrazinamide Not assoc w R
clpC1 4038293 c.2412G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4038782 c.1923G>C synonymous_variant 0.23 pyrazinamide Uncertain significance
clpC1 4038790 c.1915C>T synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4038815 c.1890G>T synonymous_variant 0.22 pyrazinamide Uncertain significance
clpC1 4038968 c.1737G>A synonymous_variant 0.92 pyrazinamide Not assoc w R - Interim
clpC1 4039586 c.1119G>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039610 c.1095G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039616 c.1089G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039622 c.1083C>G synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039817 c.888A>T synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039820 c.885T>G synonymous_variant 0.13 pyrazinamide Uncertain significance
clpC1 4039831 c.874T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4039832 c.873C>G synonymous_variant 0.14 pyrazinamide Uncertain significance
clpC1 4040354 c.351A>G synonymous_variant 0.21 pyrazinamide Uncertain significance
panD 4045034 c.-753A>T upstream_gene_variant 0.13 pyrazinamide Uncertain significance
embC 4241086 c.1224G>C synonymous_variant 0.22 ethambutol Uncertain significance
embC 4241104 c.1242G>A synonymous_variant 0.24 ethambutol Not assoc w R - Interim
embC 4241509 c.1647A>G synonymous_variant 1.0 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embB 4248064 c.1551G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embB 4248070 c.1557T>C synonymous_variant 0.16 ethambutol Uncertain significance
embB 4248085 c.1572T>C synonymous_variant 0.16 ethambutol Uncertain significance
embB 4248097 c.1584C>G synonymous_variant 0.14 ethambutol Uncertain significance
embB 4248127 c.1614G>C synonymous_variant 0.13 ethambutol Uncertain significance
embB 4248133 c.1620C>G synonymous_variant 0.16 ethambutol Uncertain significance
embB 4248142 c.1629T>C synonymous_variant 0.16 ethambutol Uncertain significance
embB 4248143 c.1630T>C synonymous_variant 0.15 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R