TB-Profiler result

Run: ERR9786384
Summary

Run ID: ERR9786384

Sample name:

Date: 2025-09-15T16:49:17.547240

Number of reads: 2761345

Percentage reads mapped: 89.76

Median coverage: 137.0

Strain: lineage4.1.2.1

Spoligotype:

Drug-resistance: Sensitive

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Lineage Table: The lineage is inferred by analysing lineage specific SNPs
Lineage Family RDs Frequency
lineage4 Euro-American None 100.0
lineage4.1 Euro-American None 100.0
lineage4.1.2 Euro-American None 100.0
lineage4.1.2.1 Euro-American (Haarlem) RD182 98.88
Drug resistance: This table reports drug-resistance associated mutations found in known resistance genes
Drug Resistance Supporting mutations WHO confidence Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid
Drug resistance-Associated Mutations: This table reports mutations found in candidate resistance genes which have been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence Comment
Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance
Gene Chromosome position Mutation Type Estimated fraction Drugs Confidence
gyrA 7362 p.Glu21Gln missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7538 c.237G>A synonymous_variant 0.15 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7547 c.246C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7559 c.258G>C synonymous_variant 0.16 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7571 c.270G>T synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7585 p.Ser95Thr missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
gyrA 7587 c.286C>T synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7607 c.306C>G synonymous_variant 0.18 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 7622 c.321C>T synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7628 c.327G>C synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7631 c.330G>C synonymous_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7637 c.336C>G synonymous_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7652 c.351C>T synonymous_variant 0.19 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7658 c.357A>T synonymous_variant 0.18 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7664 c.363T>C synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7670 c.369A>G synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7694 c.393A>G synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7697 c.396C>G synonymous_variant 0.16 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7710 c.409T>C synonymous_variant 0.17 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7727 c.426G>T synonymous_variant 0.14 levofloxacin Uncertain significance
moxifloxacin Uncertain significance
gyrA 7775 c.474C>T synonymous_variant 0.15 levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
gyrA 9304 p.Gly668Asp missense_variant 1.0 levofloxacin Not assoc w R
moxifloxacin Not assoc w R
fgd1 491591 p.Lys270Met missense_variant 0.94 clofazimine Not assoc w R
delamanid Uncertain significance
pretomanid Uncertain significance
mshA 575679 p.Asn111Ser missense_variant 0.92 ethionamide Not assoc w R
isoniazid Not assoc w R
ccsA 620173 p.Val95Ile missense_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620181 c.291G>C synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620198 p.Gln103Leu missense_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620249 p.Ser120Cys missense_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620256 c.366C>G synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620262 c.372C>G synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620283 c.393T>C synonymous_variant 0.16 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620284 p.Ala132Pro missense_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620288 p.Arg133Gln missense_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620307 c.417C>T synonymous_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
ccsA 620319 c.429C>T synonymous_variant 0.15 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
Rv0565c 657269 p.Ser68Pro missense_variant 0.96 ethionamide Uncertain significance
rpoB 760115 c.309C>T synonymous_variant 0.93 rifampicin Not assoc w R
rpoB 760223 c.417T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 760235 c.429T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 760253 c.447T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 760283 c.477G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 760307 c.501T>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 760313 c.507G>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoB 760331 c.525G>T synonymous_variant 0.15 rifampicin Uncertain significance
rpoB 760991 c.1185G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 761015 c.1209G>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 761021 c.1215G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 761027 c.1221A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761273 c.1467T>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 761282 c.1476C>T synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 761318 c.1512G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 761327 c.1521A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoB 761345 c.1539G>C synonymous_variant 0.2 rifampicin Uncertain significance
rpoB 761354 c.1548C>G synonymous_variant 0.21 rifampicin Uncertain significance
rpoB 761360 c.1554T>C synonymous_variant 0.22 rifampicin Not assoc w R - Interim
rpoB 761362 p.Ser519Thr missense_variant 0.22 rifampicin Uncertain significance
rpoB 761375 c.1569G>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoB 761408 c.1602G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoB 761414 c.1608A>G synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoB 761423 c.1617T>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoB 761435 c.1629T>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoB 761437 p.Ala544Glu missense_variant 0.21 rifampicin Uncertain significance
rpoB 761439 p.Asp545Asn missense_variant 0.21 rifampicin Uncertain significance
rpoB 761444 c.1638T>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoB 761447 c.1641C>G synonymous_variant 0.21 rifampicin Uncertain significance
rpoB 761465 c.1659G>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoB 761471 c.1665C>G synonymous_variant 0.2 rifampicin Uncertain significance
rpoB 761492 c.1686G>C synonymous_variant 0.19 rifampicin Uncertain significance
rpoB 761495 c.1689G>A synonymous_variant 0.19 rifampicin Uncertain significance
rpoB 762299 c.2493G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoB 762329 c.2523G>C synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoB 762338 c.2532T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 762347 c.2541T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoB 762362 p.Glu852Asp missense_variant 0.16 rifampicin Uncertain significance
rpoB 762369 c.2563T>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 762374 c.-996G>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoC 762380 c.-990T>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoC 762395 c.-975G>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoC 762398 c.-972T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoB 762404 c.2598T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 762410 c.-960T>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoB 762416 c.2610A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoB 762995 c.3189G>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoB 763070 c.3264T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 763741 c.372C>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 763816 c.447C>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 763835 p.Ala156Met missense_variant 0.16 rifampicin Uncertain significance
rpoC 763851 p.Ala161Gly missense_variant 0.16 rifampicin Uncertain significance
rpoC 763855 c.486C>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 763858 c.489A>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 763963 c.594C>T synonymous_variant 1.0 rifampicin Not assoc w R - Interim
rpoC 764365 c.996C>T synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 764560 c.1191T>C synonymous_variant 0.15 rifampicin Not assoc w R - Interim
rpoC 764566 c.1197C>G synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoC 765150 p.Gly594Glu missense_variant 1.0 rifampicin Not assoc w R
rpoC 765541 c.2172C>G synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 765553 c.2184C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 765556 c.2187G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 765562 c.2193G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 765565 c.2196G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 765583 c.2214G>T synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 765613 p.His748Gln missense_variant 0.18 rifampicin Uncertain significance
rpoC 765796 c.2427C>T synonymous_variant 0.13 rifampicin Uncertain significance
rpoC 766426 c.3057C>T synonymous_variant 0.14 rifampicin Uncertain significance
rpoC 766447 c.3078T>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766456 c.3087C>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 766459 c.3090G>T synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 766483 c.3114G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 766528 c.3159T>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoC 766543 c.3174C>G synonymous_variant 0.16 rifampicin Uncertain significance
rpoC 766894 c.3525T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 766895 c.3526T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 766900 c.3531T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 766918 c.3549C>T synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoC 766933 c.3564A>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766945 c.3576A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 766963 c.3594T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 766972 c.3603G>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 766978 c.3609C>T synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 766981 c.3612T>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 766987 c.3618G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoC 767032 c.3663G>C synonymous_variant 0.21 rifampicin Uncertain significance
rpoC 767059 c.3690T>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoC 767062 c.3693C>A synonymous_variant 0.18 rifampicin Uncertain significance
rpoC 767098 c.3729T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoC 767134 c.3765C>A synonymous_variant 0.14 rifampicin Uncertain significance
mmpL5 775639 p.Ile948Val missense_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
rpsL 781395 c.-165T>C upstream_gene_variant 1.0 streptomycin Not assoc w R
fbiC 1304675 p.Gly582Asp missense_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304682 c.1752C>G synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304691 c.1761G>C synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304694 c.1764A>G synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304703 c.1773C>G synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304709 c.1779C>G synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304715 c.1785G>C synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304724 c.1794A>G synonymous_variant 0.18 clofazimine Not assoc w R - Interim
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
fbiC 1304727 c.1797A>G synonymous_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304742 c.1812T>G synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304748 c.1818T>C synonymous_variant 0.16 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304757 c.1827A>G synonymous_variant 0.16 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304763 c.1833C>G synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304778 p.Asp616Glu missense_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304784 c.1854T>G synonymous_variant 0.17 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304787 c.1857T>C synonymous_variant 0.19 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304799 c.1869G>C synonymous_variant 0.19 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304808 c.1878C>G synonymous_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304811 c.1881C>G synonymous_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304817 c.1887T>C synonymous_variant 0.2 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304826 c.1896G>C synonymous_variant 0.2 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304829 c.1899T>C synonymous_variant 0.2 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304832 c.1902C>T synonymous_variant 0.19 clofazimine Not assoc w R - Interim
delamanid Not assoc w R - Interim
pretomanid Uncertain significance
fbiC 1304853 c.1923C>T synonymous_variant 0.18 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304856 c.1926C>G synonymous_variant 0.19 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304869 c.1939C>T synonymous_variant 0.16 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304910 c.1980G>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1304916 c.1986T>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305006 c.2076A>G synonymous_variant 0.16 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
fbiC 1305015 c.2085G>C synonymous_variant 0.15 clofazimine Uncertain significance
delamanid Uncertain significance
pretomanid Uncertain significance
rrs 1471659 n.-187C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
rrl 1473836 n.179A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473876 n.219G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1473898 n.241C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474030 n.373G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474717 n.1060A>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474794 n.1137C>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474812 n.1155G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474831 n.1174A>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474950 n.1293G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474952 n.1296_1300delCATCC non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474961 n.1304T>G non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474962 n.1305T>C non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474963 n.1306G>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474964 n.1307T>A non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474967 n.1311_1315delGGGTG non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1474991 n.1334T>C non_coding_transcript_exon_variant 0.22 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475006 n.1349A>G non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475017 n.1360_1361insT non_coding_transcript_exon_variant 0.24 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475061 n.1404C>T non_coding_transcript_exon_variant 0.21 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475088 n.1431A>T non_coding_transcript_exon_variant 0.19 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475213 n.1556C>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475252 n.1595C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475253 n.1596T>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475266 n.1609T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475267 n.1610G>A non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475273 n.1616T>G non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475275 n.1618C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475276 n.1619T>C non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475289 n.1632G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475291 n.1634A>C non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475313 n.1656G>A non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475315 n.1658A>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475355 n.1698C>T non_coding_transcript_exon_variant 0.18 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475369 n.1712G>T non_coding_transcript_exon_variant 0.2 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475419 n.1762C>T non_coding_transcript_exon_variant 0.16 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475429 n.1772G>A non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475659 n.2002G>A non_coding_transcript_exon_variant 0.15 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475883 n.2226A>G non_coding_transcript_exon_variant 0.17 capreomycin Uncertain significance
linezolid Uncertain significance
rrl 1475988 n.2331A>G non_coding_transcript_exon_variant 0.15 capreomycin Not assoc w R
linezolid Uncertain significance
rrl 1476049 n.2392C>T non_coding_transcript_exon_variant 0.14 capreomycin Uncertain significance
linezolid Uncertain significance
inhA 1674443 p.Ala81Val missense_variant 0.14 ethionamide Uncertain significance
isoniazid Uncertain significance
inhA 1674452 p.Ala84Glu missense_variant 0.16 ethionamide Uncertain significance
isoniazid Uncertain significance
rpsA 1834030 c.489C>G synonymous_variant 0.15 pyrazinamide Uncertain significance
rpsA 1834609 c.1068T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834618 c.1077G>A synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834622 c.1081_1083delTCGinsAGC synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834633 c.1092A>G synonymous_variant 0.17 pyrazinamide Uncertain significance
rpsA 1834639 c.1098T>C synonymous_variant 0.17 pyrazinamide Uncertain significance
tsnR 1854300 p.Leu232Pro missense_variant 1.0 linezolid Not assoc w R
tlyA 1917972 c.33A>G synonymous_variant 1.0 capreomycin Not assoc w R
bacA 2064398 p.Gly111Ser missense_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
streptomycin Uncertain significance
Rv1979c 2223293 c.-129A>G upstream_gene_variant 1.0 bedaquiline Not assoc w R - Interim
clofazimine Not assoc w R
kasA 2518076 c.-39C>T upstream_gene_variant 0.92 isoniazid Uncertain significance
Rv2477c 2783512 c.531A>G synonymous_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783521 c.522G>C synonymous_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783554 c.489C>T synonymous_variant 0.14 amikacin Not assoc w R - Interim
ethambutol Not assoc w R - Interim
kanamycin Not assoc w R - Interim
levofloxacin Not assoc w R - Interim
moxifloxacin Not assoc w R - Interim
rifampicin Not assoc w R - Interim
streptomycin Uncertain significance
Rv2477c 2783572 c.471A>C synonymous_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783584 p.Ala153Pro missense_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783593 c.450T>C synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783628 p.Ala139Ser missense_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783656 c.387G>C synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783659 c.384A>G synonymous_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783674 c.369T>C synonymous_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783680 c.363G>A synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783683 c.360A>G synonymous_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783700 p.Thr115Ser missense_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783718 c.325T>C synonymous_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783719 c.324A>G synonymous_variant 0.17 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783751 p.Ile98Val missense_variant 0.16 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783758 p.Asp95Glu missense_variant 0.15 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2477c 2783799 p.Asp82Asn missense_variant 0.14 amikacin Uncertain significance
ethambutol Uncertain significance
kanamycin Uncertain significance
levofloxacin Uncertain significance
moxifloxacin Uncertain significance
rifampicin Uncertain significance
streptomycin Uncertain significance
Rv2680 2996034 c.-71G>A upstream_gene_variant 0.24 capreomycin Uncertain significance
Rv2680 2996136 p.Ser11Asn missense_variant 0.17 capreomycin Uncertain significance
ald 3086788 c.-32T>C upstream_gene_variant 1.0 cycloserine Uncertain significance
mtrB 3625065 p.Met517Leu missense_variant 1.0 bedaquiline Uncertain significance
rifampicin Not assoc w R
mtrA 3627756 c.-407A>T upstream_gene_variant 0.98 bedaquiline Uncertain significance
rifampicin Uncertain significance
rpoA 3877887 c.621G>A synonymous_variant 0.14 rifampicin Not assoc w R - Interim
rpoA 3877962 c.546G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3877974 c.534G>C synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3877986 c.522G>C synonymous_variant 0.16 rifampicin Uncertain significance
rpoA 3877989 c.519A>G synonymous_variant 0.16 rifampicin Not assoc w R - Interim
rpoA 3878001 c.507A>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878019 c.489A>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoA 3878022 c.486T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878028 c.480G>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878031 c.477T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878040 c.468T>C synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878046 c.462T>C synonymous_variant 0.17 rifampicin Uncertain significance
rpoA 3878055 c.453A>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoA 3878145 c.362_363insGT frameshift_variant 0.16 rifampicin Uncertain significance
rpoA 3878160 c.348C>G synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878169 c.339G>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878184 c.324C>T synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878187 c.321C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoA 3878193 c.315T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878205 c.303T>C synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878214 c.294C>T synonymous_variant 0.17 rifampicin Not assoc w R - Interim
rpoA 3878217 c.291A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878247 c.261G>C synonymous_variant 0.2 rifampicin Uncertain significance
rpoA 3878250 c.258C>G synonymous_variant 0.2 rifampicin Uncertain significance
rpoA 3878264 p.Ser82Gly missense_variant 0.19 rifampicin Uncertain significance
rpoA 3878271 c.237T>C synonymous_variant 0.21 rifampicin Not assoc w R - Interim
rpoA 3878283 p.Glu75Asp missense_variant 0.2 rifampicin Uncertain significance
rpoA 3878292 c.216T>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878298 c.210A>G synonymous_variant 0.18 rifampicin Not assoc w R - Interim
rpoA 3878304 c.204G>C synonymous_variant 0.18 rifampicin Uncertain significance
rpoA 3878307 c.201C>G synonymous_variant 0.18 rifampicin Uncertain significance
rpoA 3878313 c.195G>C synonymous_variant 0.2 rifampicin Not assoc w R - Interim
rpoA 3878322 c.186A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878331 c.177A>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878334 c.174T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878337 c.171T>C synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878364 c.144A>G synonymous_variant 0.2 rifampicin Uncertain significance
rpoA 3878385 c.123C>G synonymous_variant 0.19 rifampicin Uncertain significance
rpoA 3878391 c.117T>G synonymous_variant 0.19 rifampicin Not assoc w R - Interim
rpoA 3878415 c.93C>T synonymous_variant 0.15 rifampicin Uncertain significance
rpoA 3878785 c.-278T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878788 c.-281G>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878791 c.-284C>G upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3878797 c.-290G>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3878809 c.-302T>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3878833 c.-326C>G upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878836 c.-329G>C upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878839 c.-332C>G upstream_gene_variant 0.19 rifampicin Uncertain significance
rpoA 3878853 c.-346G>A upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878878 c.-371T>C upstream_gene_variant 0.26 rifampicin Uncertain significance
rpoA 3878889 c.-382A>G upstream_gene_variant 0.27 rifampicin Uncertain significance
rpoA 3878894 c.-387A>G upstream_gene_variant 0.25 rifampicin Uncertain significance
rpoA 3878908 c.-402_-401delACinsCG upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878914 c.-407T>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878917 c.-410G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878929 c.-422G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878938 c.-431T>C upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878947 c.-440G>C upstream_gene_variant 0.22 rifampicin Uncertain significance
rpoA 3878968 c.-461T>C upstream_gene_variant 0.23 rifampicin Uncertain significance
rpoA 3878974 c.-469_-467delATCinsGTG upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3878998 c.-491C>G upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3879005 c.-499_-498delAAinsCG upstream_gene_variant 0.21 rifampicin Uncertain significance
rpoA 3879013 c.-506A>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3879016 c.-509A>G upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3879034 c.-527G>A upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3879037 c.-530G>C upstream_gene_variant 0.2 rifampicin Uncertain significance
rpoA 3879079 c.-572A>G upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3879088 c.-581A>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3879094 c.-587T>C upstream_gene_variant 0.18 rifampicin Uncertain significance
rpoA 3879121 c.-614T>G upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3879127 c.-620T>C upstream_gene_variant 0.17 rifampicin Uncertain significance
rpoA 3879154 c.-647T>C upstream_gene_variant 0.15 rifampicin Uncertain significance
rpoA 3879160 c.-653A>G upstream_gene_variant 0.16 rifampicin Uncertain significance
rpoA 3879169 c.-662G>C upstream_gene_variant 0.16 rifampicin Uncertain significance
clpC1 4038965 c.1740T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038989 c.1716T>C synonymous_variant 0.15 pyrazinamide Uncertain significance
clpC1 4038997 c.1708T>C synonymous_variant 0.17 pyrazinamide Not assoc w R - Interim
clpC1 4039022 c.1683A>G synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039037 c.1668T>C synonymous_variant 0.18 pyrazinamide Uncertain significance
clpC1 4039073 c.1632C>G synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039661 c.1044T>G synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039664 c.1041G>C synonymous_variant 0.17 pyrazinamide Uncertain significance
clpC1 4039694 c.1011G>C synonymous_variant 0.16 pyrazinamide Uncertain significance
clpC1 4039742 c.963C>T synonymous_variant 0.15 pyrazinamide Uncertain significance
embC 4239298 c.-565C>T upstream_gene_variant 1.0 ethambutol Not assoc w R
embC 4240831 c.969T>G synonymous_variant 0.15 ethambutol Uncertain significance
embC 4240936 c.1074A>G synonymous_variant 0.15 ethambutol Uncertain significance
embC 4240951 c.1089C>G synonymous_variant 0.16 ethambutol Uncertain significance
embC 4240954 p.Ile364Met missense_variant 0.16 ethambutol Uncertain significance
embC 4241086 c.1224G>C synonymous_variant 0.14 ethambutol Uncertain significance
embC 4241095 c.1233C>T synonymous_variant 0.16 ethambutol Uncertain significance
embC 4242643 c.2781C>T synonymous_variant 1.0 ethambutol Not assoc w R
embC 4242803 p.Val981Leu missense_variant 0.99 ethambutol Not assoc w R
embB 4248199 c.1686A>T synonymous_variant 0.14 ethambutol Uncertain significance
embB 4248220 c.1707A>T synonymous_variant 0.15 ethambutol Uncertain significance
whiB6 4338595 c.-75delG upstream_gene_variant 1.0 amikacin Not assoc w R
capreomycin Not assoc w R
kanamycin Not assoc w R
whiB6 4338732 c.-211C>T upstream_gene_variant 1.0 amikacin Uncertain significance
capreomycin Uncertain significance
kanamycin Uncertain significance
gid 4407990 c.213A>G synonymous_variant 1.0 streptomycin Uncertain significance