TB-Profiler result

Run: ERR11466174
Summary

Run ID: ERR11466174

Sample name:

Date: 2024-10-05T05:21:10.857019

Number of reads: 2654665

Percentage reads mapped: 97.8

Median coverage: 81.0

Strain: lineage4.8

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.8 Euro-American (mainly T) RD219 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol embB p.Asn399Asp Mutation from literature
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance Mutation from literature
embB 4247708 p.Asn399Asp missense_variant 0.13 ethambutol Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 0.99 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
ccsA 619609 c.-282G>C upstream_gene_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620265 c.375C>G synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620268 c.378G>C synonymous_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620283 c.393T>C synonymous_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620284 p.Ala132Pro missense_variant 0.12 kanamycin
capreomycin
amikacin
ccsA 620288 p.Arg133Gln missense_variant 0.12 kanamycin
capreomycin
amikacin
ccsA 620295 c.405G>T synonymous_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620298 c.408G>C synonymous_variant 0.13 kanamycin
capreomycin
amikacin
ccsA 620310 c.420C>T synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620317 p.Val143Leu missense_variant 0.14 kanamycin
capreomycin
amikacin
ccsA 620733 c.843G>C synonymous_variant 0.12 kanamycin
capreomycin
amikacin
ccsA 620734 c.844C>A synonymous_variant 0.12 kanamycin
capreomycin
amikacin
ccsA 620739 c.849A>G synonymous_variant 0.12 kanamycin
capreomycin
amikacin
ccsA 620742 c.852G>C synonymous_variant 0.12 kanamycin
capreomycin
amikacin
ccsA 620745 c.855G>C synonymous_variant 0.12 kanamycin
capreomycin
amikacin
ccsA 620748 c.858T>A synonymous_variant 0.12 kanamycin
capreomycin
amikacin
ccsA 620763 c.873G>A synonymous_variant 0.15 kanamycin
capreomycin
amikacin
ccsA 620769 c.879C>G synonymous_variant 0.14 kanamycin Not assoc w R - Interim
capreomycin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv0565c 656265 c.1204_1205delAC frameshift_variant 1.0 ethionamide Uncertain significance
nusG 734141 c.-113G>A upstream_gene_variant 0.98 rifampicin Uncertain significance
nusG 734451 c.198G>C synonymous_variant 0.14 rifampicin
nusG 734457 c.204C>G synonymous_variant 0.14 rifampicin
nusG 734472 c.219T>C synonymous_variant 0.15 rifampicin
nusG 734475 c.222T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
nusG 734658 c.405A>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoB 761150 c.1344A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761153 c.1347G>C synonymous_variant 0.16 rifampicin
rpoB 761165 c.1359G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761180 c.1374A>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761189 c.1383T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761195 c.1389G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761207 c.1401C>T synonymous_variant 0.19 rifampicin
rpoB 761213 c.1407G>C synonymous_variant 0.18 rifampicin
rpoB 761219 c.1413G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 762131 c.2325C>G synonymous_variant 0.14 rifampicin
rpoB 762206 c.2400C>G synonymous_variant 0.14 rifampicin
rpoB 762233 c.2427G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762246 c.2440C>T synonymous_variant 0.16 rifampicin
rpoB 762254 c.2448T>G synonymous_variant 0.17 rifampicin
rpoB 762257 c.2451C>G synonymous_variant 0.15 rifampicin
rpoB 762266 c.2460T>C synonymous_variant 0.13 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763028 c.3222T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 763031 c.3225T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763034 c.3228C>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763148 c.-222G>C upstream_gene_variant 0.15 rifampicin
rpoC 763158 c.-212C>T upstream_gene_variant 0.14 rifampicin
rpoB 763166 c.3360A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763190 c.-180C>T upstream_gene_variant 0.13 rifampicin
rpoC 764353 c.984G>C synonymous_variant 0.15 rifampicin
rpoC 764365 c.996C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764510 c.1141C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764521 c.1152T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764527 c.1158C>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoC 764536 c.1167G>C synonymous_variant 0.14 rifampicin
rpoC 764539 c.1170C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764548 c.1179G>A synonymous_variant 0.18 rifampicin
rpoC 764551 c.1182G>C synonymous_variant 0.17 rifampicin
rpoC 764554 c.1185C>T synonymous_variant 0.16 rifampicin
rpoC 764560 c.1191T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764575 c.1206T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764593 c.1224C>T synonymous_variant 0.14 rifampicin
rpoC 764611 c.1242G>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.13 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.13 rifampicin
rpoC 766462 c.3093G>C synonymous_variant 0.14 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.16 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.16 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.17 rifampicin
rpoC 766522 c.3153C>G synonymous_variant 0.16 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.15 rifampicin
rpoC 766531 c.3162G>C synonymous_variant 0.14 rifampicin
rpoC 766540 p.Asp1057Glu missense_variant 0.14 rifampicin
rpoC 766549 c.3180G>C synonymous_variant 0.17 rifampicin
rpoC 766765 c.3396A>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766801 c.3432C>G synonymous_variant 0.15 rifampicin
rpoC 766804 c.3435A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.16 rifampicin
rpoC 766933 c.3564A>G synonymous_variant 0.15 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.17 rifampicin
rpoC 766996 c.3627C>T synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.15 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.14 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGC synonymous_variant 0.14 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.18 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 767119 c.3750A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.18 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 0.97 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rplC 800627 c.-182C>T upstream_gene_variant 0.13 linezolid
rplC 800648 c.-161A>T upstream_gene_variant 0.13 linezolid
fbiC 1304580 c.1650T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304613 c.1683T>C synonymous_variant 0.18 pretomanid
delamanid
clofazimine
fbiC 1304634 c.1704C>G synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fbiC 1304640 c.1710A>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304646 c.1716T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304778 c.1848T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
fbiC 1304784 c.1854T>C synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304787 c.1857T>G synonymous_variant 0.14 pretomanid
delamanid
clofazimine
fbiC 1304937 c.2007G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304958 c.2028T>G synonymous_variant 0.21 pretomanid
delamanid
clofazimine
fbiC 1304983 c.2053C>T synonymous_variant 0.21 pretomanid
delamanid
clofazimine
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.16 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.14 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.12 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin Uncertain significance
amikacin Uncertain significance
rrl 1473806 n.149C>T non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473986 n.329T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473987 n.330G>A non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1473995 n.338G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474001 n.344C>T non_coding_transcript_exon_variant 1.0 capreomycin Not assoc w R
linezolid Not assoc w R
rrl 1474009 n.352A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474093 n.436G>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474099 n.442G>A non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475402 n.1745C>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475436 n.1779C>T non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.12 capreomycin
linezolid
rrl 1475761 n.2104_2106delCGCinsGT non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475765 n.2111delG non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.21 capreomycin
linezolid
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833589 c.48A>T synonymous_variant 0.16 pyrazinamide
rpsA 1833595 c.54T>C synonymous_variant 0.16 pyrazinamide
rpsA 1833661 c.120A>G synonymous_variant 0.15 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.14 pyrazinamide
rpsA 1833940 c.399C>G synonymous_variant 0.13 pyrazinamide
rpsA 1833971 c.430C>T synonymous_variant 0.14 pyrazinamide
rpsA 1833979 c.438T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834000 c.459G>C synonymous_variant 0.14 pyrazinamide
tlyA 1917972 c.33A>G synonymous_variant 0.98 capreomycin Not assoc w R
PPE35 2168149 p.Pro822Ser missense_variant 0.96 pyrazinamide Not assoc w R
PPE35 2169149 c.1464G>C synonymous_variant 1.0 pyrazinamide Not assoc w R - Interim
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518864 c.750G>C synonymous_variant 0.13 isoniazid
Rv2477c 2783758 p.Asp95Glu missense_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.14 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2680 2995848 c.-257G>A upstream_gene_variant 0.99 capreomycin
Rv3236c 3613636 c.-520A>G upstream_gene_variant 0.99 pyrazinamide Not assoc w R
lpqB 3625594 c.-684T>C upstream_gene_variant 0.13 rifampicin
bedaquiline
lpqB 3625602 c.-692T>C upstream_gene_variant 0.14 rifampicin
bedaquiline
lpqB 3625612 c.-702G>C upstream_gene_variant 0.16 rifampicin
bedaquiline
mtrB 3625616 p.Arg333Ala missense_variant 0.17 rifampicin
bedaquiline
lpqB 3625624 c.-714C>G upstream_gene_variant 0.17 rifampicin
bedaquiline
mtrB 3625636 c.978C>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3625656 c.958T>C synonymous_variant 0.13 rifampicin Not assoc w R - Interim
bedaquiline Not assoc w R - Interim
rpoA 3877613 p.Ile299Val missense_variant 0.12 rifampicin
rpoA 3877656 c.852T>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.14 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.21 rifampicin
rpoA 3878364 c.144A>T synonymous_variant 0.19 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.21 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.19 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.19 rifampicin
rpoA 3878388 c.120C>G synonymous_variant 0.18 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.19 rifampicin
rpoA 3878415 c.93C>T synonymous_variant 0.17 rifampicin
rpoA 3878424 c.84G>C synonymous_variant 0.16 rifampicin
rpoA 3878436 c.72A>G synonymous_variant 0.16 rifampicin
rpoA 3878442 c.66G>C synonymous_variant 0.15 rifampicin
rpoA 3878454 c.54A>C synonymous_variant 0.16 rifampicin
rpoA 3878736 c.-229A>G upstream_gene_variant 0.21 rifampicin
rpoA 3878737 c.-230G>C upstream_gene_variant 0.2 rifampicin
rpoA 3878742 c.-235G>A upstream_gene_variant 0.2 rifampicin
rpoA 3878746 c.-239A>G upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878749 c.-242G>T upstream_gene_variant 0.22 rifampicin
rpoA 3878761 c.-254G>C upstream_gene_variant 0.24 rifampicin
rpoA 3878764 c.-257A>G upstream_gene_variant 0.24 rifampicin
rpoA 3878785 c.-278T>G upstream_gene_variant 0.27 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878806 c.-299C>G upstream_gene_variant 0.25 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.26 rifampicin
rpoA 3878824 c.-317G>C upstream_gene_variant 0.25 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.24 rifampicin
rpoA 3878836 c.-331_-329delAAGinsTCC upstream_gene_variant 0.22 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.22 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3878914 c.-407T>C upstream_gene_variant 0.13 rifampicin Uncertain significance
rpoA 3878917 c.-410G>A upstream_gene_variant 0.14 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.12 rifampicin
clpC1 4038749 c.1956C>G synonymous_variant 0.14 pyrazinamide
clpC1 4038755 c.1950G>T synonymous_variant 0.15 pyrazinamide
clpC1 4038770 c.1935C>T synonymous_variant 0.15 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.16 pyrazinamide
clpC1 4038812 c.1893T>C synonymous_variant 0.12 pyrazinamide
clpC1 4038845 c.1860G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038860 c.1845G>C synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4038878 c.1827A>G synonymous_variant 0.13 pyrazinamide Not assoc w R - Interim
clpC1 4038914 c.1791G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.13 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.2 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039004 c.1701C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039022 c.1683A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039064 c.1641C>T synonymous_variant 0.18 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.12 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.14 pyrazinamide
clpC1 4039729 p.Asp326Asn missense_variant 0.94 pyrazinamide Not assoc w R
clpC1 4039898 c.807C>G synonymous_variant 0.13 pyrazinamide
clpC1 4040318 c.387C>G synonymous_variant 0.13 pyrazinamide
panD 4044737 c.-456T>C upstream_gene_variant 0.14 pyrazinamide
panD 4044746 c.-467_-465delGTGinsATC upstream_gene_variant 0.15 pyrazinamide
panD 4044752 c.-471T>C upstream_gene_variant 0.16 pyrazinamide
panD 4044989 c.-708T>C upstream_gene_variant 0.15 pyrazinamide
panD 4045000 c.-719A>C upstream_gene_variant 0.18 pyrazinamide
panD 4045001 c.-720G>C upstream_gene_variant 0.18 pyrazinamide
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embA 4246305 p.Ser1025Glu missense_variant 0.14 ethambutol
embA 4246308 p.Thr1026Ala missense_variant 0.14 ethambutol
embB 4246316 c.-198T>G upstream_gene_variant 0.13 ethambutol
embB 4246319 c.-195G>C upstream_gene_variant 0.12 ethambutol
embB 4247491 c.978G>C synonymous_variant 0.13 ethambutol
embB 4247539 c.1026T>C synonymous_variant 0.14 ethambutol
embB 4247746 c.1233C>T synonymous_variant 0.12 ethambutol
embB 4247761 c.1248T>C synonymous_variant 0.13 ethambutol
embB 4247773 c.1260G>A synonymous_variant 0.13 ethambutol
embB 4247776 c.1263G>T synonymous_variant 0.14 ethambutol
embB 4247797 c.1284C>G synonymous_variant 0.15 ethambutol
embB 4247800 c.1287A>T synonymous_variant 0.16 ethambutol
embB 4247803 c.1290G>C synonymous_variant 0.17 ethambutol
embB 4247815 c.1302C>G synonymous_variant 0.14 ethambutol
embB 4247819 p.Val436Ile missense_variant 0.16 ethambutol Uncertain significance
embB 4247830 c.1317A>G synonymous_variant 0.13 ethambutol Not assoc w R - Interim
embB 4247866 c.1353G>C synonymous_variant 0.15 ethambutol
embB 4247875 c.1362G>C synonymous_variant 0.15 ethambutol
embB 4247876 c.1363C>T synonymous_variant 0.15 ethambutol
embB 4247881 c.1368G>C synonymous_variant 0.15 ethambutol
embB 4247887 c.1374C>T synonymous_variant 0.14 ethambutol Not assoc w R - Interim
embB 4247905 c.1392G>C synonymous_variant 0.12 ethambutol Not assoc w R - Interim
embB 4247956 c.1443G>C synonymous_variant 0.16 ethambutol Not assoc w R - Interim
embB 4247974 c.1461C>G synonymous_variant 0.15 ethambutol
embB 4248007 c.1494C>G synonymous_variant 0.13 ethambutol
embB 4248035 p.Val508Ile missense_variant 0.14 ethambutol
embB 4248040 c.1527C>G synonymous_variant 0.13 ethambutol
embB 4248041 p.Ala510Thr missense_variant 0.13 ethambutol Uncertain significance
embB 4248044 p.Lys511Ala missense_variant 0.14 ethambutol
embB 4248070 c.1557T>C synonymous_variant 0.13 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 kanamycin Not assoc w R
capreomycin Not assoc w R
amikacin Not assoc w R