TB-Profiler result

Run: ERR4831618
Summary

Run ID: ERR4831618

Sample name:

Date: 01-04-2023 21:02:50

Number of reads: 948709

Percentage reads mapped: 80.06

Strain: lineage2.1

Drug-resistance: MDR-TB

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Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations
Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family Main Spoligotype RDs Frequency
lineage2 East-Asian Beijing RD105 1.0
lineage2.1 East-Asian (non-Beijing) None None 1.0
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs
rpoB 761140 p.His445Arg missense_variant 0.83 rifampicin
rpsL 781687 p.Lys43Arg missense_variant 0.97 streptomycin
katG 2155168 p.Ser315Thr missense_variant 1.0 isoniazid
embB 4247429 p.Met306Val missense_variant 0.96 ethambutol
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction
gyrA 7362 p.Glu21Gln missense_variant 1.0
gyrA 7585 p.Ser95Thr missense_variant 1.0
gyrA 7763 c.462T>G synonymous_variant 0.14
gyrA 7775 c.474C>T synonymous_variant 0.16
gyrA 7784 c.483A>G synonymous_variant 0.16
gyrA 7790 c.489G>C synonymous_variant 0.17
gyrA 7796 c.495G>T synonymous_variant 0.18
gyrA 7799 c.498A>G synonymous_variant 0.19
gyrA 7802 c.501C>G synonymous_variant 0.18
gyrA 7832 c.531G>T synonymous_variant 0.22
gyrA 7835 c.534A>G synonymous_variant 0.22
gyrA 7841 c.540C>T synonymous_variant 0.21
gyrA 7847 c.546G>C synonymous_variant 0.22
gyrA 7859 c.558A>C synonymous_variant 0.2
gyrA 7865 c.564T>C synonymous_variant 0.17
gyrA 7886 c.585T>G synonymous_variant 0.19
gyrA 7906 p.Phe202Tyr missense_variant 0.12
gyrA 8480 c.1179C>T synonymous_variant 0.12
gyrA 8504 c.1203G>C synonymous_variant 0.14
gyrA 8561 c.1260A>C synonymous_variant 0.12
gyrA 8571 c.1270C>T synonymous_variant 0.14
gyrA 8600 c.1299G>A synonymous_variant 0.15
gyrA 8603 c.1302A>C synonymous_variant 0.15
gyrA 9304 p.Gly668Asp missense_variant 1.0
fgd1 491490 c.708C>T synonymous_variant 0.14
fgd1 491499 c.717G>C synonymous_variant 0.16
fgd1 491512 p.Asn244Glu missense_variant 0.16
fgd1 491542 c.760T>C synonymous_variant 0.14
fgd1 491563 c.781_783delAGCinsTCG synonymous_variant 0.16
fgd1 491571 c.789C>T synonymous_variant 0.17
fgd1 491595 c.813C>T synonymous_variant 0.14
fgd1 491742 c.960T>C synonymous_variant 1.0
rpoB 760235 c.429T>C synonymous_variant 0.14
rpoB 760244 c.438G>C synonymous_variant 0.14
rpoB 760283 c.477G>C synonymous_variant 0.18
rpoB 760298 c.492G>C synonymous_variant 0.14
rpoB 760310 c.504G>C synonymous_variant 0.14
rpoB 760316 c.510C>G synonymous_variant 0.14
rpoB 760325 c.519G>C synonymous_variant 0.14
rpoB 760331 c.525G>C synonymous_variant 0.15
rpoB 760334 c.528G>T synonymous_variant 0.15
rpoB 760340 c.534G>T synonymous_variant 0.15
rpoB 760357 p.Thr184Ser missense_variant 0.15
rpoB 760361 c.555T>C synonymous_variant 0.13
rpoB 760376 p.Asp190Glu missense_variant 0.14
rpoB 760646 c.840C>G synonymous_variant 0.14
rpoB 760655 c.849A>G synonymous_variant 0.19
rpoB 760661 c.855A>C synonymous_variant 0.19
rpoB 760670 c.864G>C synonymous_variant 0.17
rpoB 760674 c.868T>C synonymous_variant 0.17
rpoB 760679 c.873A>G synonymous_variant 0.17
rpoB 760683 c.877T>C synonymous_variant 0.17
rpoB 760721 c.915C>G synonymous_variant 0.24
rpoB 760724 c.918T>C synonymous_variant 0.24
rpoB 760730 c.924T>C synonymous_variant 0.23
rpoB 760748 c.942C>G synonymous_variant 0.22
rpoB 760751 c.945G>C synonymous_variant 0.22
rpoB 760755 p.His317Asn missense_variant 0.21
rpoB 760759 p.Val318Ala missense_variant 0.21
rpoB 760764 p.Glu320Gln missense_variant 0.21
rpoB 760769 c.963C>G synonymous_variant 0.2
rpoB 760784 c.978G>T synonymous_variant 0.22
rpoB 760793 c.987A>G synonymous_variant 0.19
rpoB 760805 c.999G>C synonymous_variant 0.12
rpoB 760817 c.1011A>G synonymous_variant 0.15
rpoB 760820 c.1014T>C synonymous_variant 0.18
rpoB 760826 c.1020C>G synonymous_variant 0.18
rpoB 760830 c.1024T>C synonymous_variant 0.18
rpoB 760841 c.1035T>C synonymous_variant 0.18
rpoB 761132 c.1326G>T synonymous_variant 0.14
rpoB 761133 c.1327T>C synonymous_variant 0.14
rpoB 761147 c.1341C>T synonymous_variant 0.19
rpoB 761148 p.Arg448Gly missense_variant 0.85
rpoB 761165 c.1359G>C synonymous_variant 0.17
rpoB 761180 c.1374A>C synonymous_variant 0.21
rpoB 761189 c.1383T>C synonymous_variant 0.21
rpoB 761195 c.1389G>C synonymous_variant 0.22
rpoB 761198 c.1392G>T synonymous_variant 0.22
rpoB 761213 c.1407G>C synonymous_variant 0.22
rpoB 761217 p.Pro471Ser missense_variant 0.22
rpoB 761234 c.1428G>C synonymous_variant 0.21
rpoB 761240 c.1434C>T synonymous_variant 0.19
rpoB 761249 c.1443A>G synonymous_variant 0.2
rpoB 761261 c.1455G>T synonymous_variant 0.15
rpoB 761264 c.1458C>G synonymous_variant 0.15
rpoB 762047 c.2241G>A synonymous_variant 0.13
rpoB 762053 c.2247T>C synonymous_variant 0.13
rpoB 762062 c.2256T>C synonymous_variant 0.15
rpoB 762065 c.2259T>C synonymous_variant 0.15
rpoB 762083 c.2277T>C synonymous_variant 0.15
rpoB 762086 c.2280G>C synonymous_variant 0.16
rpoB 762101 c.2295C>G synonymous_variant 0.17
rpoB 762114 p.Ile770Val missense_variant 0.14
rpoB 762131 c.2325C>G synonymous_variant 0.12
rpoB 762143 c.2337T>C synonymous_variant 0.12
rpoB 762149 c.2343G>C synonymous_variant 0.14
rpoB 762158 c.2352G>C synonymous_variant 0.14
rpoB 762167 c.2361T>C synonymous_variant 0.17
rpoB 762176 c.2370T>C synonymous_variant 0.15
rpoB 762185 c.2379G>C synonymous_variant 0.15
rpoB 762308 c.2502G>C synonymous_variant 0.13
rpoB 762329 c.2523G>C synonymous_variant 0.13
rpoB 762341 c.2535G>C synonymous_variant 0.16
rpoB 762347 c.2541T>C synonymous_variant 0.18
rpoB 762350 c.2544C>T synonymous_variant 0.18
rpoB 762362 p.Glu852Asp missense_variant 0.23
rpoB 762369 c.2563T>C synonymous_variant 0.23
rpoC 762374 c.-996G>C upstream_gene_variant 0.26
rpoC 762395 c.-975G>C upstream_gene_variant 0.21
rpoC 762398 c.-972T>C upstream_gene_variant 0.21
rpoC 762401 c.-969G>C upstream_gene_variant 0.22
rpoC 762404 c.-966T>C upstream_gene_variant 0.23
rpoC 762410 c.-960T>C upstream_gene_variant 0.22
rpoC 762416 c.-954A>G upstream_gene_variant 0.22
rpoC 762434 c.-936T>C upstream_gene_variant 0.19
rpoC 762443 c.-927G>C upstream_gene_variant 0.2
rpoC 762449 c.-921C>A upstream_gene_variant 0.18
rpoC 762452 c.-918G>C upstream_gene_variant 0.18
rpoC 763028 c.-342T>C upstream_gene_variant 0.13
rpoC 763031 c.-339T>C upstream_gene_variant 1.0
rpoC 763053 c.-317T>C upstream_gene_variant 0.2
rpoC 763070 c.-300T>C upstream_gene_variant 0.15
rpoC 763085 c.-285C>G upstream_gene_variant 0.19
rpoC 763103 c.-267G>C upstream_gene_variant 0.15
rpoC 763115 c.-255T>C upstream_gene_variant 0.21
rpoC 763127 c.-243G>C upstream_gene_variant 0.19
rpoC 763130 c.-240G>A upstream_gene_variant 0.19
rpoC 763133 c.-237G>C upstream_gene_variant 0.18
rpoC 763136 c.-234C>T upstream_gene_variant 0.19
rpoC 763142 c.-228C>G upstream_gene_variant 0.24
rpoC 763160 c.-210G>T upstream_gene_variant 0.32
rpoC 763166 c.-204A>G upstream_gene_variant 0.3
rpoC 763169 c.-201A>G upstream_gene_variant 0.29
rpoC 763190 c.-180C>T upstream_gene_variant 0.27
rpoC 763199 c.-171G>C upstream_gene_variant 0.26
rpoC 763202 c.-168A>G upstream_gene_variant 0.26
rpoC 763205 c.-165G>T upstream_gene_variant 0.26
rpoC 763206 c.-164_-163delAGinsTC upstream_gene_variant 0.26
rpoC 763217 c.-153G>C upstream_gene_variant 0.32
rpoC 763226 c.-144A>G upstream_gene_variant 0.29
rpoB 763227 p.Leu1141Met missense_variant 0.27
rpoC 763232 c.-138C>T upstream_gene_variant 0.26
rpoB 763235 p.Glu1143Asp missense_variant 0.24
rpoB 763241 p.Glu1145Asp missense_variant 0.24
rpoC 763259 c.-111G>C upstream_gene_variant 0.22
rpoC 763262 c.-108C>T upstream_gene_variant 0.17
rpoC 763265 c.-105G>C upstream_gene_variant 0.17
rpoC 763268 c.-102C>G upstream_gene_variant 0.17
rpoC 763283 c.-87T>C upstream_gene_variant 0.16
rpoC 763289 c.-81C>G upstream_gene_variant 0.15
rpoC 763444 c.75T>C synonymous_variant 0.12
rpoC 763456 c.87A>G synonymous_variant 0.13
rpoC 763468 c.99G>C synonymous_variant 0.16
rpoC 763486 c.117T>C synonymous_variant 0.17
rpoC 763492 c.123G>T synonymous_variant 0.14
rpoC 763528 c.159G>A synonymous_variant 0.17
rpoC 763660 c.291T>G synonymous_variant 0.13
rpoC 763741 c.372C>T synonymous_variant 0.15
rpoC 764182 p.Asp271Glu missense_variant 0.14
rpoC 764188 c.819A>G synonymous_variant 0.14
rpoC 764371 c.1002G>C synonymous_variant 0.17
rpoC 764380 c.1011G>C synonymous_variant 0.17
rpoC 764387 c.1018T>C synonymous_variant 0.2
rpoC 764405 c.1036_1038delAGGinsCGC synonymous_variant 0.23
rpoC 764431 c.1062G>C synonymous_variant 0.28
rpoC 764434 c.1065A>G synonymous_variant 0.25
rpoC 764435 c.1066_1068delAGGinsCGA synonymous_variant 0.25
rpoC 764446 c.1077T>C synonymous_variant 0.27
rpoC 764449 c.1080G>C synonymous_variant 0.27
rpoC 764458 c.1089G>C synonymous_variant 0.28
rpoC 764461 c.1092A>G synonymous_variant 0.28
rpoC 764485 c.1116G>C synonymous_variant 0.43
rpoC 764491 c.1122G>T synonymous_variant 0.39
rpoC 764497 c.1128A>G synonymous_variant 0.35
rpoC 764500 c.1131C>G synonymous_variant 0.35
rpoC 764512 c.1143G>T synonymous_variant 0.34
rpoC 764521 c.1152T>C synonymous_variant 0.35
rpoC 764527 c.1158C>T synonymous_variant 0.39
rpoC 764536 c.1167G>T synonymous_variant 0.4
rpoC 764539 c.1170C>G synonymous_variant 0.4
rpoC 764575 c.1206T>G synonymous_variant 0.4
rpoC 764605 c.1236G>C synonymous_variant 0.39
rpoC 764611 c.1242G>T synonymous_variant 0.4
rpoC 764623 c.1254C>G synonymous_variant 0.35
rpoC 764626 c.1257C>T synonymous_variant 0.38
rpoC 764632 c.1263T>C synonymous_variant 0.33
rpoC 764650 c.1281G>T synonymous_variant 0.3
rpoC 764701 c.1332C>G synonymous_variant 0.17
rpoC 764713 c.1344G>T synonymous_variant 0.17
rpoC 764716 c.1347G>C synonymous_variant 0.17
rpoC 764746 c.1377G>T synonymous_variant 0.13
rpoC 764858 c.1489T>C synonymous_variant 0.14
rpoC 764875 c.1506C>T synonymous_variant 0.14
rpoC 764878 c.1509C>G synonymous_variant 0.14
rpoC 764887 c.1518G>C synonymous_variant 0.14
rpoC 764888 c.1519T>C synonymous_variant 0.14
rpoC 764911 c.1542A>G synonymous_variant 0.19
rpoC 764912 p.Met515Gln missense_variant 0.19
rpoC 764935 c.1566T>C synonymous_variant 0.14
rpoC 765121 c.1752G>A synonymous_variant 1.0
rpoC 765404 p.Leu679Met missense_variant 0.12
rpoC 765425 p.Lys686Glu missense_variant 0.15
rpoC 765445 c.2076G>C synonymous_variant 0.14
rpoC 765452 p.Ala695Arg missense_variant 0.14
rpoC 765480 p.Tyr704Phe missense_variant 0.12
rpoC 765800 p.Phe811Leu missense_variant 0.16
rpoC 765811 c.2442T>G synonymous_variant 0.14
rpoC 765817 c.2448G>C synonymous_variant 0.16
rpoC 765823 c.2454C>A synonymous_variant 0.16
rpoC 765826 c.2457T>C synonymous_variant 0.16
rpoC 765835 c.2466C>T synonymous_variant 0.17
rpoC 765871 c.2502T>C synonymous_variant 0.17
rpoC 765875 p.Val836Ile missense_variant 0.17
rpoC 765886 c.2517C>G synonymous_variant 0.12
rpoC 765904 c.2535C>G synonymous_variant 0.13
rpoC 766837 c.3468G>C synonymous_variant 0.16
rpoC 766843 c.3474T>C synonymous_variant 0.14
rpoC 766846 c.3477C>G synonymous_variant 0.13
rpoC 766931 p.Ala1188Thr missense_variant 0.12
rpoC 766942 c.3573C>T synonymous_variant 0.19
rpoC 766945 c.3576A>C synonymous_variant 0.19
rpoC 766948 c.3579G>C synonymous_variant 0.19
rpoC 766963 c.3594T>C synonymous_variant 0.15
mmpL5 775639 p.Ile948Val missense_variant 1.0
mmpL5 775798 p.Phe895Ile missense_variant 0.12
mmpL5 775817 c.2664T>C synonymous_variant 0.12
mmpL5 775829 c.2652C>G synonymous_variant 0.12
mmpL5 775847 c.2634G>A synonymous_variant 0.12
mmpL5 775856 c.2625T>C synonymous_variant 0.12
mmpL5 775966 p.Ala839Ser missense_variant 0.12
mmpL5 776100 p.Thr794Ile missense_variant 1.0
rpsL 781395 c.-165T>C upstream_gene_variant 1.0
rpsL 781838 c.279G>C synonymous_variant 0.13
rpsL 781841 c.282C>T synonymous_variant 0.14
rplC 800618 c.-191T>C upstream_gene_variant 0.13
rplC 800633 c.-176T>C upstream_gene_variant 0.14
rplC 800645 c.-164C>G upstream_gene_variant 0.15
rplC 800648 c.-161A>G upstream_gene_variant 0.15
rplC 800654 c.-155T>C upstream_gene_variant 0.14
fbiC 1304443 p.Ala505Thr missense_variant 1.0
fbiC 1304646 c.1716T>C synonymous_variant 0.17
fbiC 1304670 c.1740G>C synonymous_variant 0.16
fbiC 1304671 p.Val581Thr missense_variant 0.16
fbiC 1304675 p.Gly582Asp missense_variant 0.16
fbiC 1304694 c.1764A>G synonymous_variant 0.16
fbiC 1304715 c.1785G>T synonymous_variant 0.17
fbiC 1304724 c.1794A>G synonymous_variant 0.15
fbiC 1304727 c.1797A>C synonymous_variant 0.13
fbiC 1304742 c.1812T>C synonymous_variant 0.13
Rv1258c 1407375 c.-36delC upstream_gene_variant 1.0
rrs 1471659 n.-187C>T upstream_gene_variant 1.0
rrs 1471758 n.-88G>A upstream_gene_variant 0.23
rrs 1472019 n.174G>A non_coding_transcript_exon_variant 0.13
rrs 1472446 n.601T>A non_coding_transcript_exon_variant 0.17
rrs 1472452 n.607G>A non_coding_transcript_exon_variant 0.18
rrs 1472464 n.619A>G non_coding_transcript_exon_variant 0.16
rrs 1472846 n.1001C>A non_coding_transcript_exon_variant 0.19
rrs 1472847 n.1002G>C non_coding_transcript_exon_variant 0.2
rrs 1472849 n.1004C>G non_coding_transcript_exon_variant 0.19
rrs 1472850 n.1005T>C non_coding_transcript_exon_variant 0.19
rrs 1472857 n.1012A>G non_coding_transcript_exon_variant 0.2
rrs 1472858 n.1013G>T non_coding_transcript_exon_variant 0.2
rrs 1472860 n.1015C>G non_coding_transcript_exon_variant 0.2
rrs 1472861 n.1016G>T non_coding_transcript_exon_variant 0.2
rrs 1472973 n.1128A>T non_coding_transcript_exon_variant 0.17
rrs 1473104 n.1259C>T non_coding_transcript_exon_variant 0.2
rrs 1473110 n.1265T>G non_coding_transcript_exon_variant 0.13
rrs 1473111 n.1266A>G non_coding_transcript_exon_variant 0.16
rrs 1473290 n.1445C>T non_coding_transcript_exon_variant 0.13
rrs 1473301 n.1456T>C non_coding_transcript_exon_variant 0.13
rrl 1473807 n.150T>C non_coding_transcript_exon_variant 0.12
rrl 1473823 n.166T>C non_coding_transcript_exon_variant 0.12
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.13
rrl 1473899 n.242A>G non_coding_transcript_exon_variant 0.13
rrl 1474135 n.478G>A non_coding_transcript_exon_variant 0.15
rrl 1474140 n.483C>T non_coding_transcript_exon_variant 0.15
rrl 1474174 n.517A>G non_coding_transcript_exon_variant 0.13
rrl 1474181 n.524C>T non_coding_transcript_exon_variant 0.12
rrl 1474185 n.528G>A non_coding_transcript_exon_variant 0.12
rrl 1474249 n.592G>T non_coding_transcript_exon_variant 0.33
rrl 1474266 n.609T>C non_coding_transcript_exon_variant 0.36
rrl 1474269 n.612C>T non_coding_transcript_exon_variant 0.38
rrl 1474292 n.635T>G non_coding_transcript_exon_variant 0.19
rrl 1474294 n.638_649delCTCTCCGGAGGA non_coding_transcript_exon_variant 0.2
rrl 1474308 n.651G>T non_coding_transcript_exon_variant 0.18
rrl 1474310 n.653T>G non_coding_transcript_exon_variant 0.18
rrl 1474417 n.762_765delACGC non_coding_transcript_exon_variant 0.14
rrl 1474432 n.775C>T non_coding_transcript_exon_variant 0.16
rrl 1474439 n.782A>G non_coding_transcript_exon_variant 0.19
rrl 1474446 n.789C>T non_coding_transcript_exon_variant 0.19
rrl 1474673 n.1016T>C non_coding_transcript_exon_variant 0.14
rrl 1474677 n.1020A>G non_coding_transcript_exon_variant 0.14
rrl 1474753 n.1096A>G non_coding_transcript_exon_variant 0.17
rrl 1474760 n.1103A>G non_coding_transcript_exon_variant 0.16
rrl 1474794 n.1137C>T non_coding_transcript_exon_variant 0.15
rrl 1474803 n.1146G>A non_coding_transcript_exon_variant 0.13
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.13
rrl 1475120 n.1463G>T non_coding_transcript_exon_variant 0.16
rrl 1475295 n.1638C>T non_coding_transcript_exon_variant 0.15
rrl 1475353 n.1696A>T non_coding_transcript_exon_variant 0.18
rrl 1475354 n.1697A>G non_coding_transcript_exon_variant 0.18
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.18
rrl 1475363 n.1706C>T non_coding_transcript_exon_variant 0.17
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.15
rrl 1475379 n.1722G>A non_coding_transcript_exon_variant 0.15
rrl 1475380 n.1723C>A non_coding_transcript_exon_variant 0.15
rrl 1475381 n.1724G>C non_coding_transcript_exon_variant 0.15
rrl 1475382 n.1725A>G non_coding_transcript_exon_variant 0.15
rrl 1475395 n.1738T>C non_coding_transcript_exon_variant 0.15
rrl 1475396 n.1739C>G non_coding_transcript_exon_variant 0.15
rrl 1475397 n.1740G>T non_coding_transcript_exon_variant 0.15
rrl 1475398 n.1741C>T non_coding_transcript_exon_variant 0.15
rrl 1475403 n.1746T>A non_coding_transcript_exon_variant 0.15
rrl 1475404 n.1747A>T non_coding_transcript_exon_variant 0.15
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.27
rrl 1475429 n.1772G>T non_coding_transcript_exon_variant 0.27
rrl 1475452 n.1795C>A non_coding_transcript_exon_variant 0.31
rrl 1475479 n.1822C>G non_coding_transcript_exon_variant 0.27
rrl 1475483 n.1826C>T non_coding_transcript_exon_variant 0.27
rrl 1475505 n.1848G>A non_coding_transcript_exon_variant 0.21
rrl 1475526 n.1869C>A non_coding_transcript_exon_variant 0.25
rrl 1475531 n.1874C>T non_coding_transcript_exon_variant 0.23
rrl 1475544 n.1887A>T non_coding_transcript_exon_variant 0.25
rrl 1475545 n.1888T>G non_coding_transcript_exon_variant 0.25
rrl 1475602 n.1945G>C non_coding_transcript_exon_variant 0.14
rrl 1475603 n.1946G>C non_coding_transcript_exon_variant 0.14
rrl 1475612 n.1955G>C non_coding_transcript_exon_variant 0.12
rrl 1475615 n.1958C>G non_coding_transcript_exon_variant 0.12
rrl 1475616 n.1959A>G non_coding_transcript_exon_variant 0.12
rrl 1475618 n.1961C>T non_coding_transcript_exon_variant 0.12
rrl 1475629 n.1972G>C non_coding_transcript_exon_variant 0.12
rrl 1475753 n.2096C>T non_coding_transcript_exon_variant 0.17
rrl 1475762 n.2105G>T non_coding_transcript_exon_variant 0.18
rrl 1475763 n.2106C>T non_coding_transcript_exon_variant 0.18
rrl 1475764 n.2107A>C non_coding_transcript_exon_variant 0.17
rrl 1475765 n.2108A>G non_coding_transcript_exon_variant 0.17
rrl 1475775 n.2118G>A non_coding_transcript_exon_variant 0.23
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.2
rrl 1475991 n.2334T>C non_coding_transcript_exon_variant 0.19
rrl 1475995 n.2338G>A non_coding_transcript_exon_variant 0.19
rrl 1476030 n.2373A>G non_coding_transcript_exon_variant 0.22
rrl 1476032 n.2375C>A non_coding_transcript_exon_variant 0.26
rrl 1476033 n.2376T>G non_coding_transcript_exon_variant 0.24
rrl 1476035 n.2378G>C non_coding_transcript_exon_variant 0.25
rrl 1476044 n.2387T>G non_coding_transcript_exon_variant 0.24
rrl 1476046 n.2389G>T non_coding_transcript_exon_variant 0.24
rrl 1476047 n.2390G>T non_coding_transcript_exon_variant 0.24
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.24
rrl 1476088 n.2431A>C non_coding_transcript_exon_variant 0.33
rrl 1476099 n.2442A>G non_coding_transcript_exon_variant 0.3
rrl 1476103 n.2446C>G non_coding_transcript_exon_variant 0.3
rrl 1476105 n.2448G>A non_coding_transcript_exon_variant 0.29
rrl 1476106 n.2449A>T non_coding_transcript_exon_variant 0.29
rrl 1476110 n.2453G>C non_coding_transcript_exon_variant 0.28
rrl 1476115 n.2458T>C non_coding_transcript_exon_variant 0.28
rrl 1476131 n.2474C>T non_coding_transcript_exon_variant 0.31
rrl 1476160 n.2503T>C non_coding_transcript_exon_variant 0.24
rrl 1476214 n.2557G>T non_coding_transcript_exon_variant 0.29
rrl 1476215 n.2558C>T non_coding_transcript_exon_variant 0.29
rrl 1476224 n.2567A>G non_coding_transcript_exon_variant 0.33
rrl 1476251 n.2594T>G non_coding_transcript_exon_variant 0.37
rrl 1476256 n.2599A>T non_coding_transcript_exon_variant 0.39
rrl 1476260 n.2603A>G non_coding_transcript_exon_variant 0.4
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.38
rrl 1476297 n.2640C>T non_coding_transcript_exon_variant 0.34
rrl 1476299 n.2642C>T non_coding_transcript_exon_variant 0.35
rrl 1476529 n.2872A>G non_coding_transcript_exon_variant 0.35
rrl 1476540 n.2883C>T non_coding_transcript_exon_variant 0.26
rrl 1476583 n.2926G>A non_coding_transcript_exon_variant 0.21
rrl 1476584 n.2927C>T non_coding_transcript_exon_variant 0.21
rrl 1476594 n.2937C>T non_coding_transcript_exon_variant 0.21
rrl 1476597 n.2940G>A non_coding_transcript_exon_variant 0.21
rrl 1476603 n.2946G>A non_coding_transcript_exon_variant 0.15
rrl 1476628 n.2971T>A non_coding_transcript_exon_variant 0.12
rpsA 1833628 c.87G>C synonymous_variant 0.12
rpsA 1833661 c.120A>G synonymous_variant 0.14
rpsA 1833664 c.123C>A synonymous_variant 0.14
rpsA 1833676 c.135A>G synonymous_variant 0.13
rpsA 1833679 c.138G>T synonymous_variant 0.13
rpsA 1833685 c.144G>T synonymous_variant 0.12
rpsA 1833694 c.153G>C synonymous_variant 0.12
rpsA 1833697 c.156C>G synonymous_variant 0.12
rpsA 1833703 c.162C>T synonymous_variant 0.12
rpsA 1833724 c.183C>T synonymous_variant 0.12
rpsA 1833760 c.219C>T synonymous_variant 0.12
rpsA 1833808 c.267G>C synonymous_variant 0.14
rpsA 1833811 c.270G>T synonymous_variant 0.15
rpsA 1833829 c.288A>G synonymous_variant 0.19
rpsA 1833832 c.291G>A synonymous_variant 0.18
rpsA 1833838 c.297G>C synonymous_variant 0.18
rpsA 1833841 c.300C>G synonymous_variant 0.17
rpsA 1833847 c.306C>G synonymous_variant 0.17
rpsA 1833856 c.315A>G synonymous_variant 0.15
rpsA 1833862 c.321G>T synonymous_variant 0.15
rpsA 1833894 p.Ala118Glu missense_variant 0.15
rpsA 1833904 c.363G>A synonymous_variant 0.13
rpsA 1833928 c.387G>C synonymous_variant 0.19
rpsA 1833949 c.408T>C synonymous_variant 0.18
rpsA 1833970 c.429G>T synonymous_variant 0.15
rpsA 1833976 c.435C>T synonymous_variant 0.15
rpsA 1833979 c.438T>C synonymous_variant 0.15
rpsA 1833991 c.450C>A synonymous_variant 0.22
rpsA 1834000 c.459G>C synonymous_variant 0.22
rpsA 1834009 c.468C>T synonymous_variant 0.23
rpsA 1834012 c.471G>T synonymous_variant 0.23
rpsA 1834015 c.474G>C synonymous_variant 0.24
rpsA 1834021 c.480C>T synonymous_variant 0.23
rpsA 1834030 c.489C>G synonymous_variant 0.21
rpsA 1834177 c.636A>C synonymous_variant 1.0
rpsA 1834213 c.672G>C synonymous_variant 0.13
rpsA 1834234 c.693G>C synonymous_variant 0.15
rpsA 1834240 c.699T>C synonymous_variant 0.15
rpsA 1834246 c.705G>C synonymous_variant 0.15
rpsA 1834249 c.708T>C synonymous_variant 0.15
rpsA 1834252 c.711C>G synonymous_variant 0.18
rpsA 1834261 c.720A>G synonymous_variant 0.18
rpsA 1834264 c.723G>C synonymous_variant 0.19
rpsA 1834279 c.738C>T synonymous_variant 0.2
rpsA 1834297 c.756C>T synonymous_variant 0.26
rpsA 1834303 c.762T>G synonymous_variant 0.24
rpsA 1834306 c.765T>C synonymous_variant 0.24
rpsA 1834345 c.804C>T synonymous_variant 0.27
rpsA 1834348 c.807T>C synonymous_variant 0.27
rpsA 1834361 c.820T>C synonymous_variant 0.3
rpsA 1834366 c.825A>G synonymous_variant 0.3
rpsA 1834396 c.855G>C synonymous_variant 0.27
rpsA 1834411 c.870T>C synonymous_variant 0.24
rpsA 1834423 c.882G>T synonymous_variant 0.24
rpsA 1834451 c.910T>C synonymous_variant 0.23
rpsA 1834456 c.915T>G synonymous_variant 0.23
rpsA 1834468 c.927A>G synonymous_variant 0.24
rpsA 1834489 c.948T>C synonymous_variant 0.23
rpsA 1834498 c.957C>T synonymous_variant 0.16
rpsA 1834513 c.972C>G synonymous_variant 0.21
rpsA 1834520 p.Ala327Ser missense_variant 0.25
rpsA 1834528 c.987T>C synonymous_variant 0.23
rpsA 1834540 c.999G>C synonymous_variant 0.21
rpsA 1834543 c.1002C>G synonymous_variant 0.21
rpsA 1834546 c.1005T>C synonymous_variant 0.23
rpsA 1834554 c.1014_1015delTG frameshift_variant 0.18
rpsA 1834558 c.1017_1018insAG frameshift_variant 0.17
rpsA 1834606 c.1065C>T synonymous_variant 0.22
rpsA 1834609 c.1068T>C synonymous_variant 0.22
rpsA 1834619 c.1078T>C synonymous_variant 0.19
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.19
rpsA 1834633 c.1092A>G synonymous_variant 0.17
rpsA 1834639 c.1098T>C synonymous_variant 0.17
tlyA 1917972 c.33A>G synonymous_variant 1.0
katG 2154724 p.Arg463Leu missense_variant 1.0
katG 2155506 c.606C>A synonymous_variant 1.0
katG 2155716 c.396T>G synonymous_variant 0.14
katG 2155722 c.390G>C synonymous_variant 0.15
katG 2155728 c.384G>C synonymous_variant 0.15
katG 2155742 p.Gly124Arg missense_variant 0.15
katG 2155747 p.Ala122Gly missense_variant 0.15
katG 2155749 c.363C>T synonymous_variant 0.15
katG 2155752 c.360C>T synonymous_variant 0.15
katG 2155764 p.His116Glu missense_variant 0.15
katG 2155769 p.Ile115Val missense_variant 0.15
katG 2155770 c.342C>G synonymous_variant 0.15
katG 2155782 c.330C>A synonymous_variant 0.17
PPE35 2167926 p.Leu896Ser missense_variant 1.0
PPE35 2170065 p.Ala183Glu missense_variant 1.0
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0
kasA 2518085 c.-30C>A upstream_gene_variant 1.0
kasA 2518624 c.510C>G synonymous_variant 0.17
kasA 2518636 c.522C>A synonymous_variant 0.18
kasA 2518639 c.525G>T synonymous_variant 0.18
kasA 2518642 c.528A>G synonymous_variant 0.17
kasA 2518645 c.531G>C synonymous_variant 0.18
kasA 2518656 p.Ala181Gly missense_variant 0.18
kasA 2518663 c.549T>C synonymous_variant 0.19
kasA 2518672 c.558G>C synonymous_variant 0.18
kasA 2518678 c.564C>T synonymous_variant 0.19
folC 2747660 c.-62G>C upstream_gene_variant 1.0
thyA 3073822 p.Arg217Gln missense_variant 1.0
ald 3086788 c.-32T>C upstream_gene_variant 1.0
fprA 3473996 c.-11_-10insA upstream_gene_variant 1.0
rpoA 3877728 c.780C>G synonymous_variant 0.16
rpoA 3877731 c.777G>T synonymous_variant 0.16
rpoA 3877734 c.774G>C synonymous_variant 0.17
rpoA 3877737 c.771G>C synonymous_variant 0.16
rpoA 3877743 c.765T>C synonymous_variant 0.18
rpoA 3877749 c.759C>T synonymous_variant 0.16
rpoA 3877818 c.690A>G synonymous_variant 0.15
rpoA 3877848 c.660C>T synonymous_variant 0.15
rpoA 3877856 c.652T>C synonymous_variant 0.18
rpoA 3877857 c.651G>A synonymous_variant 0.19
rpoA 3877866 c.642G>C synonymous_variant 0.2
rpoA 3877875 c.633T>A synonymous_variant 0.2
rpoA 3877878 c.630G>C synonymous_variant 0.19
rpoA 3877887 c.621G>C synonymous_variant 0.21
rpoA 3877893 c.615C>T synonymous_variant 0.17
rpoA 3877905 c.603A>G synonymous_variant 0.17
rpoA 3877908 c.600T>C synonymous_variant 0.17
rpoA 3877920 c.588G>C synonymous_variant 0.16
rpoA 3877923 c.585C>T synonymous_variant 0.16
rpoA 3877926 c.582G>C synonymous_variant 0.17
rpoA 3878061 c.447G>A synonymous_variant 0.14
rpoA 3878070 c.438T>C synonymous_variant 0.14
rpoA 3878082 c.426T>C synonymous_variant 0.17
rpoA 3878103 c.405A>G synonymous_variant 0.15
rpoA 3878118 c.390T>C synonymous_variant 0.14
rpoA 3878127 c.381G>C synonymous_variant 0.12
rpoA 3878160 c.348C>G synonymous_variant 0.16
rpoA 3878163 c.345C>T synonymous_variant 0.16
rpoA 3878187 c.321C>A synonymous_variant 0.23
rpoA 3878193 c.315T>C synonymous_variant 0.21
rpoA 3878197 p.Glu104Ala missense_variant 0.22
rpoA 3878205 c.303T>C synonymous_variant 0.25
rpoA 3878217 c.291A>G synonymous_variant 0.21
rpoA 3878238 c.270C>T synonymous_variant 0.2
rpoA 3878244 c.264G>A synonymous_variant 0.2
rpoA 3878247 c.261G>C synonymous_variant 0.21
rpoA 3878256 c.252G>C synonymous_variant 0.18
rpoA 3878264 p.Ser82Gly missense_variant 0.2
rpoA 3878271 c.237T>C synonymous_variant 0.2
rpoA 3878283 p.Glu75Asp missense_variant 0.21
rpoA 3878292 c.216T>C synonymous_variant 0.23
rpoA 3878298 c.210A>G synonymous_variant 0.2
clpC1 4038563 c.2142C>T synonymous_variant 0.12
clpC1 4038584 c.2121G>A synonymous_variant 0.21
clpC1 4038587 c.2118C>G synonymous_variant 0.2
clpC1 4038596 c.2109A>G synonymous_variant 0.23
clpC1 4038602 c.2103G>C synonymous_variant 0.22
clpC1 4038623 c.2082A>G synonymous_variant 0.24
clpC1 4038640 p.Asp689Asn missense_variant 0.2
clpC1 4038647 c.2058T>G synonymous_variant 0.19
clpC1 4038658 p.Lys683Gln missense_variant 0.19
clpC1 4038660 c.2044_2045delTCinsAG synonymous_variant 0.2
clpC1 4038662 c.2043T>C synonymous_variant 0.2
clpC1 4038671 c.2034T>G synonymous_variant 0.2
clpC1 4038679 p.Pro676Ala missense_variant 0.18
clpC1 4038683 c.2022T>C synonymous_variant 0.18
clpC1 4038695 c.2010C>G synonymous_variant 0.19
clpC1 4038704 c.2001T>C synonymous_variant 0.16
clpC1 4038710 c.1995G>C synonymous_variant 0.19
clpC1 4038713 c.1992T>C synonymous_variant 0.17
clpC1 4038725 c.1980C>G synonymous_variant 0.19
clpC1 4038740 c.1965G>C synonymous_variant 0.14
clpC1 4038755 c.1950G>C synonymous_variant 0.2
clpC1 4038767 c.1938G>T synonymous_variant 0.2
clpC1 4038770 c.1935C>T synonymous_variant 0.2
clpC1 4038773 c.1932T>C synonymous_variant 0.2
clpC1 4038776 c.1929G>A synonymous_variant 0.2
clpC1 4038779 c.1926C>G synonymous_variant 0.21
clpC1 4038782 c.1923G>C synonymous_variant 0.21
clpC1 4038790 c.1915C>T synonymous_variant 0.18
clpC1 4038812 c.1893T>C synonymous_variant 0.18
clpC1 4038815 c.1890G>C synonymous_variant 0.18
clpC1 4038842 c.1863G>C synonymous_variant 0.19
clpC1 4038860 c.1845G>C synonymous_variant 0.17
clpC1 4038878 c.1827A>G synonymous_variant 0.17
clpC1 4038890 c.1815G>A synonymous_variant 0.13
clpC1 4038953 c.1752A>G synonymous_variant 0.14
clpC1 4038956 c.1749T>C synonymous_variant 0.15
clpC1 4038965 c.1740T>C synonymous_variant 0.14
clpC1 4039286 c.1419T>C synonymous_variant 0.13
clpC1 4039295 c.1410A>C synonymous_variant 0.12
clpC1 4039382 c.1323C>G synonymous_variant 0.13
clpC1 4039412 c.1293T>G synonymous_variant 0.13
clpC1 4039415 p.Glu430Asp missense_variant 0.13
clpC1 4039442 c.1263A>G synonymous_variant 0.13
clpC1 4039454 c.1251A>T synonymous_variant 0.13
clpC1 4039457 c.1248C>T synonymous_variant 0.12
clpC1 4039463 c.1242C>G synonymous_variant 0.13
clpC1 4039466 c.1239T>C synonymous_variant 0.13
clpC1 4039469 c.1236T>C synonymous_variant 0.13
clpC1 4039472 c.1233G>C synonymous_variant 0.13
clpC1 4039478 c.1227G>C synonymous_variant 0.13
clpC1 4039481 c.1224T>C synonymous_variant 0.14
clpC1 4039484 c.1221T>C synonymous_variant 0.15
clpC1 4039487 c.1218G>C synonymous_variant 0.15
clpC1 4039517 c.1188C>G synonymous_variant 0.15
clpC1 4039541 c.1164C>G synonymous_variant 0.13
clpC1 4039556 c.1149G>C synonymous_variant 0.14
clpC1 4039559 c.1146C>G synonymous_variant 0.17
clpC1 4039570 p.Met379Leu missense_variant 0.17
clpC1 4039574 p.Ala377Gly missense_variant 0.16
clpC1 4039577 c.1128T>C synonymous_variant 0.16
clpC1 4039589 c.1116G>C synonymous_variant 0.14
clpC1 4039592 c.1113G>C synonymous_variant 0.14
clpC1 4039610 c.1095G>C synonymous_variant 0.19
clpC1 4039616 c.1089G>C synonymous_variant 0.23
clpC1 4039622 c.1083C>T synonymous_variant 0.23
clpC1 4039649 c.1056G>C synonymous_variant 0.17
clpC1 4039682 c.1023C>G synonymous_variant 0.14
clpC1 4039793 c.912C>G synonymous_variant 0.13
clpC1 4040003 c.702G>C synonymous_variant 0.17
clpC1 4040021 c.684A>C synonymous_variant 0.15
clpC1 4040033 c.672G>C synonymous_variant 0.14
clpC1 4040042 c.663C>T synonymous_variant 0.15
clpC1 4040087 c.618G>C synonymous_variant 0.16
clpC1 4040090 c.613_615delTCTinsAGC synonymous_variant 0.17
clpC1 4040093 c.612C>G synonymous_variant 0.17
clpC1 4040126 c.579C>T synonymous_variant 0.17
clpC1 4040411 c.294T>C synonymous_variant 0.12
clpC1 4040441 c.264C>G synonymous_variant 0.12
clpC1 4040444 c.261C>G synonymous_variant 0.12
clpC1 4040450 c.255A>G synonymous_variant 0.12
clpC1 4040459 c.246C>G synonymous_variant 0.13
clpC1 4040462 c.243C>T synonymous_variant 0.13
clpC1 4040465 c.240T>C synonymous_variant 0.12
clpC1 4040841 c.-138delG upstream_gene_variant 1.0
embA 4242643 c.-590C>T upstream_gene_variant 1.0
embB 4246088 c.-426A>G upstream_gene_variant 1.0
embB 4248097 c.1584C>G synonymous_variant 0.12
embB 4249385 p.Glu958Lys missense_variant 0.12
aftB 4267647 p.Asp397Gly missense_variant 1.0
whiB6 4338595 c.-75delG upstream_gene_variant 1.0
gid 4407588 c.615A>G synonymous_variant 1.0