TB-Profiler result

Run: ERR9786384
Summary

Run ID: ERR9786384

Sample name:

Date: 2024-04-16T05:18:19.504698

Number of reads: 2761345

Percentage reads mapped: 89.76

Median coverage: 137.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4.1 Euro-American None 0.97
lineage4.1.2 Euro-American None 0.99
lineage4.1.2.1 Euro-American (Haarlem) RD182 0.99
lineage4 Euro-American None 1.0
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7538 c.237G>A synonymous_variant 0.15 levofloxacin
moxifloxacin
gyrA 7547 c.246C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7628 c.327G>C synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7631 c.330G>C synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7637 c.336C>G synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7652 c.351C>T synonymous_variant 0.19 levofloxacin
moxifloxacin
gyrA 7658 c.357A>T synonymous_variant 0.18 levofloxacin
moxifloxacin
gyrA 7664 c.363T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7670 c.369A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7694 c.393A>G synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7697 c.396C>G synonymous_variant 0.16 levofloxacin
moxifloxacin
gyrA 7710 c.409T>C synonymous_variant 0.17 levofloxacin
moxifloxacin
gyrA 7727 c.426G>T synonymous_variant 0.14 levofloxacin
moxifloxacin
gyrA 7775 c.474C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 0.94 clofazimine Not assoc w R
pretomanid
delamanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 0.92 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620173 p.Val95Ile missense_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620181 c.291G>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620198 p.Gln103Leu missense_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620249 p.Ser120Cys missense_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620256 c.366C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620262 c.372C>G synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620283 c.393T>C synonymous_variant 0.16 capreomycin
amikacin
kanamycin
ccsA 620284 p.Ala132Pro missense_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620288 p.Arg133Gln missense_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620307 c.417C>T synonymous_variant 0.15 capreomycin
amikacin
kanamycin
ccsA 620319 c.429C>T synonymous_variant 0.15 capreomycin
amikacin
kanamycin
Rv0565c 657269 p.Ser68Pro missense_variant 0.96 ethionamide Uncertain significance
rpoB 760115 c.309C>T synonymous_variant 0.93 rifampicin Not assoc w R
rpoB 760223 c.417T>C synonymous_variant 0.16 rifampicin
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.18 rifampicin
rpoB 760313 c.507G>C synonymous_variant 0.18 rifampicin
rpoB 760331 c.525G>T synonymous_variant 0.15 rifampicin
rpoB 760991 c.1185G>C synonymous_variant 0.16 rifampicin
rpoB 761015 c.1209G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.16 rifampicin
rpoB 761027 c.1221A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.17 rifampicin
rpoB 761318 c.1512G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.2 rifampicin
rpoB 761354 c.1548C>G synonymous_variant 0.21 rifampicin
rpoB 761360 c.1554T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.22 rifampicin
rpoB 761375 c.1569G>C synonymous_variant 0.21 rifampicin
rpoB 761408 c.1602G>C synonymous_variant 0.19 rifampicin
rpoB 761414 c.1608A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.21 rifampicin
rpoB 761435 c.1629T>C synonymous_variant 0.21 rifampicin
rpoB 761437 p.Ala544Glu missense_variant 0.21 rifampicin
rpoB 761439 p.Asp545Asn missense_variant 0.21 rifampicin
rpoB 761444 c.1638T>C synonymous_variant 0.21 rifampicin
rpoB 761447 c.1641C>G synonymous_variant 0.21 rifampicin
rpoB 761465 c.1659G>C synonymous_variant 0.21 rifampicin
rpoB 761471 c.1665C>G synonymous_variant 0.2 rifampicin
rpoB 761492 c.1686G>C synonymous_variant 0.19 rifampicin
rpoB 761495 c.1689G>A synonymous_variant 0.19 rifampicin
rpoB 762299 c.2493G>C synonymous_variant 0.16 rifampicin
rpoB 762329 c.2523G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.17 rifampicin
rpoB 762347 c.2541T>C synonymous_variant 0.17 rifampicin
rpoB 762362 p.Glu852Asp missense_variant 0.16 rifampicin
rpoB 762369 c.2563T>C synonymous_variant 0.16 rifampicin
rpoC 762374 c.-996G>C upstream_gene_variant 0.17 rifampicin
rpoC 762380 c.-990T>G upstream_gene_variant 0.17 rifampicin
rpoC 762395 c.-975G>C upstream_gene_variant 0.17 rifampicin
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.19 rifampicin
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.14 rifampicin
rpoC 763816 c.447C>G synonymous_variant 0.16 rifampicin
rpoC 763835 p.Ala156Met missense_variant 0.16 rifampicin
rpoC 763851 p.Ala161Gly missense_variant 0.16 rifampicin
rpoC 763855 c.486C>T synonymous_variant 0.16 rifampicin
rpoC 763858 c.489A>G synonymous_variant 0.16 rifampicin
rpoC 763963 c.594C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765541 c.2172C>G synonymous_variant 0.17 rifampicin
rpoC 765553 c.2184C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.16 rifampicin
rpoC 765562 c.2193G>C synonymous_variant 0.17 rifampicin
rpoC 765565 c.2196G>C synonymous_variant 0.17 rifampicin
rpoC 765583 c.2214G>T synonymous_variant 0.18 rifampicin
rpoC 765613 p.His748Gln missense_variant 0.18 rifampicin
rpoC 765796 c.2427C>T synonymous_variant 0.13 rifampicin
rpoC 766426 c.3057C>T synonymous_variant 0.14 rifampicin
rpoC 766447 c.3078T>C synonymous_variant 0.15 rifampicin
rpoC 766456 c.3087C>G synonymous_variant 0.16 rifampicin
rpoC 766459 c.3090G>T synonymous_variant 0.16 rifampicin
rpoC 766483 c.3114G>C synonymous_variant 0.16 rifampicin
rpoC 766528 c.3159T>C synonymous_variant 0.15 rifampicin
rpoC 766543 c.3174C>G synonymous_variant 0.16 rifampicin
rpoC 766894 c.3525T>C synonymous_variant 0.17 rifampicin
rpoC 766895 c.3526T>C synonymous_variant 0.17 rifampicin
rpoC 766900 c.3531T>C synonymous_variant 0.17 rifampicin
rpoC 766918 c.3549C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.18 rifampicin
rpoC 766978 c.3609C>T synonymous_variant 0.18 rifampicin
rpoC 766981 c.3612T>C synonymous_variant 0.18 rifampicin
rpoC 766987 c.3618G>C synonymous_variant 0.17 rifampicin
rpoC 767032 c.3663G>C synonymous_variant 0.21 rifampicin
rpoC 767059 c.3690T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.18 rifampicin
rpoC 767098 c.3729T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.14 rifampicin
mmpL5 775639 p.Ile948Val missense_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
fbiC 1304675 p.Gly582Asp missense_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304682 c.1752C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304691 c.1761G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304694 c.1764A>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304703 c.1773C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304709 c.1779C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304715 c.1785G>C synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304724 c.1794A>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304727 c.1797A>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304742 c.1812T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304748 c.1818T>C synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304757 c.1827A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304763 c.1833C>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304778 p.Asp616Glu missense_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304784 c.1854T>G synonymous_variant 0.17 clofazimine
pretomanid
delamanid
fbiC 1304787 c.1857T>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304799 c.1869G>C synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304808 c.1878C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304811 c.1881C>G synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304817 c.1887T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304826 c.1896G>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304829 c.1899T>C synonymous_variant 0.2 clofazimine
pretomanid
delamanid
fbiC 1304832 c.1902C>T synonymous_variant 0.19 clofazimine Not assoc w R - Interim
pretomanid
delamanid Not assoc w R - Interim
fbiC 1304853 c.1923C>T synonymous_variant 0.18 clofazimine
pretomanid
delamanid
fbiC 1304856 c.1926C>G synonymous_variant 0.19 clofazimine
pretomanid
delamanid
fbiC 1304869 c.1939C>T synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1304910 c.1980G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1304916 c.1986T>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
fbiC 1305006 c.2076A>G synonymous_variant 0.16 clofazimine
pretomanid
delamanid
fbiC 1305015 c.2085G>C synonymous_variant 0.15 clofazimine
pretomanid
delamanid
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474030 n.373G>A non_coding_transcript_exon_variant 0.15 capreomycin
linezolid
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1474950 n.1293G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1474952 n.1296_1300delCATCC non_coding_transcript_exon_variant 0.17 capreomycin
linezolid
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474962 n.1305T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.18 capreomycin
linezolid
rrl 1474967 n.1311_1315delGGGTG non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.22 capreomycin
linezolid
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475017 n.1360_1361insT non_coding_transcript_exon_variant 0.24 capreomycin
linezolid
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.19 capreomycin
linezolid
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475253 n.1596T>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.16 capreomycin
linezolid
rrl 1475289 n.1632G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.2 capreomycin
linezolid
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.15 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674443 p.Ala81Val missense_variant 0.14 ethionamide
isoniazid
inhA 1674452 p.Ala84Glu missense_variant 0.16 ethionamide
isoniazid
rpsA 1834030 c.489C>G synonymous_variant 0.15 pyrazinamide
rpsA 1834609 c.1068T>C synonymous_variant 0.17 pyrazinamide
rpsA 1834618 c.1077G>A synonymous_variant 0.17 pyrazinamide
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.17 pyrazinamide
rpsA 1834633 c.1092A>G synonymous_variant 0.17 pyrazinamide
rpsA 1834639 c.1098T>C synonymous_variant 0.17 pyrazinamide
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064398 p.Gly111Ser missense_variant 1.0 streptomycin
kanamycin
capreomycin
amikacin
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 clofazimine Not assoc w R
bedaquiline Not assoc w R - Interim
kasA 2518076 c.-39C>T upstream_gene_variant 0.92 isoniazid
Rv2477c 2783512 c.531A>G synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783521 c.522G>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783554 c.489C>T synonymous_variant 0.14 ethambutol Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
streptomycin
levofloxacin Not assoc w R - Interim
kanamycin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
amikacin Not assoc w R - Interim
Rv2477c 2783572 c.471A>C synonymous_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783584 c.457_459delGCCinsCG frameshift_variant&synonymous_variant 0.16 ethambutol Uncertain significance
moxifloxacin Uncertain significance
streptomycin Uncertain significance
levofloxacin Uncertain significance
kanamycin Uncertain significance
rifampicin Uncertain significance
amikacin Uncertain significance
Rv2477c 2783593 c.450T>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783628 p.Ala139Ser missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783656 c.387G>C synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783659 c.384A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783674 c.369T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783680 c.363G>A synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783683 c.360A>G synonymous_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783700 p.Thr115Ser missense_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783718 c.325T>C synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783719 c.324A>G synonymous_variant 0.17 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783751 p.Ile98Val missense_variant 0.16 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783758 p.Asp95Glu missense_variant 0.15 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2477c 2783799 p.Asp82Asn missense_variant 0.14 ethambutol
moxifloxacin
streptomycin
levofloxacin
kanamycin
rifampicin
amikacin
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.24 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.17 capreomycin
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3627756 c.-407A>T upstream_gene_variant 0.98 bedaquiline
rifampicin
rpoA 3877887 c.621G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>C synonymous_variant 0.16 rifampicin
rpoA 3877974 c.534G>C synonymous_variant 0.15 rifampicin
rpoA 3877986 c.522G>C synonymous_variant 0.16 rifampicin
rpoA 3877989 c.519A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>C synonymous_variant 0.18 rifampicin
rpoA 3878022 c.486T>C synonymous_variant 0.17 rifampicin
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin
rpoA 3878040 c.468T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.17 rifampicin
rpoA 3878055 c.453A>G synonymous_variant 0.18 rifampicin
rpoA 3878145 c.362_363insGT frameshift_variant 0.16 rifampicin
rpoA 3878160 c.348C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.18 rifampicin
rpoA 3878193 c.315T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878214 c.294C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.2 rifampicin
rpoA 3878250 c.258C>G synonymous_variant 0.2 rifampicin
rpoA 3878264 p.Ser82Gly missense_variant 0.19 rifampicin
rpoA 3878271 c.237T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.18 rifampicin
rpoA 3878307 c.201C>G synonymous_variant 0.18 rifampicin
rpoA 3878313 c.195G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>G synonymous_variant 0.2 rifampicin
rpoA 3878385 c.123C>G synonymous_variant 0.19 rifampicin
rpoA 3878391 c.117T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.15 rifampicin
rpoA 3878785 c.-278T>C upstream_gene_variant 0.15 rifampicin
rpoA 3878788 c.-281G>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878791 c.-284C>G upstream_gene_variant 0.15 rifampicin
rpoA 3878797 c.-290G>C upstream_gene_variant 0.18 rifampicin
rpoA 3878809 c.-302T>C upstream_gene_variant 0.2 rifampicin
rpoA 3878833 c.-326C>G upstream_gene_variant 0.19 rifampicin
rpoA 3878836 c.-329G>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878839 c.-332C>G upstream_gene_variant 0.19 rifampicin
rpoA 3878853 c.-346G>A upstream_gene_variant 0.23 rifampicin
rpoA 3878878 c.-371T>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878889 c.-382A>G upstream_gene_variant 0.27 rifampicin
rpoA 3878894 c.-387A>G upstream_gene_variant 0.25 rifampicin
rpoA 3878908 c.-402_-401delACinsCG upstream_gene_variant 0.22 rifampicin
rpoA 3878914 c.-407T>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878929 c.-422G>C upstream_gene_variant 0.22 rifampicin
rpoA 3878938 c.-431T>C upstream_gene_variant 0.21 rifampicin
rpoA 3878947 c.-440G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGG upstream_gene_variant 0.21 rifampicin
rpoA 3878998 c.-491C>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.21 rifampicin
rpoA 3879013 c.-506A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879016 c.-509A>G upstream_gene_variant 0.2 rifampicin
rpoA 3879034 c.-527G>A upstream_gene_variant 0.2 rifampicin
rpoA 3879037 c.-530G>C upstream_gene_variant 0.2 rifampicin
rpoA 3879079 c.-572A>G upstream_gene_variant 0.18 rifampicin
rpoA 3879088 c.-581A>C upstream_gene_variant 0.18 rifampicin
rpoA 3879094 c.-587T>C upstream_gene_variant 0.18 rifampicin
rpoA 3879121 c.-614T>G upstream_gene_variant 0.17 rifampicin
rpoA 3879127 c.-620T>C upstream_gene_variant 0.17 rifampicin
rpoA 3879154 c.-647T>C upstream_gene_variant 0.15 rifampicin
rpoA 3879160 c.-653A>G upstream_gene_variant 0.16 rifampicin
rpoA 3879169 c.-662G>C upstream_gene_variant 0.16 rifampicin
clpC1 4038965 c.1740T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038989 c.1716T>C synonymous_variant 0.15 pyrazinamide
clpC1 4038997 c.1708T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.18 pyrazinamide
clpC1 4039037 c.1668T>C synonymous_variant 0.18 pyrazinamide
clpC1 4039073 c.1632C>G synonymous_variant 0.16 pyrazinamide
clpC1 4039661 c.1044T>G synonymous_variant 0.17 pyrazinamide
clpC1 4039664 c.1041G>C synonymous_variant 0.17 pyrazinamide
clpC1 4039694 c.1011G>C synonymous_variant 0.16 pyrazinamide
clpC1 4039742 c.963C>T synonymous_variant 0.15 pyrazinamide
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4240831 c.969T>G synonymous_variant 0.15 ethambutol
embC 4240936 c.1074A>G synonymous_variant 0.15 ethambutol
embC 4240951 c.1089C>G synonymous_variant 0.16 ethambutol
embC 4240954 p.Ile364Met missense_variant 0.16 ethambutol
embC 4241086 c.1224G>C synonymous_variant 0.14 ethambutol
embC 4241095 c.1233C>T synonymous_variant 0.16 ethambutol
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.99 ethambutol Not assoc w R
embB 4248199 c.1686A>T synonymous_variant 0.14 ethambutol
embB 4248220 c.1707A>T synonymous_variant 0.15 ethambutol
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 capreomycin Not assoc w R
amikacin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 capreomycin
amikacin
kanamycin
gid 4407990 c.213A>G synonymous_variant 1.0 streptomycin