Run ID: SRR29050770
Sample name:
Date: 2025-02-11T12:23:01.260662
Number of reads: 95951
Percentage reads mapped: 54.48
Median coverage: 2.0
Strain: lineage4.9
Spoligotype:
Drug-resistance: Sensitive
| Lineage | Family | RDs | Frequency |
|---|---|---|---|
| lineage4 | Euro-American | None | 1.0 |
| lineage4.9 | Euro-American (H37Rv-like) | None | 0.98 |
| Drug | Resistance | Supporting mutations | WHO confidence | Comment |
|---|---|---|---|---|
| rifampicin | ||||
| isoniazid | ||||
| ethambutol | ||||
| pyrazinamide | ||||
| streptomycin | ||||
| fluoroquinolones | ||||
| moxifloxacin | ||||
| ofloxacin | ||||
| levofloxacin | ||||
| ciprofloxacin | ||||
| aminoglycosides | ||||
| amikacin | ||||
| capreomycin | ||||
| kanamycin | ||||
| cycloserine | ||||
| ethionamide | ||||
| clofazimine | ||||
| para-aminosalicylic_acid | ||||
| delamanid | ||||
| bedaquiline | ||||
| linezolid |
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
|---|
| Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
|---|---|---|---|---|---|---|
| gyrA | 8903 | c.1602T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8912 | c.1611G>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8915 | c.1614A>G | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8930 | c.1629C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8939 | c.1638T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8942 | c.1641G>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8946 | c.1645_1647delTTGinsCTC | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| gyrA | 8983 | p.Cys561Ser | missense_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8987 | c.1686C>G | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8990 | c.1689C>A | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8996 | c.1695T>C | synonymous_variant | 1.0 | levofloxacin | |
| moxifloxacin | ||||||
| gyrA | 8998 | p.Leu566Trp | missense_variant | 1.0 | levofloxacin | Uncertain significance |
| moxifloxacin | Uncertain significance | |||||
| gyrA | 9023 | c.1722A>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
| moxifloxacin | Not assoc w R - Interim | |||||
| nusG | 734472 | c.219T>C | synonymous_variant | 0.9 | rifampicin | |
| nusG | 734475 | c.222T>C | synonymous_variant | 0.91 | rifampicin | Not assoc w R - Interim |
| nusG | 734505 | c.252G>A | synonymous_variant | 0.93 | rifampicin | |
| nusG | 734532 | c.279A>G | synonymous_variant | 0.91 | rifampicin | Not assoc w R - Interim |
| nusG | 734541 | c.288A>G | synonymous_variant | 0.9 | rifampicin | Not assoc w R - Interim |
| nusG | 734544 | c.291C>T | synonymous_variant | 0.9 | rifampicin | |
| rpoB | 760130 | p.Asp108Glu | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoB | 760184 | c.378A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 761921 | c.2115C>T | synonymous_variant | 0.9 | rifampicin | |
| rpoB | 761951 | c.2145G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 761969 | c.2163G>A | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 762014 | c.2208C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoB | 762065 | c.2259T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoB | 762068 | c.2262C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 763969 | c.600C>T | synonymous_variant | 0.93 | rifampicin | Not assoc w R - Interim |
| rpoC | 763978 | c.609C>T | synonymous_variant | 0.93 | rifampicin | |
| rpoC | 763991 | p.Ile208Leu | missense_variant | 0.92 | rifampicin | |
| rpoC | 763996 | c.627T>C | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 764002 | c.633C>G | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 764005 | c.636G>C | synonymous_variant | 0.92 | rifampicin | Not assoc w R - Interim |
| rpoC | 764011 | c.642T>C | synonymous_variant | 0.93 | rifampicin | |
| rpoC | 764024 | c.655_657delTTGinsCTC | synonymous_variant | 0.93 | rifampicin | |
| rpoC | 764040 | p.Ser224Thr | missense_variant | 0.93 | rifampicin | |
| rpoC | 764044 | c.675T>G | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 764059 | c.690G>C | synonymous_variant | 0.92 | rifampicin | |
| rpoC | 764083 | c.714A>G | synonymous_variant | 0.86 | rifampicin | |
| rpoC | 764092 | c.723C>T | synonymous_variant | 0.85 | rifampicin | |
| rpoC | 764098 | c.729A>G | synonymous_variant | 0.85 | rifampicin | Not assoc w R - Interim |
| rpoC | 764593 | c.1224C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 764611 | c.1242G>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765319 | c.1950A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765328 | p.His653Gln | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 765330 | p.Ser654Asn | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 765334 | c.1965C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765339 | p.Gln657Arg | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 765343 | c.1974G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765356 | p.Met663Leu | missense_variant | 1.0 | rifampicin | |
| rpoC | 765367 | c.1998C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765370 | c.2001G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765383 | p.Met672Leu | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 765409 | c.2040T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765412 | c.2043T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765421 | c.2052C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765499 | c.2130C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765529 | c.2160C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765547 | c.2178C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765556 | c.2187G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765559 | c.2190G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765562 | c.2193G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765578 | c.2209C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765583 | c.2214G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765592 | c.2223C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765595 | c.2226G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765622 | p.Glu751Asp | missense_variant | 1.0 | rifampicin | |
| rpoC | 765625 | c.2256C>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765628 | c.2259G>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765655 | c.2286T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765658 | c.2289C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765685 | c.2316G>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765694 | c.2325G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765700 | c.2331T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765728 | p.Gln787Lys | missense_variant | 1.0 | rifampicin | |
| rpoC | 765734 | c.2365T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 765739 | c.2370G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765751 | c.2382C>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 765753 | p.Asp795Ala | missense_variant | 1.0 | rifampicin | Uncertain significance |
| rpoC | 765844 | c.2475C>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766607 | p.Ile1080Leu | missense_variant | 1.0 | rifampicin | |
| rpoC | 766630 | c.3261G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766657 | c.3288A>G | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766666 | c.3297C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 766672 | c.3303T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766726 | c.3357T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766738 | c.3369G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766981 | c.3612T>C | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 766996 | c.3627C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767033 | c.3664_3666delTCGinsAGT | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 767059 | c.3690T>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767062 | c.3693C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 767098 | c.3729T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767107 | c.3738C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767119 | c.3750A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| rpoC | 767134 | c.3765C>A | synonymous_variant | 1.0 | rifampicin | |
| rpoC | 767152 | c.3783T>G | synonymous_variant | 1.0 | rifampicin | |
| rpsL | 781649 | c.90T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781655 | c.96T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781676 | c.117C>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781682 | c.123T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781715 | c.156T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781718 | c.159C>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781721 | c.162C>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781728 | c.169T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781751 | c.192G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781754 | c.195G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781760 | c.201T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781763 | c.204C>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781766 | c.207C>T | synonymous_variant | 1.0 | streptomycin | Not assoc w R - Interim |
| rpsL | 781814 | c.255C>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781817 | c.258G>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781832 | c.273T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781868 | c.309T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781871 | c.312G>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781892 | c.333A>G | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781898 | c.339A>T | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781916 | c.357T>C | synonymous_variant | 1.0 | streptomycin | |
| rpsL | 781929 | p.Gly124Ser | missense_variant | 1.0 | streptomycin | Uncertain significance |
| rpsL | 781933 | c.374G>A | splice_region_variant&stop_retained_variant | 1.0 | streptomycin | |
| fbiC | 1304082 | c.1152C>G | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304087 | p.Tyr386Phe | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304092 | p.Met388Leu | missense_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304127 | c.1197A>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | Not assoc w R - Interim | |||||
| fbiC | 1304130 | c.1200G>A | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| fbiC | 1304142 | c.1212G>C | synonymous_variant | 1.0 | pretomanid | |
| delamanid | ||||||
| clofazimine | ||||||
| rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 1.0 | capreomycin | Uncertain significance |
| linezolid | Uncertain significance | |||||
| rpsA | 1833661 | p.Glu40Asp | missense_variant | 1.0 | pyrazinamide | |
| rpsA | 1833667 | c.126C>G | synonymous_variant | 1.0 | pyrazinamide | |
| rpsA | 1833703 | c.162C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| rpsA | 1833976 | c.435C>T | synonymous_variant | 0.9 | pyrazinamide | |
| rpsA | 1833979 | c.438T>C | synonymous_variant | 0.9 | pyrazinamide | |
| Rv2477c | 2783395 | c.648T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783410 | c.633G>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783422 | c.621T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783427 | p.Pro206Ala | missense_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | Uncertain significance | |||||
| ethambutol | Uncertain significance | |||||
| amikacin | ||||||
| Rv2477c | 2783428 | c.615C>T | synonymous_variant | 1.0 | kanamycin | Not assoc w R - Interim |
| levofloxacin | Not assoc w R - Interim | |||||
| moxifloxacin | Not assoc w R - Interim | |||||
| streptomycin | ||||||
| rifampicin | Not assoc w R - Interim | |||||
| ethambutol | ||||||
| amikacin | Not assoc w R - Interim | |||||
| Rv2477c | 2783461 | c.582T>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783464 | c.579A>G | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783467 | c.576G>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| Rv2477c | 2783473 | c.570A>C | synonymous_variant | 1.0 | kanamycin | |
| levofloxacin | ||||||
| moxifloxacin | ||||||
| streptomycin | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| amikacin | ||||||
| pepQ | 2859864 | c.555T>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| pepQ | 2859870 | c.549T>C | synonymous_variant | 1.0 | bedaquiline | |
| clofazimine | ||||||
| Rv2752c | 3066504 | c.-313C>G | upstream_gene_variant | 0.91 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066507 | c.-316C>T | upstream_gene_variant | 0.91 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066513 | c.-322C>G | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066543 | c.-352C>A | upstream_gene_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066549 | c.-358T>C | upstream_gene_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066560 | c.-369C>T | upstream_gene_variant | 0.9 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066597 | c.-406C>T | upstream_gene_variant | 0.91 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066603 | c.-412A>G | upstream_gene_variant | 0.91 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066617 | c.-426G>A | upstream_gene_variant | 0.91 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066618 | c.-427A>G | upstream_gene_variant | 0.91 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066633 | c.-442T>C | upstream_gene_variant | 0.91 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| Rv2752c | 3066662 | c.-471C>T | upstream_gene_variant | 0.92 | levofloxacin | |
| moxifloxacin | ||||||
| isoniazid | ||||||
| rifampicin | ||||||
| ethambutol | ||||||
| thyX | 3067814 | c.132T>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067823 | c.123G>C | synonymous_variant | 0.92 | para-aminosalicylic_acid | |
| thyX | 3067826 | c.120C>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067847 | c.99C>G | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| thyX | 3067850 | c.96A>C | synonymous_variant | 1.0 | para-aminosalicylic_acid | |
| mtrB | 3625095 | p.Glu507Gln | missense_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625102 | c.-192A>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625105 | c.1509C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625117 | c.-207T>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625123 | c.-213T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625134 | c.-224T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625135 | c.-225A>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625138 | c.-228C>G | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625141 | c.-231T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625159 | c.-251_-249delTTGinsCTT | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625174 | c.-264C>A | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625177 | c.1437C>T | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | Not assoc w R - Interim | |||||
| mtrB | 3625222 | c.1392T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625240 | c.-330T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625243 | c.-333T>C | upstream_gene_variant | 1.0 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625255 | c.-345T>G | upstream_gene_variant | 0.9 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625267 | c.1347T>C | synonymous_variant | 0.91 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625270 | c.-360G>C | upstream_gene_variant | 0.91 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625285 | c.-375G>C | upstream_gene_variant | 0.91 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625298 | p.Ala439Val | missense_variant | 0.91 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625301 | p.Ala438Gly | missense_variant | 0.86 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625312 | c.-402G>C | upstream_gene_variant | 0.87 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625327 | c.-417A>G | upstream_gene_variant | 0.87 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625333 | c.-423C>T | upstream_gene_variant | 0.87 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625345 | c.-435T>C | upstream_gene_variant | 0.87 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625351 | c.1263T>C | synonymous_variant | 0.87 | rifampicin | Not assoc w R - Interim |
| bedaquiline | ||||||
| lpqB | 3625372 | c.-462A>G | upstream_gene_variant | 0.86 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625375 | c.-465A>G | upstream_gene_variant | 0.86 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625381 | c.-471T>G | upstream_gene_variant | 0.79 | rifampicin | |
| bedaquiline | ||||||
| mtrB | 3625386 | p.Ala410Pro | missense_variant | 0.79 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625393 | c.-483G>A | upstream_gene_variant | 0.73 | rifampicin | |
| bedaquiline | ||||||
| lpqB | 3625396 | c.-486G>C | upstream_gene_variant | 0.79 | rifampicin | |
| bedaquiline | ||||||
| rpoA | 3877731 | c.777G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877734 | c.774G>T | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3877737 | c.771G>C | synonymous_variant | 1.0 | rifampicin | |
| rpoA | 3878938 | c.-431T>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoA | 3878947 | c.-440G>C | upstream_gene_variant | 1.0 | rifampicin | Uncertain significance |
| rpoA | 3878953 | c.-446C>T | upstream_gene_variant | 1.0 | rifampicin | |
| rpoA | 3879022 | c.-515G>C | upstream_gene_variant | 0.87 | rifampicin | |
| rpoA | 3879033 | c.-526C>T | upstream_gene_variant | 0.87 | rifampicin | |
| rpoA | 3879034 | c.-527G>C | upstream_gene_variant | 0.87 | rifampicin | |
| rpoA | 3879037 | c.-530G>C | upstream_gene_variant | 0.87 | rifampicin | |
| rpoA | 3879061 | c.-554C>T | upstream_gene_variant | 0.87 | rifampicin | |
| rpoA | 3879088 | c.-581A>C | upstream_gene_variant | 0.85 | rifampicin | |
| rpoA | 3879094 | c.-587T>C | upstream_gene_variant | 0.87 | rifampicin | |
| rpoA | 3879121 | c.-614T>G | upstream_gene_variant | 0.86 | rifampicin | |
| rpoA | 3879124 | c.-617G>C | upstream_gene_variant | 0.86 | rifampicin | |
| rpoA | 3879127 | c.-620T>C | upstream_gene_variant | 0.86 | rifampicin | |
| rpoA | 3879148 | c.-641G>A | upstream_gene_variant | 0.93 | rifampicin | |
| rpoA | 3879154 | c.-647T>C | upstream_gene_variant | 1.0 | rifampicin | |
| rpoA | 3879160 | c.-653A>G | upstream_gene_variant | 1.0 | rifampicin | |
| clpC1 | 4038623 | c.2082A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038647 | c.2058T>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038658 | p.Lys683Gln | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038661 | p.Ser682Thr | missense_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038662 | c.2043T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038671 | c.2034T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038683 | c.2022T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038692 | c.2013C>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038695 | c.2010C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038698 | c.2007C>T | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038701 | c.2004G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038704 | c.2001T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038713 | c.1992T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038860 | c.1845G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038878 | c.1827A>G | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038881 | c.1824C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038884 | c.1821C>T | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038905 | c.1800A>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038908 | c.1797C>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038914 | c.1791G>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038923 | c.1780_1782delCTAinsTTG | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038953 | c.1752A>G | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038956 | c.1749T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038965 | c.1740T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038971 | c.1734T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038974 | c.1731T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4038989 | c.1716T>C | synonymous_variant | 1.0 | pyrazinamide | |
| clpC1 | 4038997 | c.1708T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| clpC1 | 4040551 | c.154T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
| embC | 4241086 | c.1224G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241101 | c.1239G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241121 | p.Ser420Asn | missense_variant | 1.0 | ethambutol | |
| embC | 4241125 | c.1263G>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241131 | c.1269G>A | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241140 | c.1278A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4241141 | p.Ile427Val | missense_variant | 1.0 | ethambutol | Uncertain significance |
| embC | 4241158 | c.1296T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241161 | c.1299C>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embC | 4241162 | c.1300T>C | synonymous_variant | 1.0 | ethambutol | |
| embC | 4241179 | c.1317G>A | synonymous_variant | 1.0 | ethambutol | |
| embA | 4242799 | c.-434T>C | upstream_gene_variant | 0.6 | ethambutol | |
| embA | 4245136 | p.Tyr635Phe | missense_variant | 0.91 | ethambutol | |
| embA | 4245153 | p.Ile641Val | missense_variant | 0.9 | ethambutol | |
| embB | 4247437 | c.924A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247470 | c.957T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247494 | c.981G>A | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247497 | c.984T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247500 | c.987C>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247506 | c.993C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
| embB | 4247512 | c.999T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4247519 | c.1006C>T | synonymous_variant | 1.0 | ethambutol | |
| embB | 4248337 | c.1824G>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4249486 | c.2973T>G | synonymous_variant | 1.0 | ethambutol | |
| embB | 4249487 | c.2974T>C | synonymous_variant | 1.0 | ethambutol | |
| embB | 4249492 | c.2979C>A | synonymous_variant | 1.0 | ethambutol |
