TB-Profiler result

Run: SRR13861305
Summary

Run ID: SRR13861305

Sample name:

Date: 2024-10-04T16:50:26.296199

Number of reads: 1033699

Percentage reads mapped: 34.49

Median coverage: 36.0

Strain: lineage4.9

Spoligotype:

Drug-resistance: Other

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 1.0
lineage4.9 Euro-American (H37Rv-like) None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin rrs n.462C>T Uncertain significance Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
rrs 1472307 n.462C>T non_coding_transcript_exon_variant 0.27 streptomycin Uncertain significance Mutation from literature
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
dnaA 1425 c.1426dupG frameshift_variant 0.92 isoniazid Uncertain significance
gyrA 6760 c.-542G>C upstream_gene_variant 0.18 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.28 levofloxacin
moxifloxacin
gyrA 7715 c.414G>C synonymous_variant 0.31 levofloxacin
moxifloxacin
gyrA 7728 c.427_429delAGGinsCGC synonymous_variant 0.3 levofloxacin
moxifloxacin
gyrA 7760 c.459C>T synonymous_variant 0.27 levofloxacin
moxifloxacin
gyrA 7763 c.462T>C synonymous_variant 0.26 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7799 c.498A>G synonymous_variant 0.24 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7835 c.534A>G synonymous_variant 0.22 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7838 c.537C>G synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9626 c.2325T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9629 c.2328C>G synonymous_variant 0.23 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9630 p.Val777Ile missense_variant 0.23 levofloxacin
moxifloxacin
gyrA 9635 c.2334T>C synonymous_variant 0.23 levofloxacin
moxifloxacin
gyrA 9644 c.2343T>C synonymous_variant 0.22 levofloxacin
moxifloxacin
gyrA 9647 c.2346C>T synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9650 c.2349G>C synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9665 c.2364A>G synonymous_variant 0.21 levofloxacin
moxifloxacin
gyrA 9666 p.Arg789Gly missense_variant 0.21 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 9674 c.2373T>C synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9677 c.2376C>T synonymous_variant 0.2 levofloxacin
moxifloxacin
gyrA 9701 c.2400T>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
fgd1 491181 c.399T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491191 p.Gly137Arg missense_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491194 c.412_414delCTAinsTTG synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491232 c.450T>C synonymous_variant 0.2 pretomanid
delamanid
clofazimine
fgd1 491241 p.Asp153Glu missense_variant 0.18 pretomanid
delamanid
clofazimine
fgd1 491244 c.462T>C synonymous_variant 0.16 pretomanid
delamanid
clofazimine
fgd1 491259 c.477T>C synonymous_variant 0.15 pretomanid
delamanid
clofazimine
nusG 734625 c.372T>C synonymous_variant 0.19 rifampicin
nusG 734634 c.381G>C synonymous_variant 0.2 rifampicin
nusG 734643 c.390G>C synonymous_variant 0.19 rifampicin
nusG 734652 c.399T>C synonymous_variant 0.17 rifampicin
nusG 734655 c.402G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734658 c.405A>G synonymous_variant 0.17 rifampicin Not assoc w R
nusG 734661 c.408A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
nusG 734664 c.411T>G synonymous_variant 0.16 rifampicin
nusG 734673 c.420A>G synonymous_variant 0.18 rifampicin
nusG 734679 c.426C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
nusG 734680 p.Ala143Ser missense_variant 0.17 rifampicin
rpoB 760181 c.375T>C synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoB 760184 c.378A>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 760196 c.390C>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760361 c.555T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760728 p.Tyr308Asn missense_variant 0.92 rifampicin
rpoB 760985 c.1179G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 760991 c.1185G>C synonymous_variant 0.16 rifampicin
rpoB 761102 c.1296A>G synonymous_variant 0.17 rifampicin
rpoB 761222 c.1416G>C synonymous_variant 0.18 rifampicin
rpoB 761579 c.1773G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761606 c.1800C>G synonymous_variant 0.18 rifampicin
rpoB 761612 c.1806G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 761723 c.1917_1919delAGAinsG frameshift_variant&synonymous_variant 0.17 rifampicin
rpoB 761732 c.1926C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761735 c.1929C>G synonymous_variant 0.17 rifampicin
rpoB 761747 c.1941G>C synonymous_variant 0.19 rifampicin
rpoB 761750 c.1944G>C synonymous_variant 0.19 rifampicin
rpoB 761765 c.1959T>C synonymous_variant 0.2 rifampicin
rpoB 761772 p.His656Ala missense_variant 0.23 rifampicin
rpoB 761778 p.Asn658Asp missense_variant 0.21 rifampicin
rpoB 761852 c.2046C>G synonymous_variant 0.2 rifampicin
rpoB 761858 c.2052G>C synonymous_variant 0.23 rifampicin
rpoB 761864 c.2058G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoB 761873 c.2067A>G synonymous_variant 0.22 rifampicin
rpoB 761885 c.2079T>C synonymous_variant 0.22 rifampicin
rpoB 761891 c.2085G>C synonymous_variant 0.19 rifampicin
rpoB 761906 c.2100C>G synonymous_variant 0.19 rifampicin
rpoB 761909 c.2103T>C synonymous_variant 0.19 rifampicin
rpoB 761912 c.2106T>C synonymous_variant 0.19 rifampicin
rpoB 761915 p.Asp703Glu missense_variant 0.19 rifampicin
rpoB 761916 p.Asp704Asn missense_variant 0.19 rifampicin
rpoB 761954 c.2148C>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761999 c.2193G>C synonymous_variant 0.16 rifampicin
rpoB 762284 c.2478G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762293 c.2487T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762317 c.2511A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 762329 c.2523G>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.15 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.15 rifampicin
rpoC 763528 c.159G>A synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763546 c.177A>G synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 763570 c.201G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763594 c.225C>T synonymous_variant 0.31 rifampicin Not assoc w R - Interim
rpoC 763633 c.264T>C synonymous_variant 0.29 rifampicin Not assoc w R - Interim
rpoC 763636 c.267T>C synonymous_variant 0.27 rifampicin
rpoC 763642 c.273G>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 763658 c.289_291delCTTinsTTG synonymous_variant 0.19 rifampicin
rpoC 763675 c.306C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 763696 c.327T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763702 c.333C>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 763708 c.339G>A synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 763709 c.340C>T synonymous_variant 0.19 rifampicin
rpoC 763714 c.345G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763717 c.348T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 763723 c.354G>C synonymous_variant 0.2 rifampicin
rpoC 763732 c.363C>G synonymous_variant 0.19 rifampicin
rpoC 763735 c.366G>C synonymous_variant 0.19 rifampicin
rpoC 763744 c.375G>C synonymous_variant 0.16 rifampicin
rpoC 763928 p.Glu187* stop_gained 0.9 rifampicin
rpoC 764131 c.762T>C synonymous_variant 0.19 rifampicin
rpoC 764161 c.792G>C synonymous_variant 0.16 rifampicin
rpoC 764188 c.819A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764626 c.1257C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 764632 c.1263T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoC 764644 c.1275G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764650 c.1281G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764714 c.1345C>T synonymous_variant 0.21 rifampicin
rpoC 764720 c.1351C>T synonymous_variant 0.19 rifampicin
rpoC 764809 c.1440C>T synonymous_variant 0.18 rifampicin Not assoc w R
rpoC 764812 c.1443C>G synonymous_variant 0.18 rifampicin
rpoC 764815 c.1446A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 764824 c.1455T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 764830 c.1461C>G synonymous_variant 0.19 rifampicin
rpoC 764858 c.1489T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 764872 c.1503A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 764893 c.1524T>C synonymous_variant 0.2 rifampicin
rpoC 764995 c.1626C>G synonymous_variant 0.22 rifampicin Not assoc w R
rpoC 765007 c.1638T>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765019 c.1650A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 765022 c.1653G>C synonymous_variant 0.17 rifampicin
rpoC 765404 p.Leu679Val missense_variant 0.16 rifampicin
rpoC 765478 c.2109T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765499 c.2130C>G synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 765658 c.2289C>T synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoC 765700 c.2331T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765734 c.2365T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765739 c.2370G>C synonymous_variant 0.25 rifampicin Not assoc w R - Interim
rpoC 765751 c.2382C>G synonymous_variant 0.26 rifampicin
rpoC 765753 p.Asp795Ala missense_variant 0.26 rifampicin Uncertain significance
rpoC 765772 c.2403C>G synonymous_variant 0.29 rifampicin
rpoC 765784 c.2415C>G synonymous_variant 0.28 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.24 rifampicin
rpoC 765811 c.2442T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765814 c.2445A>G synonymous_variant 0.23 rifampicin Not assoc w R - Interim
rpoC 765826 c.2457T>C synonymous_variant 0.26 rifampicin Not assoc w R - Interim
rpoC 765835 c.2466C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765883 c.2514C>G synonymous_variant 0.21 rifampicin
rpoC 765886 c.2517C>G synonymous_variant 0.22 rifampicin
rpoC 765892 c.2523T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoC 765928 c.2559C>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 765967 c.2598C>T synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 765970 c.2601C>T synonymous_variant 0.17 rifampicin
rpoC 765979 c.2610C>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765982 c.2613C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 765985 c.2616C>T synonymous_variant 0.17 rifampicin
rpoC 765994 c.2625A>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766009 c.2640G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766010 c.2641_2642delTCinsAG synonymous_variant 0.16 rifampicin
rpoC 766021 c.2652G>C synonymous_variant 0.18 rifampicin
rpoC 766155 p.Ala929Val missense_variant 0.95 rifampicin
rpoC 766390 c.3021C>T synonymous_variant 0.19 rifampicin
rpoC 766408 c.3039C>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766426 c.3057C>T synonymous_variant 0.26 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.27 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.26 rifampicin
rpoC 766484 p.Val1039Ile missense_variant 0.26 rifampicin Uncertain significance
rpoC 766492 c.3123T>C synonymous_variant 0.26 rifampicin
rpoC 766495 c.3126C>T synonymous_variant 0.28 rifampicin Not assoc w R - Interim
rpoC 766522 c.3153C>G synonymous_variant 0.26 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.28 rifampicin
rpoC 766531 c.3162G>T synonymous_variant 0.27 rifampicin
rpoC 766543 c.3174C>T synonymous_variant 0.25 rifampicin
rpoC 766843 c.3474T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoC 766861 c.3492G>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoC 766864 c.3495G>C synonymous_variant 0.19 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.17 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.17 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.15 rifampicin
mmpL5 777185 c.1296G>T synonymous_variant 1.0 bedaquiline
clofazimine
rpsL 781682 c.123T>C synonymous_variant 0.15 streptomycin
rpsL 781715 c.156T>C synonymous_variant 0.19 streptomycin
rpsL 781728 c.169T>C synonymous_variant 0.2 streptomycin
rpsL 781736 c.177T>C synonymous_variant 0.2 streptomycin
rpsL 781751 c.192G>C synonymous_variant 0.19 streptomycin
rpsL 781754 c.195G>C synonymous_variant 0.18 streptomycin
rpsL 781760 c.201T>C synonymous_variant 0.2 streptomycin
rpsL 781793 c.234G>C synonymous_variant 0.19 streptomycin
rpsL 781832 c.273T>C synonymous_variant 0.17 streptomycin
rpsL 781841 c.282C>G synonymous_variant 0.17 streptomycin
rpsL 781868 c.309T>C synonymous_variant 0.17 streptomycin
rpsL 781871 c.312G>C synonymous_variant 0.17 streptomycin
rpsL 781916 c.357T>C synonymous_variant 0.16 streptomycin
rpsL 781929 p.Gly124Ser missense_variant 0.18 streptomycin Uncertain significance
rplC 800648 c.-161A>C upstream_gene_variant 0.26 linezolid
rplC 800654 c.-155T>C upstream_gene_variant 0.26 linezolid
rplC 800693 c.-116A>G upstream_gene_variant 0.24 linezolid
rplC 800771 c.-38C>T upstream_gene_variant 0.2 linezolid
rplC 800794 c.-15_-9delAGATTGGinsGAGTT upstream_gene_variant 0.2 linezolid
rplC 800814 c.6A>G synonymous_variant 0.18 linezolid
rplC 800817 c.9A>T synonymous_variant 0.19 linezolid
fbiC 1302932 p.Val1Gly missense_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1303151 p.Gly74Asp missense_variant 1.0 pretomanid
delamanid
clofazimine
fbiC 1305298 p.Lys790Gln missense_variant 0.95 pretomanid
delamanid
clofazimine
Rv1258c 1406311 c.1030C>T synonymous_variant 1.0 streptomycin
pyrazinamide
isoniazid
rrs 1472075 n.230A>G non_coding_transcript_exon_variant 0.15 kanamycin Uncertain significance
capreomycin Uncertain significance
streptomycin
amikacin Uncertain significance
rrl 1475881 n.2224T>C non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.17 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476281 n.2624T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rpsA 1833661 c.120A>G synonymous_variant 0.21 pyrazinamide
rpsA 1833667 c.126C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833724 c.183C>G synonymous_variant 0.18 pyrazinamide
rpsA 1833727 c.186G>C synonymous_variant 0.19 pyrazinamide
rpsA 1833742 c.201A>G synonymous_variant 0.2 pyrazinamide
rpsA 1833874 c.333T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834275 p.Ile245Thr missense_variant 1.0 pyrazinamide
rpsA 1834546 c.1005T>C synonymous_variant 0.16 pyrazinamide
rpsA 1834555 c.1014T>C synonymous_variant 0.15 pyrazinamide
rpsA 1834606 c.1065C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.19 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.17 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.24 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834666 c.1125G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834669 c.1128G>C synonymous_variant 0.23 pyrazinamide
rpsA 1834688 c.1147_1149delAGTinsTCC synonymous_variant 0.2 pyrazinamide
rpsA 1834732 c.1191T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834733 p.Ala398Pro missense_variant 0.25 pyrazinamide
rpsA 1834753 c.1212T>C synonymous_variant 0.24 pyrazinamide
rpsA 1834765 c.1224A>G synonymous_variant 0.21 pyrazinamide
tlyA 1917936 c.-4C>A upstream_gene_variant 1.0 capreomycin
bacA 2064894 c.-166C>G upstream_gene_variant 1.0 kanamycin
capreomycin
streptomycin
amikacin
ndh 2101676 p.Ala456Val missense_variant 1.0 isoniazid
delamanid
ethionamide
PPE35 2170823 c.-212delT upstream_gene_variant 1.0 pyrazinamide
pncA 2289356 c.-115G>T upstream_gene_variant 1.0 pyrazinamide
kasA 2518234 p.Glu40Asp missense_variant 1.0 isoniazid
Rv2477c 2783092 c.951A>G synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
amikacin
Rv2477c 2783095 c.948C>G synonymous_variant 0.24 kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin Not assoc w R - Interim
rifampicin Not assoc w R
ethambutol Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783110 c.933C>A synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783116 c.927T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783140 c.903C>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783158 c.885A>G synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783185 c.858G>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783194 c.849A>G synonymous_variant 0.29 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783203 c.840C>T synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783221 c.822G>T synonymous_variant 0.3 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783224 c.819C>G synonymous_variant 0.31 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783230 c.813T>C synonymous_variant 0.27 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783235 c.808T>C synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783243 p.Thr267Ser missense_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783247 c.796T>C synonymous_variant 0.25 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783254 c.789A>G synonymous_variant 0.28 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783263 c.780G>C synonymous_variant 0.24 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2477c 2783278 c.765A>G synonymous_variant 0.26 kanamycin
levofloxacin
moxifloxacin
streptomycin
rifampicin
ethambutol
amikacin
Rv2752c 3064837 p.Leu452Trp missense_variant 0.97 levofloxacin
moxifloxacin
isoniazid
rifampicin
ethambutol
thyX 3067367 c.579G>C synonymous_variant 0.2 para-aminosalicylic_acid
thyX 3067376 c.570G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067391 c.555G>C synonymous_variant 0.18 para-aminosalicylic_acid
thyX 3067394 c.552G>C synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067412 c.534C>G synonymous_variant 0.22 para-aminosalicylic_acid
thyX 3067439 c.507A>G synonymous_variant 0.19 para-aminosalicylic_acid
thyX 3067445 c.501C>G synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067451 c.495G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyX 3067457 c.489C>G synonymous_variant 0.15 para-aminosalicylic_acid
thyX 3067465 p.Ile161Val missense_variant 0.15 para-aminosalicylic_acid
thyX 3067466 c.480G>C synonymous_variant 0.15 para-aminosalicylic_acid
thyA 3073872 p.Ile200Val missense_variant 0.18 para-aminosalicylic_acid
thyA 3073878 c.594G>A synonymous_variant 0.17 para-aminosalicylic_acid
thyA 3073892 c.580T>C synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073893 c.579C>G synonymous_variant 0.19 para-aminosalicylic_acid
thyA 3073925 c.547T>C synonymous_variant 0.2 para-aminosalicylic_acid
thyA 3073926 c.546G>C synonymous_variant 0.21 para-aminosalicylic_acid
thyA 3073929 c.543T>C synonymous_variant 0.23 para-aminosalicylic_acid
thyA 3073989 c.483T>C synonymous_variant 0.15 para-aminosalicylic_acid
Rv3083 3449643 p.Asn380Lys missense_variant 1.0 ethionamide Uncertain significance
Rv3236c 3611967 p.Ser384Pro missense_variant 1.0 pyrazinamide
lpqB 3624119 c.792C>G synonymous_variant 0.18 rifampicin
bedaquiline
lpqB 3624124 p.Leu263Val missense_variant 0.19 rifampicin
bedaquiline
lpqB 3624125 c.786A>G synonymous_variant 0.18 rifampicin
bedaquiline
mtrA 3626846 c.504G>A synonymous_variant 0.25 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626858 c.-245A>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3626861 c.-248C>G upstream_gene_variant 0.25 rifampicin
bedaquiline
mtrB 3626866 c.-253T>C upstream_gene_variant 0.24 rifampicin
bedaquiline
mtrB 3626885 c.-272A>C upstream_gene_variant 0.27 rifampicin
bedaquiline
mtrB 3626903 c.-290T>C upstream_gene_variant 0.26 rifampicin
bedaquiline
mtrA 3626912 c.438T>C synonymous_variant 0.24 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626930 c.-317A>G upstream_gene_variant 0.3 rifampicin
bedaquiline
mtrA 3626939 c.411A>G synonymous_variant 0.29 rifampicin Not assoc w R - Interim
bedaquiline
mtrB 3626942 c.-329A>G upstream_gene_variant 0.26 rifampicin
bedaquiline
fbiB 3642581 c.1047A>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642593 c.1059G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiB 3642602 c.1068A>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642605 c.1071A>G synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiB 3642614 c.1080C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642620 c.1086T>C synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiB 3642656 c.1122G>C synonymous_variant 0.25 pretomanid
delamanid
clofazimine
fbiB 3642659 c.1125C>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642668 c.1134A>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642677 c.1143A>G synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642680 c.1146A>G synonymous_variant 0.27 pretomanid
delamanid
clofazimine
fbiB 3642684 c.1150T>C synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642694 p.Ala387Gly missense_variant 0.23 pretomanid
delamanid
clofazimine
fbiB 3642696 c.1162C>T synonymous_variant 0.24 pretomanid
delamanid
clofazimine
fbiB 3642701 c.1167C>G synonymous_variant 0.23 pretomanid
delamanid
clofazimine
fbiB 3642710 c.1176G>C synonymous_variant 0.21 pretomanid
delamanid
clofazimine
rpoA 3877756 p.Ile251Thr missense_variant 0.84 rifampicin
rpoA 3877857 c.651G>A synonymous_variant 0.22 rifampicin
rpoA 3877866 c.642G>C synonymous_variant 0.21 rifampicin
rpoA 3877872 c.636C>T synonymous_variant 0.24 rifampicin Not assoc w R - Interim
rpoA 3877875 c.633T>G synonymous_variant 0.19 rifampicin
rpoA 3877899 p.Ser203Thr missense_variant 0.22 rifampicin
rpoA 3877905 c.603A>G synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877908 p.Asn200Ser missense_variant 0.21 rifampicin
rpoA 3877953 c.555G>A synonymous_variant 0.21 rifampicin
rpoA 3877962 c.546G>T synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3877986 c.522G>C synonymous_variant 0.24 rifampicin
rpoA 3878065 p.Pro148Arg missense_variant 0.88 rifampicin
ddn 3986977 p.Pro45Arg missense_variant 1.0 pretomanid
delamanid
clpC1 4038368 c.2337T>C synonymous_variant 0.14 pyrazinamide
clpC1 4038398 c.2307G>T synonymous_variant 0.16 pyrazinamide
clpC1 4038403 c.2302T>C synonymous_variant 0.19 pyrazinamide Not assoc w R - Interim
clpC1 4038419 c.2286T>C synonymous_variant 0.17 pyrazinamide
clpC1 4038434 c.2271G>C synonymous_variant 0.17 pyrazinamide
clpC1 4038444 p.Ala754Lys missense_variant 0.18 pyrazinamide
clpC1 4038446 c.2259T>C synonymous_variant 0.18 pyrazinamide
clpC1 4038452 c.2253G>C synonymous_variant 0.18 pyrazinamide
clpC1 4038461 p.Ala748Asp missense_variant 0.17 pyrazinamide
clpC1 4039442 c.1263A>G synonymous_variant 0.24 pyrazinamide
clpC1 4039448 c.1257A>G synonymous_variant 0.23 pyrazinamide Not assoc w R - Interim
clpC1 4039454 c.1251A>G synonymous_variant 0.21 pyrazinamide Not assoc w R - Interim
clpC1 4039463 c.1242C>G synonymous_variant 0.18 pyrazinamide
clpC1 4039466 c.1239T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039469 c.1236T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039481 c.1224T>G synonymous_variant 0.2 pyrazinamide Not assoc w R - Interim
clpC1 4039484 c.1221T>G synonymous_variant 0.2 pyrazinamide
clpC1 4039517 c.1188C>G synonymous_variant 0.22 pyrazinamide
clpC1 4039610 c.1095G>C synonymous_variant 0.21 pyrazinamide
clpC1 4039616 c.1089G>C synonymous_variant 0.18 pyrazinamide
clpC1 4039622 c.1083C>G synonymous_variant 0.17 pyrazinamide
clpC1 4039682 c.1023C>G synonymous_variant 0.15 pyrazinamide
clpC1 4039685 c.1020C>T synonymous_variant 0.15 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.15 pyrazinamide
clpC1 4040273 c.432T>C synonymous_variant 0.14 pyrazinamide Not assoc w R - Interim
clpC1 4040354 c.351A>G synonymous_variant 0.17 pyrazinamide
clpC1 4040363 c.342A>C synonymous_variant 0.17 pyrazinamide
clpC1 4040369 c.336C>G synonymous_variant 0.18 pyrazinamide
clpC1 4040380 c.325T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040381 c.324T>C synonymous_variant 0.2 pyrazinamide
clpC1 4040387 c.318A>G synonymous_variant 0.2 pyrazinamide
clpC1 4040393 c.312G>C synonymous_variant 0.18 pyrazinamide Not assoc w R - Interim
clpC1 4040411 c.294T>C synonymous_variant 0.16 pyrazinamide Not assoc w R - Interim
clpC1 4040538 p.Leu56Arg missense_variant 0.92 pyrazinamide
glpK 4138636 p.Arg374Gly missense_variant 0.98 levofloxacin
moxifloxacin
isoniazid
streptomycin
rifampicin
ethambutol
embC 4240726 c.864G>C synonymous_variant 0.17 ethambutol Not assoc w R - Interim
embA 4245342 p.Ser704Pro missense_variant 1.0 ethambutol
embB 4248711 c.2198_2199insT frameshift_variant 1.0 ethambutol
aftB 4267498 p.Glu447Lys missense_variant 0.97 ethambutol Uncertain significance
aftB 4268559 p.Leu93Gln missense_variant 1.0 ethambutol
whiB6 4338743 c.-223_-222insC upstream_gene_variant 1.0 kanamycin
capreomycin
amikacin