TB-Profiler result

Run: ERR4813861
Summary

Run ID: ERR4813861

Sample name:

Date: 2024-03-26T16:04:45.449859

Number of reads: 3005541

Percentage reads mapped: 93.5

Median coverage: 104.0

Strain: lineage4.3.3

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.3 Euro-American (LAM) None 0.99
lineage4 Euro-American None 1.0
lineage4.3.3 Euro-American (LAM) RD115 0.99
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid fbiC c.1039_1041delGTTinsAC Assoc w R - Interim Confers DLM-PMD cross-resistance
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
fbiC 1303969 c.1039_1041delGTTinsAC frameshift_variant&missense_variant 0.17 pretomanid Assoc w R - Interim Confers DLM-PMD cross-resistance
delamanid Assoc w R - Interim Confers DLM-PMD cross-resistance
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.15 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7538 c.237G>A synonymous_variant 0.12 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8040 p.Gly247Ser missense_variant 0.97 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 8198 c.897T>C synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8207 c.906T>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 8225 c.924T>C synonymous_variant 0.13 levofloxacin
moxifloxacin
gyrA 8234 c.933T>G synonymous_variant 0.13 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8399 c.1098T>C synonymous_variant 0.14 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 8420 c.1119T>C synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 8423 c.1122G>C synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
rpoB 761097 c.1291_1292delAGinsTC synonymous_variant 0.13 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.15 rifampicin
rpoB 761249 c.1443A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 761255 c.1449T>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761261 c.1455G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761492 c.1686G>C synonymous_variant 0.14 rifampicin
rpoB 761531 c.1725C>G synonymous_variant 0.15 rifampicin
rpoC 762989 c.-381G>C upstream_gene_variant 0.14 rifampicin
rpoB 762995 c.3189G>T synonymous_variant 0.13 rifampicin Not assoc w R - Interim
rpoB 763040 c.3234C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 763076 c.-294C>G upstream_gene_variant 0.16 rifampicin
rpoB 763085 c.3279C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763528 c.159G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764995 c.1626C>G synonymous_variant 1.0 rifampicin Not assoc w R
rpoC 765700 c.2331T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765772 c.2403C>G synonymous_variant 0.15 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.17 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.18 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.12 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>G synonymous_variant 0.15 rifampicin
rpoC 766945 c.3576A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.16 rifampicin
rpoC 766978 c.3609C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766996 c.3627C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 767009 c.3640_3642delTCGinsAGC synonymous_variant 0.16 rifampicin
rpoC 767014 c.3645G>C synonymous_variant 0.17 rifampicin
rpoC 767033 c.3664_3666delTCGinsAGT synonymous_variant 0.17 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.16 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
mmpR5 779033 p.Asp15Ala missense_variant 1.0 clofazimine
bedaquiline
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
rpsL 781682 c.123T>C synonymous_variant 0.14 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.13 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.13 streptomycin
rpsL 781859 c.300T>C synonymous_variant 0.14 streptomycin Not assoc w R - Interim
rpsL 781868 c.309T>C synonymous_variant 0.13 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.14 streptomycin
rpsL 781892 c.333A>G synonymous_variant 0.14 streptomycin
rpsL 781898 c.339A>T synonymous_variant 0.14 streptomycin
fbiC 1303947 c.1017T>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303948 p.Gly340Arg missense_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1303973 p.Gly348Ala missense_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1303981 p.Val351Ile missense_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1303995 c.1065C>T synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304001 c.1071C>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304008 c.1078T>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304634 c.1704C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304640 c.1710A>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304646 c.1716T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304658 c.1728C>G synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304670 c.1740G>T synonymous_variant 0.13 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.14 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.14 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrs 1472969 n.1124A>G non_coding_transcript_exon_variant 0.16 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472970 n.1125C>G non_coding_transcript_exon_variant 0.16 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472977 n.1132G>C non_coding_transcript_exon_variant 0.17 streptomycin
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1472978 n.1133T>C non_coding_transcript_exon_variant 0.18 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473145 n.1300C>T non_coding_transcript_exon_variant 0.13 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrs 1473166 n.1321G>A non_coding_transcript_exon_variant 0.12 streptomycin Uncertain significance
kanamycin Uncertain significance
capreomycin Uncertain significance
amikacin Uncertain significance
rrl 1474012 n.355C>T non_coding_transcript_exon_variant 0.13 capreomycin
linezolid
rrl 1474639 n.982G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474823 n.1166C>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid
rrl 1474904 n.1247G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474956 n.1299C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474959 n.1302C>T non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474962 n.1306delG non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474970 n.1313G>A non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475006 n.1349A>T non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.12 capreomycin
linezolid
rrl 1475333 n.1676T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>C non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475599 n.1942A>G non_coding_transcript_exon_variant 0.15 capreomycin
linezolid Uncertain significance
rrl 1475608 n.1951T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475638 n.1981C>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475642 n.1985T>C non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475657 n.2000A>G non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475659 n.2002G>T non_coding_transcript_exon_variant 0.14 capreomycin
linezolid
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1476056 n.2399G>A non_coding_transcript_exon_variant 0.88 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476086 n.2429G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.13 capreomycin Uncertain significance
linezolid
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.13 capreomycin Not assoc w R
linezolid Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
PPE35 2169834 p.Gly260Glu missense_variant 1.0 pyrazinamide
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518919 p.Gly269Ser missense_variant 0.97 isoniazid
Rv2477c 2783512 c.531A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783691 c.352C>T synonymous_variant 0.13 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783700 p.Thr115Ser missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783761 c.282G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783766 p.Met93Leu missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783794 c.249G>A synonymous_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783797 p.Asp82Glu missense_variant 0.13 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783815 c.228A>G synonymous_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2784463 c.-421G>T upstream_gene_variant 0.97 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2752c 3065824 p.Pro123Leu missense_variant 1.0 ethambutol Not assoc w R
moxifloxacin Uncertain significance
levofloxacin Not assoc w R
rifampicin Not assoc w R
isoniazid Not assoc w R - Interim
thyA 3073868 p.Thr202Ala missense_variant 0.98 para-aminosalicylic_acid
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
Rv3083 3449390 p.Arg296Leu missense_variant 1.0 ethionamide
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
rpoA 3877953 c.555G>A synonymous_variant 0.14 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878271 c.237T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3878292 c.216T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.15 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoA 3878346 c.162T>C synonymous_variant 0.16 rifampicin
rpoA 3878364 c.144A>G synonymous_variant 0.16 rifampicin
rpoA 3878367 c.141C>G synonymous_variant 0.15 rifampicin
rpoA 3878370 c.138T>C synonymous_variant 0.16 rifampicin
rpoA 3878376 c.132G>C synonymous_variant 0.17 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.16 rifampicin
rpoA 3878391 c.117T>C synonymous_variant 0.17 rifampicin
rpoA 3878396 c.112C>T synonymous_variant 0.17 rifampicin
clpC1 4038287 c.2418C>T synonymous_variant 0.93 pyrazinamide Not assoc w R
clpC1 4038368 c.2337T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038388 c.2317T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.13 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.13 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.13 pyrazinamide
clpC1 4038498 p.Ser736Thr missense_variant 0.16 pyrazinamide
clpC1 4038530 p.Glu725Asp missense_variant 0.16 pyrazinamide
clpC1 4038536 c.2169C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038596 c.2109A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038623 c.2082A>G synonymous_variant 0.16 pyrazinamide
clpC1 4038640 p.Asp689Asn missense_variant 0.16 pyrazinamide
clpC1 4038653 c.2052C>T synonymous_variant 0.14 pyrazinamide
clpC1 4038658 p.Lys683Gln missense_variant 0.13 pyrazinamide
clpC1 4038661 p.Ser682Thr missense_variant 0.13 pyrazinamide
clpC1 4038662 c.2043T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038671 c.2034T>C synonymous_variant 0.13 pyrazinamide
clpC1 4038683 c.2022T>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038695 c.2010C>G synonymous_variant 0.16 pyrazinamide
clpC1 4038701 c.2004G>C synonymous_variant 0.14 pyrazinamide
clpC1 4038704 c.2001T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038707 c.1998C>G synonymous_variant 0.15 pyrazinamide
clpC1 4038710 c.1995G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038713 c.1992T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038740 c.1965G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038755 c.1950G>C synonymous_variant 0.15 pyrazinamide
clpC1 4038773 c.1932T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038782 c.1923G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038790 c.1915C>T synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4038812 c.1893T>C synonymous_variant 0.16 pyrazinamide
clpC1 4038815 c.1890G>T synonymous_variant 0.17 pyrazinamide
clpC1 4038851 c.1854G>A synonymous_variant 0.18 pyrazinamide
clpC1 4038878 c.1827A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4038908 c.1797C>G synonymous_variant 0.2 pyrazinamide
clpC1 4038914 c.1791G>C synonymous_variant 0.2 pyrazinamide
clpC1 4038923 c.1782A>G synonymous_variant 0.19 pyrazinamide
clpC1 4038932 c.1773G>C synonymous_variant 0.21 pyrazinamide
clpC1 4038953 c.1752A>G synonymous_variant 0.21 pyrazinamide
clpC1 4038956 c.1749T>C synonymous_variant 0.23 pyrazinamide
clpC1 4038965 c.1740T>C synonymous_variant 0.25 pyrazinamide
clpC1 4038971 c.1734T>C synonymous_variant 0.26 pyrazinamide
clpC1 4038974 c.1731T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4038989 c.1716T>C synonymous_variant 0.22 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.21 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.19 pyrazinamide
clpC1 4039085 c.1620A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039090 c.1615C>T synonymous_variant 0.19 pyrazinamide
clpC1 4039097 c.1608G>C synonymous_variant 0.19 pyrazinamide
clpC1 4039103 c.1602T>C synonymous_variant 0.17 pyrazinamide
clpC1 4039106 c.1599G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039112 c.1593C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039121 c.1584T>C synonymous_variant 0.16 pyrazinamide
clpC1 4039124 c.1581C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039127 c.1578G>A synonymous_variant 0.17 pyrazinamide
clpC1 4039142 c.1563A>G synonymous_variant 0.17 pyrazinamide
clpC1 4039145 c.1560G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039169 p.Glu512Asp missense_variant 0.15 pyrazinamide
clpC1 4039183 c.1522T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039268 c.1437C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039274 c.1431G>C synonymous_variant 0.15 pyrazinamide Not assoc w R - Interim
clpC1 4039286 c.1419T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039289 c.1416T>C synonymous_variant 0.14 pyrazinamide
clpC1 4039295 c.1410A>C synonymous_variant 0.14 pyrazinamide
clpC1 4039298 c.1407T>C synonymous_variant 0.15 pyrazinamide
clpC1 4039319 c.1386T>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4039322 c.1383T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039328 c.1377A>T synonymous_variant 0.18 pyrazinamide
clpC1 4039334 c.1371G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039337 p.Thr456Gln missense_variant 0.16 pyrazinamide
clpC1 4039364 c.1341C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039388 c.1317C>A synonymous_variant 0.17 pyrazinamide
clpC1 4039391 c.1314T>G synonymous_variant 0.16 pyrazinamide
clpC1 4039409 c.1296T>C synonymous_variant 0.13 pyrazinamide
clpC1 4039412 c.1293T>G synonymous_variant 0.13 pyrazinamide
clpC1 4039789 p.Ser306Thr missense_variant 0.13 pyrazinamide
embC 4241264 p.Gly468Ser missense_variant 1.0 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 0.99 capreomycin
amikacin
kanamycin
gid 4408156 p.Leu16Arg missense_variant 1.0 streptomycin Not assoc w R