Run ID: ERR6198317
Sample name:
Date: 2024-04-16T07:36:27.169915
Number of reads: 1385489
Percentage reads mapped: 84.96
Median coverage: 35.0
Strain: La1.2
Spoligotype:
Drug-resistance: Other
Lineage | Family | RDs | Frequency |
---|---|---|---|
La1.2 | M.bovis | None | 0.99 |
La1 | M.bovis | None | 0.99 |
Drug | Resistance | Supporting mutations | WHO confidence | Comment |
---|---|---|---|---|
rifampicin | ||||
isoniazid | ||||
ethambutol | ||||
pyrazinamide | pncA | p.His57Asp | Assoc w R | |
streptomycin | ||||
fluoroquinolones | ||||
moxifloxacin | ||||
ofloxacin | ||||
levofloxacin | ||||
ciprofloxacin | ||||
aminoglycosides | ||||
amikacin | ||||
capreomycin | ||||
kanamycin | ||||
cycloserine | ||||
ethionamide | ||||
clofazimine | ||||
para-aminosalicylic_acid | ||||
delamanid | fgd1 | c.412_414delCTAinsTG | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
bedaquiline | ||||
linezolid |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence | Comment |
---|---|---|---|---|---|---|---|
fgd1 | 491194 | c.412_414delCTAinsTG | frameshift_variant&stop_gained | 0.2 | delamanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance |
pretomanid | Assoc w R - Interim | Confers DLM-PMD cross-resistance | |||||
pncA | 2289073 | p.His57Asp | missense_variant | 1.0 | pyrazinamide | Assoc w R |
Gene | Chromosome position | Mutation | Type | Estimated fraction | Drugs | Confidence |
---|---|---|---|---|---|---|
dnaA | 467 | p.His156Arg | missense_variant | 1.0 | isoniazid | Not assoc w R |
gyrB | 5752 | c.513G>A | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6406 | c.1167C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrB | 6446 | p.Ala403Ser | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Uncertain significance | |||||
gyrA | 7362 | p.Glu21Gln | missense_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7585 | p.Ser95Thr | missense_variant | 0.98 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 7821 | c.520C>T | synonymous_variant | 0.95 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8285 | c.984C>T | synonymous_variant | 1.0 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8603 | c.1302A>G | synonymous_variant | 0.24 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8619 | c.1318T>C | synonymous_variant | 0.28 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8624 | c.1323G>C | synonymous_variant | 0.27 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8636 | c.1335A>C | synonymous_variant | 0.32 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8642 | c.1341A>G | synonymous_variant | 0.3 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8672 | c.1371A>G | synonymous_variant | 0.3 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 8693 | c.1392T>C | synonymous_variant | 0.32 | levofloxacin | |
moxifloxacin | ||||||
gyrA | 8741 | c.1440C>T | synonymous_variant | 0.95 | levofloxacin | Not assoc w R - Interim |
moxifloxacin | Not assoc w R - Interim | |||||
gyrA | 9143 | c.1842T>C | synonymous_variant | 1.0 | levofloxacin | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
gyrA | 9304 | p.Gly668Glu | missense_variant | 1.0 | levofloxacin | |
moxifloxacin | ||||||
Rv0010c | 13197 | p.Thr121Ser | missense_variant | 1.0 | isoniazid | Not assoc w R |
Rv0010c | 13228 | c.330delG | frameshift_variant | 1.0 | isoniazid | Uncertain significance |
fgd1 | 491133 | c.351A>C | synonymous_variant | 0.27 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491144 | p.Ala121Asp | missense_variant | 0.29 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491166 | c.384G>C | synonymous_variant | 0.26 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491178 | c.396G>A | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491181 | c.399T>C | synonymous_variant | 0.22 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491191 | p.Gly137Arg | missense_variant | 0.21 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491203 | p.Gln141Glu | missense_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491206 | c.424C>T | synonymous_variant | 0.19 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491212 | p.Ser144Arg | missense_variant | 0.18 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491232 | c.450T>C | synonymous_variant | 0.26 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491241 | p.Asp153Glu | missense_variant | 0.26 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491244 | c.462T>C | synonymous_variant | 0.26 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491250 | c.468G>C | synonymous_variant | 0.26 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fgd1 | 491742 | c.960T>C | synonymous_variant | 1.0 | clofazimine | Not assoc w R |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
Rv0565c | 656297 | p.Asn392Asp | missense_variant | 0.85 | ethionamide | |
Rv0565c | 657578 | c.-108T>C | upstream_gene_variant | 1.0 | ethionamide | |
nusG | 734451 | c.198G>C | synonymous_variant | 0.17 | rifampicin | |
nusG | 734454 | c.201A>G | synonymous_variant | 0.17 | rifampicin | |
nusG | 734460 | c.207G>T | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoB | 760913 | c.1107C>T | synonymous_variant | 0.25 | rifampicin | |
rpoB | 760917 | c.1111_1113delCGCinsAG | frameshift_variant&missense_variant | 0.27 | rifampicin | |
rpoB | 760928 | c.1122G>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoB | 760938 | c.1132C>T | synonymous_variant | 0.29 | rifampicin | |
rpoB | 762284 | c.2478G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 762803 | c.-567C>T | upstream_gene_variant | 0.92 | rifampicin | |
rpoC | 762863 | c.-507T>G | upstream_gene_variant | 0.3 | rifampicin | |
rpoB | 763031 | c.3225T>C | synonymous_variant | 1.0 | rifampicin | Not assoc w R |
rpoC | 763945 | c.576T>C | synonymous_variant | 0.29 | rifampicin | |
rpoC | 763948 | c.579G>C | synonymous_variant | 0.3 | rifampicin | |
rpoC | 763951 | c.582G>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 763960 | c.591T>G | synonymous_variant | 0.29 | rifampicin | Not assoc w R - Interim |
rpoC | 763969 | c.600C>T | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 763978 | c.609C>G | synonymous_variant | 0.28 | rifampicin | |
rpoC | 763991 | p.Ile208Leu | missense_variant | 0.24 | rifampicin | |
rpoC | 764002 | c.633C>G | synonymous_variant | 0.31 | rifampicin | |
rpoC | 764005 | c.636G>C | synonymous_variant | 0.3 | rifampicin | Not assoc w R - Interim |
rpoC | 764024 | c.655T>C | synonymous_variant | 0.3 | rifampicin | |
rpoC | 764044 | c.675T>C | synonymous_variant | 0.26 | rifampicin | |
rpoC | 764059 | c.690G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 764932 | c.1563C>G | synonymous_variant | 0.2 | rifampicin | |
rpoC | 764948 | c.1579T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764968 | c.1599T>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 764995 | c.1626C>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R |
rpoC | 765421 | c.2052C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 765451 | c.2082C>T | synonymous_variant | 0.29 | rifampicin | |
rpoC | 765469 | c.2100G>C | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 765478 | c.2109T>C | synonymous_variant | 0.28 | rifampicin | Not assoc w R - Interim |
rpoC | 765499 | c.2130C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 765508 | c.2139C>G | synonymous_variant | 0.25 | rifampicin | Not assoc w R - Interim |
rpoC | 765517 | c.2148C>G | synonymous_variant | 0.24 | rifampicin | Not assoc w R - Interim |
rpoC | 765529 | c.2160C>T | synonymous_variant | 0.24 | rifampicin | |
rpoC | 765553 | c.2184C>T | synonymous_variant | 0.22 | rifampicin | Not assoc w R - Interim |
rpoC | 765556 | c.2187G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 765562 | c.2193G>C | synonymous_variant | 0.24 | rifampicin | |
rpoC | 765578 | c.2209C>T | synonymous_variant | 0.24 | rifampicin | |
rpoC | 765589 | c.2220G>C | synonymous_variant | 0.23 | rifampicin | |
rpoC | 765613 | p.His748Gln | missense_variant | 0.18 | rifampicin | |
rpoC | 765625 | c.2256C>G | synonymous_variant | 0.16 | rifampicin | Not assoc w R - Interim |
rpoC | 765628 | c.2259G>C | synonymous_variant | 0.17 | rifampicin | Not assoc w R - Interim |
rpoC | 765631 | p.Asp754Glu | missense_variant | 0.19 | rifampicin | |
rpoC | 766843 | c.3474T>C | synonymous_variant | 0.35 | rifampicin | Not assoc w R - Interim |
rpoC | 766861 | c.3492G>T | synonymous_variant | 0.37 | rifampicin | |
rpoC | 766864 | c.3495G>C | synonymous_variant | 0.33 | rifampicin | |
mmpL5 | 775639 | p.Ile948Val | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
mmpL5 | 776100 | p.Thr794Ile | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
rpsL | 781395 | c.-165T>C | upstream_gene_variant | 1.0 | streptomycin | Not assoc w R |
rpsL | 781808 | c.249C>T | synonymous_variant | 0.16 | streptomycin | |
Rv1129c | 1254562 | c.-28T>C | upstream_gene_variant | 1.0 | moxifloxacin | Not assoc w R |
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
Rv1129c | 1254582 | c.-48A>G | upstream_gene_variant | 1.0 | moxifloxacin | Uncertain significance |
levofloxacin | Uncertain significance | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
fbiC | 1302899 | c.-32A>G | upstream_gene_variant | 1.0 | clofazimine | Uncertain significance |
pretomanid | ||||||
delamanid | Uncertain significance | |||||
fbiC | 1303846 | p.Phe306Val | missense_variant | 0.27 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303854 | c.924T>C | synonymous_variant | 0.28 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303857 | c.927C>G | synonymous_variant | 0.28 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303860 | c.930A>G | synonymous_variant | 0.27 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303866 | p.Glu312Asp | missense_variant | 0.26 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303869 | c.939T>C | synonymous_variant | 0.26 | clofazimine | Not assoc w R - Interim |
pretomanid | ||||||
delamanid | Not assoc w R - Interim | |||||
fbiC | 1303875 | c.945G>C | synonymous_variant | 0.25 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303878 | c.948G>A | synonymous_variant | 0.25 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303884 | c.954T>G | synonymous_variant | 0.25 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303890 | c.960G>C | synonymous_variant | 0.25 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303893 | c.963G>C | synonymous_variant | 0.27 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303905 | c.975G>C | synonymous_variant | 0.26 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303911 | c.981G>C | synonymous_variant | 0.27 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
fbiC | 1303961 | p.Arg344Leu | missense_variant | 0.25 | clofazimine | |
pretomanid | ||||||
delamanid | ||||||
sigE | 1364961 | c.549A>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
Rv1258c | 1406663 | c.678C>T | synonymous_variant | 1.0 | streptomycin | |
isoniazid | ||||||
pyrazinamide | ||||||
embR | 1417554 | c.-207C>G | upstream_gene_variant | 1.0 | ethambutol | |
rrs | 1471659 | n.-187C>T | upstream_gene_variant | 1.0 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1471925 | n.80T>C | non_coding_transcript_exon_variant | 0.17 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471932 | n.87A>G | non_coding_transcript_exon_variant | 0.17 | streptomycin | |
kanamycin | ||||||
capreomycin | ||||||
amikacin | ||||||
rrs | 1471934 | n.89A>G | non_coding_transcript_exon_variant | 0.17 | streptomycin | Uncertain significance |
kanamycin | ||||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471969 | n.124T>C | non_coding_transcript_exon_variant | 0.24 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1471970 | n.125G>A | non_coding_transcript_exon_variant | 0.24 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472075 | n.230A>G | non_coding_transcript_exon_variant | 0.23 | streptomycin | |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrs | 1472108 | n.263C>T | non_coding_transcript_exon_variant | 0.18 | streptomycin | Uncertain significance |
kanamycin | Uncertain significance | |||||
capreomycin | Uncertain significance | |||||
amikacin | Uncertain significance | |||||
rrl | 1473752 | n.95G>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | |
linezolid | ||||||
rrl | 1473756 | n.99G>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473758 | n.101G>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1473806 | n.149C>T | non_coding_transcript_exon_variant | 0.31 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473877 | n.220G>A | non_coding_transcript_exon_variant | 0.32 | capreomycin | |
linezolid | ||||||
rrl | 1473898 | n.241C>T | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1473899 | n.242A>C | non_coding_transcript_exon_variant | 0.35 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474717 | n.1060A>T | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474760 | n.1103A>G | non_coding_transcript_exon_variant | 0.18 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474812 | n.1155G>A | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1474831 | n.1174A>G | non_coding_transcript_exon_variant | 0.16 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1474991 | n.1334T>C | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1474995 | n.1338T>G | non_coding_transcript_exon_variant | 0.31 | capreomycin | |
linezolid | ||||||
rrl | 1475005 | n.1348C>T | non_coding_transcript_exon_variant | 0.36 | capreomycin | |
linezolid | ||||||
rrl | 1475013 | n.1356G>A | non_coding_transcript_exon_variant | 0.38 | capreomycin | |
linezolid | ||||||
rrl | 1475027 | n.1370G>T | non_coding_transcript_exon_variant | 0.36 | capreomycin | |
linezolid | ||||||
rrl | 1475028 | n.1371G>T | non_coding_transcript_exon_variant | 0.36 | capreomycin | |
linezolid | ||||||
rrl | 1475088 | n.1431A>T | non_coding_transcript_exon_variant | 0.28 | capreomycin | |
linezolid | ||||||
rrl | 1475369 | n.1712G>T | non_coding_transcript_exon_variant | 0.19 | capreomycin | |
linezolid | ||||||
rrl | 1475419 | n.1762C>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475429 | n.1772G>A | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1475436 | n.1779C>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475599 | n.1942A>G | non_coding_transcript_exon_variant | 0.2 | capreomycin | |
linezolid | Uncertain significance | |||||
rrl | 1475608 | n.1951T>C | non_coding_transcript_exon_variant | 0.25 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1475619 | n.1962C>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | |
linezolid | ||||||
rrl | 1475638 | n.1981C>T | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475642 | n.1985T>C | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475657 | n.2000A>G | non_coding_transcript_exon_variant | 0.23 | capreomycin | |
linezolid | ||||||
rrl | 1475659 | n.2002G>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | |
linezolid | ||||||
rrl | 1476086 | n.2429G>A | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476214 | n.2557G>T | non_coding_transcript_exon_variant | 0.22 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476215 | n.2558C>T | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476224 | n.2567A>G | non_coding_transcript_exon_variant | 0.24 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476281 | n.2624T>C | non_coding_transcript_exon_variant | 0.17 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476628 | n.2971T>A | non_coding_transcript_exon_variant | 0.27 | capreomycin | Uncertain significance |
linezolid | Uncertain significance | |||||
rrl | 1476689 | n.3032A>T | non_coding_transcript_exon_variant | 0.33 | capreomycin | |
linezolid | ||||||
rrl | 1476690 | n.3033C>T | non_coding_transcript_exon_variant | 0.3 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476693 | n.3036G>A | non_coding_transcript_exon_variant | 0.3 | capreomycin | |
linezolid | ||||||
rrl | 1476695 | n.3038T>A | non_coding_transcript_exon_variant | 0.31 | capreomycin | |
linezolid | ||||||
rrl | 1476716 | n.3059A>C | non_coding_transcript_exon_variant | 0.26 | capreomycin | Uncertain significance |
linezolid | ||||||
rrl | 1476723 | n.3066T>A | non_coding_transcript_exon_variant | 0.29 | capreomycin | |
linezolid | ||||||
rrl | 1476726 | n.3069A>G | non_coding_transcript_exon_variant | 0.25 | capreomycin | |
linezolid | ||||||
inhA | 1674624 | c.423A>T | synonymous_variant | 0.25 | ethionamide | |
isoniazid | ||||||
rpsA | 1833422 | c.-120G>T | upstream_gene_variant | 1.0 | pyrazinamide | |
rpsA | 1833661 | c.120A>G | synonymous_variant | 0.21 | pyrazinamide | |
rpsA | 1833721 | c.180A>G | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833727 | c.186G>C | synonymous_variant | 0.17 | pyrazinamide | |
rpsA | 1833742 | c.201A>G | synonymous_variant | 0.24 | pyrazinamide | |
rpsA | 1833745 | c.204G>C | synonymous_variant | 0.22 | pyrazinamide | |
rpsA | 1833760 | c.219C>T | synonymous_variant | 0.2 | pyrazinamide | Not assoc w R - Interim |
rpsA | 1833771 | p.Asn77Ser | missense_variant | 0.18 | pyrazinamide | |
rpsA | 1833793 | c.252C>T | synonymous_variant | 0.18 | pyrazinamide | |
rpsA | 1833874 | c.333T>C | synonymous_variant | 0.2 | pyrazinamide | |
rpsA | 1834859 | p.Ala440Thr | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
tlyA | 1917972 | c.33A>G | synonymous_variant | 1.0 | capreomycin | Not assoc w R |
bacA | 2062922 | p.Ile603Val | missense_variant | 1.0 | streptomycin | Not assoc w R |
kanamycin | Not assoc w R | |||||
capreomycin | Not assoc w R | |||||
amikacin | Not assoc w R | |||||
ndh | 2102106 | p.Gly313Arg | missense_variant | 1.0 | ethionamide | Uncertain significance |
delamanid | Uncertain significance | |||||
isoniazid | Not assoc w R - Interim | |||||
ndh | 2103173 | c.-132delG | upstream_gene_variant | 1.0 | ethionamide | |
delamanid | ||||||
isoniazid | ||||||
katG | 2154724 | p.Arg463Leu | missense_variant | 1.0 | isoniazid | Not assoc w R |
katG | 2155503 | c.609C>T | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
katG | 2156025 | c.87C>A | synonymous_variant | 1.0 | isoniazid | Not assoc w R |
katG | 2156465 | c.-354C>T | upstream_gene_variant | 1.0 | isoniazid | Not assoc w R - Interim |
PPE35 | 2167926 | p.Leu896Ser | missense_variant | 1.0 | pyrazinamide | Not assoc w R |
PPE35 | 2168011 | p.Ser868Arg | missense_variant | 1.0 | pyrazinamide | Uncertain significance |
PPE35 | 2168814 | c.1798dupA | frameshift_variant | 1.0 | pyrazinamide | Uncertain significance |
Rv1979c | 2222308 | p.Asp286Gly | missense_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
Rv1979c | 2223293 | c.-129A>G | upstream_gene_variant | 1.0 | clofazimine | Not assoc w R |
bedaquiline | Not assoc w R - Interim | |||||
kasA | 2518132 | c.18C>T | synonymous_variant | 1.0 | isoniazid | |
Rv2477c | 2782927 | c.1116A>G | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R - Interim | |||||
streptomycin | Not assoc w R | |||||
levofloxacin | Not assoc w R - Interim | |||||
kanamycin | Not assoc w R - Interim | |||||
rifampicin | Not assoc w R | |||||
amikacin | Not assoc w R - Interim | |||||
Rv2681 | 2997325 | p.Ala196Val | missense_variant | 1.0 | capreomycin | Uncertain significance |
thyX | 3067781 | c.165C>G | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyX | 3067786 | p.Thr54Ala | missense_variant | 0.79 | para-aminosalicylic_acid | |
thyX | 3067799 | c.147G>A | synonymous_variant | 0.2 | para-aminosalicylic_acid | |
thyX | 3067802 | c.144C>G | synonymous_variant | 0.19 | para-aminosalicylic_acid | |
ald | 3086728 | c.-92C>T | upstream_gene_variant | 1.0 | cycloserine | |
ald | 3086788 | c.-32T>C | upstream_gene_variant | 1.0 | cycloserine | |
ald | 3087084 | c.266delA | frameshift_variant | 1.0 | cycloserine | |
fbiD | 3339154 | p.Ile13Leu | missense_variant | 1.0 | clofazimine | Uncertain significance |
pretomanid | ||||||
delamanid | Uncertain significance | |||||
Rv3083 | 3448745 | p.Ile81Ser | missense_variant | 1.0 | ethionamide | Uncertain significance |
Rv3083 | 3448783 | p.Val94Ile | missense_variant | 1.0 | ethionamide | Uncertain significance |
lpqB | 3623442 | p.Ser490Asn | missense_variant | 0.19 | bedaquiline | |
rifampicin | ||||||
lpqB | 3623480 | c.1431C>G | synonymous_variant | 0.19 | bedaquiline | |
rifampicin | ||||||
lpqB | 3623730 | p.Ser394Leu | missense_variant | 0.96 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
lpqB | 3624350 | c.561G>T | synonymous_variant | 0.96 | bedaquiline | Not assoc w R - Interim |
rifampicin | Not assoc w R | |||||
lpqB | 3624486 | p.Asp142Gly | missense_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
lpqB | 3624593 | c.318G>A | synonymous_variant | 0.94 | bedaquiline | Not assoc w R - Interim |
rifampicin | Not assoc w R | |||||
lpqB | 3624710 | c.201G>A | synonymous_variant | 0.92 | bedaquiline | Not assoc w R - Interim |
rifampicin | Not assoc w R | |||||
mtrB | 3625065 | p.Met517Leu | missense_variant | 1.0 | bedaquiline | Uncertain significance |
rifampicin | Not assoc w R | |||||
lpqB | 3625621 | c.-711G>C | upstream_gene_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627263 | c.-650C>T | upstream_gene_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627266 | c.-653A>G | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627272 | c.-659G>T | upstream_gene_variant | 0.19 | bedaquiline | |
rifampicin | ||||||
mtrA | 3627277 | c.73C>T | synonymous_variant | 0.18 | bedaquiline | |
rifampicin | Not assoc w R - Interim | |||||
mtrB | 3627296 | c.-683T>C | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627301 | c.-688T>C | upstream_gene_variant | 0.21 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627314 | c.-701C>T | upstream_gene_variant | 0.22 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627317 | c.-704T>C | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
mtrB | 3627323 | c.-710G>A | upstream_gene_variant | 0.2 | bedaquiline | |
rifampicin | ||||||
rpoA | 3877587 | c.921A>G | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
rpoA | 3877613 | p.Ile299Val | missense_variant | 0.21 | rifampicin | |
rpoA | 3878169 | c.339G>C | synonymous_variant | 0.19 | rifampicin | Not assoc w R - Interim |
clpC1 | 4038403 | c.2302T>C | synonymous_variant | 1.0 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4038749 | c.1956C>A | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038755 | c.1950G>C | synonymous_variant | 0.17 | pyrazinamide | |
clpC1 | 4038764 | c.1941C>G | synonymous_variant | 0.18 | pyrazinamide | |
clpC1 | 4038773 | c.1932T>C | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4038782 | c.1923G>C | synonymous_variant | 0.14 | pyrazinamide | |
clpC1 | 4038790 | c.1915C>T | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039280 | c.1425G>A | synonymous_variant | 0.16 | pyrazinamide | |
clpC1 | 4039286 | c.1419T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039292 | c.1413C>T | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039298 | c.1407T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039319 | c.1386T>C | synonymous_variant | 0.17 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039322 | c.1383T>A | synonymous_variant | 0.19 | pyrazinamide | |
clpC1 | 4039454 | c.1251A>G | synonymous_variant | 0.22 | pyrazinamide | Not assoc w R - Interim |
clpC1 | 4039466 | c.1239T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039469 | c.1236T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039481 | c.1224T>C | synonymous_variant | 0.22 | pyrazinamide | |
clpC1 | 4039484 | c.1221T>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039487 | c.1218G>C | synonymous_variant | 0.21 | pyrazinamide | |
clpC1 | 4039517 | c.1188C>G | synonymous_variant | 0.15 | pyrazinamide | |
clpC1 | 4039610 | c.1095G>C | synonymous_variant | 0.2 | pyrazinamide | |
clpC1 | 4039616 | c.1089G>C | synonymous_variant | 0.21 | pyrazinamide | |
glpK | 4138377 | p.Val460Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
moxifloxacin | Not assoc w R | |||||
streptomycin | Not assoc w R | |||||
levofloxacin | Not assoc w R | |||||
rifampicin | Not assoc w R | |||||
isoniazid | Not assoc w R | |||||
embC | 4240671 | p.Thr270Ile | missense_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242643 | c.2781C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embC | 4242970 | c.3108C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embA | 4244220 | c.988C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4246864 | c.351C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
embB | 4247173 | c.660G>A | synonymous_variant | 1.0 | ethambutol | Not assoc w R - Interim |
embB | 4247646 | p.Glu378Ala | missense_variant | 1.0 | ethambutol | Not assoc w R |
aftB | 4267858 | p.Ile327Val | missense_variant | 1.0 | ethambutol | Not assoc w R |
ubiA | 4269351 | c.483C>T | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
ubiA | 4269387 | p.Glu149Asp | missense_variant | 1.0 | ethambutol | Not assoc w R |
ubiA | 4269606 | c.228T>C | synonymous_variant | 1.0 | ethambutol | Not assoc w R |
whiB6 | 4338595 | c.-75delG | upstream_gene_variant | 1.0 | capreomycin | Not assoc w R |
amikacin | Not assoc w R | |||||
kanamycin | Not assoc w R | |||||
whiB6 | 4338732 | c.-211C>T | upstream_gene_variant | 1.0 | capreomycin | |
amikacin | ||||||
kanamycin | ||||||
gid | 4407588 | c.615A>G | synonymous_variant | 1.0 | streptomycin | Not assoc w R |