TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	0.98
lineage4.9	Euro-American (H37Rv-like)	None	0.98

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472307	n.462C>T	non_coding_transcript_exon_variant	0.93	streptomycin	Uncertain significance	Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
gyrB	6268	c.1029C>G	synonymous_variant	1.0	levofloxacin
gyrB	6268	c.1029C>G	synonymous_variant	1.0	moxifloxacin
gyrB	6280	c.1041T>C	synonymous_variant	1.0	levofloxacin
gyrB	6280	c.1041T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8135	c.834C>G	synonymous_variant	1.0	levofloxacin
gyrA	8135	c.834C>G	synonymous_variant	1.0	moxifloxacin
gyrA	8156	c.855T>C	synonymous_variant	1.0	levofloxacin
gyrA	8156	c.855T>C	synonymous_variant	1.0	moxifloxacin
gyrA	8168	c.867A>G	synonymous_variant	1.0	levofloxacin
gyrA	8168	c.867A>G	synonymous_variant	1.0	moxifloxacin
gyrA	8177	c.876A>C	synonymous_variant	1.0	levofloxacin
gyrA	8177	c.876A>C	synonymous_variant	1.0	moxifloxacin
gyrA	9191	c.1890G>C	synonymous_variant	1.0	levofloxacin
gyrA	9191	c.1890G>C	synonymous_variant	1.0	moxifloxacin
gyrA	9200	c.1899A>G	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	9200	c.1899A>G	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9204	p.Ser635Thr	missense_variant	1.0	levofloxacin
gyrA	9204	p.Ser635Thr	missense_variant	1.0	moxifloxacin
gyrA	9224	c.1923C>T	synonymous_variant	1.0	levofloxacin
gyrA	9224	c.1923C>T	synonymous_variant	1.0	moxifloxacin
gyrA	9252	p.Val651Ile	missense_variant	1.0	levofloxacin	Uncertain significance
gyrA	9252	p.Val651Ile	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	9284	c.1983T>C	synonymous_variant	1.0	levofloxacin
gyrA	9284	c.1983T>C	synonymous_variant	1.0	moxifloxacin
fgd1	491601	c.819T>C	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491610	c.828A>G	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491616	c.834A>G	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fgd1	491620	p.Ile280Val	missense_variant	1.0	pretomanid
					delamanid
					clofazimine
hadA	731792	c.-138G>A	upstream_gene_variant	1.0	isoniazid
hadA	731801	c.-129C>G	upstream_gene_variant	1.0	isoniazid
hadA	731816	c.-114G>A	upstream_gene_variant	1.0	isoniazid
rpoB	760298	c.492G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760307	c.501T>C	synonymous_variant	1.0	rifampicin
rpoB	760310	c.504G>C	synonymous_variant	1.0	rifampicin
rpoB	760328	c.522G>C	synonymous_variant	1.0	rifampicin
rpoB	760331	c.525G>C	synonymous_variant	1.0	rifampicin
rpoB	760340	c.534G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760361	c.555T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760370	c.564C>G	synonymous_variant	1.0	rifampicin
rpoB	760424	c.618C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	760925	c.1119T>C	synonymous_variant	0.92	rifampicin
rpoB	760928	c.1122G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	760931	c.1125C>G	synonymous_variant	0.92	rifampicin
rpoB	760934	c.1128C>T	synonymous_variant	0.93	rifampicin
rpoB	760946	c.1140A>G	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	760982	c.1176G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	760985	c.1179G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	760991	c.1185G>C	synonymous_variant	0.91	rifampicin
rpoB	761006	c.1200C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761015	c.1209G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761021	c.1215G>C	synonymous_variant	1.0	rifampicin
rpoB	761057	c.1251G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	761102	c.1296A>G	synonymous_variant	0.93	rifampicin
rpoB	761129	c.1323G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	761132	c.1326G>T	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	761133	c.1327T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	761150	c.1344A>C	synonymous_variant	0.82	rifampicin	Not assoc w R - Interim
rpoB	761153	c.1347G>C	synonymous_variant	0.91	rifampicin
rpoB	761165	c.1359G>C	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoB	761180	c.1374A>C	synonymous_variant	0.85	rifampicin	Not assoc w R - Interim
rpoB	761189	c.1383T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	761195	c.1389G>C	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoB	761207	c.1401C>T	synonymous_variant	0.91	rifampicin
rpoB	761213	c.1407G>C	synonymous_variant	0.9	rifampicin
rpoB	761219	c.1413G>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	762149	c.2343G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoB	762167	c.2361T>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	762176	c.2370T>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoB	762185	c.2379G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	762206	c.2400C>G	synonymous_variant	0.92	rifampicin
rpoB	762233	c.2427G>C	synonymous_variant	0.93	rifampicin	Not assoc w R - Interim
rpoB	762246	c.2440C>T	synonymous_variant	0.93	rifampicin
rpoB	762254	c.2448T>G	synonymous_variant	1.0	rifampicin
rpoB	762257	c.2451C>G	synonymous_variant	1.0	rifampicin
rpoB	762266	c.2460T>C	synonymous_variant	1.0	rifampicin
rpoB	762284	c.2478G>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	762293	c.2487T>C	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoB	762314	c.2508C>T	synonymous_variant	0.91	rifampicin
rpoB	762317	c.2511A>G	synonymous_variant	0.91	rifampicin	Not assoc w R - Interim
rpoC	763441	c.72C>T	synonymous_variant	1.0	rifampicin
rpoC	763444	c.75T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763456	c.87A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763492	c.123G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763528	c.159G>A	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763546	c.177A>G	synonymous_variant	0.95	rifampicin	Not assoc w R - Interim
rpoC	763570	c.201G>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	763573	c.204G>C	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	763594	c.225C>T	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	763603	c.234C>T	synonymous_variant	0.94	rifampicin	Not assoc w R - Interim
rpoC	763606	c.237C>T	synonymous_variant	0.94	rifampicin
rpoC	763636	c.267T>C	synonymous_variant	0.92	rifampicin
rpoC	763702	c.333C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	763741	c.372C>T	synonymous_variant	1.0	rifampicin
rpoC	763765	c.396T>C	synonymous_variant	1.0	rifampicin
rpoC	763774	c.405G>C	synonymous_variant	1.0	rifampicin
rpoC	764888	c.1519T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764911	c.1542A>G	synonymous_variant	1.0	rifampicin
rpoC	764932	c.1563C>A	synonymous_variant	0.92	rifampicin	Not assoc w R - Interim
rpoC	764948	c.1579T>C	synonymous_variant	0.9	rifampicin	Not assoc w R - Interim
rpoC	765404	p.Leu679Val	missense_variant	1.0	rifampicin
rpoC	765409	c.2040T>C	synonymous_variant	1.0	rifampicin
rpoC	765421	c.2052C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765478	c.2109T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765499	c.2130C>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765529	c.2160C>T	synonymous_variant	1.0	rifampicin
rpoC	765541	c.2172C>G	synonymous_variant	1.0	rifampicin
rpoC	765553	c.2184C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765556	c.2187G>C	synonymous_variant	1.0	rifampicin
rpoC	765559	c.2190G>C	synonymous_variant	1.0	rifampicin
rpoC	765580	c.2211G>C	synonymous_variant	1.0	rifampicin
rpoC	765700	c.2331T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765734	c.2365T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765739	c.2370G>T	synonymous_variant	1.0	rifampicin
rpoC	765883	c.2514C>G	synonymous_variant	1.0	rifampicin
rpoC	765886	c.2517C>G	synonymous_variant	1.0	rifampicin
rpoC	765892	c.2523T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	765937	c.2568T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	766726	c.3357T>C	synonymous_variant	1.0	rifampicin
rpoC	766738	c.3369G>C	synonymous_variant	1.0	rifampicin
rpsL	781700	c.141G>C	synonymous_variant	1.0	streptomycin
rpsL	781703	c.144G>T	synonymous_variant	1.0	streptomycin
rpsL	781715	c.156T>C	synonymous_variant	1.0	streptomycin
rpsL	781728	c.169T>C	synonymous_variant	1.0	streptomycin
rpsL	781736	c.177T>C	synonymous_variant	1.0	streptomycin
rpsL	781742	c.183C>T	synonymous_variant	1.0	streptomycin
rpsL	781748	c.189C>G	synonymous_variant	1.0	streptomycin
rpsL	781754	c.195G>C	synonymous_variant	1.0	streptomycin
rpsL	781760	c.201T>C	synonymous_variant	1.0	streptomycin
rplC	800771	c.-38C>T	upstream_gene_variant	1.0	linezolid
fbiC	1304808	c.1878C>G	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fbiC	1304811	c.1881C>G	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fbiC	1304817	c.1887T>C	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fbiC	1304829	c.1899T>C	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fbiC	1304832	c.1902C>T	synonymous_variant	1.0	pretomanid
					delamanid	Not assoc w R - Interim
					clofazimine	Not assoc w R - Interim
fbiC	1304853	c.1923C>T	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
fbiC	1304856	c.1926C>G	synonymous_variant	1.0	pretomanid
					delamanid
					clofazimine
rrs	1472969	n.1124A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472970	n.1125C>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472977	n.1132G>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1472978	n.1133T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473105	n.1260G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrs	1473145	n.1300C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473166	n.1321G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473290	n.1445C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin
					amikacin	Uncertain significance
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473806	n.149C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473877	n.220G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473898	n.241C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1473943	n.286G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473943	n.286G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473945	n.288T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473945	n.288T>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473946	n.289A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1473946	n.289A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473986	n.329T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473987	n.330G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473987	n.330G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1473995	n.338G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474093	n.436G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474093	n.436G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474099	n.442G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474099	n.442G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474103	n.446A>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474140	n.483C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474151	n.494C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474181	n.524C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474249	n.592G>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1474904	n.1247G>A	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475291	n.1634A>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475313	n.1656G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475313	n.1656G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475315	n.1658A>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475355	n.1698C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475369	n.1712G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475419	n.1762C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475429	n.1772G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475436	n.1779C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475436	n.1779C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475483	n.1826C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475505	n.1848G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475526	n.1869C>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	0.95	capreomycin
rrl	1475599	n.1942A>G	non_coding_transcript_exon_variant	0.95	linezolid	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.95	capreomycin	Uncertain significance
rrl	1475608	n.1951T>C	non_coding_transcript_exon_variant	0.95	linezolid
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	0.92	capreomycin
rrl	1475642	n.1985T>C	non_coding_transcript_exon_variant	0.92	linezolid
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	0.93	capreomycin
rrl	1475657	n.2000A>G	non_coding_transcript_exon_variant	0.93	linezolid
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	0.93	capreomycin
rrl	1475659	n.2002G>T	non_coding_transcript_exon_variant	0.93	linezolid
rrl	1475761	n.2104_2106delCGCinsGT	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1475761	n.2104_2106delCGCinsGT	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475765	n.2111delG	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1475765	n.2111delG	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475881	n.2224T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1475988	n.2331A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476031	n.2374C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476031	n.2374C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476032	n.2375C>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476033	n.2376T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476034	n.2377C>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476045	n.2388G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476047	n.2390G>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476048	n.2391G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476048	n.2391G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476049	n.2392C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476086	n.2429G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476089	n.2432T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476095	n.2438C>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476117	n.2460G>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476117	n.2460G>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476214	n.2557G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476214	n.2557G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476224	n.2567A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476281	n.2624T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476583	n.2926G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476584	n.2927C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476594	n.2937C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.91	capreomycin	Uncertain significance
rrl	1476597	n.2940G>A	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1476603	n.2946G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476603	n.2946G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476608	n.2951C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476628	n.2971T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
inhA	1674582	c.381T>C	synonymous_variant	1.0	isoniazid
inhA	1674582	c.381T>C	synonymous_variant	1.0	ethionamide
inhA	1674585	c.384T>C	synonymous_variant	1.0	isoniazid
inhA	1674585	c.384T>C	synonymous_variant	1.0	ethionamide
rpsA	1833568	c.27G>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
rpsA	1833589	c.48A>T	synonymous_variant	1.0	pyrazinamide
rpsA	1833595	c.54T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1833742	c.201A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833745	c.204G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1833748	c.207C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833928	c.387G>C	synonymous_variant	1.0	pyrazinamide
rpsA	1833940	c.399C>G	synonymous_variant	1.0	pyrazinamide
rpsA	1833971	c.430C>T	synonymous_variant	1.0	pyrazinamide
rpsA	1834633	c.1092A>G	synonymous_variant	1.0	pyrazinamide
rpsA	1834639	c.1098T>C	synonymous_variant	1.0	pyrazinamide
rpsA	1834654	p.Glu371Asp	missense_variant	1.0	pyrazinamide
mtrA	3626759	c.591T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3626759	c.591T>C	synonymous_variant	1.0	bedaquiline
mtrA	3627146	c.204C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3627146	c.204C>T	synonymous_variant	1.0	bedaquiline
mtrB	3627167	c.-554T>C	upstream_gene_variant	1.0	rifampicin
mtrB	3627167	c.-554T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627181	c.-568T>C	upstream_gene_variant	1.0	rifampicin
mtrB	3627181	c.-568T>C	upstream_gene_variant	1.0	bedaquiline
mtrB	3627182	c.-569T>C	upstream_gene_variant	1.0	rifampicin
mtrB	3627182	c.-569T>C	upstream_gene_variant	1.0	bedaquiline
mtrA	3627188	c.162A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3627188	c.162A>G	synonymous_variant	1.0	bedaquiline
mtrB	3627209	c.-596G>A	upstream_gene_variant	1.0	rifampicin
mtrB	3627209	c.-596G>A	upstream_gene_variant	1.0	bedaquiline
mtrA	3627221	c.129C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3627221	c.129C>T	synonymous_variant	1.0	bedaquiline
mtrA	3627227	c.123T>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
mtrA	3627227	c.123T>C	synonymous_variant	1.0	bedaquiline
rpoA	3877613	p.Ile299Val	missense_variant	1.0	rifampicin
rpoA	3877896	c.612G>C	synonymous_variant	1.0	rifampicin
rpoA	3877900	p.Ser203Asn	missense_variant	1.0	rifampicin
rpoA	3877905	c.603A>G	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877909	p.Asn200Ser	missense_variant	1.0	rifampicin
rpoA	3877920	c.588G>C	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877923	c.585C>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3877926	c.582G>C	synonymous_variant	1.0	rifampicin
rpoA	3877962	c.546G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoA	3878226	c.282C>G	synonymous_variant	0.9	rifampicin
rpoA	3878232	c.276G>C	synonymous_variant	0.91	rifampicin
rpoA	3878415	c.93C>T	synonymous_variant	0.9	rifampicin
rpoA	3878424	c.84G>C	synonymous_variant	0.91	rifampicin
rpoA	3878436	c.72A>G	synonymous_variant	0.91	rifampicin
rpoA	3878806	c.-299C>G	upstream_gene_variant	0.91	rifampicin
rpoA	3878809	c.-302T>C	upstream_gene_variant	0.91	rifampicin
rpoA	3878824	c.-317G>C	upstream_gene_variant	0.91	rifampicin
rpoA	3879154	c.-647T>C	upstream_gene_variant	1.0	rifampicin
rpoA	3879160	c.-653A>G	upstream_gene_variant	1.0	rifampicin
clpC1	4039751	c.954A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039757	c.948A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039760	c.945T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039766	c.939T>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039769	c.936C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039775	c.930G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039778	c.927A>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039781	c.924G>C	synonymous_variant	1.0	pyrazinamide
clpC1	4039790	c.915C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039937	c.768G>C	synonymous_variant	0.91	pyrazinamide
clpC1	4039946	c.759A>C	synonymous_variant	0.91	pyrazinamide
clpC1	4039952	c.753T>C	synonymous_variant	0.91	pyrazinamide
clpC1	4039979	c.726C>G	synonymous_variant	1.0	pyrazinamide
clpC1	4039988	c.717C>G	synonymous_variant	1.0	pyrazinamide
embC	4240726	c.864G>C	synonymous_variant	1.0	ethambutol	Not assoc w R - Interim
embC	4240780	c.918T>C	synonymous_variant	1.0	ethambutol
embC	4240783	c.921G>C	synonymous_variant	1.0	ethambutol
embC	4240789	c.927T>C	synonymous_variant	1.0	ethambutol
embC	4240819	c.957A>G	synonymous_variant	1.0	ethambutol
embC	4240828	c.966G>A	synonymous_variant	1.0	ethambutol
embC	4240831	c.969T>G	synonymous_variant	1.0	ethambutol
embA	4245137	c.1905T>C	synonymous_variant	1.0	ethambutol
embA	4245146	c.1914G>A	synonymous_variant	1.0	ethambutol
embA	4245149	c.1917C>G	synonymous_variant	1.0	ethambutol
embA	4245153	p.Ile641Val	missense_variant	1.0	ethambutol
embA	4245182	c.1950T>C	synonymous_variant	1.0	ethambutol
embA	4245189	c.1957C>T	synonymous_variant	1.0	ethambutol
embB	4247491	c.978G>C	synonymous_variant	1.0	ethambutol
embB	4247497	c.984T>C	synonymous_variant	1.0	ethambutol

TB-Profiler result