Run ID: ERR11466174
Sample name:
Date: 2024-10-05T05:21:10.857019
Number of reads: 2654665
Percentage reads mapped: 97.8
Median coverage: 81.0
Strain: lineage4.8
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
lineage4 | Euro-American | None | 1.0 |
lineage4.8 | Euro-American (mainly T) | RD219 | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | embB | p.Asn399Asp | Mutation from literature | |
pyrazinamide | ||||
streptomycin | rrs | n.462C>T | Uncertain significance | Mutation from literature |
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | ||||
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
rrs | 1472307 | n.462C>T | non_coding_transcript_exon_variant | 0.15 | streptomycin | Uncertain significance | Mutation from literature |
embB | 4247708 | p.Asn399Asp | missense_variant | 0.13 | ethambutol | Mutation from literature |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
gyrA | 7362 | p.Glu21Gln | missense_variant | 0.99 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
ccsA | 619609 | c.-282G>C | upstream_gene_variant | 0.14 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620265 | c.375C>G | synonymous_variant | 0.15 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620268 | c.378G>C | synonymous_variant | 0.14 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620283 | c.393T>C | synonymous_variant | 0.13 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620284 | p.Ala132Pro | missense_variant | 0.12 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620288 | p.Arg133Gln | missense_variant | 0.12 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620295 | c.405G>T | synonymous_variant | 0.13 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620298 | c.408G>C | synonymous_variant | 0.13 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620310 | c.420C>T | synonymous_variant | 0.15 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620317 | p.Val143Leu | missense_variant | 0.14 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620733 | c.843G>C | synonymous_variant | 0.12 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620734 | c.844C>A | synonymous_variant | 0.12 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620739 | c.849A>G | synonymous_variant | 0.12 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620742 | c.852G>C | synonymous_variant | 0.12 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620745 | c.855G>C | synonymous_variant | 0.12 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620748 | c.858T>A | synonymous_variant | 0.12 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620763 | c.873G>A | synonymous_variant | 0.15 | kanamycin | |
capreomycin | ||||||
amikacin | ||||||
ccsA | 620769 | c.879C>G | synonymous_variant | 0.14 | kanamycin | Not assoc w R - Interim |
capreomycin | Not assoc w R - Interim | |||||
amikacin | Not assoc w R - Interim | |||||
Rv0565c | 656265 | c.1204_1205delAC | frameshift_variant | 1.0 | ethionamide | Uncertain significance |
nusG | 734141 | c.-113G>A | upstream_gene_variant | 0.98 | rifampicin | Uncertain significance |
nusG | 734451 | c.198G>C | synonymous_variant | 0.14 | rifampicin | |
nusG | 734457 | c.204C>G | synonymous_variant | 0.14 | rifampicin | |
nusG | 734472 | c.219T>C | synonymous_variant | 0.15 | rifampicin | |
nusG | 734475 | c.222T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
nusG | 734658 | c.405A>G | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
rpoB | 761150 | c.1344A>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761153 | c.1347G>C | synonymous_variant | 0.16 | rifampicin | |
rpoB | 761165 | c.1359G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 761180 | c.1374A>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761189 | c.1383T>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 761195 | c.1389G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoB | 761207 | c.1401C>T | synonymous_variant | 0.19 | rifampicin | |
rpoB | 761213 | c.1407G>C | synonymous_variant | 0.18 | rifampicin | |
rpoB | 761219 | c.1413G>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoB | 761255 | c.1449T>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 761261 | c.1455G>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 762131 | c.2325C>G | synonymous_variant | 0.14 | rifampicin | |
rpoB | 762206 | c.2400C>G | synonymous_variant | 0.14 | rifampicin | |
rpoB | 762233 | c.2427G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 762246 | c.2440C>T | synonymous_variant | 0.16 | rifampicin | |
rpoB | 762254 | c.2448T>G | synonymous_variant | 0.17 | rifampicin | |
rpoB | 762257 | c.2451C>G | synonymous_variant | 0.15 | rifampicin | |
rpoB | 762266 | c.2460T>C | synonymous_variant | 0.13 | rifampicin | |
rpoB | 762284 | c.2478G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 762293 | c.2487T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 763028 | c.3222T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 763031 | c.3225T>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 763034 | c.3228C>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoB | 763040 | c.3234C>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoB | 763070 | c.3264T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763148 | c.-222G>C | upstream_gene_variant | 0.15 | rifampicin | |
rpoC | 763158 | c.-212C>T | upstream_gene_variant | 0.14 | rifampicin | |
rpoB | 763166 | c.3360A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 763190 | c.-180C>T | upstream_gene_variant | 0.13 | rifampicin | |
rpoC | 764353 | c.984G>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 764365 | c.996C>T | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 764510 | c.1141C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 764521 | c.1152T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 764527 | c.1158C>T | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoC | 764536 | c.1167G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764539 | c.1170C>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764548 | c.1179G>A | synonymous_variant | 0.18 | rifampicin | |
rpoC | 764551 | c.1182G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 764554 | c.1185C>T | synonymous_variant | 0.16 | rifampicin | |
rpoC | 764560 | c.1191T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764566 | c.1197C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 764575 | c.1206T>G | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764593 | c.1224C>T | synonymous_variant | 0.14 | rifampicin | |
rpoC | 764611 | c.1242G>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 765883 | c.2514C>G | synonymous_variant | 0.13 | rifampicin | |
rpoC | 765886 | c.2517C>G | synonymous_variant | 0.13 | rifampicin | |
rpoC | 766462 | c.3093G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 766483 | c.3114G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766484 | p.Val1039Ile | missense_variant | 0.16 | rifampicin | Uncertain significance |
rpoC | 766492 | c.3123T>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766522 | c.3153C>G | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766528 | c.3159T>C | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766531 | c.3162G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 766540 | p.Asp1057Glu | missense_variant | 0.14 | rifampicin | |
rpoC | 766549 | c.3180G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766765 | c.3396A>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 766801 | c.3432C>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766804 | c.3435A>G | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 766861 | c.3492G>C | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.16 | rifampicin | |
rpoC | 766933 | c.3564A>G | synonymous_variant | 0.15 | rifampicin | |
rpoC | 766945 | c.3576A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 766963 | c.3594T>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoC | 766972 | c.3603G>C | synonymous_variant | 0.17 | rifampicin | |
rpoC | 766996 | c.3627C>T | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 767009 | c.3640_3642delTCGinsAGC | synonymous_variant | 0.15 | rifampicin | |
rpoC | 767014 | c.3645G>C | synonymous_variant | 0.14 | rifampicin | |
rpoC | 767033 | c.3664_3666delTCGinsAGC | synonymous_variant | 0.14 | rifampicin | |
rpoC | 767059 | c.3690T>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoC | 767062 | c.3693C>A | synonymous_variant | 0.18 | rifampicin | |
rpoC | 767098 | c.3729T>C | synonymous_variant | 0.15 | rifampicin | Not assoc w R - Interim |
rpoC | 767119 | c.3750A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 767134 | c.3765C>A | synonymous_variant | 0.18 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 0.97 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rplC | 800627 | c.-182C>T | upstream_gene_variant | 0.13 | linezolid | |
rplC | 800648 | c.-161A>T | upstream_gene_variant | 0.13 | linezolid | |
fbiC | 1304580 | c.1650T>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304613 | c.1683T>C | synonymous_variant | 0.18 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304634 | c.1704C>G | synonymous_variant | 0.16 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304640 | c.1710A>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304646 | c.1716T>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304778 | c.1848T>C | synonymous_variant | 0.15 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304784 | c.1854T>C | synonymous_variant | 0.14 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304787 | c.1857T>G | synonymous_variant | 0.14 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304937 | c.2007G>C | synonymous_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304958 | c.2028T>G | synonymous_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
fbiC | 1304983 | c.2053C>T | synonymous_variant | 0.21 | pretomanid | |
delamanid | ||||||
clofazimine | ||||||
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | kanamycin | |
capreomycin | ||||||
streptomycin | ||||||
amikacin | ||||||
rrs | 1472969 | n.1124A>G | non_coding_transcript_exon_variant | 0.16 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472970 | n.1125C>G | non_coding_transcript_exon_variant | 0.15 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472977 | n.1132G>C | non_coding_transcript_exon_variant | 0.14 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | ||||||
amikacin | Uncertain significance | |||||
rrs | 1472978 | n.1133T>C | non_coding_transcript_exon_variant | 0.14 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1473145 | n.1300C>T | non_coding_transcript_exon_variant | 0.12 | kanamycin | Uncertain significance |
capreomycin | Uncertain significance | |||||
streptomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473986 | n.329T>C | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1473987 | n.330G>A | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1473995 | n.338G>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1474001 | n.344C>T | non_coding_transcript_exon_variant | 1.0 | capreomycin | Not assoc w R |
linezolid | Not assoc w R | |||||
rrl | 1474009 | n.352A>G | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1474012 | n.355C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1474093 | n.436G>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1474099 | n.442G>A | non_coding_transcript_exon_variant | 0.13 | capreomycin | |
linezolid | ||||||
rrl | 1474794 | n.1137C>T | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474823 | n.1166C>T | non_coding_transcript_exon_variant | 0.14 | capreomycin | |
linezolid | ||||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475088 | n.1431A>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1475402 | n.1745C>T | non_coding_transcript_exon_variant | 0.13 | capreomycin | |
linezolid | ||||||
rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.13 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475429 | n.1772G>A | non_coding_transcript_exon_variant | 0.14 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475436 | n.1779C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | ||||||
rrl | 1475483 | n.1826C>T | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475505 | n.1848G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475526 | n.1869C>A | non_coding_transcript_exon_variant | 0.13 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475599 | n.1942A>G | non_coding_transcript_exon_variant | 0.15 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1475608 | n.1951T>C | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475642 | n.1985T>C | non_coding_transcript_exon_variant | 0.12 | capreomycin | |
linezolid | ||||||
rrl | 1475761 | n.2104_2106delCGCinsGT | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1475765 | n.2111delG | non_coding_transcript_exon_variant | 0.18 | capreomycin | |
linezolid | ||||||
rrl | 1475881 | n.2224T>C | non_coding_transcript_exon_variant | 0.21 | capreomycin | |
linezolid | ||||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.15 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rpsA | 1833589 | c.48A>T | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833595 | c.54T>C | synonymous_variant | 0.16 | pyrazinamide | |
rpsA | 1833661 | c.120A>G | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1833667 | c.126C>G | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1833940 | c.399C>G | synonymous_variant | 0.13 | pyrazinamide | |
rpsA | 1833971 | c.430C>T | synonymous_variant | 0.14 | pyrazinamide | |
rpsA | 1833979 | c.438T>C | synonymous_variant | 0.15 | pyrazinamide | |
rpsA | 1834000 | c.459G>C | synonymous_variant | 0.14 | pyrazinamide | |
tlyA | 1917972 | c.33A>G | synonymous_variant | 0.98 | capreomycin | Not assoc w R |
PPE35 | 2168149 | p.Pro822Ser | missense_variant | 0.96 | pyrazinamide | Not assoc w R |
PPE35 | 2169149 | c.1464G>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | bedaquiline | Not assoc w R - Interim |
clofazimine | Not assoc w R | |||||
kasA | 2518864 | c.750G>C | synonymous_variant | 0.13 | isoniazid | |
Rv2477c | 2783758 | p.Asp95Glu | missense_variant | 0.14 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2477c | 2783761 | c.282G>C | synonymous_variant | 0.14 | kanamycin | |
levofloxacin | ||||||
moxifloxacin | ||||||
streptomycin | ||||||
rifampicin | ||||||
ethambutol | ||||||
amikacin | ||||||
Rv2680 | 2995848 | c.-257G>A | upstream_gene_variant | 0.99 | capreomycin | |
Rv3236c | 3613636 | c.-520A>G | upstream_gene_variant | 0.99 | pyrazinamide | Not assoc w R |
lpqB | 3625594 | c.-684T>C | upstream_gene_variant | 0.13 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625602 | c.-692T>C | upstream_gene_variant | 0.14 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625612 | c.-702G>C | upstream_gene_variant | 0.16 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625616 | p.Arg333Ala | missense_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
lpqB | 3625624 | c.-714C>G | upstream_gene_variant | 0.17 | rifampicin | |
bedaquiline | ||||||
mtrB | 3625636 | c.978C>G | synonymous_variant | 0.23 | rifampicin | Not assoc w R - Interim |
bedaquiline | ||||||
mtrB | 3625656 | c.958T>C | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
bedaquiline | Not assoc w R - Interim | |||||
rpoA | 3877613 | p.Ile299Val | missense_variant | 0.12 | rifampicin | |
rpoA | 3877656 | c.852T>G | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3878298 | c.210A>G | synonymous_variant | 0.13 | rifampicin | Not assoc w R - Interim |
rpoA | 3878304 | c.204G>C | synonymous_variant | 0.14 | rifampicin | |
rpoA | 3878313 | c.195G>C | synonymous_variant | 0.14 | rifampicin | Not assoc w R - Interim |
rpoA | 3878322 | c.186A>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoA | 3878331 | c.177A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3878334 | c.174T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878337 | c.171T>C | synonymous_variant | 0.18 | rifampicin | Not assoc w R - Interim |
rpoA | 3878346 | c.162T>C | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3878364 | c.144A>T | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878367 | c.141C>G | synonymous_variant | 0.21 | rifampicin | |
rpoA | 3878376 | c.132G>C | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878385 | c.123C>G | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878388 | c.120C>G | synonymous_variant | 0.18 | rifampicin | |
rpoA | 3878391 | c.117T>C | synonymous_variant | 0.19 | rifampicin | |
rpoA | 3878415 | c.93C>T | synonymous_variant | 0.17 | rifampicin | |
rpoA | 3878424 | c.84G>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878436 | c.72A>G | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878442 | c.66G>C | synonymous_variant | 0.15 | rifampicin | |
rpoA | 3878454 | c.54A>C | synonymous_variant | 0.16 | rifampicin | |
rpoA | 3878736 | c.-229A>G | upstream_gene_variant | 0.21 | rifampicin | |
rpoA | 3878737 | c.-230G>C | upstream_gene_variant | 0.2 | rifampicin | |
rpoA | 3878742 | c.-235G>A | upstream_gene_variant | 0.2 | rifampicin | |
rpoA | 3878746 | c.-239A>G | upstream_gene_variant | 0.22 | rifampicin | Uncertain significance |
rpoA | 3878749 | c.-242G>T | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878761 | c.-254G>C | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3878764 | c.-257A>G | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3878785 | c.-278T>G | upstream_gene_variant | 0.27 | rifampicin | |
rpoA | 3878788 | c.-281G>C | upstream_gene_variant | 0.27 | rifampicin | Uncertain significance |
rpoA | 3878806 | c.-299C>G | upstream_gene_variant | 0.25 | rifampicin | |
rpoA | 3878809 | c.-302T>C | upstream_gene_variant | 0.26 | rifampicin | |
rpoA | 3878824 | c.-317G>C | upstream_gene_variant | 0.25 | rifampicin | |
rpoA | 3878833 | c.-326C>G | upstream_gene_variant | 0.24 | rifampicin | |
rpoA | 3878836 | c.-331_-329delAAGinsTCC | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878853 | c.-346G>A | upstream_gene_variant | 0.22 | rifampicin | |
rpoA | 3878878 | c.-371T>C | upstream_gene_variant | 0.17 | rifampicin | Uncertain significance |
rpoA | 3878914 | c.-407T>C | upstream_gene_variant | 0.13 | rifampicin | Uncertain significance |
rpoA | 3878917 | c.-410G>A | upstream_gene_variant | 0.14 | rifampicin | Uncertain significance |
rpoA | 3878938 | c.-431T>C | upstream_gene_variant | 0.12 | rifampicin | |
clpC1 | 4038749 | c.1956C>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038770 | c.1935C>T | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038812 | c.1893T>C | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4038845 | c.1860G>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038860 | c.1845G>C | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038878 | c.1827A>G | synonymous_variant | 0.13 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038914 | c.1791G>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038953 | c.1752A>G | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038956 | c.1749T>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038965 | c.1740T>C | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4038989 | c.1716T>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4038997 | c.1708T>C | synonymous_variant | 0.18 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039004 | c.1701C>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039022 | c.1683A>G | synonymous_variant | 0.24 | pyrazinamide | |
clpC1 | 4039064 | c.1641C>T | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4039097 | c.1608G>C | synonymous_variant | 0.12 | pyrazinamide | |
clpC1 | 4039517 | c.1188C>G | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4039729 | p.Asp326Asn | missense_variant | 0.94 | pyrazinamide | Not assoc w R |
clpC1 | 4039898 | c.807C>G | synonymous_variant | 0.13 | pyrazinamide | |
clpC1 | 4040318 | c.387C>G | synonymous_variant | 0.13 | pyrazinamide | |
panD | 4044737 | c.-456T>C | upstream_gene_variant | 0.14 | pyrazinamide | |
panD | 4044746 | c.-467_-465delGTGinsATC | upstream_gene_variant | 0.15 | pyrazinamide | |
panD | 4044752 | c.-471T>C | upstream_gene_variant | 0.16 | pyrazinamide | |
panD | 4044989 | c.-708T>C | upstream_gene_variant | 0.15 | pyrazinamide | |
panD | 4045000 | c.-719A>C | upstream_gene_variant | 0.18 | pyrazinamide | |
panD | 4045001 | c.-720G>C | upstream_gene_variant | 0.18 | pyrazinamide | |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embA | 4246305 | p.Ser1025Glu | missense_variant | 0.14 | ethambutol | |
embA | 4246308 | p.Thr1026Ala | missense_variant | 0.14 | ethambutol | |
embB | 4246316 | c.-198T>G | upstream_gene_variant | 0.13 | ethambutol | |
embB | 4246319 | c.-195G>C | upstream_gene_variant | 0.12 | ethambutol | |
embB | 4247491 | c.978G>C | synonymous_variant | 0.13 | ethambutol | |
embB | 4247539 | c.1026T>C | synonymous_variant | 0.14 | ethambutol | |
embB | 4247746 | c.1233C>T | synonymous_variant | 0.12 | ethambutol | |
embB | 4247761 | c.1248T>C | synonymous_variant | 0.13 | ethambutol | |
embB | 4247773 | c.1260G>A | synonymous_variant | 0.13 | ethambutol | |
embB | 4247776 | c.1263G>T | synonymous_variant | 0.14 | ethambutol | |
embB | 4247797 | c.1284C>G | synonymous_variant | 0.15 | ethambutol | |
embB | 4247800 | c.1287A>T | synonymous_variant | 0.16 | ethambutol | |
embB | 4247803 | c.1290G>C | synonymous_variant | 0.17 | ethambutol | |
embB | 4247815 | c.1302C>G | synonymous_variant | 0.14 | ethambutol | |
embB | 4247819 | p.Val436Ile | missense_variant | 0.16 | ethambutol | Uncertain significance |
embB | 4247830 | c.1317A>G | synonymous_variant | 0.13 | ethambutol | Not assoc w R - Interim |
embB | 4247866 | c.1353G>C | synonymous_variant | 0.15 | ethambutol | |
embB | 4247875 | c.1362G>C | synonymous_variant | 0.15 | ethambutol | |
embB | 4247876 | c.1363C>T | synonymous_variant | 0.15 | ethambutol | |
embB | 4247881 | c.1368G>C | synonymous_variant | 0.15 | ethambutol | |
embB | 4247887 | c.1374C>T | synonymous_variant | 0.14 | ethambutol | Not assoc w R - Interim |
embB | 4247905 | c.1392G>C | synonymous_variant | 0.12 | ethambutol | Not assoc w R - Interim |
embB | 4247956 | c.1443G>C | synonymous_variant | 0.16 | ethambutol | Not assoc w R - Interim |
embB | 4247974 | c.1461C>G | synonymous_variant | 0.15 | ethambutol | |
embB | 4248007 | c.1494C>G | synonymous_variant | 0.13 | ethambutol | |
embB | 4248035 | p.Val508Ile | missense_variant | 0.14 | ethambutol | |
embB | 4248040 | c.1527C>G | synonymous_variant | 0.13 | ethambutol | |
embB | 4248041 | p.Ala510Thr | missense_variant | 0.13 | ethambutol | Uncertain significance |
embB | 4248044 | p.Lys511Ala | missense_variant | 0.14 | ethambutol | |
embB | 4248070 | c.1557T>C | synonymous_variant | 0.13 | ethambutol | |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | kanamycin | Not assoc w R |
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R |