TB-Profiler

Lineage	Family	RDs	Frequency
lineage4	Euro-American	None	1.0
lineage4.9	Euro-American (H37Rv-like)	None	1.0

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence	Comment
rrs	1472733	n.888G>A	non_coding_transcript_exon_variant	0.28	streptomycin	Uncertain significance	Mutation from literature

Non-Associated Mutations: This table reports mutations found in candidate resistance genes which have not been associated with drug resistance

Gene	Chromosome position	Mutation	Type	Estimated fraction	Drugs	Confidence
rpoC	764620	c.1251G>C	synonymous_variant	0.5	rifampicin
rpoC	764626	c.1257C>T	synonymous_variant	0.46	rifampicin	Not assoc w R - Interim
rpoC	764632	c.1263T>C	synonymous_variant	0.57	rifampicin	Not assoc w R - Interim
rpoC	764635	c.1266C>G	synonymous_variant	0.64	rifampicin
rpoC	764644	c.1275G>T	synonymous_variant	0.67	rifampicin	Not assoc w R - Interim
rpoC	764650	c.1281G>T	synonymous_variant	1.0	rifampicin	Not assoc w R - Interim
rpoC	764667	p.Gly433Asp	missense_variant	1.0	rifampicin	Uncertain significance
rpoC	764674	c.1305G>A	synonymous_variant	1.0	rifampicin
rrs	1472094	n.249T>A	non_coding_transcript_exon_variant	0.75	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472106	n.261G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472108	n.263C>A	non_coding_transcript_exon_variant	0.52	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1472113	n.268T>C	non_coding_transcript_exon_variant	0.52	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472127	n.282C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472128	n.283G>C	non_coding_transcript_exon_variant	0.59	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472129	n.284G>C	non_coding_transcript_exon_variant	0.93	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472137	n.292G>A	non_coding_transcript_exon_variant	0.44	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472150	n.305T>A	non_coding_transcript_exon_variant	0.47	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472150	n.305T>G	non_coding_transcript_exon_variant	0.53	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472151	n.306C>A	non_coding_transcript_exon_variant	0.64	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472160	n.315C>T	non_coding_transcript_exon_variant	0.8	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472172	n.327T>C	non_coding_transcript_exon_variant	0.88	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472210	n.365A>C	non_coding_transcript_exon_variant	0.55	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472215	n.370A>G	non_coding_transcript_exon_variant	0.69	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472223	n.378C>G	non_coding_transcript_exon_variant	0.26	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472225	n.380C>A	non_coding_transcript_exon_variant	0.89	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472228	n.383G>C	non_coding_transcript_exon_variant	0.27	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472234	n.389T>C	non_coding_transcript_exon_variant	0.7	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472251	n.406G>C	non_coding_transcript_exon_variant	0.97	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472279	n.434T>G	non_coding_transcript_exon_variant	0.75	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472517	n.672T>C	non_coding_transcript_exon_variant	0.93	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472530	n.685G>A	non_coding_transcript_exon_variant	0.34	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472537	n.692C>T	non_coding_transcript_exon_variant	0.41	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472544	n.699C>T	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472545	n.700A>G	non_coding_transcript_exon_variant	0.53	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472549	n.704G>A	non_coding_transcript_exon_variant	0.5	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472557	n.712G>A	non_coding_transcript_exon_variant	0.46	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472571	n.726G>C	non_coding_transcript_exon_variant	0.99	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472572	n.727T>C	non_coding_transcript_exon_variant	0.5	kanamycin	Uncertain significance
					capreomycin
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472573	n.728C>T	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472579	n.734G>A	non_coding_transcript_exon_variant	0.48	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>C	non_coding_transcript_exon_variant	0.47	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472581	n.736A>T	non_coding_transcript_exon_variant	0.43	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472582	n.737G>A	non_coding_transcript_exon_variant	0.47	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472584	n.739A>C	non_coding_transcript_exon_variant	0.47	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472598	n.753A>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472599	n.754G>T	non_coding_transcript_exon_variant	0.35	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472607	n.762G>T	non_coding_transcript_exon_variant	0.4	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472608	n.763T>A	non_coding_transcript_exon_variant	0.37	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472616	n.771G>A	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472697	n.852T>C	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472713	n.868T>C	non_coding_transcript_exon_variant	0.6	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472714	n.869A>G	non_coding_transcript_exon_variant	0.34	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472715	n.870C>T	non_coding_transcript_exon_variant	0.66	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472716	n.871C>T	non_coding_transcript_exon_variant	0.49	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472719	n.874G>A	non_coding_transcript_exon_variant	0.32	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1472734	n.889C>T	non_coding_transcript_exon_variant	0.4	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472741	n.896G>A	non_coding_transcript_exon_variant	0.31	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472742	n.897C>T	non_coding_transcript_exon_variant	0.46	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472744	n.899A>G	non_coding_transcript_exon_variant	0.65	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472779	n.934G>A	non_coding_transcript_exon_variant	0.42	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1472781	n.936C>T	non_coding_transcript_exon_variant	0.61	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472793	n.948A>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472803	n.958T>A	non_coding_transcript_exon_variant	0.76	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472824	n.979T>A	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1472828	n.983T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473056	n.1211A>T	non_coding_transcript_exon_variant	0.73	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473068	n.1223A>G	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473148	n.1303G>A	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473150	n.1305T>G	non_coding_transcript_exon_variant	0.31	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473158	n.1313T>C	non_coding_transcript_exon_variant	0.98	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473161	n.1316A>C	non_coding_transcript_exon_variant	0.32	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473163	n.1318C>T	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473172	n.1327T>C	non_coding_transcript_exon_variant	0.63	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473173	n.1328C>T	non_coding_transcript_exon_variant	0.63	kanamycin	Uncertain significance
					capreomycin	Not assoc w R
					streptomycin	Not assoc w R
					amikacin	Not assoc w R
rrs	1473177	n.1332G>T	non_coding_transcript_exon_variant	0.67	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473179	n.1334C>T	non_coding_transcript_exon_variant	0.31	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473192	n.1347A>G	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Not assoc w R
rrs	1473193	n.1348G>C	non_coding_transcript_exon_variant	0.54	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473199	n.1356delA	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473204	n.1359C>G	non_coding_transcript_exon_variant	0.54	kanamycin
					capreomycin
					streptomycin
					amikacin
rrs	1473205	n.1360T>C	non_coding_transcript_exon_variant	0.96	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473215	n.1370A>G	non_coding_transcript_exon_variant	0.27	kanamycin
					capreomycin
					streptomycin	Uncertain significance
					amikacin
rrs	1473248	n.1403G>A	non_coding_transcript_exon_variant	0.86	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473249	n.1404T>C	non_coding_transcript_exon_variant	1.0	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrs	1473255	n.1410A>G	non_coding_transcript_exon_variant	0.92	kanamycin	Uncertain significance
					capreomycin	Uncertain significance
					streptomycin	Uncertain significance
					amikacin	Uncertain significance
rrl	1474171	n.514C>G	non_coding_transcript_exon_variant	0.67	capreomycin
rrl	1474171	n.514C>G	non_coding_transcript_exon_variant	0.67	linezolid
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.41	capreomycin	Uncertain significance
rrl	1474184	n.527C>T	non_coding_transcript_exon_variant	0.41	linezolid	Uncertain significance
rrl	1474185	n.528G>A	non_coding_transcript_exon_variant	0.88	capreomycin	Uncertain significance
rrl	1474185	n.528G>A	non_coding_transcript_exon_variant	0.88	linezolid
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.82	capreomycin	Uncertain significance
rrl	1474186	n.529A>G	non_coding_transcript_exon_variant	0.82	linezolid	Uncertain significance
rrl	1474208	n.551C>T	non_coding_transcript_exon_variant	0.78	capreomycin
rrl	1474208	n.551C>T	non_coding_transcript_exon_variant	0.78	linezolid
rrl	1474213	n.556G>A	non_coding_transcript_exon_variant	0.74	capreomycin
rrl	1474213	n.556G>A	non_coding_transcript_exon_variant	0.74	linezolid
rrl	1474218	n.561T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474218	n.561T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474252	n.595T>A	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1474252	n.595T>A	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1474263	n.606G>C	non_coding_transcript_exon_variant	0.9	capreomycin
rrl	1474263	n.606G>C	non_coding_transcript_exon_variant	0.9	linezolid
rrl	1474472	n.815T>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474472	n.815T>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474476	n.819C>T	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474476	n.819C>T	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474483	n.826C>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474483	n.826C>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474488	n.831G>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474488	n.831G>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474496	n.839C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474496	n.839C>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474507	n.850G>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474507	n.850G>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474516	n.859C>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474516	n.859C>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474537	n.880G>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474551	n.894G>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474551	n.894G>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474558	n.901G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474582	n.925T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474582	n.925T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474584	n.927C>G	non_coding_transcript_exon_variant	0.9	capreomycin	Uncertain significance
rrl	1474584	n.927C>G	non_coding_transcript_exon_variant	0.9	linezolid	Uncertain significance
rrl	1474777	n.1120T>C	non_coding_transcript_exon_variant	0.81	capreomycin	Not assoc w R
rrl	1474777	n.1120T>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1474782	n.1125G>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474782	n.1125G>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474797	n.1140_1141insTT	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474797	n.1140_1141insTT	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1474802	n.1146_1147delGC	non_coding_transcript_exon_variant	0.71	capreomycin
rrl	1474802	n.1146_1147delGC	non_coding_transcript_exon_variant	0.71	linezolid
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.58	capreomycin	Uncertain significance
rrl	1474812	n.1155G>A	non_coding_transcript_exon_variant	0.58	linezolid	Uncertain significance
rrl	1474812	n.1155G>C	non_coding_transcript_exon_variant	0.42	capreomycin
rrl	1474812	n.1155G>C	non_coding_transcript_exon_variant	0.42	linezolid
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.59	capreomycin	Uncertain significance
rrl	1474823	n.1166C>G	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1474824	n.1167A>G	non_coding_transcript_exon_variant	0.41	capreomycin	Uncertain significance
rrl	1474824	n.1167A>G	non_coding_transcript_exon_variant	0.41	linezolid	Uncertain significance
rrl	1474825	n.1168G>T	non_coding_transcript_exon_variant	0.41	capreomycin
rrl	1474825	n.1168G>T	non_coding_transcript_exon_variant	0.41	linezolid
rrl	1474826	n.1169T>A	non_coding_transcript_exon_variant	0.41	capreomycin
rrl	1474826	n.1169T>A	non_coding_transcript_exon_variant	0.41	linezolid
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1474827	n.1170C>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1474830	n.1173A>C	non_coding_transcript_exon_variant	0.47	capreomycin
rrl	1474830	n.1173A>C	non_coding_transcript_exon_variant	0.47	linezolid
rrl	1474831	n.1174A>C	non_coding_transcript_exon_variant	0.45	capreomycin	Uncertain significance
rrl	1474831	n.1174A>C	non_coding_transcript_exon_variant	0.45	linezolid	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.52	capreomycin	Uncertain significance
rrl	1474831	n.1174A>T	non_coding_transcript_exon_variant	0.52	linezolid	Uncertain significance
rrl	1474839	n.1182C>T	non_coding_transcript_exon_variant	0.64	capreomycin	Uncertain significance
rrl	1474839	n.1182C>T	non_coding_transcript_exon_variant	0.64	linezolid	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	0.54	capreomycin	Uncertain significance
rrl	1474844	n.1187G>T	non_coding_transcript_exon_variant	0.54	linezolid	Uncertain significance
rrl	1474864	n.1207_1212delCCCTTGinsTCCTTT	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1474864	n.1207_1212delCCCTTGinsTCCTTT	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475498	n.1841C>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475498	n.1841C>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475516	n.1859T>G	non_coding_transcript_exon_variant	0.89	capreomycin
rrl	1475516	n.1859T>G	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1475517	n.1860C>T	non_coding_transcript_exon_variant	0.89	capreomycin
rrl	1475517	n.1860C>T	non_coding_transcript_exon_variant	0.89	linezolid
rrl	1475518	n.1861A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475518	n.1861A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475525	n.1868G>A	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475525	n.1868G>A	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475538	n.1881T>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475538	n.1881T>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475539	n.1882A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475539	n.1882A>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475542	n.1885A>G	non_coding_transcript_exon_variant	0.94	capreomycin	Uncertain significance
rrl	1475542	n.1885A>G	non_coding_transcript_exon_variant	0.94	linezolid	Uncertain significance
rrl	1475544	n.1887A>T	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475544	n.1887A>T	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475545	n.1888T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475545	n.1888T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475549	n.1892T>C	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475549	n.1892T>C	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475574	n.1917C>G	non_coding_transcript_exon_variant	1.0	capreomycin
rrl	1475574	n.1917C>G	non_coding_transcript_exon_variant	1.0	linezolid
rrl	1475783	n.2126T>G	non_coding_transcript_exon_variant	0.45	capreomycin	Uncertain significance
rrl	1475783	n.2126T>G	non_coding_transcript_exon_variant	0.45	linezolid	Uncertain significance
rrl	1475791	n.2134A>G	non_coding_transcript_exon_variant	0.27	capreomycin	Uncertain significance
rrl	1475791	n.2134A>G	non_coding_transcript_exon_variant	0.27	linezolid	Uncertain significance
rrl	1475803	n.2146T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475803	n.2146T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475804	n.2147G>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475804	n.2147G>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475816	n.2159C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475816	n.2159C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475817	n.2160A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1475817	n.2160A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1475858	n.2201T>C	non_coding_transcript_exon_variant	0.78	capreomycin	Uncertain significance
rrl	1475858	n.2201T>C	non_coding_transcript_exon_variant	0.78	linezolid	Uncertain significance
rrl	1475874	n.2217C>T	non_coding_transcript_exon_variant	0.58	capreomycin
rrl	1475874	n.2217C>T	non_coding_transcript_exon_variant	0.58	linezolid
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476260	n.2603A>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476280	n.2623A>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476280	n.2623A>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476294	n.2637A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476295	n.2638C>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.57	capreomycin	Uncertain significance
rrl	1476296	n.2639C>T	non_coding_transcript_exon_variant	0.57	linezolid	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.57	capreomycin	Uncertain significance
rrl	1476297	n.2640C>A	non_coding_transcript_exon_variant	0.57	linezolid	Uncertain significance
rrl	1476299	n.2642C>A	non_coding_transcript_exon_variant	0.41	capreomycin
rrl	1476299	n.2642C>A	non_coding_transcript_exon_variant	0.41	linezolid
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.55	capreomycin	Uncertain significance
rrl	1476302	n.2645G>A	non_coding_transcript_exon_variant	0.55	linezolid	Uncertain significance
rrl	1476308	n.2651G>T	non_coding_transcript_exon_variant	0.38	capreomycin
rrl	1476308	n.2651G>T	non_coding_transcript_exon_variant	0.38	linezolid
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476311	n.2654G>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476312	n.2655T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476322	n.2665C>A	non_coding_transcript_exon_variant	0.31	capreomycin
rrl	1476322	n.2665C>A	non_coding_transcript_exon_variant	0.31	linezolid
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.43	capreomycin	Uncertain significance
rrl	1476332	n.2675G>C	non_coding_transcript_exon_variant	0.43	linezolid	Uncertain significance
rrl	1476336	n.2679C>T	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1476336	n.2679C>T	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1476357	n.2700T>C	non_coding_transcript_exon_variant	0.41	capreomycin
rrl	1476357	n.2700T>C	non_coding_transcript_exon_variant	0.41	linezolid
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.75	capreomycin	Uncertain significance
rrl	1476358	n.2701T>C	non_coding_transcript_exon_variant	0.75	linezolid	Uncertain significance
rrl	1476359	n.2702C>T	non_coding_transcript_exon_variant	0.49	capreomycin
rrl	1476359	n.2702C>T	non_coding_transcript_exon_variant	0.49	linezolid
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.34	capreomycin	Uncertain significance
rrl	1476368	n.2711T>C	non_coding_transcript_exon_variant	0.34	linezolid
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.67	capreomycin	Uncertain significance
rrl	1476369	n.2712C>T	non_coding_transcript_exon_variant	0.67	linezolid	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.63	capreomycin	Uncertain significance
rrl	1476372	n.2715T>C	non_coding_transcript_exon_variant	0.63	linezolid	Uncertain significance
rrl	1476381	n.2724G>A	non_coding_transcript_exon_variant	0.51	capreomycin
rrl	1476381	n.2724G>A	non_coding_transcript_exon_variant	0.51	linezolid
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.76	capreomycin	Uncertain significance
rrl	1476382	n.2725A>G	non_coding_transcript_exon_variant	0.76	linezolid	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.46	capreomycin	Uncertain significance
rrl	1476383	n.2726T>A	non_coding_transcript_exon_variant	0.46	linezolid	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.51	capreomycin	Uncertain significance
rrl	1476408	n.2751G>A	non_coding_transcript_exon_variant	0.51	linezolid	Uncertain significance
rrl	1476411	n.2754G>A	non_coding_transcript_exon_variant	0.38	capreomycin
rrl	1476411	n.2754G>A	non_coding_transcript_exon_variant	0.38	linezolid
rrl	1476417	n.2760T>C	non_coding_transcript_exon_variant	0.33	capreomycin	Uncertain significance
rrl	1476417	n.2760T>C	non_coding_transcript_exon_variant	0.33	linezolid
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.32	capreomycin	Uncertain significance
rrl	1476425	n.2768G>T	non_coding_transcript_exon_variant	0.32	linezolid	Uncertain significance
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.47	capreomycin	Not assoc w R
rrl	1476428	n.2771C>T	non_coding_transcript_exon_variant	0.47	linezolid	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.25	capreomycin	Uncertain significance
rrl	1476429	n.2772A>C	non_coding_transcript_exon_variant	0.25	linezolid	Uncertain significance
rrl	1476443	n.2786G>A	non_coding_transcript_exon_variant	0.4	capreomycin
rrl	1476443	n.2786G>A	non_coding_transcript_exon_variant	0.4	linezolid
rrl	1476455	n.2798C>T	non_coding_transcript_exon_variant	0.42	capreomycin
rrl	1476455	n.2798C>T	non_coding_transcript_exon_variant	0.42	linezolid
rrl	1476463	n.2806C>T	non_coding_transcript_exon_variant	0.34	capreomycin
rrl	1476463	n.2806C>T	non_coding_transcript_exon_variant	0.34	linezolid
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.59	capreomycin	Not assoc w R
rrl	1476466	n.2809C>T	non_coding_transcript_exon_variant	0.59	linezolid	Uncertain significance
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	1.0	capreomycin	Not assoc w R
rrl	1476481	n.2824T>C	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.81	capreomycin	Not assoc w R
rrl	1476506	n.2849T>C	non_coding_transcript_exon_variant	0.81	linezolid	Uncertain significance
rrl	1476513	n.2856G>T	non_coding_transcript_exon_variant	0.59	capreomycin
rrl	1476513	n.2856G>T	non_coding_transcript_exon_variant	0.59	linezolid
rrl	1476517	n.2860C>T	non_coding_transcript_exon_variant	0.86	capreomycin	Uncertain significance
rrl	1476517	n.2860C>T	non_coding_transcript_exon_variant	0.86	linezolid
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476519	n.2862C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476524	n.2867C>A	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476528	n.2871A>G	non_coding_transcript_exon_variant	0.85	capreomycin	Uncertain significance
rrl	1476528	n.2871A>G	non_coding_transcript_exon_variant	0.85	linezolid
rrl	1476530	n.2873C>G	non_coding_transcript_exon_variant	0.91	capreomycin
rrl	1476530	n.2873C>G	non_coding_transcript_exon_variant	0.91	linezolid
rrl	1476537	n.2880A>G	non_coding_transcript_exon_variant	0.96	capreomycin	Uncertain significance
rrl	1476537	n.2880A>G	non_coding_transcript_exon_variant	0.96	linezolid	Uncertain significance
rrl	1476539	n.2882A>G	non_coding_transcript_exon_variant	0.77	capreomycin	Uncertain significance
rrl	1476539	n.2882A>G	non_coding_transcript_exon_variant	0.77	linezolid	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	1.0	capreomycin	Uncertain significance
rrl	1476540	n.2883C>G	non_coding_transcript_exon_variant	1.0	linezolid	Uncertain significance
rrl	1476544	n.2887T>C	non_coding_transcript_exon_variant	0.77	capreomycin	Uncertain significance
rrl	1476544	n.2887T>C	non_coding_transcript_exon_variant	0.77	linezolid

Drug	Resistance	Supporting mutations	WHO confidence	Comment
rifampicin
isoniazid
ethambutol
pyrazinamide
streptomycin	rrs	n.888G>A	Uncertain significance	Mutation from literature
fluoroquinolones
moxifloxacin
ofloxacin
levofloxacin
ciprofloxacin
aminoglycosides
amikacin
capreomycin
kanamycin
cycloserine
ethionamide
clofazimine
para-aminosalicylic_acid
delamanid
bedaquiline
linezolid

TB-Profiler result