TB-Profiler

Lineage	Family	RDs	Frequency
La1.3	M.bovis	None	1.0
La1	M.bovis	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
pncA	2289073	p.His57Asp	missense_variant	1.0	pyrazinamide	Assoc w R

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
dnaA	45	c.45G>A	synonymous_variant	1.0	isoniazid
dnaA	467	p.His156Arg	missense_variant	1.0	isoniazid	Not assoc w R
gyrB	5752	c.513G>A	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	5752	c.513G>A	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrB	6406	c.1167C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrB	6446	p.Ala403Ser	missense_variant	1.0	levofloxacin	Not assoc w R
gyrB	6446	p.Ala403Ser	missense_variant	1.0	moxifloxacin	Uncertain significance
gyrA	7362	p.Glu21Gln	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7362	p.Glu21Gln	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	7585	p.Ser95Thr	missense_variant	1.0	moxifloxacin	Not assoc w R
gyrA	8285	c.984C>T	synonymous_variant	1.0	levofloxacin	Not assoc w R - Interim
gyrA	8285	c.984C>T	synonymous_variant	1.0	moxifloxacin	Not assoc w R - Interim
gyrA	9143	c.1842T>C	synonymous_variant	1.0	levofloxacin	Not assoc w R
gyrA	9143	c.1842T>C	synonymous_variant	1.0	moxifloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	levofloxacin	Not assoc w R
gyrA	9304	p.Gly668Asp	missense_variant	1.0	moxifloxacin	Not assoc w R
Rv0010c	13197	p.Thr121Ser	missense_variant	1.0	isoniazid	Not assoc w R
Rv0010c	13228	c.330delG	frameshift_variant	1.0	isoniazid	Uncertain significance
Rv0010c	13441	p.Thr40Pro	missense_variant	1.0	isoniazid	Uncertain significance
Rv0010c	13460	c.99T>C	synonymous_variant	1.0	isoniazid	Not assoc w R
fgd1	491742	c.960T>C	synonymous_variant	1.0	clofazimine	Not assoc w R
					pretomanid
					delamanid	Not assoc w R - Interim
Rv0565c	656579	p.Cys298Arg	missense_variant	1.0	ethionamide	Uncertain significance
Rv0565c	657578	c.-108T>C	upstream_gene_variant	1.0	ethionamide
rpoB	759589	c.-218G>A	upstream_gene_variant	1.0	rifampicin	Uncertain significance
rpoB	763031	c.3225T>C	synonymous_variant	1.0	rifampicin	Not assoc w R
rpoC	764536	c.1167G>C	synonymous_variant	0.11	rifampicin
rpoC	764539	c.1170C>G	synonymous_variant	0.11	rifampicin	Not assoc w R - Interim
rpoC	764566	c.1197C>G	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoC	764575	c.1206T>G	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoC	764581	c.1212T>C	synonymous_variant	0.15	rifampicin
rpoC	764582	p.Leu405Met	missense_variant	0.15	rifampicin
rpoC	764623	c.1254C>G	synonymous_variant	0.17	rifampicin	Not assoc w R - Interim
rpoC	764632	c.1263T>C	synonymous_variant	0.17	rifampicin	Not assoc w R - Interim
rpoC	764644	c.1275G>C	synonymous_variant	0.14	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>C	synonymous_variant	0.15	rifampicin
rpoC	764662	c.1293G>C	synonymous_variant	0.15	rifampicin	Not assoc w R - Interim
rpoC	764677	c.1308C>G	synonymous_variant	0.15	rifampicin	Not assoc w R - Interim
rpoC	764695	c.1326T>C	synonymous_variant	0.12	rifampicin
rpoC	765751	c.2382C>T	synonymous_variant	1.0	rifampicin
mmpL5	775639	p.Ile948Val	missense_variant	0.99	clofazimine	Not assoc w R
mmpL5	775639	p.Ile948Val	missense_variant	0.99	bedaquiline	Not assoc w R - Interim
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	clofazimine	Not assoc w R
mmpL5	776100	p.Thr794Ile	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
rpsL	781395	c.-165T>C	upstream_gene_variant	1.0	streptomycin	Not assoc w R
rpsL	781402	c.-158A>G	upstream_gene_variant	1.0	streptomycin
rplC	800651	c.-158G>A	upstream_gene_variant	1.0	linezolid
Rv1129c	1254562	c.-28T>C	upstream_gene_variant	0.99	moxifloxacin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
Rv1129c	1254582	c.-48A>G	upstream_gene_variant	1.0	moxifloxacin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
fbiC	1302899	c.-32A>G	upstream_gene_variant	1.0	clofazimine	Uncertain significance
					pretomanid
					delamanid	Uncertain significance
embR	1417554	c.-207C>G	upstream_gene_variant	1.0	ethambutol
rrs	1471659	n.-187C>T	upstream_gene_variant	1.0	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472133	n.288G>A	non_coding_transcript_exon_variant	0.14	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472148	n.303T>C	non_coding_transcript_exon_variant	0.15	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.15	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472155	n.310C>T	non_coding_transcript_exon_variant	0.15	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472215	n.370A>G	non_coding_transcript_exon_variant	0.15	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>G	non_coding_transcript_exon_variant	0.15	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472234	n.389T>C	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472655	n.810G>T	non_coding_transcript_exon_variant	0.18	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472660	n.815T>C	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472661	n.816A>G	non_coding_transcript_exon_variant	0.17	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472673	n.828T>G	non_coding_transcript_exon_variant	0.13	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472675	n.832delC	non_coding_transcript_exon_variant	0.12	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472682	n.837T>A	non_coding_transcript_exon_variant	0.15	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472683	n.838T>C	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472686	n.841G>A	non_coding_transcript_exon_variant	0.16	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1472687	n.842A>T	non_coding_transcript_exon_variant	0.16	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472692	n.847T>C	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472713	n.868T>C	non_coding_transcript_exon_variant	0.17	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472714	n.869A>G	non_coding_transcript_exon_variant	0.17	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472952	n.1107T>C	non_coding_transcript_exon_variant	0.16	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472955	n.1110C>T	non_coding_transcript_exon_variant	0.15	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472956	n.1111T>C	non_coding_transcript_exon_variant	0.17	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472973	n.1128A>G	non_coding_transcript_exon_variant	0.18	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472987	n.1142G>A	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472990	n.1145A>G	non_coding_transcript_exon_variant	0.21	streptomycin	Uncertain significance
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1472996	n.1151T>C	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473055	n.1210C>T	non_coding_transcript_exon_variant	0.21	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.23	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473062	n.1217T>G	non_coding_transcript_exon_variant	0.23	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473065	n.1220C>A	non_coding_transcript_exon_variant	0.22	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473088	n.1243A>G	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473089	n.1244A>T	non_coding_transcript_exon_variant	0.21	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473100	n.1255G>A	non_coding_transcript_exon_variant	0.22	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473104	n.1259C>T	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473110	n.1265T>G	non_coding_transcript_exon_variant	0.21	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473111	n.1266A>G	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473121	n.1276T>C	non_coding_transcript_exon_variant	0.21	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473123	n.1278A>T	non_coding_transcript_exon_variant	0.21	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473147	n.1302G>A	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin
					amikacin	Uncertain significance
rrs	1473148	n.1303G>A	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473163	n.1318C>T	non_coding_transcript_exon_variant	0.18	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473164	n.1319C>T	non_coding_transcript_exon_variant	0.18	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1473252	n.1407T>C	non_coding_transcript_exon_variant	0.2	streptomycin	Uncertain significance
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473262	n.1417T>C	non_coding_transcript_exon_variant	0.23	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473276	n.1431A>C	non_coding_transcript_exon_variant	0.16	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473283	n.1438T>C	non_coding_transcript_exon_variant	0.19	streptomycin
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473301	n.1456T>G	non_coding_transcript_exon_variant	0.14	streptomycin
					kanamycin
					capreomycin
					amikacin
rrs	1473314	n.1469A>G	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin
					capreomycin
					amikacin
rrs	1473315	n.1470T>C	non_coding_transcript_exon_variant	0.19	streptomycin	Uncertain significance
					kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1474542	n.885A>G	non_coding_transcript_exon_variant	0.12	capreomycin
rrl	1474542	n.885A>G	non_coding_transcript_exon_variant	0.12	linezolid
rrl	1474551	n.894G>C	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474551	n.894G>C	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1474558	n.901G>T	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1474558	n.901G>T	non_coding_transcript_exon_variant	0.14	linezolid	Uncertain significance
rrl	1474626	n.969T>C	non_coding_transcript_exon_variant	0.21	capreomycin	Uncertain significance
rrl	1474626	n.969T>C	non_coding_transcript_exon_variant	0.21	linezolid	Uncertain significance
rrl	1474632	n.975G>T	non_coding_transcript_exon_variant	0.19	capreomycin	Uncertain significance
rrl	1474632	n.975G>T	non_coding_transcript_exon_variant	0.19	linezolid	Uncertain significance
rrl	1474636	n.979A>T	non_coding_transcript_exon_variant	0.19	capreomycin	Uncertain significance
rrl	1474636	n.979A>T	non_coding_transcript_exon_variant	0.19	linezolid
rrl	1474637	n.980C>T	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1474637	n.980C>T	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1474638	n.981C>G	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1474638	n.981C>G	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1474639	n.982G>C	non_coding_transcript_exon_variant	0.19	capreomycin	Uncertain significance
rrl	1474639	n.982G>C	non_coding_transcript_exon_variant	0.19	linezolid	Uncertain significance
rrl	1474658	n.1001A>T	non_coding_transcript_exon_variant	0.21	capreomycin
rrl	1474658	n.1001A>T	non_coding_transcript_exon_variant	0.21	linezolid
rrl	1474663	n.1006C>T	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1474663	n.1006C>T	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1474676	n.1019T>A	non_coding_transcript_exon_variant	0.24	capreomycin	Uncertain significance
rrl	1474676	n.1019T>A	non_coding_transcript_exon_variant	0.24	linezolid	Uncertain significance
rrl	1474709	n.1053_1056delTGGT	non_coding_transcript_exon_variant	0.19	capreomycin	Uncertain significance
rrl	1474709	n.1053_1056delTGGT	non_coding_transcript_exon_variant	0.19	linezolid	Uncertain significance
rrl	1474717	n.1060_1061insGTGAG	non_coding_transcript_exon_variant	0.18	capreomycin
rrl	1474717	n.1060_1061insGTGAG	non_coding_transcript_exon_variant	0.18	linezolid
rrl	1474734	n.1077G>T	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1474734	n.1077G>T	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1474749	n.1092C>T	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1474753	n.1097delC	non_coding_transcript_exon_variant	0.17	capreomycin	Uncertain significance
rrl	1474753	n.1097delC	non_coding_transcript_exon_variant	0.17	linezolid	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.18	capreomycin	Uncertain significance
rrl	1474760	n.1103A>G	non_coding_transcript_exon_variant	0.18	linezolid	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.19	capreomycin	Uncertain significance
rrl	1474779	n.1122G>A	non_coding_transcript_exon_variant	0.19	linezolid	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.19	capreomycin	Uncertain significance
rrl	1474780	n.1123C>T	non_coding_transcript_exon_variant	0.19	linezolid	Uncertain significance
rrl	1474794	n.1137C>G	non_coding_transcript_exon_variant	0.22	capreomycin
rrl	1474794	n.1137C>G	non_coding_transcript_exon_variant	0.22	linezolid
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.22	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.22	linezolid	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1474830	n.1173A>C	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1474830	n.1173A>C	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1474831	n.1174A>G	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1474832	n.1175A>T	non_coding_transcript_exon_variant	0.2	capreomycin	Uncertain significance
rrl	1474832	n.1175A>T	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.2	capreomycin	Not assoc w R
rrl	1474864	n.1207C>T	non_coding_transcript_exon_variant	0.2	linezolid	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1474904	n.1247G>C	non_coding_transcript_exon_variant	0.14	linezolid	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474905	n.1248T>C	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1474913	n.1256T>C	non_coding_transcript_exon_variant	0.13	capreomycin	Uncertain significance
rrl	1474913	n.1256T>C	non_coding_transcript_exon_variant	0.13	linezolid	Uncertain significance
rrl	1476325	n.2668A>C	non_coding_transcript_exon_variant	0.16	capreomycin
rrl	1476325	n.2668A>C	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.28	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.28	linezolid	Uncertain significance
rrl	1476491	n.2834T>C	non_coding_transcript_exon_variant	0.2	capreomycin
rrl	1476491	n.2834T>C	non_coding_transcript_exon_variant	0.2	linezolid
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.18	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.18	linezolid	Uncertain significance
rrl	1476515	n.2858C>T	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1476515	n.2858C>T	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1476517	n.2860C>T	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1476517	n.2860C>T	non_coding_transcript_exon_variant	0.16	linezolid
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	0.15	linezolid	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.16	capreomycin	Uncertain significance
rrl	1476525	n.2868A>G	non_coding_transcript_exon_variant	0.16	linezolid	Uncertain significance
rrl	1476528	n.2871A>G	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1476528	n.2871A>G	non_coding_transcript_exon_variant	0.15	linezolid
rrl	1476530	n.2873C>A	non_coding_transcript_exon_variant	0.15	capreomycin
rrl	1476530	n.2873C>A	non_coding_transcript_exon_variant	0.15	linezolid
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1476536	n.2879G>A	non_coding_transcript_exon_variant	0.15	linezolid	Uncertain significance
rrl	1476537	n.2880A>G	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1476537	n.2880A>G	non_coding_transcript_exon_variant	0.15	linezolid	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1476538	n.2881A>G	non_coding_transcript_exon_variant	0.15	linezolid	Uncertain significance
rrl	1476539	n.2882A>G	non_coding_transcript_exon_variant	0.15	capreomycin	Uncertain significance
rrl	1476539	n.2882A>G	non_coding_transcript_exon_variant	0.15	linezolid	Uncertain significance
rrl	1476540	n.2883C>T	non_coding_transcript_exon_variant	0.14	capreomycin	Uncertain significance
rrl	1476540	n.2883C>T	non_coding_transcript_exon_variant	0.14	linezolid
rrl	1476728	n.3071T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1476728	n.3071T>C	non_coding_transcript_exon_variant	1.0	linezolid
rpsA	1834859	p.Ala440Thr	missense_variant	1.0	pyrazinamide	Uncertain significance
tsnR	1854300	p.Leu232Pro	missense_variant	1.0	linezolid	Not assoc w R
tlyA	1917972	c.33A>G	synonymous_variant	1.0	capreomycin	Not assoc w R
bacA	2062922	p.Ile603Val	missense_variant	1.0	streptomycin	Not assoc w R
					kanamycin	Not assoc w R
					capreomycin	Not assoc w R
					amikacin	Not assoc w R
ndh	2103173	c.-132delG	upstream_gene_variant	1.0	ethionamide
					delamanid
					isoniazid
katG	2154724	p.Arg463Leu	missense_variant	1.0	isoniazid	Not assoc w R
katG	2155503	c.609C>T	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156025	c.87C>A	synonymous_variant	1.0	isoniazid	Not assoc w R
katG	2156465	c.-354C>T	upstream_gene_variant	1.0	isoniazid	Not assoc w R - Interim
PPE35	2167926	p.Leu896Ser	missense_variant	1.0	pyrazinamide	Not assoc w R
PPE35	2168011	p.Ser868Arg	missense_variant	1.0	pyrazinamide	Uncertain significance
PPE35	2168814	c.1798dupA	frameshift_variant	1.0	pyrazinamide	Uncertain significance
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2222308	p.Asp286Gly	missense_variant	1.0	bedaquiline	Not assoc w R - Interim
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	clofazimine	Not assoc w R
Rv1979c	2223293	c.-129A>G	upstream_gene_variant	1.0	bedaquiline	Not assoc w R - Interim
kasA	2518132	c.18C>T	synonymous_variant	1.0	isoniazid
kasA	2519305	c.1191A>G	synonymous_variant	1.0	isoniazid
Rv2477c	2782927	c.1116A>G	synonymous_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R - Interim
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R - Interim
					kanamycin	Not assoc w R - Interim
					rifampicin	Not assoc w R
					amikacin	Not assoc w R - Interim
Rv2681	2997325	p.Ala196Val	missense_variant	1.0	capreomycin	Uncertain significance
ald	3086728	c.-92C>T	upstream_gene_variant	1.0	cycloserine
ald	3086788	c.-32T>C	upstream_gene_variant	1.0	cycloserine
ald	3087084	c.266delA	frameshift_variant	1.0	cycloserine
Rv3083	3448283	c.-221C>G	upstream_gene_variant	1.0	ethionamide
Rv3083	3448783	p.Val94Ile	missense_variant	1.0	ethionamide	Uncertain significance
Rv3236c	3613818	c.-702C>T	upstream_gene_variant	1.0	pyrazinamide
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3623730	p.Ser394Leu	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624350	c.561G>T	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624350	c.561G>T	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	bedaquiline	Uncertain significance
lpqB	3624486	p.Asp142Gly	missense_variant	1.0	rifampicin	Not assoc w R
lpqB	3624593	c.318G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624593	c.318G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
lpqB	3624710	c.201G>A	synonymous_variant	1.0	bedaquiline	Not assoc w R - Interim
lpqB	3624710	c.201G>A	synonymous_variant	1.0	rifampicin	Not assoc w R
mtrB	3625065	p.Met517Leu	missense_variant	1.0	bedaquiline	Uncertain significance
mtrB	3625065	p.Met517Leu	missense_variant	1.0	rifampicin	Not assoc w R
rpoA	3878630	c.-124delC	upstream_gene_variant	1.0	rifampicin	Not assoc w R
clpC1	4038403	c.2302T>C	synonymous_variant	1.0	pyrazinamide	Not assoc w R - Interim
glpK	4138377	p.Val460Ala	missense_variant	1.0	ethambutol	Not assoc w R
					moxifloxacin	Not assoc w R
					streptomycin	Not assoc w R
					levofloxacin	Not assoc w R
					rifampicin	Not assoc w R
					isoniazid	Not assoc w R
glpK	4139183	c.572dupG	frameshift_variant	0.49	ethambutol	Uncertain significance
					moxifloxacin	Uncertain significance
					streptomycin	Uncertain significance
					levofloxacin	Uncertain significance
					rifampicin	Uncertain significance
					isoniazid	Uncertain significance
embC	4240671	p.Thr270Ile	missense_variant	1.0	ethambutol	Not assoc w R
embC	4242643	c.2781C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embC	4242970	c.3108C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4244220	c.988C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embA	4244895	p.Thr555Ala	missense_variant	1.0	ethambutol
embB	4246551	p.Asn13Ser	missense_variant	1.0	ethambutol	Not assoc w R
embB	4246864	c.351C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
embB	4247646	p.Glu378Ala	missense_variant	1.0	ethambutol	Not assoc w R
aftB	4267858	p.Ile327Val	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269351	c.483C>T	synonymous_variant	1.0	ethambutol	Not assoc w R
ubiA	4269387	p.Glu149Asp	missense_variant	1.0	ethambutol	Not assoc w R
ubiA	4269606	c.228T>C	synonymous_variant	1.0	ethambutol	Not assoc w R
whiB6	4338595	c.-75delG	upstream_gene_variant	1.0	capreomycin	Not assoc w R
					amikacin	Not assoc w R
					kanamycin	Not assoc w R
whiB6	4338732	c.-211C>T	upstream_gene_variant	1.0	capreomycin
					amikacin
					kanamycin
gid	4407588	c.615A>G	synonymous_variant	1.0	streptomycin	Not assoc w R

TB-Profiler result